Monoclonal Antibodies to Disrupt Progression of Early Covid-19 Infection
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By the end of 2020, more than 19 million Americans had received the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.1 Although a substantial proportion of these ...
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Early results suggest monoclonal antibody cocktails may be useful in prophylaxis or early disease but less effective in treating critically ill patients when inflammation dominates.
“Early results suggest that monoclonal antibody cocktails may be useful in prophylaxis or early disease but are less effective in treating patients who are critically ill when inflammation dominates the clinical picture41.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [41]
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REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
Weinreich, D. M., Sivapalasingam, S., Norton, T., Ali, S., Gao, H., Bhore, R., Musser, B. J., Soo, Y., Rofail, D., Im, J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035002 · Cited by 1,642 · see citing works
Çevik, M., Tate, M., Lloyd, O., Maraolo, A. E., Schafers, J., & Ho, A. Y. W. (2020) · The Lancet Microbe · doi:10.1016/s2666-5247(20)30172-5 · Cited by 1,334 · see citing works
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
Chen, P., Nirula, A., Heller, B., Gottlieb, R. L., Boscia, J., Morris, J., Huhn, G., Cardona, J., Mocherla, B., Stosor, V., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2029849 · Cited by 1,282 · see citing works
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
Hansen, J., Baum, A., Pascal, K. E., Russo, V., Giordano, S., Wloga, E., Fulton, B. O., Yan, Y., Koon, K., Patel, K., et al. (2020) · Science · doi:10.1126/science.abd0827 · Cited by 1,210 · see citing works
Dong, E., Ratcliff, J. D., Goyea, T. D., Katz, A., Lau, R., Ng, T. K., Garcia, B., Bolt, E., Prata, S., Zhang, D., et al. (2022) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(22)00434-0 · Cited by 286 · see citing works
Monoclonal Antibodies for Prevention and Treatment of COVID-19
Marovich, M., Mascola, J. R., & Cohen, M. S. (2020) · JAMA · doi:10.1001/jama.2020.10245 · Cited by 272 · see citing works
Self-citationFruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
Renn, A., Fu, Y., Hu, X., Hall, M. D., & Simeonov, A. M. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.07.004 · Cited by 115 · see citing works
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Research works printed but not linked: 1
- [5]Jones BE, Brown-Augsburger PL, Corbett KS, et al. LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection. October 1, 2020 (https://www.biorxiv.org/content/10.1101/2020.09.30.318972v1). preprint. · DOI
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Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection
Cromer, D., Juno, J. A., Khoury, D., Reynaldi, A., Wheatley, A. K., Kent, S. J., & Davenport, M. P. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00550-x · Cited by 265 · see citing works
- Authors
- Cohen, M. S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Cohen, Myron S.
- ORCID
- Cohen, Myron S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-01-21
- Volume
- 384
- Issue
- 3
- Pages
- 289-291
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7844860
- OpenAlex
- W3124782715
- Cited by
- 80
- References
- 8
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 11 · 2022: 22 · 2021: 43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- monoclonal antibodies, COVID-19 pandemic, SARS-CoV-2, early infection, disease progression, neutralizing antibodies
- MeSH terms
- COVID-19, SARS-CoV-2, Antibodies, Monoclonal, Antibodies, Viral, Humans, Outpatients, Antibodies, Neutralizing
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