The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
GM-CSF Autoantibodies and Neutrophil Dysfunction in Pulmonary Alveolar Proteinosis
Open accessAbstract
BACKGROUND: Increased mortality from infection in patients with pulmonary alveolar proteinosis occurs in association with high levels of autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). We tested the hypothesis that neutrophil functions are impaired in patients with pulmonary alveolar proteinosis and that GM-CSF autoantibodies cause the dysfunction. METHODS: We studied 12 subjects with pulmonary alveolar proteinosis, 61 healthy control subjects, and 12 control subjects with either cystic fibrosis or end-stage liver disease. We also studied GM-CSF-/- mice and wild-type mice. We evaluated basal neutrophil functions, neutrophil functions after priming by GM-CSF to augment antimicrobial functions, and the effects of highly purified GM-CSF autoantibodies on neutrophil functions in vitro and in vivo. RESULTS: Neutrophils from subjects with pulmonary alveolar proteinosis had normal ultrastructure and differentiation markers but impaired basal functions and antimicrobial functions after GM-CSF priming. GM-CSF-/- mice also had reduced basal neutrophil functions, but functions after GM-CSF priming were unimpaired. The neutrophil dysfunction characteristic of pulmonary alveolar proteinosis was reproduced in a dose-dependent fashion in blood specimens from healthy control subjects after incubation with affinity-purified GM-CSF autoantibodies isolated from patients with pulmonary alveolar proteinosis. The injection of mouse GM-CSF antibodies into wild-type mice also caused neutrophil dysfunction. CONCLUSIONS: The antimicrobial functions of neutrophils are impaired in patients with pulmonary alveolar proteinosis, owing to the presence of GM-CSF autoantibodies. The effects of these autoantibodies show that GM-CSF is an essential regulator of neutrophil functions.
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Cites
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,566
Pulmonary Alveolar Proteinosis
Rosen, S. H., Castleman, B., Liebow, A. A., Enzinger, F. M., & Hunt, R. T. N. (1958) · New England Journal of Medicine · doi:10.1056/nejm195806052582301 · Cited by 1,150
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Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis
Dranoff, G., Crawford, A. D., Sadelain, M., Ream, B., Rashid, A., Bronson, R. T., Dickersin, G. R., Bachurski, C. J., Mark, E. L., Whitsett, J. A., et al. (1994) · Science · doi:10.1126/science.8171324 · Cited by 879
THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW
Bainton, D. F., Ullyot, J. L., & Farquhar, M. G. (1971) · The Journal of Experimental Medicine · doi:10.1084/jem.134.4.907 · Cited by 857
Pulmonary Alveolar Proteinosis
Trapnell, B. C., Whitsett, J. A., & Nakata, K. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023226 · Cited by 790
Self-citationPulmonary Alveolar Proteinosis: Progress in the First 44 Years
Seymour, J. F., & Presneill, J. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109105 · Cited by 697
GM-CSF Regulates Alveolar Macrophage Differentiation and Innate Immunity in the Lung through PU.1
Shibata, Y., Berclaz, P.-Y., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., & Trapnell, B. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00218-7 · Cited by 618
Self-citationKitamura, T., Tanaka, N., Watanabe, J., Uchida, Kanegasaki, S., Yamada, Y., & Nakata, K. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.6.875 · Cited by 563
Iwasaki, H., Somoza, C., Shigematsu, H., Duprez, E. A., Iwasaki-Arai, J., Mizuno, S.-I., Arinobu, Y., Geary, K., Zhang, P., Dayaram, T., et al. (2005) · Blood · doi:10.1182/blood-2005-03-0860 · Cited by 433
Cited by
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311
Inoue, Y., Trapnell, B. C., Tazawa, R., Arai, T., Takada, T., Hizawa, N., Kasahara, Y., Tatsumi, K., Hojo, M., Ichiwata, T., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1271oc · Cited by 490
Self-citationFamilial pulmonary alveolar proteinosis caused by mutations in CSF2RA
Suzuki, T., Sakagami, T., Rubin, B. K., Nogee, L. M., Wood, R. E., Zimmerman, S. L., Smolarek, T., Dishop, M. K., Wert, S. E., Whitsett, J. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080990 · Cited by 305
Self-citationQuail, D. F., Olson, O. C., Bhardwaj, P., Walsh, L. A., Akkari, L., Quick, M. L., Chen, I.-C., Wendel, N., Ben-Chetrit, N., Walker, J., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3578 · Cited by 277
Distinct Responses of Human Monocyte Subsets to Aspergillus fumigatus Conidia
Serbina, N. V., Cherny, M., Shi, C., Bleau, S. A., Collins, N. H., Young, J. W., & Pamer, E. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803398 · Cited by 70
Metadata
- Authors
- Uchida, K., Beck, D. C., Yamamoto, T., Berclaz, P.-Y., Abe, S., Staudt, M. K., Carey, B. C., Filippi, M.-D., Wert, S. E., Denson, L. A., Puchalski, J. T., Hauck, D. M., & Trapnell, B. C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-02-08
- Volume
- 356
- Issue
- 6
- Pages
- 567-579
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2093440835
- Cited by
- 317
- References
- 34
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Uchida, K., Beck, D. C., Yamamoto, T., Berclaz, P.-Y., Abe, S., Staudt, M. K., Carey, B. C., Filippi, M.-D., Wert, S. E., Denson, L. A., Puchalski, J. T., Hauck, D. M., & Trapnell, B. C. (2007). GM-CSF Autoantibodies and Neutrophil Dysfunction in Pulmonary Alveolar Proteinosis. New England Journal of Medicine. https://doi.org/10.1056/nejmoa062505
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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