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Cited by 503

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Transmission of Rabies Virus from an Organ Donor to Four Transplant Recipients

Open access
Srinivasan, Arjun, Burton, Elizabeth C., Kuehnert, Matthew J., Rupprecht, Charles, Sutker, William L., Ksiazek, Thomas G., Paddock, Christopher D., Guarner, Jeannette, Shieh, Wun-Ju, Goldsmith, Cynthia, Hanlon, Cathleen A., Zoretic, James, Fischbach, Bernard, Niezgoda, Michael, El-Feky, Waleed H., Orciari, Lillian, Sanchez, Edmund Q., Likos, Anna, Klintmalm, Goran B., Cardo, Denise, LeDuc, James, Chamberland, Mary E., Jernigan, Daniel B., Zaki, Sherif R.·2005·New England Journal of Medicine
DOI 10.1056/nejmoa043018
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Abstract

BACKGROUND: In 2004, four recipients of kidneys, a liver, and an arterial segment from a common organ donor died of encephalitis of an unknown cause. METHODS: We reviewed the medical records of the organ donor and the recipients. Blood, cerebrospinal fluid, and tissues from the recipients were tested with a variety of assays and pathological stains for numerous causes of encephalitis. Samples from the recipients were also inoculated into mice. RESULTS: The organ donor had been healthy before having a subarachnoid hemorrhage that led to his death. Encephalitis developed in all four recipients within 30 days after transplantation and was accompanied by rapid neurologic deterioration characterized by agitated delirium, seizures, respiratory failure, and coma. They died an average of 13 days after the onset of neurologic symptoms. Mice inoculated with samples from the affected patients became ill seven to eight days later, and electron microscopy of central nervous system (CNS) tissue demonstrated rhabdovirus particles. Rabies-specific immunohistochemical and direct fluorescence antibody staining demonstrated rabies virus in multiple tissues from all recipients. Cytoplasmic inclusions consistent with Negri bodies were seen in CNS tissue from all recipients. Antibodies against rabies virus were present in three of the four recipients and the donor. The donor had told others of being bitten by a bat. CONCLUSIONS: This report documenting the transmission of rabies virus from an organ donor to multiple recipients underscores the challenges of preventing and detecting transmission of unusual pathogens through transplantation.

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Metadata

Authors
Srinivasan, A., Burton, E. C., Kuehnert, M. J., Rupprecht, C., Sutker, W. L., Ksiazek, T. G., Paddock, C. D., Guarner, J., Shieh, W.-J., Goldsmith, C., Hanlon, C. A., Zoretic, J., Fischbach, B., Niezgoda, M., El-Feky, W. H., Orciari, L., Sanchez, E. Q., Likos, A., Klintmalm, G. B., Cardo, D., LeDuc, J., Chamberland, M. E., Jernigan, D. B., & Zaki, S. R.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2005-03-17
Volume
352
Issue
11
Pages
1103-1111
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa043018
OpenAlex
W2128005020
Cited by
503
References
22
FWCI
13.20
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Transmission of Rabies Virus from an Organ Donor to Four Transplant Recipients. https://app.cochat.ai/papers/10.1056/nejmoa043018
The paper
Srinivasan, A., Burton, E. C., Kuehnert, M. J., Rupprecht, C., Sutker, W. L., Ksiazek, T. G., Paddock, C. D., Guarner, J., Shieh, W.-J., Goldsmith, C., Hanlon, C. A., Zoretic, J., Fischbach, B., Niezgoda, M., El-Feky, W. H., Orciari, L., Sanchez, E. Q., Likos, A., Klintmalm, G. B., . . . Zaki, S. R. (2005). Transmission of Rabies Virus from an Organ Donor to Four Transplant Recipients. New England Journal of Medicine. https://doi.org/10.1056/nejmoa043018

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.