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Cited by 618Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsOpioid Use Disorder Treatment

The DOI matches its Crossref record, with a small difference in title or year; 32 of the 32 references it cites were found in a registry or an index.

Naltrexone in the Treatment of Alcohol Dependence

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Krystal, John H., Cramer, Joyce A., Krol, William F., Kirk, Gail F., Rosenheck, Robert A.·2001·New England Journal of Medicine
DOI 10.1056/nejmoa011127
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Abstract

BACKGROUND: Although naltrexone, an opiate-receptor antagonist, has been approved by the Food and Drug Administration for the treatment of alcohol dependence, its efficacy is uncertain. METHODS: We conducted a multicenter, double-blind, placebo-controlled evaluation of naltrexone as an adjunct to standardized psychosocial treatment. We randomly assigned 627 veterans (almost all men) with chronic, severe alcohol dependence to 12 months of naltrexone (50 mg once daily), 3 months of naltrexone followed by 9 months of placebo, or 12 months of placebo. All patients were offered individual counseling and programs to improve their compliance with study medication and were encouraged to attend Alcoholics Anonymous meetings. RESULTS: There were 209 patients in each group; all had been sober for at least five days before randomization. At 13 weeks, we found no significant difference in the number of days to relapse between patients in the two naltrexone groups (mean, 72.3 days) and the placebo group (mean, 62.4 days; 95 percent confidence interval for the difference between groups, -3.0 to 22.8). At 52 weeks, there were no significant differences among the three groups in the percentage of days on which drinking occurred and the number of drinks per drinking day. CONCLUSIONS: Our findings do not support the use of naltrexone for the treatment of men with chronic, severe alcohol dependence.

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  1. Swift RM, 1999, Alcohol Res Health, 23, 207
  2. Monti PM, 1999, Alcohol Clin Exp Res, 23, 1386
  3. 10.2307/2281868 · DOI · Paper page
  4. Collins JF, Dorus W. Patient selection bias in analyses using only compliant patients. In: Cramer JA, Spilker B, eds. Patient compliance in medical practice and clinical trials. New York: Raven Press, 1991:335-48.

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Metadata

Authors
Krystal, J. H., Cramer, J. A., Krol, W. F., Kirk, G. F., & Rosenheck, R. A.
Affiliations
Yale University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2001-12-13
Volume
345
Issue
24
Pages
1734-1739
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa011127
OpenAlex
W2108258874
Cited by
618
References
32
Citations by year
2026: 4 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 71 · 2019: 9 · 2018: 18 · 2017: 17 · 2016: 19 · 2015: 21 · 2014: 23 · 2013: 23 · 2012: 25
FWCI
29.39
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Department of Veterans Affairs
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
naltrexone, alcoholism, opioid antagonists, relapse prevention, veterans, adjunct pharmacotherapy, psychosocial interventions, Alcoholics Anonymous
MeSH terms
Alcoholics Anonymous, Alcoholism, Combined Modality Therapy, Counseling, Double-Blind Method, Female, Humans, Male, Middle Aged, Naltrexone, Narcotic Antagonists, Patient Compliance, Recurrence, Multivariate Analysis, Treatment Failure

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