The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2
Open accessAbstract
BACKGROUND: Regular use of aspirin reduces the risk of a colorectal neoplasm, but the mechanism by which aspirin affects carcinogenesis in the colon is not well understood. METHODS: We estimated cyclooxygenase-2 (COX-2) expression by immunohistochemical assay of sections from paraffin-embedded colorectal-cancer specimens from two large cohorts of participants who provided data on aspirin use from a questionnaire every 2 years. We applied Cox regression to a competing-risks analysis to compare the effects of aspirin use on the relative risk of colorectal cancer in relation to the expression of COX-2 in the tumor. RESULTS: During 2,446,431 person-years of follow-up of 82,911 women and 47,363 men, we found 636 incident colorectal cancers that were accessible for determination of COX-2 expression. Of the tumors, 423 (67%) had moderate or strong COX-2 expression. The effect of aspirin use differed significantly in relation to COX-2 expression (P for heterogeneity=0.02). Regular aspirin use conferred a significant reduction in the risk of colorectal cancers that overexpressed COX-2 (multivariate relative risk, 0.64; 95% confidence interval [CI], 0.52 to 0.78), whereas regular aspirin use had no influence on tumors with weak or absent expression of COX-2 (multivariate relative risk, 0.96; 95% CI, 0.73 to 1.26). The age-standardized incidence rate for cancers that overexpressed COX-2 was 37 per 100,000 person-years among regular aspirin users, as compared with 56 per 100,000 person-years among those who did not use aspirin regularly; in contrast, the rate for cancers with weak or absent COX-2 expression was 27 per 100,000 person-years among regular aspirin users, as compared with 28 per 100,000 person-years among nonregular aspirin users. CONCLUSIONS: Regular use of aspirin appears to reduce the risk of colorectal cancers that overexpress COX-2 but not the risk of colorectal cancers with weak or absent expression of COX-2.
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Molecular Basis of Colorectal Cancer
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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
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Self-citationCOX-2 expression positively correlates with PD-L1 expression in human melanoma cells
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New drugs are not enough‑drug repositioning in oncology: An update
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Metadata
- Authors
- Chan, A. T., Ogino, S., & Fuchs, C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-05-24
- Volume
- 356
- Issue
- 21
- Pages
- 2131-2142
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2037952228
- Cited by
- 781
- References
- 4
- FWCI
- 38.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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