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2023 ESC Guidelines for the management of cardiomyopathies

Arbelo, Elena, Protonotarios, Alexandros, Gimeno, Juan R, Arbustini, Eloisa, Barriales-Villa, Roberto, Basso, Cristina, Bezzina, Connie R, Biagini, Elena, Blom, Nico A, de Boer, Rudolf A, De Winter, Tim, Elliott, Perry M, Flather, Marcus, Garcia-Pavia, Pablo, Haugaa, Kristina H, Ingles, Jodie, Jurcut, Ruxandra Oana, Klaassen, Sabine, Limongelli, Giuseppe, Loeys, Bart, Mogensen, Jens, Olivotto, Iacopo, Pantazis, Antonis, Sharma, Sanjay, Van Tintelen, J Peter, Ware, James S, Kaski, Juan Pablo, ESC Scientific Document Group, Charron, Philippe, Imazio, Massimo, Abdelhamid, Magdy, Aboyans, Victor, Arad, Michael, Asselbergs, Folkert W, Asteggiano, Riccardo, Bilinska, Zofia, Bonnet, Damien, Bundgaard, Henning, Cardim, Nuno Miguel, Čelutkienė, Jelena, Cikes, Maja, De Ferrari, Gaetano Maria, Dusi, Veronica, Falk, Volkmar, Fauchier, Laurent, Gandjbakhch, Estelle, Heliö, Tiina, Koskinas, Konstantinos, Kotecha, Dipak, Landmesser, Ulf, Lazaros, George, Lewis, Basil S, Linhart, Ales, Løchen, Maja-Lisa, Meder, Benjamin, Mindham, Richard, Moon, James, Nielsen, Jens Cosedis, Petersen, Steffen, Prescott, Eva, Sheppard, Mary N, Sinagra, Gianfranco, Sitges, Marta, Tfelt-Hansen, Jacob, Touyz, Rhian, Veltrop, Rogier, Veselka, Josef, Wahbi, Karim, Wilde, Arthur, Zeppenfeld, Katja, Kichou, Brahim, Sisakian, Hamayak, Scherr, Daniel, Gerber, Bernhard, Džubur, Alen, Gospodinova, Mariana, Planinc, Ivo, Moustra, Hera Heracleous, Zemánek, David, Jensen, Morten Steen Kvistholm, Samir, Ahmad, Palm, Kairit, Heliö, Tiina, Wahbi, Karim, Schulze-Bahr, Eric, Haralambos, Vlachopoulos, Sepp, Róbert, Aðalsteinsdóttir, Berglind, Ward, Deirdre, Blich, Miry, Sinagra, Gianfranco, Poniku, Afrim, Lunegova, Olga, Rudzitis, Ainars, Kassab, Roland, Barysienė, Jūratė, Huijnen, Steve, Felice, Tiziana, Vataman, Eleonora, Pavlovic, Nikola, Doghmi, Nawal, Asselbergs, Folkert W, Kostovska, Elizabeta Srbinovska, Almaas, Vibeke Marie, Biernacka, Elżbieta Katarzyna, Brito, Dulce, Rosca, Monica, Zavatta, Marco, Ristic, Arsen, Goncalvesová, Eva, Šinkovec, Matjaž, Cañadas-Godoy, Victoria, Platonov, Pyotr G, Saguner, Ardan M, Saadi, Ahmad Rasheed Al, Kammoun, Ikram, Celik, Ahmet, Nesukay, Elena, Abdullaev, Timur, Prescott, Eva, James, Stefan, Arbelo, Elena, Baigent, Colin, Borger, Michael A, Buccheri, Sergio, Ibanez, Borja, Køber, Lars, Koskinas, Konstantinos C, McEvoy, John William, Mihaylova, Borislava, Mindham, Richard, Neubeck, Lis, Nielsen, Jens Cosedis, Pasquet, Agnes, Rakisheva, Amina, Rocca, Bianca, Rossello, Xavier, Vaartjes, Ilonca, Vrints, Christiaan, Witkowski, Adam, Zeppenfeld, Katja·2023·European Heart Journal

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  • Both the 2024 ACC/AHA and 2023 ESC guidelines give non-dihydropyridine calcium channel blockers a class I recommendation for patients in whom beta blockers are ineffective or not well tolerated.

    “Both the 2024 ACC/AHA and 2023 ESC guidelines give non-dihydropyridine CCBs a class I recommendation for patients in whom β blockers are ineffective or not well tolerated (table 2). 1 22”

    From Current management of hypertrophic cardiomyopathy (2025) · cites this paper as [1]

    Section 7.1.4.1 says verapamil can be used when beta-blockers are contraindicated or ineffective, and diltiazem should be considered when beta-blockers and verapamil are not tolerated or are contraindicated. The retrieved passages do not establish a Class I recommendation for both drugs, and the diltiazem condition is narrower than the claim states. This verdict addresses only the cited ESC guideline, not the ACC/AHA guideline. (LLM, conf=0.76)

    Experimental — accuracy not yet measured
  • Current ESC and ACC guidelines recommend anti-obstructive therapy (beta-blockers or verapamil) to reduce gradient and symptoms in HOCM.

    “Current guidelines from the European Society of Cardiology (ESC) and the American College of Cardiology (ACC) recommend anti-obstructive therapy, i.e., beta-blockers or verapamil to reduce gradient and symptoms (6–8).”
  • The 2023 ESC guidelines assigned a class 2a recommendation to use cardiac myosin inhibitors in patients with symptomatic hypertrophic cardiomyopathy with left ventricular outflow tract obstruction, in addition to beta blockers or calcium channel blockers or as monotherapy when beta blockers, calcium channel blockers, or disopyramide are not tolerated or contraindicated, before considering septal减少

    “The 2023 ESC guidelines assigned a class 2a recommendation to use of CMIs in patients with symptomatic hypertrophic cardiomyopathy with LVOT obstruction, in addition to β blockers or CCBs or as monotherapy when β blockers, CCBs, or disopyramide are not tolerated or contraindicated, before considering SRT. 1”

    From Current management of hypertrophic cardiomyopathy (2025) · cites this paper as [1]

  • US guidelines primarily take a dichotomized, algorithmic approach, whereas the European guidelines advise use of the HCM Risk-SCD calculator.

    “US guidelines primarily take a dichotomized, algorithmic approach, 22 whereas the European guidelines advise use of the HCM Risk-SCD calculator”

    From Current management of hypertrophic cardiomyopathy (2025) · cites this paper as [1]

  • The diagnosis of HCM was based on the latest ESC guidelines for the diagnosis and management of hypertrophic cardiomyopathies.

    “The diagnosis of HCM was based on the latest ESC guidelines for the diagnosis and management of hypertrophic cardiomyopathies: patients with familial or genetically diagnosed HCM with wall thickness ≥13 mm in one or more left ventricular myocardial segments or patients with wall thickness ≥15 mm in the absence of any other cause of hypertrophy (7, 8).”

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Authors
Arbelo, E., Protonotarios, A., Gimeno, J. R., Arbustini, E., Barriales-Villa, R., Basso, C., Bezzina, C. R., Biagini, E., Blom, N. A., de Boer, R. A., De Winter, T., Elliott, P. M., Flather, M., Garcia-Pavia, P., Haugaa, K. H., Ingles, J., Jurcut, R. O., Klaassen, S., Limongelli, G., Loeys, B., Mogensen, J., Olivotto, I., Pantazis, A., Sharma, S., Van Tintelen, J. P., Ware, J. S., Kaski, J. P., ESC Scientific Document Group, Charron, P., Imazio, M., Abdelhamid, M., Aboyans, V., Arad, M., Asselbergs, F. W., Asteggiano, R., Bilinska, Z., Bonnet, D., Bundgaard, H., Cardim, N. M., Čelutkienė, J., Cikes, M., De Ferrari, G. M., Dusi, V., Falk, V., Fauchier, L., Gandjbakhch, E., Heliö, T., Koskinas, K., Kotecha, D., Landmesser, U., Lazaros, G., Lewis, B. S., Linhart, A., Løchen, M.-L., Meder, B., Mindham, R., Moon, J., Nielsen, J. C., Petersen, S., Prescott, E., Sheppard, M. N., Sinagra, G., Sitges, M., Tfelt-Hansen, J., Touyz, R., Veltrop, R., Veselka, J., Wahbi, K., Wilde, A., Zeppenfeld, K., Kichou, B., Sisakian, H., Scherr, D., Gerber, B., Džubur, A., Gospodinova, M., Planinc, I., Moustra, H. H., Zemánek, D., Jensen, M. S. K., Samir, A., Palm, K., Heliö, T., Wahbi, K., Schulze-Bahr, E., Haralambos, V., Sepp, R., Aðalsteinsdóttir, B., Ward, D., Blich, M., Sinagra, G., Poniku, A., Lunegova, O., Rudzitis, A., Kassab, R., Barysienė, J., Huijnen, S., Felice, T., Vataman, E., Pavlovic, N., Doghmi, N., Asselbergs, F. W., Kostovska, E. S., Almaas, V. M., Biernacka, E. K., Brito, D., Rosca, M., Zavatta, M., Ristic, A., Goncalvesová, E., Šinkovec, M., Cañadas-Godoy, V., Platonov, P. G., Saguner, A. M., Saadi, A. R. A., Kammoun, I., Celik, A., Nesukay, E., Abdullaev, T., Prescott, E., James, S., Arbelo, E., Baigent, C., Borger, M. A., Buccheri, S., Ibanez, B., Køber, L., Koskinas, K. C., McEvoy, J. W., Mihaylova, B., Mindham, R., Neubeck, L., Nielsen, J. C., Pasquet, A., Rakisheva, A., Rocca, B., Rossello, X., Vaartjes, I., Vrints, C., Witkowski, A., & Zeppenfeld, K.
Affiliations
  • (Task Force Co-ordinator) ( )
  • (Italy)
  • (Spain)
  • (Netherlands)
  • (Belgium)
  • (United Kingdom)
  • (Sweden)
  • (Australia)
  • (Romania)
  • (Germany)
  • (Denmark)
  • (Chairperson) ( )
Venue
European Heart Journal
Published
2023-08-25
Volume
44
Issue
37
Pages
3503-3626
ISSN
  • 0195-668X
  • 1522-9645
Cited by
2,844
References
50
Language
en

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