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Survival after Treatment of Rabies with Induction of Coma
Open accessAbstract
We report the survival of a 15-year-old girl in whom clinical rabies developed one month after she was bitten by a bat. Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered. The patient was treated with ketamine, midazolam, ribavirin, and amantadine. Probable drug-related toxic effects included hemolysis, pancreatitis, acidosis, and hepatotoxicity. Lumbar puncture after eight days showed an increased level of rabies antibody, and sedation was tapered. Paresis and sensory denervation then resolved. The patient was removed from isolation after 31 days and discharged to her home after 76 days. At nearly five months after her initial hospitalization, she was alert and communicative, but with choreoathetosis, dysarthria, and an unsteady gait.
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Cited by
Current status of rabies and prospects for elimination
Fooks, A. R., Banyard, A. C., Horton, D. L., Johnson, N., McElhinney, L. M., & Jackson, A. C. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62707-5 · Cited by 579
Human rabies: neuropathogenesis, diagnosis, and management
Hemachudha, T., Ugolini, G., Wacharapluesadee, S., Sungkarat, W., Shuangshoti, S., & Laothamatas, J. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70038-3 · Cited by 446
Bats as a continuing source of emerging infections in humans
Wong, S., Lau, S., Woo, P., & Yuen, K. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.520 · Cited by 321
Novel Vaccines to Human Rabies
Ertl, H. C. J. (2009) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000515 · Cited by 93
Pathak, S., Horton, D. L., Lucas, S., Brown, D., Quaderi, S., Polhill, S., Walker, D., Nastouli, E., Núñez, A., Wise, E. L., et al. (2014) · Virology Journal · doi:10.1186/1743-422x-11-63 · Cited by 19
Metadata
- Authors
- Willoughby, R. E., Tieves, K. S., Hoffman, G. M., Ghanayem, N. S., Amlie-Lefond, C. M., Schwabe, M. J., Chusid, M. J., & Rupprecht, C. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-06-16
- Volume
- 352
- Issue
- 24
- Pages
- 2508-2514
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2101824976
- Cited by
- 661
- References
- 0
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Survival after Treatment of Rabies with Induction of Coma. https://app.cochat.ai/papers/10.1056/nejmoa050382
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- Willoughby, R. E., Tieves, K. S., Hoffman, G. M., Ghanayem, N. S., Amlie-Lefond, C. M., Schwabe, M. J., Chusid, M. J., & Rupprecht, C. E. (2005). Survival after Treatment of Rabies with Induction of Coma. New England Journal of Medicine. https://doi.org/10.1056/nejmoa050382
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
