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Cited by 785

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

The Epidemiology of Childhood Cardiomyopathy in Australia

Open access
Nugent, Alan W., Daubeney, Piers E.F., Chondros, Patty, Carlin, John B., Cheung, Michael, Wilkinson, Lynette C., Davis, Andrew M., Kahler, Stephen G., Chow, C.W., Wilkinson, James L., Weintraub, Robert G.·2003·New England Journal of Medicine

Abstract

BACKGROUND: The incidence and age distribution of primary cardiomyopathy in children are not well defined. We undertook a population-based, retrospective cohort study in Australia to document the epidemiology of childhood cardiomyopathy. METHODS: We analyzed all cases of primary cardiomyopathy in children who presented between 1987 and 1996 and who were younger than 10 years of age. Children were recruited from multiple sources, and cases of cardiomyopathy were classified according to World Health Organization guidelines. RESULTS: Over the 10-year period, 314 new cases of primary cardiomyopathy were identified, for an annual incidence of 1.24 per 100,000 children younger than 10 years of age (95 percent confidence interval, 1.11 to 1.38). Dilated cardiomyopathy made up 58.6 percent of cases, hypertrophic cardiomyopathy 25.5 percent, restrictive cardiomyopathy 2.5 percent, and left ventricular noncompaction 9.2 percent of cases. The incidence of all types of cardiomyopathy except restrictive declined rapidly after infancy. In 11 cases (3.5 percent), sudden death was the first symptom. There was a male predominance among children with hypertrophic and unclassified cardiomyopathy. Indigenous children had a higher incidence of dilated cardiomyopathy than nonindigenous children (relative risk, 2.67; 95 percent confidence interval, 1.42 to 4.63) and a higher rate of death as the presenting symptom (16.7 percent vs. 2.6 percent, P=0.02). Lymphocytic myocarditis was present in 25 of 62 children with dilated cardiomyopathy (40.3 percent) who underwent cardiac histologic examination within two months after presentation. CONCLUSIONS: Lymphocytic myocarditis and left ventricular noncompaction are important causes of childhood cardiomyopathy in Australia. The timing and severity of presentation in children with cardiomyopathy are related to the type of cardiomyopathy, as well as to genetic and ethnic factors.

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Metadata

Authors
Nugent, A. W., Daubeney, P. E. F., Chondros, P., Carlin, J. B., Cheung, M., Wilkinson, L. C., Davis, A. M., Kahler, S. G., Chow, C. W., Wilkinson, J. L., & Weintraub, R. G.
Venue
New England Journal of Medicine
Published
2003-04-24
Volume
348
Issue
17
Pages
1639-1646
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2043985983
Cited by
785
References
20
FWCI
13.62
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Epidemiology of Childhood Cardiomyopathy in Australia. https://app.cochat.ai/papers/10.1056/nejmoa021737
The paper
Nugent, A. W., Daubeney, P. E. F., Chondros, P., Carlin, J. B., Cheung, M., Wilkinson, L. C., Davis, A. M., Kahler, S. G., Chow, C. W., Wilkinson, J. L., & Weintraub, R. G. (2003). The Epidemiology of Childhood Cardiomyopathy in Australia. New England Journal of Medicine. https://doi.org/10.1056/nejmoa021737

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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