The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
GM-CSF Regulates Alveolar Macrophage Differentiation and Innate Immunity in the Lung through PU.1
Open accessAbstract
GM-CSF gene targeted (GM(-/-)) mice are susceptible to respiratory infections and develop alveolar proteinosis due to defects in innate immune function and surfactant catabolism in alveolar macrophages (AMs), respectively. Reduced cell adhesion, phagocytosis, pathogen killing, mannose- and Toll-like receptor expression, and LPS- or peptidoglycan-stimulated TNFalpha release were observed in AMs from GM(-/-) mice. The transcription factor PU.1 was markedly reduced in AMs of GM(-/-) mice in vivo and was restored by selective expression of GM-CSF in the lungs of SPC-GM/GM(-/-) transgenic mice. Retrovirus-mediated expression of PU.1 in AMs from GM(-/-) mice rescued host defense functions and surfactant catabolism by AMs. We conclude that PU.1 mediates GM-CSF-dependent effects on terminal differentiation of AMs regulating innate immune functions and surfactant catabolism by AMs.
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Citations
Cites
Regulation of B lymphocyte and macrophage development by graded expression of PU.1
DeKoter, R. P., & Singh, H. (2000) · Science · doi:10.1126/science.288.5470.1439 · Cited by 749
Transcription Factors, Normal Myeloid Development, and Leukemia
Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood · doi:10.1182/blood.v90.2.489 · Cited by 735
The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., & Tenen, D. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53496-7 · Cited by 301
DeKoter, R. P., Walsh, J. C., & Singh, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4456 · Cited by 296 · cited 1×
“AMs are vital to normal lung PU.1 promotes both the proliferation (Celada et al., 1996)surfactant metabolism, to which they contribute by caand differentiation (DeKoter et al., 1998) of myeloid pro-tabolism of both surfactant lipids and surfactant progenitors.”
BackgroundRehli, M., Poltorak, A., Schwarzfischer, L., Krause, S. W., Andreesen, R., & Beutler, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9773 · Cited by 233
Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
Chen, H., Zhang, P., Voso, M., Hohaus, S., Gonzalez, D., Glass, C., Zhang, D., & Tenen, D. (1995) · Blood · doi:10.1182/blood.v85.10.2918.bloodjournal85102918 · Cited by 216
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The transcription factor PU.1 is involved in macrophage proliferation.
Celada, A., Borràs, F. E., Soler, C., Lloberas, J., Klemsz, M., van Beveren, C., McKercher, S., & Maki, R. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.61 · Cited by 152 · cited 1×
“AMs are vital to normal lung PU.1 promotes both the proliferation (Celada et al., 1996)surfactant metabolism, to which they contribute by caand differentiation (DeKoter et al., 1998) of myeloid pro-tabolism of both surfactant lipids and surfactant progenitors.”
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Cited by
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067
Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673
Ushach, I., & Zlotnik, A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0316-144r · Cited by 551
Beyond stem cells: self-renewal of differentiated macrophages
Sieweke, M. H., & Allen, J. E. (2013) · Science · doi:10.1126/science.1242974 · Cited by 503
Inoue, Y., Trapnell, B. C., Tazawa, R., Arai, T., Takada, T., Hizawa, N., Kasahara, Y., Tatsumi, K., Hojo, M., Ichiwata, T., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1271oc · Cited by 490
Self-citation
Metadata
- Authors
- Shibata, Y., Berclaz, P.-Y., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., & Trapnell, B. C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 15
- Issue
- 4
- Pages
- 557-567
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2040739057
- Cited by
- 618
- References
- 8
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shibata, Y., Berclaz, P.-Y., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., & Trapnell, B. C. (2001). GM-CSF Regulates Alveolar Macrophage Differentiation and Innate Immunity in the Lung through PU.1. Immunity. https://doi.org/10.1016/s1074-7613(01)00218-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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