The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing
Open accessAbstract
BACKGROUND: Although dyspnea is a common symptom, there has been only limited investigation of its prognostic significance among patients referred for cardiac evaluation. METHODS: We studied 17,991 patients undergoing myocardial-perfusion single-photon-emission computed tomography during stress and at rest. Patients were divided into five categories on the basis of symptoms at presentation (none, nonanginal chest pain, atypical angina, typical angina, and dyspnea). Multivariable analysis was used to assess the incremental prognostic value of symptom categories in predicting the risk of death from cardiac causes and from any cause. In addition, the prognosis associated with various symptoms at presentation was compared in subgroups selected on the basis of propensity analysis. RESULTS: After a mean (+/-SD) follow-up of 2.7+/-1.7 years, the rate of death from cardiac causes and from any cause was significantly higher among patients with dyspnea (both those previously known to have coronary artery disease and those with no known history of coronary artery disease) than among patients with other or no symptoms at presentation. Among patients with no known history of coronary artery disease, those with dyspnea had four times the risk of sudden death from cardiac causes of asymptomatic patients and more than twice the risk of patients with typical angina. Dyspnea was associated with a significant increase in the risk of death among each clinically relevant subgroup and remained an independent predictor of the risk of death from cardiac causes (P<0.001) and from any cause (P<0.001) after adjustment for other significant factors by multivariable and propensity analysis. CONCLUSIONS: In a large series of patients, self-reported dyspnea identified a subgroup of otherwise asymptomatic patients at increased risk for death from cardiac causes and from any cause. Our results suggest that an assessment of dyspnea should be incorporated into the clinical evaluation of patients referred for cardiac stress testing.
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“In our EAS PheWAS of introgressed loci matching Denisovan/Neanderthal loci, we identified an association with “shortness of breath walking on level ground”, which is a trait related to cardiovascular health [36].”
From Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations (2022) · cites this paper as [36]
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“bejaht diese auf Befragung, ist seine kardiale Sterblichkeit deutlich erhöht [1].”
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Self-citationPatient-reported dyspnoea predicts six-fold increased hospital mortality
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“The stimulus and aetiology are complex; however, amongst patients with dyspnoea and CAD, the risk of death from cardiac cause is four times greater compared to asymptomatic patients and more than twice the risk compared to patients with typical angina [3].”
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“Recent studies report that the risk of cardiac-related death is 4 times greater in patients with dyspnea than asymptomatic patients, and twice that in patients with angina alone (Abidov et al., 2005; Bergeron et al., 2004).”
InfluentialSignificance of Dyspnoea as a symptom in the Emergency Department of the Primary Healthcare Centre
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Self-citationImplications of Potential Undiagnosed HFpEF on Symptomatic Response With Coronary Revascularization
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“Dyspnea has acquired greater clinical relevance as it has been recognized as an isolated initial symptom associated with exercise or physical exertion (Douglas et al., 2023), as well as a prognostic factor in stable angina (Abidov et al., 2005).”
Behnam, I., Moghaddam, M. B., Dalir, Z., & Moghaddam, M. B. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-05108-6
“Dyspnea was associated with a significantly increased risk of mortality in each clinically relevant subgroup and was identified as an independent predictor of cardiac-related death ( P 0.001) as well as all-cause mortality ( P 0.001), even after adjusting for other key variables [35].”
InfluentialPROBLEMS AND METHODS OF DIFFERENTIAL DIAGNOSIS OF DYSPNEA
A., S. D., N., B. Y., & V., K. (2025) · "Medical & pharmaceutical journal "Pulse" · doi:10.26787/nydha-2686-6838-2025-27-6-27-34
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Self-citationLi, Y.-S., Ren, Q., Zhang, J., Liang, Y.-C., Han, Y.-L., & Zhang, Q.-Y. (2024) · Reviews in cardiovascular medicine · doi:10.31083/j.rcm2506197
“However, other studies have re-ported conflicting results, indicating that dyspnea is associated with worse clinical outcomes among CAD patients [21–24].”
ResultIMPACT OF DYSPNEA ON ACTIVITIES OF DAILY LIVING
Barey, S. A. S., & Williams, J. (2021) · IDC international journal · doi:10.47211/idcij.2021.v08i02.018
“This model mirrors the conceptual models of pain and dyspnea, with sensory and affective components interacting together (9).”
Bestehorn, F., Bestehorn, M., & Kirches, C. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2101.07029
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“The challenges have caused practitioners to miss early diagnosis of acute coronary syndrome and sometimes leads to catastrophic events, such as cardiac arrest; patients presenting with only dyspnea of cardiac origin are reported to have a twofold increased risk for sudden death [3].”
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Take a deep breath and check your heart.
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Dyspnea Has Prognostic Significance
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A PATIENT WITH CHEST PAIN AND ST-SEGMENT ELEVATION ON A RESTING ECG – A CASE STUDY
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Self-citationStratifying Symptomatic Patients Using the Exercise Test and Other Tools
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“tomography using symptom-limited stress induced by either a treadmill exercise (66%) or a vasodilator (34%) ( 36 ) . Patients were divided into five categories according to their self-reported symptoms of chest pain and dyspnea at the time of testing: none; nonanginal chest pain; atypical angina; typical angina; and,…”
Method
Metadata
- Authors
- Abidov, A., Rozanski, A., Hachamovitch, R., Hayes, S. W., Aboul-Enein, F., Cohen, I., Friedman, J. D., Germano, G., & Berman, D. S.
- Affiliations
- Cedars-Sinai Medical Center (US)
- St. Luke's-Roosevelt Hospital Center (US)
- University of Southern California (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-11-03
- Volume
- 353
- Issue
- 18
- Pages
- 1889-1898
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2156185661
- Cited by
- 297
- References
- 32
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 5 · 2017: 18 · 2016: 17 · 2015: 15 · 2014: 13 · 2013: 24 · 2012: 11
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- dyspnea, prognosis, cardiac stress testing, myocardial perfusion imaging, sudden cardiac death, mortality, coronary artery disease, asymptomatic patients, chest pain, angina pectoris, symptom assessment
- MeSH terms
- Aged, Angina Pectoris, Coronary Disease, Dyspnea, Exercise Test, Female, Follow-Up Studies, Heart Diseases, Humans, Male, Middle Aged, Mortality, Prognosis, Risk Factors, Thallium Radioisotopes, Tomography, Emission-Computed, Single-Photon
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