Drug repurposing in cancer

Sleire, Linda; Førde, Hilde Elise; Netland, Inger Anne; Leiss, Lina; Skeie, Bente Sandvei; Enger, Per Øyvind

doi:10.1016/j.phrs.2017.07.013

Cited by 333Cancer Mechanisms and TherapyComputational Drug Discovery MethodsMetabolism, Diabetes, and Cancer

Drug repurposing in cancer

Sleire, Linda, Førde, Hilde Elise, Netland, Inger Anne, Leiss, Lina, Skeie, Bente Sandvei, Enger, Per Øyvind·2017·Pharmacological Research

DOI 10.1016/j.phrs.2017.07.013

Open this paper in CoChat — free account

Abstract

Cancer is a major health issue worldwide, and the global burden of cancer is expected to increase in the coming years. Whereas the limited success with current therapies has driven huge investments into drug development, the average number of FDA approvals per year has declined since the 1990s. This unmet need for more effective anti-cancer drugs has sparked a growing interest for drug repurposing, i.e. using drugs already approved for other indications to treat cancer. As such, data both from pre-clinical experiments, clinical trials and observational studies have demonstrated anti-tumor efficacy for compounds within a wide range of drug classes other than cancer. Whereas some of them induce cancer cell death or suppress various aspects of cancer cell behavior in established tumors, others may prevent cancer development. Here, we provide an overview of promising candidates for drug repurposing in cancer, as well as studies describing the biological mechanisms underlying their anti-neoplastic effects.

Integrity signals

Registry

Crossref · 10.1016/j.phrs.2017.07.013

Cites

326 of 326 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Drug repurposing has gained traction as an alternative approach to anti-cancer drug discovery.
“Drug repurposing has therefore gained traction as an alternative approach to anti‐cancer drug discovery [7].”
From Pyrvinium Pamoate Alone and With Gemcitabine Exhibits Anti‐Pancreatic Cancer Activity in <scp>2D</scp> and <scp>3D</scp> Cell Culture Models (2024) · cites this paper as [7]

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works
Can the pharmaceutical industry reduce attrition rates?
Kola, I., & Landis, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1470 · Cited by 4,167 · see citing works
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works
How to improve R&D productivity: the pharmaceutical industry's grand challenge
Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., Persinger, C. C., Munos, B. H., Lindborg, S. R., & Schacht, A. L. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3078 · Cited by 3,566 · see citing works
Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene<SUBTITLE>Results From a 3-Year Randomized Clinical Trial</SUBTITLE>
Ettinger, B. (1999) · JAMA · doi:10.1001/jama.282.7.637 · Cited by 3,366 · see citing works
Clinical development success rates for investigational drugs
Hay, M., Thomas, D. W., Craighead, J. L., Economides, C., & Rosenthal, J. (2014) · Nature Biotechnology · doi:10.1038/nbt.2786 · Cited by 2,536 · see citing works
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015
McGuire, S. (2016) · Advances in Nutrition · doi:10.3945/an.116.012211 · Cited by 1,900 · see citing works
The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women: Results From the MORE Randomized Trial
Cummings, S. R., Eckert, S., Krueger, K. A., Grady, D., Powles, T. J., Cauley, J. A., Norton, L., Nickelsen, T., Bjarnason, N. H., Morrow, M., et al. (1999) · JAMA · doi:10.1001/jama.281.23.2189 · Cited by 1,872 · see citing works
Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes<SUBTITLE>The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial</SUBTITLE>
Vogel, V. G. (2006) · JAMA · doi:10.1001/jama.295.23.joc60074 · Cited by 1,652 · see citing works
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
Rothwell, P. M., Fowkes, F. G. R., Belch, J. F., Ogawa, H., Warlow, C. P., & Meade, T. W. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62110-1 · Cited by 1,497 · see citing works
The renaissance of GSK3
Cohen, P., & Frame, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096075 · Cited by 1,478 · see citing works
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
Rothwell, P. M., Wilson, M., Elwin, C.-E., Norrving, B., Algra, A., Warlow, C. P., & Meade, T. W. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61543-7 · Cited by 1,351 · see citing works
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works
Low-Dose Aspirin for the Prevention of Atherothrombosis
Patrono, C., Rodríguez, L. A. G., Landolfi, R., & Baigent, C. (2005) · New England Journal of Medicine · doi:10.1056/nejmra052717 · Cited by 1,217 · see citing works
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602619 · Cited by 1,105 · see citing works
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
Zakikhani, M., Dowling, R., Fantus, I. G., Sonenberg, N., & Pollak, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1500 · Cited by 1,048 · see citing works
Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis
Larsson, S. C., Orsini, N., & Wolk, A. (2005) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dji375 · Cited by 1,038 · see citing works
Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994 · see citing works
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
Dowling, R. J. O., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2310 · Cited by 933 · see citing works
The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930 · see citing works
Estimating The Cost Of New Drug Development: Is It Really $802 Million?
Adams, C., & Brantner, V. V. (2006) · Health Affairs · doi:10.1377/hlthaff.25.2.420 · Cited by 917 · see citing works
NF-κB as a Therapeutic Target in Multiple Myeloma
Hideshima, T., Chauhan, D., Richardson, P. G. G., Mitsiades, C. S., Mitsiades, N., Hayashi, T., Munshi, N. C., Dang, L., Castro, A. C., Palombella, V. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200360200 · Cited by 894 · see citing works
Diabetes mellitus and risk of breast cancer: A meta‐analysis
Larsson, S. C., Mantzoros, C. S., & Wolk, A. (2007) · International Journal of Cancer · doi:10.1002/ijc.22717 · Cited by 875 · see citing works
Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement
Bibbins-Domingo, K. B., & on behalf of the U.S. Preventive Services Task Force* (2016) · Annals of Internal Medicine · doi:10.7326/m16-0577 · Cited by 853 · see citing works
AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling
Bolster, D. R., Crozier, S. J., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200171200 · Cited by 851 · see citing works
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials
Algra, A. M., & Rothwell, P. M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70112-2 · Cited by 833 · see citing works
The role of hypoxia-inducible factors in tumorigenesis
Rankin, E. B., & Giaccia, A. J. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.21 · Cited by 806 · cited 1× · see citing works
“increased in tumors, and are associated with a worse prognosis (78).”
Background
The effect of raloxifene on risk of breast cancer in postmenopausal women : results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
Cummings, S. R. (1999) · Medical Entomology and Zoology · Cited by 797 · see citing works
Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2
Chan, A. T., Ogino, S., & Fuchs, C. S. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067208 · Cited by 776 · see citing works
Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
Cuzick, J. M., Otto, F., Baron, J. A., Brown, P. H., Burn, J., Greenwald, P., Jankowski, J. A., Vecchia, C. L., Meyskens, F. L., Senn, H. J., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70035-x · Cited by 713 · see citing works
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Birsoy, K., Possemato, R., Lorbeer, F. K., Bayraktar, E. C., Thiru, P., Yucel, B., Wang, T., Chen, W. W., Clish, C. B., & Sabatini, D. M. (2014) · Nature · doi:10.1038/nature13110 · Cited by 710 · see citing works
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
Hawley, S. A., Gadalla, A. E., Olsen, G. S., & Hardie, D. G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2420 · Cited by 696 · see citing works
Continuing Outcomes Relevant to Evista: Breast Cancer Incidence in Postmenopausal Osteoporotic Women in a Randomized Trial of Raloxifene
Martino, S., Cauley, J. A., Barrett-Connor, E., Powles, T. J., Mershon, J., Disch, D., Secrest, R. J., Cummings, S. R., & For the CORE Investigators (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh319 · Cited by 684 · see citing works
Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity
Chen, D., Cui, Q. C., Yang, H., & Dou, Q. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2126 · Cited by 678 · see citing works
Continued Breast Cancer Risk Reduction in Postmenopausal Women Treated with Raloxifene: 4-Year Results from the MORE Trial
Cauley, J. A., Norton, L., Lippman, M. E., Eckert, S., Krueger, K. A., Purdie, D. W., Farrerons, J., Karasik, A., Mellstrom, D., Ng, K. W., et al. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1006478317173 · Cited by 678 · see citing works
Neural plasticity to stress and antidepressant treatment
Duman, R. S., Malberg, J. E., & Thome, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00177-8 · Cited by 644 · see citing works
Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer
Vogel, V. G., Costantino, J. P., Wickerham, D. L., Cronin, W. M., Cecchini, R. S., Atkins, J. N., Bevers, T. B., Fehrenbacher, L., Pajon, E. R., Wade, J. L., et al. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0076 · Cited by 644 · see citing works
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809763105 · Cited by 624 · cited 1× · see citing works
“eradicate established xenograft tumors by suppressing HIF-1α and HIF-2α expression (77).”
Background
Thalidomide
FRANKS, M. E., Macpherson, G. R., & Figg, W. D. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16308-3 · Cited by 616 · see citing works
The statins as anticancer agents.
Chan, K., Oza, A. M., & Siu, L. L. (2003) · PubMed · Cited by 607 · see citing works
The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy
Murata, H., Hruz, P. W., & Mueckler, M. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000228200 · Cited by 579 · see citing works
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis
Wong, W. W.-L., Dimitroulakos, J., Minden, M., & Penn, L. Z. (2002) · Leukemia · doi:10.1038/sj.leu.2402476 · Cited by 579 · see citing works
Diabetes mellitus and risk of endometrial cancer: a meta-analysis
Friberg, E., Orsini, N., Mantzoros, C. S., & Wolk, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0681-5 · Cited by 567 · see citing works
Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis
Noto, H., Goto, A., Tsujimoto, T., & Noda, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033411 · Cited by 566 · see citing works
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
Kim, J., Tang, J. Y., Gong, R., Kim, J., Lee, J. J., Clemons, K. V., Chong, C. R., Chang, K. S., Fereshteh, M., Gardner, D., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.02.027 · Cited by 527 · see citing works
Arachidonic Acid Oxygenation by COX-1 and COX-2
Marnett, L. J., Rowlinson, S. W., Goodwin, D. C., Kalgutkar, A. S. S., & Lanzo, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.22903 · Cited by 524 · see citing works
Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs
Golub, L. M., Ramamurthy, N. S., McNamara, T. F., Greenwald, R. A., & Rifkin, B. R. (1991) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411910020030201 · Cited by 523 · see citing works
Aspirin and Risk of Hemorrhagic Stroke
He, J., Whelton, P. K., Vu, B., & Klag, M. J. (1998) · JAMA · doi:10.1001/jama.280.22.1930 · Cited by 518 · see citing works
Molecular Targets of Lithium Action
Phiel, C. J., & Klein, P. S. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.789 · Cited by 513 · see citing works
The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
Sobolewski, C., Cerella, C., Dicato, M. A., Ghibelli, L., & Diederich, M. F. (2010) · International Journal of Cell Biology · doi:10.1155/2010/215158 · Cited by 477 · see citing works
Beta-Blocker Use Is Associated With Improved Relapse-Free Survival in Patients With Triple-Negative Breast Cancer
Melhem‐Bertrandt, A., Chávez‐MacGregor, M., Lei, X. J., Brown, E. N., Lee, R. T., Meric‐Bernstam, F., Sood, A. K., Conzen, S. D., Hortobágyi, G. N., & Gonzalez-Angulo, A. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.4441 · Cited by 467 · see citing works
Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
Bodmer, M., Meier, C., Krähenbühl, S., Jick, S. S., & Meier, C. R. (2010) · Diabetes Care · doi:10.2337/dc09-1791 · Cited by 466 · see citing works
Beta-Blocker Drug Therapy Reduces Secondary Cancer Formation in Breast Cancer and Improves Cancer Specific Survival
Powe, D. G., Voss, M. J., Zänker, K. S., Habashy, H. O., Green, A. R., Ellis, I. O., & Entschladen, F. (2010) · Oncotarget · doi:10.18632/oncotarget.197 · Cited by 462 · see citing works
Aspirin and colorectal cancer: the promise of precision chemoprevention
Drew, D. A., Cao, Y., & Chan, A. T. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.4 · Cited by 452 · see citing works
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis.
Horman, S., Browne, G., Krause, U., Patel, J., Vertommen, D., Bertrand, L., Lavoinne, A., Hue, L., Proud, C. G., & Rider, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01077-1 · Cited by 440 · see citing works
A review of thalidomide's history and current dermatological applications
Perri, A. J., & Hsu, S. (2003) · Dermatology Online Journal · doi:10.5070/d35fk5w0qv · Cited by 432 · see citing works
Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review
Franciosi, M., Lucisano, G., Lapice, E., Strippoli, G. F. M., Pellegrini, F., & Nicolucci, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071583 · Cited by 428 · see citing works
Metformin directly acts on mitochondria to alter cellular bioenergetics
Andrzejewski, S., Gravel, S., Pollak, M., & St‐Pierre, J. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-12 · Cited by 424 · see citing works
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
Marzano, C., Gandin, V., Folda, A., Scutari, G., Bindoli, A., & Rigobello, M. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.021 · Cited by 415 · see citing works
Norepinephrine Up-regulates the Expression of Vascular Endothelial Growth Factor, Matrix Metalloproteinase (MMP)-2, and MMP-9 in Nasopharyngeal Carcinoma Tumor Cells
Yang, E. V., Sood, A. K., Chen, M., Li, Y., Eubank, T. D., Marsh, C. B., Jewell, S., Flavahan, N. A., Morrison, C., Yeh, P.-E., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2496 · Cited by 407 · see citing works
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., Mcburnie, W., Fleming, S., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20080557 · Cited by 396 · see citing works
Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial
Kordes, S., Pollak, M., Zwinderman, A. H., Mathôt, R. A. A., Weterman, M. J., Beeker, A., Punt, C. J. A., Richel, D. J., & Wilmink, J. W. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00027-3 · Cited by 387 · see citing works
The Status of Disulfiram: A Half of a Century Later
Suh, J. J., Pettinati, H. M., Kampman, K. M., & O'Brien, C. P. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000222512.25649.08 · Cited by 382 · see citing works
Discovery, mechanisms of action and combination therapy of artemisinin
Cui, L., & Su, X. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.68 · Cited by 374 · see citing works
Treatment of Osteosarcoma
PORTER, K. A., CALNE, R. Y., & ZUKOSKI, C. F. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90940-7 · Cited by 369 · see citing works
Role of prostaglandin E 2 -dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression
Chang, S.-H., Liu, C. H., Conway, R. E., Han, D. K. M., Nithipatikom, K., Trifan, O. C., Lane, T. F., & Hla, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2535911100 · Cited by 361 · see citing works
Resolvins, docosatrienes, and neuroprotectins, novel omega‐3‐derived mediators, and their endogenous aspirin‐triggered epimers
Serhan, C. N., Arita, M., Hong, S., & Gotlinger, K. H. (2004) · Lipids · doi:10.1007/s11745-004-1339-7 · Cited by 349 · see citing works
Cancer drug discovery by repurposing: teaching new tricks to old dogs
Gupta, S. C., Sung, B., Prasad, S., Webb, L. J., & Aggarwal, B. B. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.06.005 · Cited by 340 · see citing works
Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial
Higurashi, T., Hosono, K., Takahashi, H., Komiya, Y., Umezawa, S., Sakai, E., Uchiyama, T., Taniguchi, L., Hata, Y., Uchiyama, S., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00565-3 · Cited by 331 · see citing works
Antipyretics: mechanisms of action and clinical use in fever suppression
Aronoff, D. M., & Neilson, E. G. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00834-8 · Cited by 327 · see citing works
Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo
Gills, J. J., LoPiccolo, J., Tsurutani, J., Shoemaker, R. H., Best, C. J. M., Abu-Asab, M. S., Borojerdi, J. P., Warfel, N. A., Gardner, E. R., Danish, M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0161 · Cited by 320 · see citing works
Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action
Hou, J., Wang, D., Zhang, R., & Wang, H. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0197 · Cited by 319 · see citing works
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
Takada, Y., Bhardwaj, A., Potdar, P. D., & Aggarwal, B. B. (2004) · Oncogene · doi:10.1038/sj.onc.1208169 · Cited by 310 · see citing works
Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers.
Masur, K., Niggemann, B., Zänker, K. S., & Entschladen, F. (2001) · PubMed · Cited by 308 · see citing works
Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer
Sadeghi, N., Abbruzzese, J. L., Yeung, S. J., Hassan, M. M., & Li, D. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2994 · Cited by 306 · see citing works
Diabetes mellitus and risk of bladder cancer: a meta-analysis
Larsson, S. C., Orsini, N., Brismar, K., & Wolk, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0468-0 · Cited by 303 · see citing works
Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models.
Mirabelli, C. K., Johnson, R. K., Sung, C. M., Faucette, L. F., Muirhead, K. A., & Crooke, S. T. (1985) · PubMed · Cited by 295 · see citing works
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
Hadad, S. M., Iwamoto, T., Jordan, L. B., Purdie, C. A., Bray, S. E., Baker, L., Jellema, G. L., Deharo, S., Hardie, D. G., Pusztai, L., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1612-1 · Cited by 293 · see citing works
Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma
Kim, D. J., Kim, J., Spaunhurst, K., Montoya, J., Khodosh, R., Chandra, K., Fu, T., Gilliam, A., Molgo, M., Beachy, P. A., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.9525 · Cited by 289 · see citing works
Cancer Drugs in the United States: Justum Pretium—The Just Price
Kantarjian, H. M., Fojo, T., Mathisen, M. S., & Zwelling, L. A. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.1845 · Cited by 283 · see citing works
Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent
Pantziarka, P. (2014) · ecancermedicalscience · doi:10.3332/ecancer.2014.485 · Cited by 280 · see citing works
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.
McConkey, D. J., Lin, Y., Nutt, L. K., Ozel, H. Z., & Newman, R. A. (2000) · PubMed · Cited by 280 · see citing works
A DRUG SENSITISING THE ORGANISM TO ETHYL ALCOHOL
Hald, J., & Jacobsen, E. (1948) · The Lancet · doi:10.1016/s0140-6736(48)91514-1 · Cited by 277 · see citing works
Statin use and cancer risk: a comprehensive review
Boudreau, D. M., Yu, O., & Johnson, J. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740331003662620 · Cited by 274 · see citing works
Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2.
Pugh, S., & Thomas, G. A. O. (1994) · Gut · doi:10.1136/gut.35.5.675 · Cited by 266 · see citing works
Angiogenesis inhibition by minocycline.
Tamargo, R. J., Bok, R., & Brem, H. (1991) · PubMed · Cited by 253 · see citing works
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
Fiskus, W. C., Saba, N. S., Shen, M., Ghias, M. H., Liu, J., Gupta, S. D., Chauhan, L., Rao, R., Gunewardena, S., Schorno, K., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2033 · Cited by 249 · see citing works
Inhibition of Angiogenesis by the Antifungal Drug Itraconazole
Chong, C. R., Xu, J., Lu, J., Bhat, S., Sullivan, D. J., & Liu, J. O. (2007) · ACS Chemical Biology · doi:10.1021/cb600362d · Cited by 210 · see citing works
Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells
Kometiani, P., Liu, L., & Askari, A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.007302 · Cited by 208 · see citing works
Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer
He, X., Esteva, F. J., Ensor, J., Hortobágyi, G. N., Lee, M., & Yeung, S. J. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr534 · Cited by 205 · see citing works
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme
Bai, R.-Y., Staedtke, V., Aprhys, C. M., Gallia, G. L., & Riggins, G. J. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor077 · Cited by 201 · see citing works
Distinct perturbation of the translatome by the antidiabetic drug metformin
Larsson, O. S., Morita, M., Topisirović, I., Alain, T., Blouin, M., Pollak, M., & Sonenberg, N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201689109 · Cited by 199 · see citing works
Management of thalidomide toxicity.
Ghobrial, I. M., & Rajkumar, S. V. (2003) · PubMed · Cited by 196 · see citing works
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo
Fan, C., Zheng, W., Fu, X., Li, X., Wong, Y.-S., & Chen, T. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.132 · Cited by 193 · see citing works
Potential applications for biguanides in oncology
Pollak, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67232 · Cited by 188 · see citing works
Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer
Antonarakis, E. S., Heath, E. I., Smith, D. C., Rathkopf, D., Blackford, A. L., Danila, D. C., King, S., Frost, A., Ajiboye, A. S., Zhao, M., et al. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-314 · Cited by 180 · see citing works
Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking
Liu, R., Li, J., Zhang, T., Zou, L., Chen, Y., Wang, K., Lei, Y., Yuan, K., Li, Y., Lan, J., et al. (2014) · Autophagy · doi:10.4161/auto.28912 · Cited by 178 · see citing works
Relationship of Type II Diabetes and Metformin Use to Ovarian Cancer Progression, Survival, and Chemosensitivity
Romero, I. L., McCormick, A., McEwen, K. A., Park, S., Karrison, T. G., Yamada, S. D., Pannain, S., & Lengyel, E. R. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3182393ab3 · Cited by 177 · see citing works
Untitled work
(2002) · PubMed · Cited by 177 · see citing works
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
Elder, R. T., Xu, X., Williams, J. W., Gong, H., Finnegan, A., & Chong, A. S. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.22 · Cited by 174 · see citing works
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth
Liu, N., Li, X., Huang, H., Zhao, C., Liao, S., Yang, C., Liu, S., Song, W., Lan, X., Lan, X., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2113 · Cited by 174 · see citing works
ecancermedicalscience
Pantziarka, P., Bouche, G., Meheus, L., Sukhatme, V. V., Sukhatme, V. P., & Vikas, P. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2014.442 · Cited by 173 · see citing works
Differential Induction of Apoptosis by Antidepressants in Glioma and Neuroblastoma Cell Lines: Evidence for p-c-Jun, Cytochrome c, and Caspase-3 Involvement
Levkovitz, Y., Gil‐Ad, I., Zeldich, E., Dayag, M., & Weizman, A. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:1:029 · Cited by 172 · see citing works
Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.
Elder, D. J. E., Hague, A., Hicks, D. J., & Paraskeva, C. (1996) · PubMed · Cited by 172 · see citing works
Untitled work
(2002) · PubMed · Cited by 170 · see citing works
Itraconazole Inhibits Angiogenesis and Tumor Growth in Non–Small Cell Lung Cancer
Aftab, B. T., Dobromilskaya, I., Liu, J. O., & Rudin, C. M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0691 · Cited by 167 · see citing works
Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status
Nishihara, R., Lochhead, P. J., Kuchiba, A., Jung, S., Yamauchi, M., Liao, X., Imamura, Y., Qian, Z. R., Morikawa, T., Wang, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.6599 · Cited by 166 · see citing works
Cancer incidence in the multicenter aids cohort study before and during the HAART era
Seaberg, E. C., Wiley, D. J., Martı́nez-Maza, O., Chmiel, J. S., Kingsley, L., Tang, Y., Margolick, J. B., & Jacobson, L. P. (2010) · Cancer · doi:10.1002/cncr.25530 · Cited by 162 · see citing works
Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non‐antimicrobial tetracycline analog (COL‐3) in a metastatic prostate cancer model
Lokeshwar, B. L., Selzer, M. G., Zhu, B., Block, N. L., & Golub, L. M. (2001) · International Journal of Cancer · doi:10.1002/ijc.10168 · Cited by 161 · see citing works
Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy
Pore, N., Gupta, A., Cerniglia, G. J., Jiang, Z., Bernhard, E. J., Evans, S. M., Koch, C. J., Hahn, S. M., & Maity, A. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1239 · Cited by 157 · see citing works
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
Mattar, T., Kochhar, K. S., Bartlett, R. R., Bremer, E. G., & Finnegan, A. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81704-4 · Cited by 155 · see citing works
Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients
He, X., Tu, S., Lee, M., & Yeung, S. J. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr020 · Cited by 154 · see citing works
Dihydroartemisinin Is Cytotoxic to Papillomavirus-Expressing Epithelial Cells In vitro and In vivo
Disbrow, G. L., Baege, A. C., Kierpiec, K. A., Yuan, H., Centeno, J. A., Thibodeaux, C. A., Hartmann, D., & Schlegel, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1216 · Cited by 154 · see citing works
The discovery of aspirin's antithrombotic effects.
Miner, J. J., & Hoffhines, A. J. (2007) · PubMed · Cited by 153 · see citing works
Mebendazole Induces Apoptosis via Bcl-2 Inactivation in Chemoresistant Melanoma Cells
Doudican, N., Rodriguez, A., Osman, I., & Orlow, S. J. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2159 · Cited by 152 · see citing works
Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer
Garrett, C. R., Hassabo, H. M., Bhadkamkar, N. A., Wen, S., Baladandayuthapani, V., Kee, B. K., Eng, C., & Hassan, M. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.71 · Cited by 151 · see citing works
Raloxifene
Clemett, D., & Spencer, C. M. (2000) · Drugs · doi:10.2165/00003495-200060020-00013 · Cited by 150 · see citing works
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells
Shin, S. Y., Lee, K. S., Choi, Y., Lim, H. J., Lee, M. H., Lim, Y., & Lee, Y. H. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt169 · Cited by 149 · see citing works
Phase 2 Study of Pemetrexed and Itraconazole as Second-Line Therapy for Metastatic Nonsquamous Non–Small-Cell Lung Cancer
Rudin, C. M., Brahmer, J. R., Juergens, R. A., Hann, C. L., Ettinger, D. S., Sebree, R., Smith, R. D., Aftab, B. T., Huang, P., & Liu, J. O. (2013) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31828c3950 · Cited by 145 · see citing works
Pharmacologic therapy of diabetes and overall cancer risk and mortality: a meta-analysis of 265 studies
Wu, L., Zhu, J., Prokop, L. J., & Murad, M. H. (2015) · Scientific Reports · doi:10.1038/srep10147 · Cited by 144 · see citing works
Aspirin for the prevention of cardiovascular events in patients without clinical cardiovascular disease: A meta-analysis of randomized trials
Berger, J. S., Lala, A., Krantz, M. J., Baker, G. S., & Hiatt, W. R. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.04.006 · Cited by 144 · see citing works
Prophylactic Use of NSAIDs by Athletes: A Risk/Benefit Assessment
Warden, S. J. (2010) · The Physician and Sportsmedicine · doi:10.3810/psm.2010.04.1770 · Cited by 144 · see citing works
A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia
Tejman-Yarden, N., Miyamoto, Y., Leitsch, D., Santini, J., Debnath, A., Gut, J., McKerrow, J. H., Reed, S. L., & Eckmann, L. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01675-12 · Cited by 144 · see citing works
Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin
Dalva-Aydemir, S., Bajpai, R., Martinez, M. S., Adekola, K., Kandela, I. K., Wei, C., Singhal, S., Koblinski, J. E., Raje, N. S., Rosen, S. T., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1088 · Cited by 141 · see citing works
Diabetes and Risk of Non-Hodgkin's Lymphoma
Mitri, J., Castillo, J. J., & Pittas, A. G. (2008) · Diabetes Care · doi:10.2337/dc08-1034 · Cited by 140 · see citing works
HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress
Pyrko, P., Kardosh, A., Wang, W., Xiong, W., Schönthal, A. H., & Chen, T. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0796 · Cited by 140 · see citing works
Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes
Zhelev, Z., Ohba, H., Bakalova, R., Hadjimitova, V. A., Ishikawa, M., Shinohara, Y., & Baba, Y. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0738-1 · Cited by 138 · see citing works
ANTI-METASTATIC EFFECT OF ASPIRIN
Gasic, G. J., Gasic, T. B., & Murphy, S. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92581-0 · Cited by 138 · see citing works
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726
Xu, X., Williams, J. W., Gong, H., Finnegan, A., & Chong, A. S. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00303-6 · Cited by 138 · see citing works
Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
Guo, X., Xu, B., Pandey, S., Goessl, E., Brown, J. E. P., Armesilla, A. L., Darling, J. L., & Wang, W. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.09.002 · Cited by 136 · see citing works
Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
Nygren, P., Fryknäs, M., Ågerup, B., & Larsson, R. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1539-5 · Cited by 133 · see citing works
MDA-7/IL-24 is a unique cytokine–tumor suppressor in the IL-10 Family
Chada, S., Sutton, R. B., Ekmekçioglu, S., Ellerhorst, J. A., Mumm, J. B., Leitner, W. W., Yang, H.-Y., Şahin, A. A., Hunt, K. K., Fuson, K. L., et al. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.017 · Cited by 132 · see citing works
Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade
Partecke, L. I., Speerforck, S., Käding, A., Seubert, F., Kühn, S., Lorenz, E., Schwandke, S., Sendler, M., Keßler, W., Trung, D. N., et al. (2016) · Pancreatology · doi:10.1016/j.pan.2016.03.005 · Cited by 132 · see citing works
Thalidomide in cancer
Singhal, S., & Mehta, J. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(01)00146-9 · Cited by 132 · see citing works
Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells
Zhou, H., Wang, W., Wu, G.-D., Lee, J. H., & Li, A. (2007) · Vascular Pharmacology · doi:10.1016/j.vph.2007.05.002 · Cited by 129 · see citing works
The Antifungal Drug Itraconazole Inhibits Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, Trafficking, and Signaling in Endothelial Cells
Nacev, B. A., Grassi, P., Dell, A., Haslam, S. M., & Liu, J. O. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278754 · Cited by 126 · see citing works
Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer
Srirangam, A., Mitra, R., Wang, M., Gorski, J. C., Badve, S., Baldridge, L., Hamilton, J., Kishimoto, H., Hawes, J. W., Li, L., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1167 · Cited by 126 · see citing works
Inhibition of DNA Topoisomerases I and II, and Growth Inhibition of Breast Cancer MCF-7 Cells by Ouabain, Digoxin and Proscillaridin A
Bielawski, K., Winnicka, K., & Bielawska, A. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1493 · Cited by 126 · see citing works
Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.
Duivenvoorden, W., Popović, S., Lhoták, Š., Seidlitz, E. P., Hirte, H. W., Tozer, R. G., & Singh, G. (2002) · PubMed · Cited by 124 · see citing works
Digitoxin and its analogs as novel cancer therapeutics
Elbaz, H. A., Stueckle, T. A., Tse, W. W., Rojanasakul, Y., & Dinu, C. Z. (2012) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-1-4 · Cited by 123 · see citing works
Cancer risk among users of neuroleptic medication: a population-based cohort study
Dalton, S. O., Johansen, C., Poulsen, A. H., Nørgaard, M., Sørensen, H. T., McLaughlin, J. K., Mortensen, P. B., & Friis, S. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603259 · Cited by 123 · see citing works
2016 FDA drug approvals
Mullard, A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.14 · Cited by 121 · see citing works
Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09)
Rothermundt, C. A., Hayoz, S., Templeton, A. J., Winterhalder, R., Strebel, R. T., Bärtschi, D., Pollak, M., Lui, L., Endt, K., Schiess, R., et al. (2014) · European Urology · doi:10.1016/j.eururo.2013.12.057 · Cited by 120 · see citing works
Digitalis toxicity: Epidemiology and clinical use of serum concentration measurements
Smith, T. W. (1975) · The American Journal of Medicine · doi:10.1016/0002-9343(75)90118-7 · Cited by 120 · see citing works
Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage
Paranjpe, A., Zhang, R., Ali‐Osman, F., Bobustuc, G. C., & Srivenugopal, K. S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt366 · Cited by 118 · see citing works
Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
Pantziarka, P., Sukhatme, V. V., Bouche, G., Melhuis, L., & Sukhatme, V. P. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2016.610 · Cited by 118 · see citing works
Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells
Fife, R. S., Rougraff, B. T., Proctor, C., & Sledge, G. W. (1997) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(97)90130-x · Cited by 116 · see citing works
Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment
Pollak, M. (2014) · Nature Medicine · doi:10.1038/nm.3596 · Cited by 115 · see citing works
The Novel Combination of Chlorpromazine and Pentamidine Exerts Synergistic Antiproliferative Effects through Dual Mitotic Action
Lee, M. S., Johansen, L. M., Zhang, Y., Wilson, A., Keegan, M., Avery, W., Elliott, P. J., Borisy, A. A., & Keith, C. T. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2235 · Cited by 115 · see citing works
Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies
Lytras, T. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1858 · Cited by 114 · see citing works
Metformin use and improved response to therapy in esophageal adenocarcinoma
Skinner, H. D., McCurdy, M. R., Echeverria, A. E., Lin, S. H., Welsh, J. W., O’Reilly, M. S., Hofstetter, W. L., Ajani, J. A., Komaki, R. R., Cox, J. D., et al. (2012) · Acta Oncologica · doi:10.3109/0284186x.2012.718096 · Cited by 112 · see citing works
Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells
Baumann, P., Mandl–Weber, S., Völkl, A., Adam, C., Bumeder, I., Oduncu, F. S., & Schmidmaier, R. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0664 · Cited by 112 · see citing works
Cu/Zn superoxide dismutase plays a role in angiogenesis
Marikovsky, M., Nevo, N., Vadai, E., & Harris‐Cerruti, C. (2001) · International Journal of Cancer · doi:10.1002/ijc.1565 · Cited by 110 · see citing works
Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase ( HPGD )
Fink, S. P., Yamauchi, M., Nishihara, R., Jung, S., Kuchiba, A., Wu, K., Cho, E., Giovannucci, E. L., Fuchs, C. S., Ogino, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008481 · Cited by 109 · see citing works
Transcriptional regulation of cyclo-oxygenase expression: three pillars of control.
Ramsay, R. G., Ciznadija, D., Vanevski, M., & Mantamadiotis, T. (2003) · PubMed · Cited by 109 · see citing works
Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients
Wickström, M., Danielsson, K., Rickardson, L., Gullbo, J., Nygren, P., Isaksson, A., Larsson, R. L., & Lövborg, H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.016 · Cited by 109 · see citing works
Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation
Chen, T., Lin, C., Huang, P., & Wen, C. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06664.x · Cited by 107 · see citing works
Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts
Leclerc, G. M., Leclerc, G. J., Kuznetsoff, J. N., DeSalvo, J., & Barredo, J. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074420 · Cited by 106 · see citing works
Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram
Shian, S.-G., Kao, Y.-R., Wu, F. Y.-H., & Wu, C. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.5.1076 · Cited by 105 · see citing works
Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis
Ranjan, A., Gupta, P., & Srivastava, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1233 · Cited by 105 · see citing works
Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells.
Hixson, L. J., Alberts, D. S., Krutzsch, M. F., Einsphar, J., Brendel, K., Gross, P. H., Paranka, N. S., Baier, M. L., Emerson, S. S., & Pamukcu, R. (1994) · PubMed · Cited by 105 · see citing works
Metformin use and improved response to therapy in rectal cancer
Skinner, H. D., Crane, C. H., Garrett, C. R., Eng, C., Chang, G. J., Skibber, J. M., Rodrı́guez-Bigas, M. A., Kelly, P., Sandulache, V. C., Delclos, M. E., et al. (2013) · Cancer Medicine · doi:10.1002/cam4.54 · Cited by 103 · see citing works
Repurposing of approved cardiovascular drugs
Ishida, J., Konishi, M., Ebner, N., & Springer, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1031-5 · Cited by 103 · see citing works
Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer
Laskov, I., Drudi, L. M., Beauchamp, M.-C., Yasmeen, A., Ferenczy, A. S., Pollak, M., & Gotlieb, W. H. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.06.014 · Cited by 103 · see citing works
Chromosome changes in 17 human neoplasms studied with banding
Riet-Fox, M. F. D. V., Retief, A. E., & Niekerk, W. A. V. (1979) · Cancer · doi:10.1002/1097-0142(197912)44:6 · Cited by 103 · see citing works
Inhibition of tubulin polymerization by Mebendazole
Laclette, J. P., Guerra, G., & Zetina, C. R. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)90349-6 · Cited by 102 · see citing works
Sodium pump inhibition, enhanced calcium influx via sodium-calcium exchange, and positive inotropic response in cultured heart cells.
Barry, W. H., Hasin, Y., & Smith, T. W. (1985) · Circulation Research · doi:10.1161/01.res.56.2.231 · Cited by 102 · see citing works
Role of Aspirin in Cancer Prevention
Thorat, M. A., & Cuzick, J. M. (2013) · Current Oncology Reports · doi:10.1007/s11912-013-0351-3 · Cited by 101 · see citing works
Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer
Yang, J., Wei, J., Wu, Y., Wang, Z., Guo, Y., Lee, P. J., & Li, X. (2015) · Oncogenesis · doi:10.1038/oncsis.2015.18 · Cited by 101 · see citing works
Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies
McQuay, H. J., & Moore, R. A. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02723.x · Cited by 99 · see citing works
Chlorimipramine: A novel anticancer agent with a mitochondrial target
Daley, E., Wilkie, D., Loesch, A., Hargreaves, I. P., Kendall, D. A., Pilkington, G. J., & Bates, T. E. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.028 · Cited by 97 · see citing works
Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation
Sikka, A., Kaur, M., Agarwal, C., Deep, G., & Agarwal, R. (2012) · Cell Cycle · doi:10.4161/cc.19798 · Cited by 96 · see citing works
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70
Endo, H., Yano, M., Okumura, Y., & Kido, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.550 · Cited by 95 · see citing works
Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor
Larsen, A. R., Bai, R.-Y., Chung, J., Borodovsky, A., Rudin, C. M., Riggins, G. J., & Bunz, F. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0755-t · Cited by 95 · see citing works
Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial
Hadad, S. M., Coates, P. J., Jordan, L. B., Dowling, R. J. O., Chang, M. C., Done, S. J., Purdie, C. A., Goodwin, P. J., Stambolic, V., Moulder-Thompson, S. L., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3307-5 · Cited by 94 · see citing works
2015 FDA drug approvals
Mullard, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.15 · Cited by 94 · see citing works
Drug Repurposing for Gastrointestinal Stromal Tumor
Pessetto, Z. Y., Weir, S. J., Sethi, G., Broward, M. A., & Godwin, A. K. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0968 · Cited by 94 · see citing works
Dihydroartemisinin induces autophagy and inhibits the growth of iron‐loaded human myeloid leukemia K562 cells via ROS toxicity
Wang, Z., Hu, W., Zhang, J., Wu, X., & Zhou, H. (2012) · FEBS Open Bio · doi:10.1016/j.fob.2012.05.002 · Cited by 92 · see citing works
Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells
Kumar, S., Bryant, C. S., Chamala, S., Qazi, A. M., Seward, S. M., Pal, J., Steffes, C. P., Weaver, D. W., Morris, R. T., Malone, J. M., et al. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-26 · Cited by 92 · see citing works
Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality
McCowan, C., Munro, A. J., Donnan, P. T., & Steele, R. J. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.10.024 · Cited by 91 · see citing works
HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling
Yang, Y., Ikezoe, T., Takeuchi, T., Adachi, Y., Ohtsuki, Y., Takeuchi, S., Koeffler, H. P., & Taguchi, H. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00063.x · Cited by 91 · see citing works
Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells.
Palayoor, S. T., Bump, E. A., Calderwood, S. K., Bartol, S., & Coleman, C. N. (1998) · PubMed · Cited by 91 · see citing works
Neuroleptic medication and reduced risk of prostate cancer in schizophrenic patients
Mortensen, P. B. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb10325.x · Cited by 90 · see citing works
Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells
Onoda, T., Ono, T., Dhar, D. K., Yamanoi, A., Fujii, T., & Nagasue, N. (2004) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2003.12.012 · Cited by 90 · see citing works
Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K
Kim, M.-S., Kim, J., Lim, D. Y., Huang, Z., Chen, H., Langfald, A., Lubet, R. A., Grubbs, C. J., Dong, Z., & Bode, A. M. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0288 · Cited by 89 · see citing works
Thalidomide embryopathy: a model for the study of congenital incomitant horizontal strabismus.
Miller, M. T. (1991) · PubMed · Cited by 85 · see citing works
Effects of doxycycline on human prostate cancer cells in vitro
Fife, R. S., Sledge, G. W., Roth, B. J., & Proctor, C. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00003-2 · Cited by 85 · see citing works
Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1
Ba, Q., Zhou, N., Duan, J., Chen, T., Hao, M., Yang, X., Li, J., Yin, J., Chu, R., & Wang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042703 · Cited by 84 · see citing works
Thalidomide and its derivatives: emerging from the wilderness
Gordon, J., & Goggin, P. M. (2003) · Postgraduate Medical Journal · doi:10.1136/pmj.79.929.127 · Cited by 84 · see citing works
The serotonin transporter (SLC6A4) is present in B‐cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics
Meredith, E. J., Holder, M. J., Chamba, A., Challa, A., Lee, A. D., Bunce, C. M., Drayson, M. T., Pilkington, G. J., Blakely, R., Dyer, M. J. S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3477fje · Cited by 83 · see citing works
Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer
Nygren, P., & Larsson, R. (2014) · Acta Oncologica · doi:10.3109/0284186x.2013.844359 · Cited by 83 · see citing works
Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis
Perné, A., Muellner, M. K., Steinrueck, M., Craig-Mueller, N., Mayerhofer, J., Schwarzinger, I., Sloane, M. A., Uras, I. Z., Hoermann, G., Nijman, S. M. B., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008292 · Cited by 82 · see citing works
Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms
Chen, X., Shi, X., Zhao, C., Li, X., Lan, X., Liu, S., Huang, H., Liu, N., Liao, S., Zang, D., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2361 · Cited by 82 · see citing works
The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells
O’Donnell, E. F., Kopparapu, P., Koch, D. C., Jang, H. S., Phillips, J. L., Tanguay, R. L., Kerkvliet, N. I., & Kolluri, S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040926 · Cited by 81 · see citing works
Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention
Umar, A., Steele, V. E., Menter, D. G., & Hawk, E. T. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.010 · Cited by 81 · see citing works
In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug
Shi, X., Li, H., Yao, H., Liu, X., Li, L., Leung, K., Kung, H., Lu, D., Wong, M., & Lin, M. C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132072 · Cited by 80 · see citing works
Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth
Gil‐Ad, I., Shtaif, B., Levkovitz, Y., Nordenberg, J., Taler, M., Korov, I., & Weizman, A. (2006) · Oncology Reports · doi:10.3892/or.15.1.107 · Cited by 79 · see citing works
Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases
Pan, M., Chang, H., & Hung, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.02.004 · Cited by 79 · see citing works
Nelfinavir Induces Liposarcoma Apoptosis through Inhibition of Regulated Intramembrane Proteolysis of SREBP-1 and ATF6
Guan, M., Fousek, K., Jiang, C., Guo, S., Synold, T. W., Xi, B., Shih, C.-C., & Chow, W. A. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3216 · Cited by 79 · see citing works

Flagged first, then by citations

7 of the 333 references couldn’t be matched to a known paper.

Sorted by citations

The updated landscape of tumor microenvironment and drug repurposing
Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00280-x · Cited by 1,262 · see citing works
Overcoming cancer therapeutic bottleneck by drug repurposing
Zhang, Z., Zhou, L., Xie, N., Nice, E. C., Zhang, T., Cui, Y., & Huang, C. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00213-8 · Cited by 521 · see citing works
Old Drugs as New Treatments for Neurodegenerative Diseases
Durães, F., Pinto, M. M. M., & Sousa, E. (2018) · Pharmaceuticals · doi:10.3390/ph11020044 · Cited by 344 · see citing works
Polytherapy and Targeted Cancer Drug Resistance
Chatterjee, N., & Bivona, T. G. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.02.003 · Cited by 271 · see citing works
Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers
Chen, W., Yang, W. L., Chen, P., Huang, Y., & Li, F. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b14940 · Cited by 155 · see citing works
Current status and contemporary approaches to the discovery of antitumor agents from higher plants
Agarwal, G., Carcache, P. J. B., Addo, E. M., & Kinghorn, A. D. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.01.004 · Cited by 114 · see citing works
Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
Nuevo‐Tapioles, C., Santacatterina, F., Stamatakis, K., de Arenas, C. N., de Cedrón, M. G., Formentini, L., & Cuezva, J. M. (2020) · Nature Communications · doi:10.1038/s41467-020-17384-1 · Cited by 117 · see citing works
Drug combination and repurposing for cancer therapy: the example of breast cancer
Correia, A. S., Gärtner, F., & Vale, N. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e05948 · Cited by 113 · see citing works
Drug repurposing to fight colistin and carbapenem-resistant bacteria
Peyclit, L., Baron, S. A., & Rolain, J.-M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00193 · Cited by 91 · see citing works
New drugs are not enough‑drug repositioning in oncology: An update
Armando, R., Mengual G�mez, D., & Gomez, D. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.4966 · Cited by 90 · see citing works
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology
Efferth, T., & Oesch, F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.12.010 · Cited by 89 · see citing works
Old wine in new bottles: Drug repurposing in oncology
Antoszczak, M., Markowska, A., Markowska, J., & Huczyński, A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172784 · Cited by 88 · see citing works
Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway
Wang, X., Wu, X., Zhang, Z., Ma, C., Wu, T., Tang, S., Zeng, Z., Huang, S., Gong, C., Yuan, C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-36214-5 · Cited by 85 · see citing works
Improving therapy of severe infections through drug repurposing of synergistic combinations
Cheng, Y., Williamson, P. R., & Zheng, W. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.07.006 · Cited by 85 · see citing works
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions
Fu, L., Jin, W., Zhang, J., Zhu, L., Lu, J., Zhen, Y., Zhang, L., Ouyang, L., Liu, B., & Yu, H. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.09.006 · Cited by 83 · see citing works
Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: Repurposing quinacrine for lung cancer therapeutics
Vaidya, B., Kulkarni, N. S., Shukla, S. K., Parvathaneni, V., Chauhan, G., Damon, J. K., Sarode, A., Garcia, J., Kunda, N. K., Mitragotri, S., et al. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118995 · Cited by 80 · see citing works
Understanding Membrane Protein Drug Targets in Computational Perspective
Gong, J., Chen, Y., Pu, F., Sun, P., He, F., Zhang, L., Li, Y., Ma, Z., & Wang, H. (2018) · Current Drug Targets · doi:10.2174/1389450120666181204164721 · Cited by 79 · see citing works
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Mohi-ud-din, R., Chawla, A., Sharma, P., Mir, P. A., Pottoo, F. H., Reiner, Ž., Reiner, I., Ateşşahin, D. A., Sharifi‐Rad, J., Mir, R. H., et al. (2023) · European journal of medical research · doi:10.1186/s40001-023-01275-4 · Cited by 81 · see citing works
Recent contributions of quinolines to antimalarial and anticancer drug discovery research
de Walle, T. V., Cools, L., Mangelinckx, S., & D’hooghe, M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113865 · Cited by 77 · see citing works
Inhalation delivery of repurposed drugs for lung cancer: Approaches, benefits and challenges
Kumbhar, P., Manjappa, A. S., Shah, R., Jha, N. K., Singh, S. K., Dua, K., Disouza, J., & Patravale, V. B. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.015 · Cited by 76 · see citing works
Metformin: prevention of genomic instability and cancer: a review
Najafi, M., Cheki, M., Rezapoor, S., Geraily, G., Motevaseli, E., Carnovale, C., Clementi, E., & Shirazi, A. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.01.007 · Cited by 75 · see citing works
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer
Hart, P. C., Chiyoda, T., Liu, X., Weigert, M., Curtis, M., Chiang, C.-Y., Loth, R. M., Lastra, R. R., McGregor, S. M., Locasale, J. W., et al. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0409 · Cited by 73 · see citing works
Knowledge-driven drug repurposing using a comprehensive drug knowledge graph
Zhu, Y., Che, C., Jin, B., Zhang, N., Su, C., & Wang, F. (2020) · Health Informatics Journal · doi:10.1177/1460458220937101 · Cited by 73 · see citing works
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Ahmed, F., Kang, I. S., Kim, K. H., Asif, A., Rahim, C. S. A., Samantasinghar, A., Memon, F. H., & Choi, K. H. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28693 · Cited by 75 · see citing works
Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects
Nath, J., Paul, R., Ghosh, S. K., Paul, J., Singha, B., & Debnath, N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118189 · Cited by 71 · see citing works
Statin as a Potential Chemotherapeutic Agent: Current Updates as a Monotherapy, Combination Therapy, and Treatment for Anti-Cancer Drug Resistance
Pun, N. T., & Jeong, C. (2021) · Pharmaceuticals · doi:10.3390/ph14050470 · Cited by 70 · see citing works
Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases
Sajeev, A., Hegde, M., Girisa, S., Devanarayanan, T. N., Alqahtani, M. S., Abbas, M. A. E., Sil, S. K., Sethi, G., Chen, J., & Kunnumakkara, A. B. (2022) · Biomolecules · doi:10.3390/biom12091185 · Cited by 69 · see citing works
Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology
Jan, N., Sofi, S., Qayoom, H., Shabir, A., Haq, B. U., Macha, M. A., Almilaibary, A., & Mir, M. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24670 · Cited by 68 · see citing works
Drug Repurposing in Cancer Therapy: Influence of Patient’s Genetic Background in Breast Cancer Treatment
Rodrigues, R. C., Duarte, D., & Vale, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084280 · Cited by 67 · see citing works
Anthelmintics for drug repurposing: Opportunities and challenges
Alavi, S. E., & Shahmabadi, H. E. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.04.004 · Cited by 64 · see citing works
Repurposing drugs for glioblastoma: From bench to bedside
Basso, J., Miranda, A., Sousa, J., Pais, A. A. C. C., & Vitorino, C. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.039 · Cited by 63 · see citing works
New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil
Cruz-Burgos, M., Losada-García, A., Cruz-Hernández, C. D., Cortés-Ramírez, S. A., Camacho‐Arroyo, I., González-Covarrubias, V., Morales-Pacheco, M., Trujillo-Bornios, S. I., & Rodríguez‐Dorantes, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.627229 · Cited by 63 · see citing works
Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy
Chen, M., Huang, Z., Xia, M., Ding, Y., Shan, T., Guan, Z., Dai, X., Xu, X., Huang, Y., Huang, M., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.041 · Cited by 62 · see citing works
Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
Ma, Z., Woon, C. Y.-N., Liu, C., Cheng, J.-T., You, M., Sethi, G., Wong, A. L., Ho, P. C., Zhang, D., Ong, P.-S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.828856 · Cited by 62 · see citing works
Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer
Chang, Y., Jiang, J., Wu, C., Yang, W. L., Chen, L., Chen, P., Shen, J., Qian, S., Zhou, T., Wu, L., et al. (2019) · Applied Materials Today · doi:10.1016/j.apmt.2019.100492 · Cited by 62 · see citing works
Drug rechanneling: A novel paradigm for cancer treatment
Kaushik, I., Ramachandran, S., Prasad, S., & Srivastava, S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.011 · Cited by 58 · see citing works
The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells
Yang, C.-E., Lee, W., Cheng, H., Chung, C., Mi, F.-L., & Lin, C. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.01.033 · Cited by 57 · see citing works
Repurposing Itraconazole Loaded PLGA Nanoparticles for Improved Antitumor Efficacy in Non-Small Cell Lung Cancers
Alhakamy, N. A., & Md, S. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120685 · Cited by 57 · see citing works
Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
Seo, M. J., Kim, I. Y., Lee, D. M., Park, Y. J., Cho, M. Y., Jin, H. J., & Choi, K. S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05586-6 · Cited by 56 · see citing works
Drug Repurposing for Cancer Treatment: A Comprehensive Review
Khzem, A. H. A., Gomaa, M. S., Alturki, M. S., Tawfeeq, N., Sarafroz, M., Alonaizi, S. M., Faran, A. A., Alrumaihi, L. A., AlAnsari, F., & Alghamdi, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212441 · Cited by 55 · see citing works
Pathway-Based Drug-Repurposing Schemes in Cancer: The Role of Translational Bioinformatics
Lemus, E. H., & Martínez-García, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.605680 · Cited by 55 · see citing works
The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer
Florio, R., Veschi, S., di Giacomo, V., Pagotto, S., Carradori, S., Verginelli, F., Cirilli, R., Casulli, A., Grassadonia, A., Tinari, N., et al. (2019) · Cancers · doi:10.3390/cancers11122042 · Cited by 54 · see citing works
Diuretics: a contemporary pharmacological classification?
Kehrenberg, M. C. A., & Bachmann, H. S. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02228-0 · Cited by 53 · see citing works
Drug repurposing—an emerging strategy in cancer therapeutics
Turabi, K. S., Deshmukh, A. J., Paul, S., Swami, D., Siddiqui, S., Kumar, U., Naikar, S., Devarajan, S., Basu, S., Paul, M. K., et al. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02263-x · Cited by 53 · see citing works
Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches
Kang, D., Pang, X., Lian, W., Xu, L., Wang, J., Jia, H., Zhang, B., Liu, A., & Du, G. (2018) · RSC Advances · doi:10.1039/c7ra12259d · Cited by 53 · see citing works
Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications
Badria, F. A.-E. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.83082 · Cited by 53 · see citing works
Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System
Laudisi, F., Marônek, M., Grazia, A. D., Monteleone, G., & Stolfi, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144957 · Cited by 52 · see citing works
Subterminal hydroxyeicosatetraenoic acids: Crucial lipid mediators in normal physiology and disease states
Shoieb, S. M., El-Sherbeni, A. A., & El‐Kadi, A. O. S. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.12.004 · Cited by 50 · see citing works
Molecular mechanisms of anti-psychotic drugs for improvement of cancer treatment
Hendouei, N., Saghafi, F., Shadfar, F., & Hosseinimehr, S. J. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.05.031 · Cited by 49 · see citing works
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy
Jose, A., Shenoy, G. G., Rodrigues, G. S., Kumar, N. A. N., Munisamy, M., Thomas, L., Kolesar, J., Rai, G., Rao, P. P. N., & Rao, M. (2020) · Cancers · doi:10.3390/cancers12082121 · Cited by 49 · see citing works
Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function
Varalda, M., Antona, A., Bettio, V., Roy, K., Vachamaram, A., Yellenki, V., Massarotti, A., Baldanzi, G., & Capello, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.562196 · Cited by 49 · see citing works
Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2′-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs
Eissa, I. H., Alesawy, M. S., Saleh, A. M., Elkaeed, E. B., Alsfouk, B. A. A., El-Attar, A.-A. M. M., & Metwaly, A. M. (2022) · Molecules · doi:10.3390/molecules27072287 · Cited by 49 · see citing works
Statins as anti‐tumor agents: A paradigm for repurposed drugs
Tripathi, S., Gupta, E., & Galande, S. (2024) · Cancer Reports · doi:10.1002/cnr2.2078 · Cited by 50 · see citing works
The Allergic Rhinitis and Its Impact on Asthma (ARIA) Approach of Value-Added Medicines: As-Needed Treatment in Allergic Rhinitis
Bousquet, J., Toumi, M., Sousa‐Pinto, B., Antó, J. M., Bedbrook, A., Czarlewski, W., Valiulis, A., Ansotegui, I. J., Bosnic-Anticevich, S. Z., Brussino, L., et al. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.07.020 · Cited by 56 · see citing works
New perspectives in cancer: Modulation of lipid metabolism and inflammation resolution
Prevete, N., Liotti, F., Amoresano, A., Pucci, P., de Paulis, A., & Melillo, R. M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.09.024 · Cited by 46 · see citing works
Somatic selection distinguishes oncogenes and tumor suppressor genes
Chandrashekar, P. B., Ahmadinejad, N., Wang, J., Sekulić, A., Egan, J. B., Asmann, Y. W., Kumar, S., Maley, C. C., & Liu, L. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz851 · Cited by 45 · see citing works
Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy
Vitale, D. L., Icardi, A., Rosales, P., Spinelli, F. M., Sevic, I., & Alaniz, L. D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.710061 · Cited by 46 · see citing works
Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review
Siddiqui, S., Deshmukh, A. J., Mudaliar, P., Nalawade, A. J., Iyer, D., & Aich, J. (2022) · Journal of the Egyptian National Cancer Institute · doi:10.1186/s43046-022-00137-0 · Cited by 44 · see citing works
Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability
Barbieri, F., Würth, R., Pattarozzi, A., Verduci, I., Mazzola, C., Cattaneo, M. G., Tonelli, M., Solari, A., Bajetto, A., Daga, A., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00899 · Cited by 44 · see citing works
A unified platform enabling biomarker ranking and validation for 1562 drugs using transcriptomic data of 1250 cancer cell lines
Fekete, J. T., & Győrffy, B. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.06.007 · Cited by 43 · see citing works
Beta-adrenergic receptor blocker propranolol triggers anti-tumor immunity and enhances irinotecan therapy in mice colorectal cancer
Lin, Y., Liu, Y., Gao, Z., Jing, D., Bi, R., Cui, X., Cao, Q., Zhao, Q., Gao, R., Su, Y., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175718 · Cited by 43 · see citing works
Timosaponin AIII: A novel potential anti-tumor compound from Anemarrhena asphodeloides
Feng-ying, H., Song, X., Chen, J., Yao, G., & Song, S. (2018) · Steroids · doi:10.1016/j.steroids.2018.09.014 · Cited by 43 · see citing works
Repurposing of Chronically Used Drugs in Cancer Therapy: A Chance to Grasp
Hijazi, M. A., Gessner, A., & El‐Najjar, N. (2023) · Cancers · doi:10.3390/cancers15123199 · Cited by 42 · see citing works
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
Hart, P. C., Kenny, H. A., Grassl, N., Watters, K. M., Litchfield, L., Coscia, F., Blaženović, I., Ploetzky, L., Fiehn, O., Mann, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.079 · Cited by 39 · see citing works
Metformin suppresses HIF‐1α expression in cancer‐associated fibroblasts to prevent tumor‐stromal cross talk in breast cancer
Shao, S., Zhao, L., An, G., Zhang, L., Jing, X., Luo, M., Li, W., Du, M., Ning, Q., Zhao, X., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000951rr · Cited by 42 · see citing works
Current Treatments and New Possible Complementary Therapies for Epithelial Ovarian Cancer
Garrido, M. P., Fredes, A. N., Lobos‐González, L., Valenzuela, M., Vera, D. B., & Romero, C. (2021) · Biomedicines · doi:10.3390/biomedicines10010077 · Cited by 40 · see citing works
Integration of genetic variants and gene network for drug repurposing in colorectal cancer
Irham, L. M., Wong, H. S.-C., Chou, W., Adikusuma, W., Mugiyanto, E., Huang, W., & Chang, W. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105203 · Cited by 41 · see citing works
Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-Based Pharmacophore Modeling/Docking Approach
Culletta, G., Gulotta, M. R., Perricone, U., Zappalà, M., Almerico, A. M., & Tutone, M. (2020) · Computation · doi:10.3390/computation8030077 · Cited by 40 · see citing works
Drug Repurposing for the Treatment of Acute Myeloid Leukemia
Andresen, V., & Gjertsen, B. T. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00211 · Cited by 39 · see citing works
Artificial Intelligence in Drug Discovery and Development Against Antimicrobial Resistance: A Narrative Review
Ghaderzadeh, M., Shalchian, A., Irajian, G., Sadeghsalehi, H., Bialvaei, A. Z., & Sabet, B. (2024) · Iranian Journal of Medical Microbiology · doi:10.30699/ijmm.18.3.135 · Cited by 38 · see citing works
Dual Effect of Doxazosin: Anticancer Activity on SH-SY5Y Neuroblastoma Cells and Neuroprotection on an In Vitro Model of Alzheimer's Disease
Coelho, B. P., Gaelzer, M. M., Petry, F. D. S., Hoppe, J. B., Trindade, V. M. T., Salbego, C. G., & Guma, F. T. C. R. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.005 · Cited by 38 · see citing works
DLDTI: a learning-based framework for drug-target interaction identification using neural networks and network representation
Zhao, Y., Zheng, K., Guan, B., Guo, M., Song, L., Gao, J., Qu, H., Wang, Y., Zhang, Y., & Dazhuo, S. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02602-7 · Cited by 38 · see citing works
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
Tajaldini, M., Poorkhani, A., Amiriani, T., Amiriani, A., Javid, H., Aref, P., Ahmadi, F., Sadani, S., & Khori, V. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175991 · Cited by 38 · see citing works
Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer
Kwon, O., Lee, H., Kong, H., Kwon, E.-J., Park, J. E., Lee, W., Kang, S., Kim, S., Kim, W., & Cha, H. (2020) · Oncogene · doi:10.1038/s41388-020-1316-2 · Cited by 37 · see citing works
Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues
Jiang, H., Xing, J., Wang, C., Zhang, H., Yue, L., Wan, X., Chen, W., Ding, H., Xie, Y., Tao, H., et al. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob02369c · Cited by 36 · see citing works
Synthesis and Characterization of Lipophilic Salts of Metformin to Improve Its Repurposing for Cancer Therapy
Saeed, H. K., Sutar, Y. B., Patel, P. A., Bhat, R., Mallick, S., Hatada, A. E., Koomoa, D. T., Lange, I., & Date, A. A. (2021) · ACS Omega · doi:10.1021/acsomega.0c04779 · Cited by 36 · see citing works
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment
Vasconcelos, M. H., Palmeira, A., Sousa, S. M., & Xavier, C. P. R. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230130150029 · Cited by 36 · see citing works
Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death
Thirusangu, P., Pathoulas, C. L., Ray, U., Xiao, Y., Staub, J. K., Jin, L., Khurana, A., & Shridhar, V. (2021) · Cancers · doi:10.3390/cancers13092004 · Cited by 35 · see citing works
Self‐Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8+ T Cells
Tian, H., Li, W., Wang, G., Tian, Y., Yan, J., Zhou, S., Yu, X., Li, B., & Dai, Y. (2023) · Advanced Science · doi:10.1002/advs.202301661 · Cited by 34 · see citing works
Phosphorylated STAT3 (Tyr705) as a biomarker of response to pimozide treatment in triple-negative breast cancer
Dees, S., Pontiggia, L., Jasmin, J.-F., & Mercier, I. (2020) · Cancer Biology & Therapy · doi:10.1080/15384047.2020.1726718 · Cited by 34 · see citing works
How selective are clinical CDK4/6 inhibitors?
Hendrychová, D., Jorda, R., & Kryštof, V. (2020) · Medicinal Research Reviews · doi:10.1002/med.21769 · Cited by 35 · see citing works
Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species
Eales, K. L., Wilkinson, E. A., Cruickshank, G. S., Tucker, J. H. R., & Tennant, D. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32727-1 · Cited by 32 · see citing works
Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment
Nehme, R., Hallal, R., Dor, M. E., Kobeissy, F. H., Gouilleux, F., Mazurier, F., & Zibara, K. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200908114411 · Cited by 32 · see citing works
Combination of Disulfiram and Copper–Cysteamine Nanoparticles for an Enhanced Antitumor Effect on Esophageal Cancer
Chang, Y., Wu, F., Pandey, N. K., Chudal, L., Xing, M., Zhang, X., Nguyen, L., Liu, X., Liu, J. P., Chen, W., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00949 · Cited by 32 · see citing works
Propranolol inhibits neonatal Nav1.5 activity and invasiveness of MDA‐MB‐231 breast cancer cells: Effects of combination with ranolazine
Lee, A. E., Fraser, S. P., & Djamgoz, M. B. A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28868 · Cited by 32 · see citing works
Drug repositioning for cancer in the era of AI, big omics, and real-world data
Wieder, R., & Adam, N. R. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103730 · Cited by 31 · see citing works
AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia
Medeiros, H. C. D., Colturato-Kido, C., Ferraz, L. S., Costa, C. A., Moraes, V., Paredes‐Gamero, E. J., Tersariol, I. L. S., & Rodrigues, T. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108888 · Cited by 30 · see citing works
Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19
Sharma, T., Abohashrh, M., Baig, M. H., Dong, J.-J., Alam, M. M., Ahmad, I., & Irfan, S. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.02.059 · Cited by 30 · see citing works
Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity
Shi, S., Ma, B., Sun, F., Qu, C. F., Li, G., Shi, D., Liu, W., Zhang, H., & An, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101731 · Cited by 30 · see citing works
Systems Biology Understanding of the Effects of Lithium on Cancer
Ge, W., & Jakobsson, E. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00296 · Cited by 29 · see citing works
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study
Gormley, M., Yarmolinsky, J., Dudding, T., Burrows, K., Martin, R. M., Thomas, S. J., Tyrrell, J., Brennan, P., Pring, M., Boccia, S., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009525 · Cited by 30 · see citing works
Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach
Cheng, A. N., Lo, Y.-K., Lin, Y., Tang, T.-K., Hsu, C., Hsu, J. T.-A., & Lee, A. Y. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.030 · Cited by 29 · see citing works
Repositioning Aspirin to Treat Lung and Breast Cancers and Overcome Acquired Resistance to Targeted Therapy
Li, L., Hu, M., Wang, T., Chen, H., & Xu, L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01503 · Cited by 28 · see citing works
Combining repurposed drugs to treat colorectal cancer
Duarte, D., & Vale, N. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.09.012 · Cited by 29 · see citing works
Drug repurposing: An emerging strategy in alleviating skin cancer
Kumbhar, P., Kole, K., Yadav, T., Bhavar, A., Waghmare, P., Bhokare, R., Manjappa, A., Jha, N. K., Chellappan, D. K., Shinde, S., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175031 · Cited by 28 · see citing works
Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials
Ioakeim‐Skoufa, I., Tobajas-Ramos, N., Menditto, E., Aza‐Pascual‐Salcedo, M., Miguel, A. G., Orlando, V., González‐Rubio, F., Fanlo, A., AZA, C. L., Ostasz, E., et al. (2023) · Cancers · doi:10.3390/cancers15112972 · Cited by 28 · see citing works
Drug repurposing against Parkinson's disease by text mining the scientific literature
Zhu, Y., Jung, W., Wang, F., & Che, C. (2020) · Library Hi Tech · doi:10.1108/lht-08-2019-0170 · Cited by 28 · see citing works
Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma
Rebelo, R., Polónia, B. R. G., Santos, L. L., Vasconcelos, M. H., & Xavier, C. P. R. (2021) · Pharmaceuticals · doi:10.3390/ph14030280 · Cited by 28 · see citing works
Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy
Vellichirammal, N. N., Chaturvedi, N. K., Joshi, S. S., Coulter, D. W., & Guda, C. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.015 · Cited by 26 · see citing works
Docusate-Based Ionic Liquids of Anthelmintic Benzimidazoles Show Improved Pharmaceutical Processability, Lipid Solubility, and in Vitro Activity against Cryptococcus neoformans
Sutar, Y. B., Fulton, S. R., Paul, S. K., Altamirano, S., Mhatre, S., Saeed, H. K., Patel, P. A., Mallick, S., Bhat, R., Patravale, V. B., et al. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00063 · Cited by 26 · see citing works

DRUG REPURPOSING IN CANCER THERAPY: NEW HOPE FOR OLD DRUGS
Siddiqu, D. U. (2022) · International journal of applied biology and forensic
Drug rechanneling: A novel paradigm for cancer treatment
Kaushik, I., Ramachandran, S., Prasad, S., & Srivastava, S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.011 · Cited by 58 · see citing works
Drug Repurposing in Cancer Therapy: A Review of Therapeutic Potential Across Diverse Drug Classes
Yadav, V., Mandaliya, V. B., & Shah, U. (2026) · ChemistrySelect · doi:10.1002/slct.202506782
REPURPOSING DRUGS FOR CANCER THERAPY
Arzuk, E., Ergüç, A., & Karakuş, F. (2022) · Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences · doi:10.26650/jarhs2021-1133474
Cancer Drug Repurposing: Pathophysiology, Therapeutic Targeting and Translational Opportunities
Dubey, A., Kumari, M., & Singh, S. (2026) · doi:10.66261/zb5hzx68

Authors: Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø.
Affiliations: University of Bergen (NO)
Haukeland University Hospital (NO)
Corresponding author: Enger, Per Øyvind
ORCID: Leiss, Lina
Skeie, Bente Sandvei
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2017-10
Volume: 124
Pages: 74-91
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2017.07.013
OpenAlex: W2734327577
Cited by: 329
References: 333
Citations by year: 2026: 18 · 2025: 21 · 2024: 54 · 2023: 43 · 2022: 45 · 2021: 45 · 2020: 56 · 2019: 24 · 2018: 20 · 2017: 3
FWCI: 4.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: drug repurposing, cancer, anticancer agents, FDA-approved drugs, anticancer mechanism, cancer prevention, unmet medical needs, anticancer drug development
MeSH terms: Animals, Antineoplastic Agents, Humans, Neoplasms, Drug Repositioning

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Drug repurposing in cancer

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks