The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Pregnancy-Associated Plasma Protein A as a Marker of Acute Coronary Syndromes
Open accessAbstract
BACKGROUND: Circulating markers indicating the instability of atherosclerotic plaques could have diagnostic value in unstable angina or acute myocardial infarction. We evaluated pregnancy-associated plasma protein A (PAPP-A), a potentially proatherosclerotic metalloproteinase, as a marker of acute coronary syndromes. METHODS: We examined the level of expression of PAPP-A in eight culprit unstable coronary plaques and four stable plaques from eight patients who had died suddenly of cardiac causes. We also measured circulating levels of PAPP-A, C-reactive protein, and insulin-like growth factor I (IGF-I) in 17 patients with acute myocardial infarction, 20 with unstable angina, 19 with stable angina, and 13 controls without atherosclerosis. RESULTS: PAPP-A was abundantly expressed in plaque cells and extracellular matrix of ruptured and eroded unstable plaques, but not in stable plaques. Circulating PAPP-A levels were significantly higher in patients with unstable angina or acute myocardial infarction than in patients with stable angina and controls (P<0.001). A PAPP-A threshold value of 10 mlU per liter identified patients who had acute coronary syndromes with a sensitivity of 89.2 percent and a specificity of 81.3 percent. PAPP-A levels correlated with levels of C-reactive protein and free IGF-I, but not with markers of myocardial injury (troponin I and the MB isoform of creatine kinase). CONCLUSIONS: PAPP-A is present in unstable plaques, and circulating levels are elevated in acute coronary syndromes; these increased levels may reflect the instability of atherosclerotic plaques. PAPP-A is a new candidate marker of unstable angina and acute myocardial infarction.
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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
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The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
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Antman, E. M., Tanasijevic, M. J., Thompson, B., Schactman, M., McCabe, C. H., Cannon, C. P., Fischer, G. A., Fung, A. Y., Thompson, C., Wybenga, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351802 · Cited by 1,749
Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
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Self-citationCardiac Troponin T Levels for Risk Stratification in Acute Myocardial Ischemia
Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., O’Hanesian, M. A., Wagner, G. S., Kleiman, N. S., Harrell, F. E., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351801 · Cited by 1,114
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Cited by
Role of Inflammation in Atherosclerosis
Spagnoli, L. G., Bonanno, E., Sangiorgi, G., & Mauriello, A. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.038661 · Cited by 293
Mauriello, A., Sangiorgi, G., Fratoni, S., Palmieri, G., Bonanno, E., Anemona, L., Schwartz, R. S., & Spagnoli, L. G. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.054 · Cited by 238
Self-citationDe Caterina, R., & Massaro, M. (2005) · Journal of Membrane Biology · doi:10.1007/s00232-005-0783-2 · Cited by 130
Metadata
- Authors
- Bayes-Genis, A., Conover, C. A., Overgaard, M. T., Bailey, K. R., Christiansen, M., Holmes, D. R., Virmani, R., Oxvig, C., & Schwartz, R. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-10-04
- Volume
- 345
- Issue
- 14
- Pages
- 1022-1029
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2048659949
- Cited by
- 561
- References
- 29
- FWCI
- 21.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bayes-Genis, A., Conover, C. A., Overgaard, M. T., Bailey, K. R., Christiansen, M., Holmes, D. R., Virmani, R., Oxvig, C., & Schwartz, R. S. (2001). Pregnancy-Associated Plasma Protein A as a Marker of Acute Coronary Syndromes. New England Journal of Medicine. https://doi.org/10.1056/nejmoa003147
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