The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction
Open accessAbstract
BACKGROUND: Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. METHODS: In a multicenter trial, we randomly assigned 204 patients with acute myocardial infarction to receive an intracoronary infusion of progenitor cells derived from bone marrow (BMC) or placebo medium into the infarct artery 3 to 7 days after successful reperfusion therapy. RESULTS: At 4 months, the absolute improvement in the global left ventricular ejection fraction (LVEF) was significantly greater in the BMC group than in the placebo group (mean [+/-SD] increase, 5.5+/-7.3% vs. 3.0+/-6.5%; P=0.01). Patients with a baseline LVEF at or below the median value of 48.9% derived the most benefit (absolute improvement in LVEF, 5.0%; 95% confidence interval, 2.0 to 8.1). At 1 year, intracoronary infusion of BMC was associated with a reduction in the prespecified combined clinical end point of death, recurrence of myocardial infarction, and any revascularization procedure (P=0.01). CONCLUSIONS: Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction. Large-scale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality.
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Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Bittman, R., Hurley, S., Kleiman, J., & Gatlin, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030207 · Cited by 4,941
Pfeffer, M. A., McMurray, J. J. V., Velazquez, E. J., Rouleau, J.-L., Køber, L., Maggioni, A. P., Solomon, S. D., Swedberg, K., Van de Werf, F., White, H., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa032292 · Cited by 2,471
Cited by
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O'Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.019 · Cited by 2,625
AlGhamdi, K. M., Kumar, A., & Moussa, N. A. (2012) · Lasers in Medical Science · doi:10.1007/s10103-011-0885-2 · Cited by 567
Crisostomo, P. R., Wang, Y., Markel, T. A., Wang, M., Lahm, T., & Meldrum, D. R. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00437.2007 · Cited by 459
Strikingly Different Angiogenic Properties of Endothelial Progenitor Cell Subpopulations
Sieveking, D. P., Buckle, A., Celermajer, D. S., & Ng, M. K. C. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.059 · Cited by 349
Gyöngyösi, M., Wojakowski, W., Lemarchand, P., Lunde, K., Tendera, M., Bartunek, J., Marban, E., Assmus, B., Henry, T. D., Traverse, J. H., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.304346 · Cited by 313
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Metadata
- Authors
- Schächinger, V., Erbs, S., Elsässer, A., Haberbosch, W., Hambrecht, R., Hölschermann, H., Yu, J., Corti, R., Mathey, D. G., Hamm, C. W., Süselbeck, T., Assmus, B., Tonn, T., Dimmeler, S., & Zeiher, A. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-09-21
- Volume
- 355
- Issue
- 12
- Pages
- 1210-1221
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2111486034
- Cited by
- 1,890
- References
- 2
- FWCI
- 99.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schächinger, V., Erbs, S., Elsässer, A., Haberbosch, W., Hambrecht, R., Hölschermann, H., Yu, J., Corti, R., Mathey, D. G., Hamm, C. W., Süselbeck, T., Assmus, B., Tonn, T., Dimmeler, S., & Zeiher, A. M. (2006). Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction. New England Journal of Medicine. https://doi.org/10.1056/nejmoa060186
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
