Clinical effectiveness: an approach to clinical trial design more relevant to clinical practice, acknowledging the importance of individual differences

Evidence based medicine: what it is and what it isn't

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Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations

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Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis

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Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

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Algorithm for neuropathic pain treatment: An evidence based proposal

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Explanatory and Pragmatic Attitudes in Therapeutical Trials

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Opioids in chronic non-cancer pain: systematic review of efficacy and safety

Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216 · see citing works

Evidence based medicine: what it is and what it isn't. 1996.

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Explanatory and pragmatic attitudes in therapeutical trials

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Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism

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Comparative Effectiveness Research: A Report From the Institute of Medicine

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Stratified Care vs Step Care Strategies for Migraine

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Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials

Sultan, A., Gaskell, H., Derry, S., & Moore, R. A. (2008) · BMC Neurology · doi:10.1186/1471-2377-8-29 · Cited by 292 · see citing works

Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice

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Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden

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Is there a right treatment for a particular patient group? Comparison of ordinary treatment, light multidisciplinary treatment, and extensive multidisciplinary treatment for long-term sick-listed employees with musculoskeletal pain

Haldorsen, E. M. H., Grasdal, A. L., Skouen, J. S., Risa, A. E., Kronholm, K., & Ursin, H. (2002) · Pain · doi:10.1016/s0304-3959(01)00374-8 · Cited by 240 · see citing works

Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports

Moore, R. A., Derry, S., Makinson, G., & McQuay, H. J. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1704 · Cited by 223 · see citing works

Analgesic effects of treatments for non-specific low back pain: a meta-analysis of placebo-controlled randomized trials

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Enriched enrolment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review

Straube, S., Derry, S., McQuay, H. J., & Moore, R. A. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2008.03200.x · Cited by 173 · see citing works

Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results

Moore, R. A., Edwards, J. E., & McQuay, H. J. (2005) · Pain · doi:10.1016/j.pain.2005.05.001 · Cited by 172 · see citing works

Treatment Options in Knee Osteoarthritis

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Marked Interindividual Variability in the Response to Selective Inhibitors of Cyclooxygenase-2

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Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs

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Relative efficacy of oral analgesics after third molar extraction

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Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems

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Individual responder analyses for pain: does one pain scale fit all?

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Evidence-based and Evidence-biased Medicine

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Genetic variability and clinical efficacy of morphine

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A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster

Dworkin, R. H., Barbano, R. L., Tyring, S. K., Betts, R. F., McDermott, M., Pennella‐Vaughan, J., Bennett, G. J., Berber, E., Gnann, J. W., Irvine, C., et al. (2009) · Pain · doi:10.1016/j.pain.2008.12.022 · Cited by 92 · see citing works

Neuroimaging of pain mechanisms

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The number needed to treat for adalimumab, etanercept, and infliximab based on ACR50 response in three randomized controlled trials on established rheumatoid arthritis: a systematic literature review

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Prescription Drug Cost Sharing

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Efficacy, Speed of Action and Tolerability of Almotriptan in the Acute Treatment of Migraine

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Mechanisms of pain in nonmalignant disease

Harvey, V. L., & Dickenson, A. H. (2008) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328300eb24 · Cited by 25 · see citing works

Pain relief in osteoarthritis: patients' willingness to risk medication-induced gastrointestinal, cardiovascular, and cerebrovascular complications.

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Formulary Restriction of Selective Serotonin Reuptake Inhibitors for Depression

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Alpha-2-delta ligands in fibromyalgia: Is the glass half empty or full?

Clauw, D. J. (2009) · Pain · doi:10.1016/j.pain.2009.06.015 · Cited by 9 · see citing works

Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs

Lee, Y.-S., Kim, H., Wu, T., Wang, X.-M., & Dionne, R. A. (2006) · Acute Pain · doi:10.1016/j.acpain.2006.08.025 · Cited by 7 · see citing works

THE USE OF HEALTH ECONOMICS BY HOSPITAL PHARMACIST DECISION MAKERS : A SURVEY OF UK CHIEF PHARMACISTS

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Individual responder analyses for pain: does one dose fit all?

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Psychological therapies for the management of chronic pain (excluding headache) in adults

Williams, A. C. D. C., Eccleston, C., & Morley, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007407.pub3 · Cited by 1,634 · see citing works

The evidence for pharmacological treatment of neuropathic pain

Finnerup, N. B., Sindrup, S. H., & Jensen, T. S. (2010) · Pain · doi:10.1016/j.pain.2010.06.019 · Cited by 1,045 · see citing works

Gabapentin for chronic neuropathic pain and fibromyalgia in adults

Moore, A., Wiffen, P. J., Derry, S., & McQuay, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub2 · Cited by 729 · see citing works

Psychological therapies for the management of chronic pain (excluding headache) in adults

Williams, A. C. D. C., Fisher, E., Hearn, L., & Eccleston, C. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007407.pub4 · Cited by 605 · see citing works

Gabapentin for chronic neuropathic pain in adults

Wiffen, P. J., Derry, S., Bell, R. F., Rice, A. S., Tölle, T. R., Phillips, T., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub4 · Cited by 561 · see citing works

Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review

Flatters, S. J. L., Dougherty, P. M., & Colvin, L. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex229 · Cited by 393 · see citing works

The Costs and Consequences of Adequately Managed Chronic Non‐Cancer Pain and Chronic Neuropathic Pain

Andrew, R., Derry, S., Taylor, R. S., Straube, S., & Phillips, C. J. (2013) · Pain Practice · doi:10.1111/papr.12050 · Cited by 372 · see citing works

Pregabalin for neuropathic pain in adults

Derry, S., Bell, R. F., Straube, S., Wiffen, P. J., Aldington, D. J., & Moore, A. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007076.pub3 · Cited by 386 · see citing works

Opioids for cancer pain - an overview of Cochrane reviews

Wiffen, P. J., Wee, B., Derry, S., Bell, R. F., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012592.pub2 · Cited by 332 · see citing works

Amitriptyline for neuropathic pain in adults

Moore, A., Derry, S., Aldington, D. J., Cole, P., & Wiffen, P. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008242.pub3 · Cited by 309 · see citing works

Antiepileptic drugs for neuropathic pain and fibromyalgia

Wiffen, P. J., Derry, S., Moore, R. A., Aldington, D. J., Cole, P., Rice, A. S. C., Lunn, M. P., Hamunen, K., Haanpää, M. L., & Kalso, E. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010567.pub2 · Cited by 395 · see citing works

Gabapentin for chronic neuropathic pain and fibromyalgia in adults

Moore, R. A., Wiffen, P. J., Derry, S., & Rice, A. S. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub3 · Cited by 297 · see citing works

Amitriptyline for neuropathic pain and fibromyalgia in adults

Moore, R. A., Derry, S., Aldington, D. J., Cole, P., & Wiffen, P. J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008242.pub2 · Cited by 288 · see citing works

Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations

Dworkin, R. H., Turk, D. C., Peirce‐Sandner, S., Burke, L. B., Farrar, J. T., Gilron, I., Jensen, M. P., Katz, N. P., Raja, S. N., Rappaport, B. A., et al. (2012) · Pain · doi:10.1016/j.pain.2012.03.003 · Cited by 284 · see citing works

Cognitive behavioural therapies for fibromyalgia

Bernardy, K., Klose, P., Busch, A. J., Choy, E. H., & Häuser, W. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009796.pub2 · Cited by 272 · see citing works

Expect analgesic failure; pursue analgesic success

Moore, A., Derry, S., Eccleston, C., & Kalso, E. (2013) · BMJ · doi:10.1136/bmj.f2690 · Cited by 271 · see citing works

Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews

Derry, S., Wiffen, P. J., Kalso, E. A., Bell, R. F., Aldington, D. J., Phillips, T., Gaskell, H., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008609.pub2 · Cited by 253 · see citing works

Carbamazepine for acute and chronic pain in adults

Wiffen, P. J., Derry, S., Moore, R. A., & McQuay, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005451.pub2 · Cited by 197 · see citing works

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults

Wiffen, P. J., Derry, S., Moore, A., & Kalso, E. A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005451.pub3 · Cited by 190 · see citing works

Carbamazepine for acute and chronic pain in adults

Wiffen, P. J., Derry, S., Moore, R. A., & McQuay, H. J. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005451 · Cited by 178 · see citing works

Multimodal Treatment of Chronic Pain

Dale, R., & Stacey, B. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2015.08.012 · Cited by 171 · see citing works

Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome

Häuser, W., Urrútia, G., Tort, S., Üçeyler, N., & Walitt, B. T. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010292 · Cited by 164 · see citing works

Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia

Welsch, P., Üçeyler, N., Klose, P., Walitt, B. T., & Häuser, W. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010292.pub2 · Cited by 152 · see citing works

Antidepressants for pain management in adults with chronic pain: a network meta-analysis

Birkinshaw, H., Friedrich, C., Cole, P., Eccleston, C., Serfaty, M. A., Stewart, G. B., White, S. P., Moore, A., Phillippo, D., & Pincus, T. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014682.pub2 · Cited by 153 · see citing works

Oral morphine for cancer pain

Wiffen, P. J., & McQuay, H. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003868.pub2 · Cited by 140 · see citing works

Combination Drug Therapy for Chronic Pain: A Call for More Clinical Studies

Mao, J., Gold, M. S., & Bačkonja, M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.07.006 · Cited by 134 · see citing works

Examining the evidence about psychological treatments for chronic pain: Time for a paradigm shift?

Morley, S., Williams, A., & Eccleston, C. (2013) · Pain · doi:10.1016/j.pain.2013.05.049 · Cited by 123 · see citing works

Analgesic efficacy of opioids in chronic pain: recent meta‐analyses

Reinecke, H., Weber, C., Lange, K., Simon, M., Stein, C., & Sorgatz, H. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12634 · Cited by 120 · see citing works

Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents

Eccleston, C., Cooper, T. E., Fisher, E., Anderson, B. J., & Wilkinson, N. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012537.pub2 · Cited by 115 · see citing works

Cancer treatment-related neuropathic pain: proof of concept study with menthol—a TRPM8 agonist

Fallon, M., Storey, D. J., Krishan, A., Weir, C. J., Mitchell, R., Fleetwood-Walker, S. M., Scott, A., & Colvin, L. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2642-8 · Cited by 112 · see citing works

Oral morphine for cancer pain

Wiffen, P. J., Wee, B. L., & Moore, R. A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003868.pub4 · Cited by 113 · see citing works

Opioid therapy for treating rheumatoid arthritis pain

Whittle, S., Richards, B. L., Husni, M. E., & Buchbinder, R. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003113.pub3 · Cited by 106 · see citing works

Combination pharmacotherapy for the treatment of fibromyalgia in adults

Thorpe, J. B., Shum, B., Moore, A., Wiffen, P. J., & Gilron, I. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010585.pub2 · Cited by 106 · see citing works

Challenges in design and interpretation of chronic pain trials

Moore, A., Derry, S., & Wiffen, P. J. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet126 · Cited by 100 · see citing works

Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults

Derry, S., Wiffen, P. J., Moore, A., McNicol, E. D., Bell, R. F., Carr, D. B., McIntyre, M., & Wee, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012638.pub2 · Cited by 134 · see citing works

Opioids for chronic non-cancer pain in children and adolescents

Cooper, T. E., Fisher, E., Gray, A. L., Krane, E. J., Sethna, N. F., van Tilburg, M. A. L., Zernikow, B., & Wiffen, P. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012538.pub2 · Cited by 93 · see citing works

Oral paracetamol (acetaminophen) for cancer pain

Wiffen, P. J., Derry, S., Moore, A., McNicol, E. D., Bell, R. F., Carr, D. B., McIntyre, M., & Wee, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012637.pub2 · Cited by 95 · see citing works

Milnacipran for pain in fibromyalgia in adults

Cording, M., Derry, S., Phillips, T., Moore, A., & Wiffen, P. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008244.pub3 · Cited by 84 · see citing works

How do psychologically based interventions for chronic musculoskeletal pain work? A systematic review and meta-analysis of specific moderators and mediators of treatment

Murillo, C., Vo, T., Vansteelandt, S., Harrison, L. E., Cagnie, B. J., Coppieters, I., Chys, M., Timmers, I., & Meeus, M. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102160 · Cited by 85 · see citing works

Educational Interventions by Pharmacists to Patients With Chronic Pain

Bennett, M., Bagnall, A., Raine, G., Closs, S. J., Blenkinsopp, A., Dickman, A. R., & Ellershaw, J. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31821b6be4 · Cited by 81 · see citing works

Antidepressants for chronic non-cancer pain in children and adolescents

Cooper, T. E., Heathcote, L. C., Clinch, J., Gold, J. I., Howard, R. F., Lord, S. M., Schechter, N. L., Wood, C. H., & Wiffen, P. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012535.pub2 · Cited by 80 · see citing works

Antiepileptic drugs for chronic non-cancer pain in children and adolescents

Cooper, T. E., Wiffen, P. J., Heathcote, L. C., Clinch, J., Howard, R. F., Krane, E. J., Lord, S. M., Sethna, N. F., Schechter, N. L., & Wood, C. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012536.pub2 · Cited by 77 · see citing works

Composite outcomes for pain clinical trials: considerations for design and interpretation

Gewandter, J. S., McDermott, M., Evans, S. R., Katz, N. P., Markman, J. D., Simon, L. S., Turk, D. C., & Dworkin, R. H. (2021) · Pain · doi:10.1097/j.pain.0000000000002188 · Cited by 70 · see citing works

Systematic review of enriched enrolment, randomised withdrawal trial designs in chronic pain

Moore, R. A., Wiffen, P. J., Eccleston, C., Derry, S., Baron, R., Bell, R. F., Furlan, A. D., Gilron, I., Haroutounian, S., Katz, N. P., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000088 · Cited by 70 · see citing works

Paracetamol (acetaminophen) for chronic non-cancer pain in children and adolescents

Cooper, T. E., Fisher, E., Anderson, B. J., Wilkinson, N. M., Williams, D. G., & Eccleston, C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012539.pub2 · Cited by 64 · see citing works

Diversity, Equity, and Inclusion in Clinical Research: A Path Toward Precision Health for Everyone

Washington, V., Franklin, J. B., Huang, E. S., Mega, J. L., & Abernethy, A. P. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2804 · Cited by 63 · see citing works

Opioids for cancer-related pain in children and adolescents

Wiffen, P. J., Cooper, T. E., Anderson, A.-K., Gray, A. L., Grégoire, M.-C., Ljungman, G., & Zernikow, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012564.pub2 · Cited by 62 · see citing works

Amitriptyline for fibromyalgia in adults

Moore, A., Derry, S., Aldington, D. J., Cole, P., & Wiffen, P. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011824 · Cited by 59 · see citing works

Fit to targets, preferred listening levels, and self-reported outcomes for the DSL v5.0a hearing aid prescription for adults

Polonenko, M. J., Scollie, S. D., Moodie, S., Seewald, R. C., Laurnagaray, D., Shantz, J., & Richards, A. (2010) · International Journal of Audiology · doi:10.3109/14992021003713122 · Cited by 55 · see citing works

Does TENS Reduce the Intensity of Acute and Chronic Pain? A Comprehensive Appraisal of the Characteristics and Outcomes of 169 Reviews and 49 Meta-Analyses

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Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)

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