Cited by 2,412Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchViral Infections and Immunology Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

Open access

Oxman, M.N., Levin, M.J., Johnson, G.R., Schmader, K.E., Straus, S.E., Gelb, L.D., Arbeit, R.D., Simberkoff, M.S., Gershon, A.A., Davis, L.E., Weinberg, A., Boardman, K.D., Williams, H.M., Zhang, J. Hongyuan, Peduzzi, P.N., Beisel, C.E., Morrison, V.A., Guatelli, J.C., Brooks, P.A., Kauffman, C.A., Pachucki, C.T., Neuzil, K.M., Betts, R.F., Wright, P.F., Griffin, M.R., Brunell, P., Soto, N.E., Marques, A.R., Keay, S.K., Goodman, R.P., Cotton, D.J., Gnann, J.W., Loutit, J., Holodniy, M., Keitel, W.A., Crawford, G.E., Yeh, S.-S., Lobo, Z., Toney, J.F., Greenberg, R.N., Keller, P.M., Harbecke, R., Hayward, A.R., Irwin, M.R., Kyriakides, T.C., Chan, C.Y., Chan, I.S.F., Wang, W.W.B., Annunziato, P.W., Silber, J.L.·2005·New England Journal of Medicine

DOI 10.1056/nejmoa051016

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults. METHODS: We enrolled 38,546 adults 60 years of age or older in a randomized, double-blind, placebo-controlled trial of an investigational live attenuated Oka/Merck VZV vaccine ("zoster vaccine"). Herpes zoster was diagnosed according to clinical and laboratory criteria. The pain and discomfort associated with herpes zoster were measured repeatedly for six months. The primary end point was the burden of illness due to herpes zoster, a measure affected by the incidence, severity, and duration of the associated pain and discomfort. The secondary end point was the incidence of postherpetic neuralgia. RESULTS: More than 95 percent of the subjects continued in the study to its completion, with a median of 3.12 years of surveillance for herpes zoster. A total of 957 confirmed cases of herpes zoster (315 among vaccine recipients and 642 among placebo recipients) and 107 cases of postherpetic neuralgia (27 among vaccine recipients and 80 among placebo recipients) were included in the efficacy analysis. The use of the zoster vaccine reduced the burden of illness due to herpes zoster by 61.1 percent (P<0.001), reduced the incidence of postherpetic neuralgia by 66.5 percent (P<0.001), and reduced the incidence of herpes zoster by 51.3 percent (P<0.001). Reactions at the injection site were more frequent among vaccine recipients but were generally mild. CONCLUSIONS: The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa051016

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392
A sharper Bonferroni procedure for multiple tests of significance
HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829
Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases
Daut, R. L., Cleeland, C. S., & Flanery, R. C. (1983) · Pain · doi:10.1016/0304-3959(83)90143-4 · Cited by 1,562
The Nature of Herpes Zoster: A Long-Term Study and a New Hypothesis
Hope-Simpson, R. E. (1965) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576505800106 · Cited by 1,389
Comparative analysis of two rates
Miettinen, O. S., & Nurminen, M. M. (1985) · Statistics in Medicine · doi:10.1002/sim.4780040211 · Cited by 1,111
Population-Based Study of Herpes Zoster and Its Sequelae
Ragozzino, M. W., Melton, L. J., Kurland, L. T., CHU, C. P., & PERRY, H. O. (1982) · Medicine · doi:10.1097/00005792-198209000-00003 · Cited by 921
Herpes Zoster
Gnann, J. W., & Whitley, R. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmcp013211 · Cited by 781
Self-citation
Testing the validity of the Euroqol and comparing it with the SF-36 health survey questionnaire
Brazier, J. E., Jones, N., & Kind, P. (1993) · Quality of Life Research · doi:10.1007/bf00435221 · Cited by 707
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641
Self-citation
The Incidence of Herpes Zoster
Donahue, J. G. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430150071008 · Cited by 618

Flagged first, then by citations

Show all 40 references

Research works printed but not linked: 2

Hope-Simpson RE, 1965, Proc R Soc Med, 58, 9
Hope-Simpson RE, 1975, J R Coll Gen Pract, 25, 571

Sorted by citations

Items 501–600 of 1,001

Herpes Zoster as a Risk Factor for Incident Giant Cell Arteritis
England, B. R., Mikuls, T. R., Xie, F., Yang, S., Chen, L., & Curtis, J. R. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40236 · Cited by 47
Herpes zoster ophthalmicus
Li, J. Y. (2018) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000491 · Cited by 47
Risk of Herpes Zoster and Disseminated Varicella Zoster in Patients Taking Immunosuppressant Drugs at the Time of Zoster Vaccination
Cheetham, T. C., Marcy, S. M., Tseng, H. F., Sy, L. S., Liu, I. A., Bixler, F. R., Baxter, R. P., Donahue, J. G., Naleway, A. L., & Jacobsen, S. J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.04.021 · Cited by 46
Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models
Kinchington, P. R., & Goins, W. F. (2011) · Journal of NeuroVirology · doi:10.1007/s13365-011-0069-7 · Cited by 46
An inverse correlation of VZV skin-test reaction, but not antibody, with severity of herpes zoster skin symptoms and zoster-associated pain
Asada, H., Nagayama, K., Okazaki, A., Mori, Y., Okuno, Y., Takao, Y., Miyazaki, Y., Onishi, F., Okeda, M., Yano, S., et al. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.10.015 · Cited by 46
Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV
Chiu, C., McCausland, M. M., Sidney, J., Duh, F.-M. C., Rouphael, N., Mehta, A. K., Mulligan, M. J., Carrington, M. N., Wieland, A., Sullivan, N., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004008 · Cited by 46
Self-citation
Postherpetic Neuralgia: From Preclinical Models to the Clinic
Delaney, A., Colvin, L., Fallon, M., Dalziel, R. G., Mitchell, R., & Fleetwood-Walker, S. M. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.005 · Cited by 46
The epidemiology of Varicella Zoster Virus infection in Italy
the Seroepidemiology Group, Gabutti, G., Rota, M. C., Guido, M., Donno, A. D., Bella, A., Atti, M. L. C. D., & Crovari, P. (2008) · BMC Public Health · doi:10.1186/1471-2458-8-372 · Cited by 46
Boston Keratoprosthesis Treatment of Herpes Zoster Neurotrophic Keratopathy
Pavan‐Langston, D., & Dohlman, C. H. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2007.10.013 · Cited by 46
Risk factors for herpes zoster in a large cohort of unvaccinated older adults: a prospective cohort study
Liu, B. C., Heywood, A. E., Reekie, J., Banks, E., Kaldor, J. M., McIntyre, P. B., Newall, A. T., & MacIntyre, C. R. (2015) · Epidemiology and Infection · doi:10.1017/s0950268814003653 · Cited by 46
Issues in the Treatment of Neurological Conditions Caused by Reactivation of Varicella Zoster Virus (VZV)
Kennedy, P. G. E. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0430-x · Cited by 46
Mechanisms of Immune Control of Mucosal HSV Infection: A Guide to Rational Vaccine Design
Truong, N. R., Smith, J. B., Sandgren, K. J., & Cunningham, A. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00373 · Cited by 46
Burden of herpes zoster requiring hospitalization in Spain during a seven-year period (1998–2004)
de Miguel, Á. G., Gil-Prieto, R., Alvaro, A., Martín, M. S., & González, A. (2009) · BMC Infectious Diseases · doi:10.1186/1471-2334-9-55 · Cited by 46
Modelling the impact of one-dosevs. two-dose vaccination regimens on the epidemiology of varicella zoster virus in Australia
GAO, Z., Gidding, H. F., Wood, J., & MacIntyre, C. R. (2009) · Epidemiology and Infection · doi:10.1017/s0950268809990860 · Cited by 46
Herpes Zoster
Cohen, J. I. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1310369 · Cited by 46
Shingles (Herpes Zoster) Vaccine (Zostavax®): A Review of Its Use in the Prevention of Herpes Zoster and Postherpetic Neuralgia in Adults Aged ≥50 Years
Keating, G. M. (2013) · Drugs · doi:10.1007/s40265-013-0088-1 · Cited by 45
Effectiveness of the live zoster vaccine during the 10 years following vaccination: real world cohort study using electronic health records
Klein, N. P., Bartlett, J., FIREMAN, B. H., Marks, M. A., Hansen, J. R., Lewis, E. M., Aukes, L. L., & Saddier, P. (2023) · BMJ · doi:10.1136/bmj-2023-076321 · Cited by 49
Varicella zoster virus immunity: A primer
Duncan, C. J. A., & Hambleton, S. (2015) · Journal of Infection · doi:10.1016/j.jinf.2015.04.015 · Cited by 46
The Neuralgias: Diagnosis and Management
Gadient, P. M., & Smith, J. H. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0459-3 · Cited by 45
Natural history of sensory function after herpes zoster
Petersen, K. L., & Rowbotham, M. C. (2010) · Pain · doi:10.1016/j.pain.2010.04.005 · Cited by 45
Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
Patterson‐Bartlett, J., Levin, M. J., Lang, N., Schödel, F. P., Vessey, R., & Weinberg, A. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.07.051 · Cited by 45
Self-citation
A health economic model for evaluating a vaccine for the prevention of herpes zoster and post-herpetic neuralgia in the UK
Moore, L., Rémy, V., Martin, M., Beillat, M., & McGuire, A. J. (2010) · Cost Effectiveness and Resource Allocation · doi:10.1186/1478-7547-8-7 · Cited by 45
Screening and Preventive Services for Older Adults
Nicholas, J. A., & Hall, W. J. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20275 · Cited by 48
Clinical and Molecular Aspects of Varicella Zoster Virus Infection
Gilden, D., Nagel, M. A., Mahalingam, R., Mueller, N. H., Brazeau, E., Pugazhenthi, S., & Cohrs, R. J. (2008) · Future Neurology · doi:10.2217/14796708.4.1.103 · Cited by 45
Incidence of varicella zoster virus infections of the central nervous system in the elderly: a large tertiary hospital-based series (2007–2014)
Arruti, M., Piñeiro, L., Salicio, Y., Cilla, G., Goenaga, M., & de Munaín, A. L. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0519-y · Cited by 46
Complications of herpes zoster in immunocompetent older adults: Incidence in vaccine and placebo groups in two large phase 3 trials
Kovac, M., Lal, H., Cunningham, A. L., Levin, M. J., Johnson, R. W., Cámpora, L., Volpi, A., & Heineman, T. C. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.02.029 · Cited by 45
Self-citation
Epidemiology and long-term disease burden of herpes zoster and postherpetic neuralgia in Taiwan: a population-based, propensity score-matched cohort study
Lu, W., Lin, C.-W., Wang, C.-Y., Chen, L., & Hsiao, F. (2018) · BMC Public Health · doi:10.1186/s12889-018-5247-6 · Cited by 45
Immune responses to zoster vaccines
Levin, M. J., & Weinberg, A. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1560918 · Cited by 46
Self-citation
Chickenpox, Measles, and Mumps
Gershon, A. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6400-8.00022-5 · Cited by 47
Self-citation
Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries
Damm, O., Ultsch, B., Horn, J., Mikolajczyk, R., Greiner, W., & Wichmann, O. (2015) · BMC Public Health · doi:10.1186/s12889-015-1861-8 · Cited by 44
Childhood varicella-zoster virus vaccination in Belgium: Cost-effective only in the long run or without exogenous boosting?
Bilcke, J., van Hoek, A. J., & Beutels, P. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.23334 · Cited by 44
Family history and herpes zoster risk in the era of shingles vaccination
Hernandez, P. O., Javed, S., Mendoza, N., Lapolla, W. J., Hicks, L. D., & Tyring, S. K. (2011) · Journal of Clinical Virology · doi:10.1016/j.jcv.2011.08.014 · Cited by 44
Advances in the Treatment of Varicella-Zoster Virus Infections
Andreï, G., & Snoeck, R. (2013) · Advances in pharmacology · doi:10.1016/b978-0-12-405880-4.00004-4 · Cited by 44
Immunosuppressive medication use and risk of herpes zoster (HZ) in patients with systemic lupus erythematosus (SLE): A nationwide case-control study
Hu, S. C., Yen, F., Wang, T., Lin, Y., Lin, C., & Chen, G. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.059 · Cited by 44
The herpes zoster subunit vaccine
Cunningham, A. L. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1134481 · Cited by 44
Herpes Zoster Vaccines
Cunningham, A. L., & Levin, M. J. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy382 · Cited by 44
Self-citation
Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I
Zerboni, L., Reichelt, M., Jones, C. D., Zehnder, J. L., Ito, H., & Arvin, A. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706023104 · Cited by 45
Short-Term and Long-Term Effects of Highly Active Antiretroviral Therapy on the Incidence of Herpes Zoster in HIV-Infected Children
Levin, M. J., ANDERSON, J. P., Seage, G. R., & Williams, P. L. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31819550a4 · Cited by 44
Self-citation
Varicella zoster virus: review of its management
Mustafa, M. B., Arduino, P. G., & Porter, S. R. (2009) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2009.00802.x · Cited by 44
National Survey of Primary Care Physicians Regarding Herpes Zoster and the Herpes Zoster Vaccine
Hurley, L. P., Harpaz, R., Daley, M. F., Crane, L. A., Beaty, B. L., Barrow, J. C., Babbel, C. I., Marin, M., Steiner, J. F., Davidson, A. J., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/522153 · Cited by 44
Community and Patient Values for Preventing Herpes Zoster
Lieu, T. A., Ortega‐Sanchez, I. R., Ray, G. T., Rusinak, D., Yih, W. K., Choo, P. W., Shui, I. M., Kleinman, K., Harpaz, R., & Prosser, L. A. (2008) · PharmacoEconomics · doi:10.2165/00019053-200826030-00006 · Cited by 45
Varicella-Zoster Virus
Gershon, A. A. (2006) · Humana Press eBooks · doi:10.1385/1-59259-965-6:091 · Cited by 44
Self-citation
Safety and efficacy of recombinant and live herpes zoster vaccines for prevention in at-risk adults with chronic diseases and immunocompromising conditions
Sullivan, K. M., Farraye, F. A., Winthrop, K. L., Willer, D. O., Vink, P., & Silva, F. T. D. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.10.063 · Cited by 43
Incidence and risk factors of herpes zoster among adult renal transplant recipients receiving universal antiviral prophylaxis
Pavlopoulou, I. D., Poulopoulou, S., Melexopoulou, C., Papazaharia, I., Zavos, G., & Boletis, I. N. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1038-1 · Cited by 43
Eye and Periocular Skin Involvement in Herpes Zoster Infection.
Kalogeropoulos, C. D., Bassukas, I. D., Moschos, M. M., & Tabbara, K. F. (2015) · Medical Hypothesis Discovery & Innovation in Ophthalmology · Cited by 43
Safety and tolerability of zoster vaccine in adults ≥60 years old
Murray, A. V., Reisinger, K. S., Kerzner, B., Stek, J. E., Sausser, T. A., Xu, J. Z., Wang, W. W., Chan, I. S. F., Annunziato, P. W., & Parrino, J. (2011) · Human Vaccines · doi:10.4161/hv.7.11.17982 · Cited by 43
Self-citation
Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster
Morrison, V. A., Oxman, M. N., Levin, M. J., Schmader, K. E., Guatelli, J., Betts, R. F., Gelb, L., Pachucki, C. T., Keay, S. K., Menzies, B. E., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit182 · Cited by 43
Self-citation
Breadth and Functionality of Varicella-Zoster Virus Glycoprotein-Specific Antibodies Identified after Zostavax Vaccination in Humans
Sullivan, N., Monslow, M. A., Sei, J. J., Dürr, E., Davis, C. W., Chang, C. Y., McCausland, M. M., Wieland, A., Krah, D. L., Rouphael, N., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00269-18 · Cited by 43
T follicular helper cell development and functionality in immune ageing
Gustafson, C. E., Weyand, C. M., & Goronzy, J. J. (2018) · Clinical Science · doi:10.1042/cs20171157 · Cited by 43
Systematic review of the evidence on the epidemiology of herpes zoster: incidence in the general population and specific subpopulations in Spain
Mareque, M., Oyagüez, I., Moraño, R. B., & Casado, M. Á. (2019) · Public Health · doi:10.1016/j.puhe.2018.10.015 · Cited by 43
Effectiveness of the Recombinant Zoster Vaccine for Herpes Zoster Ophthalmicus in the United States
Lu, A., Sun, Y., Porco, T. C., Arnold, B. F., & Acharya, N. R. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2021.04.017 · Cited by 43
Herpes Simplex Virus 2 ICP0− Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine
Halford, W. P., Pueschel, R., & Rakowski, B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012251 · Cited by 43
Vaccination of Solid‐Organ Transplantation Candidates
Chow, J. K. L., & Golan, Y. (2009) · Clinical Infectious Diseases · doi:10.1086/644734 · Cited by 44
A Community-Based Survey to Assess Knowledge, Attitudes, Beliefs and Practices Regarding Herpes Zoster in an Urban Setting
Baalbaki, N. A., Fava, J. P., Ng, M., Okorafor, E., Nawaz, A., Chiu, W., Salim, A. M., Cha, R., & Kilgore, P. E. (2019) · Infectious Diseases and Therapy · doi:10.1007/s40121-019-00269-2 · Cited by 42
Prevention of Herpes Zoster: A Focus on the Effectiveness and Safety of Herpes Zoster Vaccines
Marra, Y., & Lalji, F. (2022) · Viruses · doi:10.3390/v14122667 · Cited by 42
Challenges in the Vaccination of the Elderly and Strategies for Improvement
Soegiarto, G., & Purnomosari, D. (2023) · Pathophysiology · doi:10.3390/pathophysiology30020014 · Cited by 45
Herpes zoster vaccine effectiveness and manifestations of herpes zoster and associated pain by vaccination status
Marin, M., Yawn, B. P., Hales, C. M., Wollan, P. C., Bialek, S. R., Zhang, J. H., Kurland, M. J., & Harpaz, R. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1016681 · Cited by 42
Self-citation
Acute Retinal Necrosis After Herpes Zoster Vaccination
Charkoudian, L. D. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.320 · Cited by 42
Practice Patterns and Opinions in the Management of Recurrent or Chronic Herpes Zoster Ophthalmicus
Sy, A., McLeod, S. D., Cohen, E. J., Margolis, T. P., Mannis, M. J., Lietman, T. M., & Acharya, N. R. (2012) · Cornea · doi:10.1097/ico.0b013e31823cbe6a · Cited by 42
Increased risk of varicella zoster virus infection in inflammatory bowel disease in an Asian population: a nationwide population-based cohort study
Tsai, S., Yang, T.-Y., Lin, C., Tsai, Y., Kuo, C. ‐., & Kao, C. (2014) · International Journal of Clinical Practice · doi:10.1111/ijcp.12508 · Cited by 42
Anti-cytokine autoantibodies in postherpetic neuralgia
Bayat, A., Burbelo, P. D., Browne, S., Quinlivan, M., Martinez, B., Holland, S. M., Buvanendran, A., Kroin, J. S., Mannes, A. J., Breuer, J., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0695-6 · Cited by 42
Discriminating between Varicella-Zoster Virus Vaccine and Wild-Type Strains by Loop-Mediated Isothermal Amplification
Higashimoto, Y., Ihira, M., Ohta, A., Inoue, S., Usui, C., Asano, Y., & Yoshikawa, T. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00216-08 · Cited by 42
Shingles (Herpes Zoster) Vaccine (Zostavax®): A Review in the Prevention of Herpes Zoster and Postherpetic Neuralgia
Keating, G. M. (2016) · BioDrugs · doi:10.1007/s40259-016-0180-7 · Cited by 42
Efficacy of varicella (VZV) vaccination: an update for the clinician
Wang, L., Zhu, L., & Zhu, H. (2016) · Therapeutic Advances in Vaccines · doi:10.1177/2051013616655980 · Cited by 42
Reactivation of Herpes Zoster Keratitis With Corneal Perforation After Zoster Vaccination
Jastrzebski, A., Brownstein, S., Ziai, S., Saleh, S., Lam, K., & Jackson, W. B. (2017) · Cornea · doi:10.1097/ico.0000000000001203 · Cited by 42
Active surveillance of 2017 seasonal influenza vaccine safety: an observational cohort study of individuals aged 6 months and older in Australia
Pillsbury, A., Glover, C., Jacoby, P. A., Quinn, H., Fathima, P., Cashman, P. M., Leeb, A., Blyth, C. C., Gold, M., Snelling, T., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-023263 · Cited by 42
Meeting the Challenges of Immunizing Adults
Bridges, C. B., Hurley, L. P., Williams, W. W., Ramakrishnan, A., Dean, A. K., & Groom, A. V. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.09.054 · Cited by 44
Exacerbation of Zoster Interstitial Keratitis After Zoster Vaccination in an Adult
Khalifa, Y. M. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.142 · Cited by 42
Determinants of non-compliance with herpes zoster vaccination in the community-dwelling elderly
Opstelten, W., van Essen, G. A., & Hak, E. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.10.047 · Cited by 42
Report of the ad-hoc consultation on aging and immunization for a future WHO research agenda on life-course immunization
Thomas-Crusells, J., McElhaney, J. E., & Aguado, M. T. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.07.025 · Cited by 39
Management of Oral Infections in Cancer Patients
Lerman, M. A., Laudenbach, J. M., Marty, F. M., Baden, L. R., & Treister, N. S. (2008) · Dental Clinics of North America · doi:10.1016/j.cden.2007.10.006 · Cited by 42
Herpes zoster and postherpetic neuralgia
Watson, C. P. N. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.101409 · Cited by 42
Public Health Impact and Cost-Effectiveness of Non-live Adjuvanted Recombinant Zoster Vaccine in Canadian Adults
McGirr, A. A., Oorschot, D. V., Widenmaier, R., Stokes, M., Ganz, M. L., Jung, H., Varghese, L., & Curran, D. (2019) · Applied Health Economics and Health Policy · doi:10.1007/s40258-019-00491-6 · Cited by 41
Comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged ≥50 years: A randomised non-inferiority clinical trial
Díez‐Domingo, J., Weinke, T., de Lomas, J. G., Meyer, C. U., Bertrand, I., Eymin, C., Thomas, S., & Sadorge, C. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.12.024 · Cited by 41
A Comparison of Herpes Zoster Incidence across the Spectrum of Chronic Kidney Disease, Dialysis and Transplantation
Lin, S., Liu, J.-H., Lin, C., Tsai, I., Chen, P., Chung, C., Liu, Y., Wang, I., Lin, H., & Huang, C.-C. (2012) · American Journal of Nephrology · doi:10.1159/000339004 · Cited by 41
Treatment of skin and soft tissue infections in the Elderly: A review
Kish, T. D., Chang, M., & Fung, H. B. (2010) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/s1543-5946(10)80002-9 · Cited by 42
Health economic evaluation of a vaccine for the prevention of herpes zoster (shingles) and post-herpetic neuralgia in adults in Belgium
Annemans, L., Bresse, X., Gobbo, C., & Papageorgiou, M. (2010) · Journal of Medical Economics · doi:10.3111/13696998.2010.502854 · Cited by 41
Herpes Zoster and Exposure to the Varicella Zoster Virus in an Era of Varicella Vaccination
Donahue, J. G., Kieke, B. A., Gargiullo, P. M., Jumaan, A. O., Berger, N. R., McCauley, J. S., & Belongia, E. A. (2010) · American Journal of Public Health · doi:10.2105/ajph.2009.160002 · Cited by 41
A Single-Center Randomized Controlled Trial of Local Methylcobalamin Injection for Subacute Herpetic Neuralgia
Xú, G., Lv, Z., Feng, Y., Tang, W., & Xú, G. (2013) · Pain Medicine · doi:10.1111/pme.12081 · Cited by 41
Herpes Zoster Vaccine Coverage in Older Adults in the U.S., 2007–2013
Zhang, D., Johnson, K. D., Newransky, C., & Acosta, C. J. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2016.08.029 · Cited by 41
The Safety and Immunologic Effectiveness of the Live Varicella-Zoster Vaccine in Patients Receiving Tumor Necrosis Factor Inhibitor Therapy
Curtis, J. R., Cofield, S. S., Bridges, S. L., Bassler, J. R., Deodhar, A. A., Ford, T. L., Huffstutter, J. E., Jankeel, A., Kivitz, A., Kamal, S., et al. (2021) · Annals of Internal Medicine · doi:10.7326/m20-6928 · Cited by 41
Managing neuropathic pain.
Galluzzi, K. E. (2007) · PubMed · Cited by 41
Safety and tolerability of a high-potency zoster vaccine in adults ≥50 years of age
Tyring, S. K., Díaz‐Mitoma, F., Padget, L. G., Nunez, M., Poland, G. A., Cassidy, W. M., Bundick, N. D., Li, J., Chan, I. S. F., Stek, J. E., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.10.027 · Cited by 41
Self-citation
Pox Parties for Grannies? Chickenpox, Exogenous Boosting, and Harmful Injustices
Malm, H., & Navin, M. C. (2020) · The American Journal of Bioethics · doi:10.1080/15265161.2020.1795528 · Cited by 40
Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond
Weinberger, B. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00249-6 · Cited by 44
Varicella-Zoster Virus Neurotropism in SCID Mouse–Human Dorsal Root Ganglia Xenografts
Zerboni, L., Reichelt, M., & Arvin, A. M. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2009_8 · Cited by 40
Preventive Misconception
Simon, A. E., Wu, A. W., Lavori, P. W., & Sugarman, J. (2007) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2007.01.007 · Cited by 40
Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?
Moosig, F., Holle, J. U., & Gross, W. L. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2826 · Cited by 40
Herpes zoster in Australia: evidence of increase in incidence in adults attributable to varicella immunization?
JARDINE, A., Conaty, S. J., & Vally, H. (2010) · Epidemiology and Infection · doi:10.1017/s0950268810001949 · Cited by 40
Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response
McElhaney, J. E. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.12 · Cited by 40
Universal varicella vaccination increased the incidence of herpes zoster in the child-rearing generation as its short-term effect
Toyama, N., & Shiraki, K. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.07.003 · Cited by 40
Comparative Antibody Responses to the Live-Attenuated and Recombinant Herpes Zoster Vaccines
Schmid, D. S., Miao, C., Leung, J. W. T., Johnson, M. J., Weinberg, A., & Levin, M. J. (2021) · Journal of Virology · doi:10.1128/jvi.00240-21 · Cited by 41
Self-citation
Herpes Zoster in Solid Organ Transplantation: Incidence and Risk Factors
Kho, M. M. L., Roest, S., Bovée, D. M., Metselaar, H. J., Hoek, R. A. S., van der Eijk, A. A., Manintveld, O. C., Roodnat, J. I., & van Besouw, N. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.645718 · Cited by 40
Vaccinations and inflammatory bowel disease – a systematic review
Chan, W. P. W., Salazar, E., Lim, T. G., Ong, W. C., & Shim, H. H. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.04.015 · Cited by 40
Evidence of increasing frequency of herpes zoster management in Australian general practice since the introduction of a varicella vaccine
Nelson, M. R., Britt, H. C., & Harrison, C. M. (2010) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb03818.x · Cited by 40
Herpes zoster and the search for an effective vaccine
Arnold, N. D., & Messaoudi, I. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12809 · Cited by 45
Management of chronic complications associated with herpes zoster ophthalmicus
Vadoothker, S., & Jeng, B. H. (2018) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000492 · Cited by 39
Vaccinations for Rheumatoid Arthritis
Perry, L., Winthrop, K. L., & Curtis, J. R. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0431-x · Cited by 39
Public Awareness and Knowledge of Herpes Zoster: Results of a Global Survey
Paek, E., & Johnson, R. W. (2009) · Gerontology · doi:10.1159/000240046 · Cited by 39
The impact of demographic changes, exogenous boosting and new vaccination policies on varicella and herpes zoster in Italy: a modelling and cost-effectiveness study
Melegaro, A., Marziano, V., Fava, E. D., Poletti, P., Tirani, M., Rizzo, C., & Merler, S. (2018) · BMC Medicine · doi:10.1186/s12916-018-1094-7 · Cited by 39

Authors: Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., Weinberg, A., Boardman, K. D., Williams, H. M., Zhang, J. H., Peduzzi, P. N., Beisel, C. E., Morrison, V. A., Guatelli, J. C., Brooks, P. A., Kauffman, C. A., Pachucki, C. T., Neuzil, K. M., Betts, R. F., Wright, P. F., Griffin, M. R., Brunell, P., Soto, N. E., Marques, A. R., Keay, S. K., Goodman, R. P., Cotton, D. J., Gnann, J. W., Loutit, J., Holodniy, M., Keitel, W. A., Crawford, G. E., Yeh, S.-S., Lobo, Z., Toney, J. F., Greenberg, R. N., Keller, P. M., Harbecke, R., Hayward, A. R., Irwin, M. R., Kyriakides, T. C., Chan, C. Y., Chan, I. S. F., Wang, W. W. B., Annunziato, P. W., & Silber, J. L.
Affiliations: University of California San Diego (US)
Durham VA Medical Center (US)
Duke Medical Center (US)
National Institutes of Health (US)
Washington University in St. Louis (US)
VA Boston Healthcare System (US)
VA NY Harbor Healthcare System (US)
Columbia University (US)
New Mexico VA Health Care System (US)
National Institute of Allergy and Infectious Diseases (US)
VA San Diego Healthcare System (US)
VA Ann Arbor Healthcare System (US)
Edward Hines, Jr. VA Hospital (US)
VA Puget Sound Health Care System (US)
University of Rochester Medicine (US)
Vanderbilt University Medical Center (US)
Baltimore VA Medical Center (US)
VA Palo Alto Health Care System (US)
Baylor College of Medicine (US)
The University of Texas at San Antonio Health Science Center (US)
Northport VA Medical Center (US)
James A. Haley Veterans' Hospital (US)
Lexington VA Health Care System (US)
University of California, Los Angeles (US)
ORCID: Levin, M.J.
Johnson, G.R.
Schmader, K.E.
Arbeit, R.D.
Simberkoff, M.S.
Gershon, A.A.
Weinberg, A.
Williams, H.M.
Peduzzi, P.N.
Neuzil, K.M.
Wright, P.F.
Griffin, M.R.
Marques, A.R.
Cotton, D.J.
Holodniy, M.
Toney, J.F.
Greenberg, R.N.
Hayward, A.R.
Irwin, M.R.
Kyriakides, T.C.
Chan, C.Y.
Annunziato, P.W.
Silber, J.L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2005-06-02
Volume: 352
Issue: 22
Pages: 2271-2284
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa051016
OpenAlex: W2131041950
Cited by: 2,412
References: 40
Citations by year: 2026: 51 · 2025: 90 · 2024: 63 · 2023: 92 · 2022: 60 · 2021: 95 · 2020: 97 · 2019: 111 · 2018: 145 · 2017: 155 · 2016: 158 · 2015: 133 · 2014: 126 · 2013: 149 · 2012: 110
FWCI: 89.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Office of Research and Development
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Keywords: herpes zoster, postherpetic neuralgia, varicella-zoster virus, live attenuated zoster vaccine, older adults, vaccine efficacy, disease burden, cell-mediated immunity, injection site reactions
MeSH terms: Aged, Double-Blind Method, Female, Follow-Up Studies, Herpes Zoster, Humans, Immunologic Memory, Male, Middle Aged, Neuralgia, Vaccines, Attenuated, Herpesvirus 3, Human, Virus Activation, Incidence, Cost of Illness, Chickenpox Vaccine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks