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Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
Open accessAbstract
Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a cough associated with bilateral pneumonia. Codeine is bioactivated by CYP2D6 into morphine, which then undergoes further glucuronidation. CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent with ultrarapid metabolism of codeine. We attribute the toxicity to this genotype, in combination with inhibition of CYP3A4 activity by other medications and a transient reduction in renal function.
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Citations
Cited by
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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
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Sistonen, J., Sajantila, A., Lao, O., Corander, J., Barbujani, G., & Fuselli, S. (2007) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000239974.69464.f2 · Cited by 398
Moore, R. A., Derry, S., McQuay, H. J., Straube, S., Aldington, D., Wiffen, P., Bell, R. F., Kalso, E., & Rowbotham, M. C. (2010) · Pain · doi:10.1016/j.pain.2009.08.007 · Cited by 98
Metadata
- Authors
- Gasche, Y., Daali, Y., Fathi, M., Chiappe, A., Cottini, S., Dayer, P., & Desmeules, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2004-12-30
- Volume
- 351
- Issue
- 27
- Pages
- 2827-2831
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1989956851
- Cited by
- 702
- References
- 0
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gasche, Y., Daali, Y., Fathi, M., Chiappe, A., Cottini, S., Dayer, P., & Desmeules, J. (2004). Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism. New England Journal of Medicine. https://doi.org/10.1056/nejmoa041888
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
