Cited by 2,412Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchViral Infections and Immunology Research

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A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

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Oxman, M.N., Levin, M.J., Johnson, G.R., Schmader, K.E., Straus, S.E., Gelb, L.D., Arbeit, R.D., Simberkoff, M.S., Gershon, A.A., Davis, L.E., Weinberg, A., Boardman, K.D., Williams, H.M., Zhang, J. Hongyuan, Peduzzi, P.N., Beisel, C.E., Morrison, V.A., Guatelli, J.C., Brooks, P.A., Kauffman, C.A., Pachucki, C.T., Neuzil, K.M., Betts, R.F., Wright, P.F., Griffin, M.R., Brunell, P., Soto, N.E., Marques, A.R., Keay, S.K., Goodman, R.P., Cotton, D.J., Gnann, J.W., Loutit, J., Holodniy, M., Keitel, W.A., Crawford, G.E., Yeh, S.-S., Lobo, Z., Toney, J.F., Greenberg, R.N., Keller, P.M., Harbecke, R., Hayward, A.R., Irwin, M.R., Kyriakides, T.C., Chan, C.Y., Chan, I.S.F., Wang, W.W.B., Annunziato, P.W., Silber, J.L.·2005·New England Journal of Medicine

DOI 10.1056/nejmoa051016

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Abstract

BACKGROUND: The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults. METHODS: We enrolled 38,546 adults 60 years of age or older in a randomized, double-blind, placebo-controlled trial of an investigational live attenuated Oka/Merck VZV vaccine ("zoster vaccine"). Herpes zoster was diagnosed according to clinical and laboratory criteria. The pain and discomfort associated with herpes zoster were measured repeatedly for six months. The primary end point was the burden of illness due to herpes zoster, a measure affected by the incidence, severity, and duration of the associated pain and discomfort. The secondary end point was the incidence of postherpetic neuralgia. RESULTS: More than 95 percent of the subjects continued in the study to its completion, with a median of 3.12 years of surveillance for herpes zoster. A total of 957 confirmed cases of herpes zoster (315 among vaccine recipients and 642 among placebo recipients) and 107 cases of postherpetic neuralgia (27 among vaccine recipients and 80 among placebo recipients) were included in the efficacy analysis. The use of the zoster vaccine reduced the burden of illness due to herpes zoster by 61.1 percent (P<0.001), reduced the incidence of postherpetic neuralgia by 66.5 percent (P<0.001), and reduced the incidence of herpes zoster by 51.3 percent (P<0.001). Reactions at the injection site were more frequent among vaccine recipients but were generally mild. CONCLUSIONS: The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults.

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A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392
A sharper Bonferroni procedure for multiple tests of significance
HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829
Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases
Daut, R. L., Cleeland, C. S., & Flanery, R. C. (1983) · Pain · doi:10.1016/0304-3959(83)90143-4 · Cited by 1,562
The Nature of Herpes Zoster: A Long-Term Study and a New Hypothesis
Hope-Simpson, R. E. (1965) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576505800106 · Cited by 1,389
Comparative analysis of two rates
Miettinen, O. S., & Nurminen, M. M. (1985) · Statistics in Medicine · doi:10.1002/sim.4780040211 · Cited by 1,111
Population-Based Study of Herpes Zoster and Its Sequelae
Ragozzino, M. W., Melton, L. J., Kurland, L. T., CHU, C. P., & PERRY, H. O. (1982) · Medicine · doi:10.1097/00005792-198209000-00003 · Cited by 921
Herpes Zoster
Gnann, J. W., & Whitley, R. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmcp013211 · Cited by 781
Self-citation
Testing the validity of the Euroqol and comparing it with the SF-36 health survey questionnaire
Brazier, J. E., Jones, N., & Kind, P. (1993) · Quality of Life Research · doi:10.1007/bf00435221 · Cited by 707
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641
Self-citation
The Incidence of Herpes Zoster
Donahue, J. G. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430150071008 · Cited by 618

Flagged first, then by citations

Show all 40 references

Research works printed but not linked: 2

Hope-Simpson RE, 1965, Proc R Soc Med, 58, 9
Hope-Simpson RE, 1975, J R Coll Gen Pract, 25, 571

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Minassian, C., Thomas, S. L., Smeeth, L. L., Douglas, I., Brauer, R., & Langan, S. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001919 · Cited by 115
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Thompson, R. R., Kong, C., Porco, T. C., Kim, E. H., Ebert, C. D., & Acharya, N. R. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1185 · Cited by 113
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Rimland, D., & Moanna, A. (2010) · Clinical Infectious Diseases · doi:10.1086/651078 · Cited by 113
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Willis, E. D., Woodward, M., Brown, E., Popmihajlov, Z., Saddier, P., Annunziato, P. W., Halsey, N. A., & Gershon, A. A. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.11.013 · Cited by 112
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Geretti, A. M. (2008) · HIV Medicine · doi:10.1111/j.1468-1293.2008.00637.x · Cited by 110
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Tseng, H. F., Bruxvoort, K. J., Ackerson, B. K., Luo, Y., Tanenbaum, H. C., Tian, Y., Zheng, C., Cheung, B., Patterson, B. J., Oorschot, D. V., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz652 · Cited by 111
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Li, Q., Chen, N., Yang, J., Zhou, M., Zhou, D., Zhang, Q., & He, L. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006866.pub2 · Cited by 111
Funding of drugs: do vaccines warrant a different approach?
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Self-citation
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Studahl, M., Lindquist, L., Eriksson, B.-M., Günther, G., Bengner, M., Franzen-Röhl, E., Fohlman, J., Bergström, T., & Aurelius, E. (2013) · Drugs · doi:10.1007/s40265-013-0007-5 · Cited by 90
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Hinman, A. R., Orenstein, W. A., Santoli, J. M., Rodewald, L. E., & Cochi, S. L. (2005) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.27.021405.102248 · Cited by 90
Infection in the Elderly
Htwe, T. H., Mushtaq, A., Robinson, S. B., Rosher, R. B., & Khardori, N. M. (2007) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2007.07.006 · Cited by 88
Disease burden and epidemiology of herpes zoster in pre-vaccine Taiwan
Lin, Y.-H., Huang, L., Chang, I., Tsai, F., Lu, C., Shao, P., & Chang, L. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.11.029 · Cited by 89
B ritish HIV A ssociation Guidelines on the Use of Vaccines in HIV ‐Positive Adults 2015
Geretti, A. M., Brook, G., Cameron, C., Chadwick, D., French, N., Heyderman, R. S., Ho, A. Y. W., Hunter, M., Ladhani, S. N., Lawton, M. D., et al. (2016) · HIV Medicine · doi:10.1111/hiv.12424 · Cited by 90
Family History as a Risk Factor for Herpes Zoster
Hicks, L. D., Cook‐Norris, R. H., Mendoza, N., Madkan, V. K., Arora, A., & Tyring, S. K. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.5.603 · Cited by 88
Post-licensure zoster vaccine effectiveness against herpes zoster and postherpetic neuralgia in older adults: a systematic review and meta-analysis
Mbinta, J. F., Nguyen, B. P., Awuni, P. M. A., Paynter, J., & Simpson, C. R. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00039-3 · Cited by 93
Postherpetic neuralgia in the elderly
Johnson, R. W., & McElhaney, J. E. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02089.x · Cited by 90
Comparison of Varicella‐Zoster Virus–Specific Immunity of Patients with Diabetes Mellitus and Healthy Individuals
Okamoto, S., Hata, A., Sadaoka, K., Yamanishi, K., & Mori, Y. (2009) · The Journal of Infectious Diseases · doi:10.1086/644646 · Cited by 88
Neuropathic Itch
Oaklander, A. L. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.04.006 · Cited by 88
Desirability and feasibility of a vaccine against cytomegalovirus
Griffiths, P. D., Plotkin, S. A., Mocarski, E. S., Pass, R. F., Schleiss, M. R., Krause, P. R., & Bialek, S. R. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.10.074 · Cited by 87
VZV-specific cell-mediated immunity, but not humoral immunity, correlates inversely with the incidence of herpes zoster and the severity of skin symptoms and zoster-associated pain: The SHEZ study
Asada, H. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.09.031 · Cited by 87
Adjuvant strategies to improve vaccination of the elderly population
Weinberger, B. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.03.014 · Cited by 87
Herpes Zoster Ophthalmicus: Comparison of Disease in Patients 60 Years and Older Versus Younger than 60 Years
Ghaznawi, N., Virdi, A. S., Dayan, A. C., Hammersmith, K. M., Rapuano, C. J., Laibson, P. R., & Cohen, E. J. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.04.002 · Cited by 86
The humanistic, economic and societal burden of Herpes Zoster in Europe: a critical review
Gater, A., Uhart, M., McCool, R., & Preaud, E. (2015) · BMC Public Health · doi:10.1186/s12889-015-1514-y · Cited by 85
Population-Based Study of the Epidemiology of Herpes Zoster in Korea
Kim, Y. J., Lee, C. N., Lim, C., Jeon, W. S., & Park, Y. M. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.12.1706 · Cited by 85
Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism
Stone, C. A., Hemler, J. A., Commins, S. P., Schuyler, A. J., Phillips, E. J., Peebles, R. S., & Fahrenholz, J. M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.10.037 · Cited by 85
Evaluation of the effect of the herpes zoster vaccination programme 3 years after its introduction in England: a population-based study
Amirthalingam, G., Andrews, N., Keel, P., Mullett, D., Correa, A., de Lusignan, S., & Ramsay, M. E. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30234-7 · Cited by 85
Herpes Zoster Among Persons Living With HIV in the Current Antiretroviral Therapy Era
Blank, L. J., Polydefkis, M. J., Moore, R. D., & Gebo, K. A. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318266cd3c · Cited by 85
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Field, H. J., & Hodge, R. A. V. (2013) · British Medical Bulletin · doi:10.1093/bmb/ldt011 · Cited by 85
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de Gomensoro, E., Giudice, G. D., & Doherty, T. M. (2018) · Annals of Medicine · doi:10.1080/07853890.2017.1417632 · Cited by 85
Epidemiology and cost of herpes zoster and postherpetic neuralgia in Germany
Ultsch, B., Köster, I., Reinhold, T., Siedler, A., Krause, G., Icks, A., Schübert, I., & Wichmann, O. (2012) · The European Journal of Health Economics · doi:10.1007/s10198-012-0452-1 · Cited by 84
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Tseng, H. F., Chi, M., Smith, N., Marcy, S. M., Sy, L. S., & Jacobsen, S. J. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis334 · Cited by 84
The temporal impact of aging on the burden of herpes zoster
Varghese, L., Standaert, B. A., Olivieri, A., & Curran, D. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0420-9 · Cited by 84
The impact of herpes zoster and post-herpetic neuralgia on quality of life: patient-reported outcomes in six European countries
Lukas, K., Edte, A., & Bertrand, I. (2011) · Journal of Public Health · doi:10.1007/s10389-011-0481-8 · Cited by 83
Major depressive disorder and immunity to varicella-zoster virus in the elderly
Irwin, M. R., Levin, M. J., Carrillo, C., Olmstead, R., Lucko, A., Lang, N., Caulfield, M. J., Weinberg, A., Chan, I. S. F., Clair, J. B. S., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.001 · Cited by 84
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Oldfield, L. M., Grzesik, P., Voorhies, A. A., Alperovich, N., MacMath, D., Najera, C. D., Chandra, D. S., Prasad, S., Noskov, V. N., Montague, M. G., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700534114 · Cited by 83
A Prospective Study of the Herpes Zoster Severity of Illness
Drolet, M., Brisson, M., Levin, M. J., Schmader, K. E., Oxman, M. N., Johnson, R. W., Camden, S., & Mansi, J. A. (2010) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181eef686 · Cited by 82
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Izurieta, H. S., Wernecke, M., Kelman, J. A., Wong, S., Forshee, R. A., Pratt, D., Lu, Y., Sun, Q., Jankosky, C., Krause, P. R., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw854 · Cited by 83
Neurologic manifestations of varicella zoster virus infections
Amlie‐Lefond, C., & Jubelt, B. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0064-z · Cited by 81
Varicella Zoster Virus-Specific Immune Responses to a Herpes Zoster Vaccine in Elderly Recipients With Major Depression and the Impact of Antidepressant Medications
Irwin, M. R., Levin, M. J., Laudenslager, M. L., Olmstead, R., Lucko, A., Lang, N., Carrillo, C., Stanley, H. A., Caulfield, M. J., Weinberg, A., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cis1208 · Cited by 81
Self-citation
Herpes Zoster and Diabetes Mellitus: A Review
Papagianni, M., Metallidis, S., & Τζιόμαλος, Κ. (2018) · Diabetes Therapy · doi:10.1007/s13300-018-0394-4 · Cited by 81
Persistence of immune response to an adjuvanted varicella-zoster virus subunit vaccine for up to year nine in older adults
Schwarz, T. F., Volpe, S. V., Catteau, G., Chlíbek, R., David, M. P., Richardus, J. H., Lal, H., Oostvogels, L., Pauksens, K., Ravault, S., et al. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1442162 · Cited by 81
Incidences of Herpes Zoster and Postherpetic Neuralgia in Japanese Adults Aged 50 Years and Older From a Community-based Prospective Cohort Study: The SHEZ Study
Takao, Y., Miyazaki, Y., Okeda, M., Onishi, F., Yano, S., Gomi, Y., Ishikawa, T., Okuno, Y., Mori, Y., Asada, H., et al. (2015) · Journal of Epidemiology · doi:10.2188/jea.je20140210 · Cited by 80

Authors: Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., Weinberg, A., Boardman, K. D., Williams, H. M., Zhang, J. H., Peduzzi, P. N., Beisel, C. E., Morrison, V. A., Guatelli, J. C., Brooks, P. A., Kauffman, C. A., Pachucki, C. T., Neuzil, K. M., Betts, R. F., Wright, P. F., Griffin, M. R., Brunell, P., Soto, N. E., Marques, A. R., Keay, S. K., Goodman, R. P., Cotton, D. J., Gnann, J. W., Loutit, J., Holodniy, M., Keitel, W. A., Crawford, G. E., Yeh, S.-S., Lobo, Z., Toney, J. F., Greenberg, R. N., Keller, P. M., Harbecke, R., Hayward, A. R., Irwin, M. R., Kyriakides, T. C., Chan, C. Y., Chan, I. S. F., Wang, W. W. B., Annunziato, P. W., & Silber, J. L.
Affiliations: University of California San Diego (US)
Durham VA Medical Center (US)
Duke Medical Center (US)
National Institutes of Health (US)
Washington University in St. Louis (US)
VA Boston Healthcare System (US)
VA NY Harbor Healthcare System (US)
Columbia University (US)
New Mexico VA Health Care System (US)
National Institute of Allergy and Infectious Diseases (US)
VA San Diego Healthcare System (US)
VA Ann Arbor Healthcare System (US)
Edward Hines, Jr. VA Hospital (US)
VA Puget Sound Health Care System (US)
University of Rochester Medicine (US)
Vanderbilt University Medical Center (US)
Baltimore VA Medical Center (US)
VA Palo Alto Health Care System (US)
Baylor College of Medicine (US)
The University of Texas at San Antonio Health Science Center (US)
Northport VA Medical Center (US)
James A. Haley Veterans' Hospital (US)
Lexington VA Health Care System (US)
University of California, Los Angeles (US)
ORCID: Levin, M.J.
Johnson, G.R.
Schmader, K.E.
Arbeit, R.D.
Simberkoff, M.S.
Gershon, A.A.
Weinberg, A.
Williams, H.M.
Peduzzi, P.N.
Neuzil, K.M.
Wright, P.F.
Griffin, M.R.
Marques, A.R.
Cotton, D.J.
Holodniy, M.
Toney, J.F.
Greenberg, R.N.
Hayward, A.R.
Irwin, M.R.
Kyriakides, T.C.
Chan, C.Y.
Annunziato, P.W.
Silber, J.L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2005-06-02
Volume: 352
Issue: 22
Pages: 2271-2284
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa051016
OpenAlex: W2131041950
Cited by: 2,412
References: 40
Citations by year: 2026: 51 · 2025: 90 · 2024: 63 · 2023: 92 · 2022: 60 · 2021: 95 · 2020: 97 · 2019: 111 · 2018: 145 · 2017: 155 · 2016: 158 · 2015: 133 · 2014: 126 · 2013: 149 · 2012: 110
FWCI: 89.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Office of Research and Development
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Keywords: herpes zoster, postherpetic neuralgia, varicella-zoster virus, live attenuated zoster vaccine, older adults, vaccine efficacy, disease burden, cell-mediated immunity, injection site reactions
MeSH terms: Aged, Double-Blind Method, Female, Follow-Up Studies, Herpes Zoster, Humans, Immunologic Memory, Male, Middle Aged, Neuralgia, Vaccines, Attenuated, Herpesvirus 3, Human, Virus Activation, Incidence, Cost of Illness, Chickenpox Vaccine

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A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

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