Releasing the brake on puberty

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction

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Puberty : ontogeny, neuroendocrinology, physiology, and disorders

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Central Precocious Puberty Caused by Mutations in the Imprinted Gene <i>MKRN3</i>

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Inactivating<i>KISS1</i>Mutation and Hypogonadotropic Hypogonadism

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Evolution, development and timing of puberty

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Obesity and Growth during Childhood and Puberty

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The GnRH pulse generator

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The Ancient Source of a Distinct Gene Family Encoding Proteins Featuring RING and C3H Zinc-Finger Motifs with Abundant Expression in Developing Brain and Nervous System

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Kisspeptin neurons from mice to men: similarities and differences

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Kisspeptin and the Hypothalamic Control of Reproduction: Lessons from the Human

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Evolutionary biology within medicine: a perspective of growing value

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Pubertal development and regulation

Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611 · see citing works

A new pathway in the control of the initiation of puberty: the MKRN3 gene

Abreu, A. P., Macedo, D. B., Brito, V. N., Kaiser, U. B., & Latronico, A. C. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0315 · Cited by 126 · see citing works

Nutritional Determinants of the Timing of Puberty

Villamor, E., & Jansen, E. C. (2015) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031914-122606 · Cited by 115 · see citing works

MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

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Molecular insights into the aetiology of female reproductive ageing

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New Causes of Central Precocious Puberty: The Role of Genetic Factors

Macedo, D. B., Brito, V. N., & Latronico, A. C. (2014) · Neuroendocrinology · doi:10.1159/000366282 · Cited by 78 · see citing works

Physiology and Disorders of Puberty

Styne, D. M., & Grumbach, M. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00025-3 · Cited by 55 · see citing works

Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation

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Sexual Precocity - Genetic Bases of Central Precocious Puberty and Autonomous Gonadal Activation

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In silico analysis of a novel MKRN 3 missense mutation in familial central precocious puberty

Neocleous, V., Shammas, C., Phelan, M. M., Nicolaou, S., Phylactou, L. A., & Skordis, N. (2015) · Clinical Endocrinology · doi:10.1111/cen.12854 · Cited by 36 · see citing works

Two Frameshift Mutations in MKRN3 in Turkish Patients with Familial Central Precocious Puberty

Şimşek, E., Demiral, M., Ceylaner, S., & Kırel, B. (2016) · Hormone Research in Paediatrics · doi:10.1159/000450923 · Cited by 25 · see citing works

Males with Paternally Inherited MKRN3 Mutations May Be Asymptomatic

Dimitrova-Mladenova, M., Stefanova, E. M., Glushkova, M., Тодорова, А., Todorov, T., Konstantinova, M. M., Kazakova, K., & Tincheva, R. S. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.08.065 · Cited by 24 · see citing works

Genetic screening of the makorin ring finger 3 gene in girls with idiopathic central precocious puberty

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Novel MKRN3 Missense Mutations Associated With Central Precocious Puberty Reveal Distinct Effects on Ubiquitination

Magnotto, J. C., Mancini, A., Bird, K., Montenegro, L. R., Tütüncüler, F., Pereira, S. A., Simas, V., Garcia, L., Roberts, S. A., Macedo, D. B., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad151 · Cited by 17 · see citing works

Absence of GPR54 and TACR3 Mutations in Sporadic Cases of Idiopathic Central Precocious Puberty

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The Key Roles of Makorin RING Finger Protein 3 (MKRN3) During the Development of Pubertal Initiation and Central Precocious Puberty (CPP)

Liu, J., Li, T., Peng, M., Luo, M., Gui, Z., Long, S.-L., Mo, Z., & He, W. (2022) · Current Molecular Medicine · doi:10.2174/1566524022666220624105430 · Cited by 12 · see citing works

Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls

Jeong, H. R., Lee, H. J., Shim, Y. S., Kang, M. J., Yang, S., & Hwang, I. T. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2019.1576615 · Cited by 12 · see citing works

MKRN3 circulating levels in girls with central precocious puberty caused by MKRN3 gene mutations

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Adult height in girls with idiopathic central precocious puberty treated with triptorelin

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Clinical Implications of Minipuberty

Juul, A. (2026) · New England Journal of Medicine · doi:10.1056/nejmra2305989 · Cited by 7 · see citing works

Identification of differentially expressed genes associated with precocious puberty by suppression subtractive hybridization in goat pituitary tissues

Liu, Y., Cao, G., Xie, Y., & Chu, M. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1990940 · Cited by 5 · see citing works

Continuation of gradual weight gain necessary for the onset of puberty may be responsible for obesity later in life.

Lehrer, S. P. (2015) · PubMed · Cited by 3 · see citing works

A Study of the Impact of Environmental Chemicals and Micronutrients on Pubertal Development in A Mexican Population

Liu, Y. (2017) · Deep Blue (University of Michigan) · Cited by 3 · see citing works

Endocrine Metabolism V

Bhagavan, N. V., & Ha, C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-416687-5.00032-4 · Cited by 2 · see citing works

A novel model of central precocious puberty disease: Paternal MKRN3 gene–modified rabbit

Chen, B., Ye, X., Chen, L., Liu, T., Li, G., Sa, C., Li, J., Liu, K., Gu, W., & Wang, G. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12544 · Cited by 1 · see citing works

Puberty

Styne, D. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-56963-7.00003-x · Cited by 1 · see citing works

Identification of Differentially Expressed Genes Associated With Precocious Puberty by Suppression Subtractive Hybridization in Goat Pituitary TissuesPreprint

Liu, Y., Cao, G., Xie, Y., & Chu, M. (2020) · Research Square · doi:10.21203/rs.3.rs-113865/v1 · Cited by 1 · see citing works

Puberty 1 Pubertal development and regulation

Abreu, A. P., & Kaiser, U. B. (2016)

Pubertal Timing, Smoking, and Sexual Activity

Lo, F. (2017) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2017.05.002

The Evolution of the Age at Menarche from Prehistorical to Modern Times

Papadimitriou, A. (2015) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2015.12.002 · Cited by 119 · see citing works

DEBATE Open Access Determinants of menarche

Karapanou, O., & Papadimitriou, A. (2013)

Changing times: The evolution of puberty

Gluckman, P. D., & Hanson, M. A. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.005 · Cited by 94 · see citing works

Commentary: The decreasing age of puberty—as much a psychosocial as biological problem?

Pierce, M. B., & Hardy, R. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr227 · Cited by 17 · see citing works

The Decline in the Age of Onset of Puberty – A Source of Concern

Mangla, M. (2023) · Current Women s Health Reviews · doi:10.2174/1573404820666230505105815