The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure
Abstract
BACKGROUND: It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure. This approach is based in part on data indicating that atrial fibrillation is a predictor of death in patients with heart failure and suggesting that the suppression of atrial fibrillation may favorably affect the outcome. However, the benefits and risks of this approach have not been adequately studied. METHODS: We conducted a multicenter, randomized trial comparing the maintenance of sinus rhythm (rhythm control) with control of the ventricular rate (rate control) in patients with a left ventricular ejection fraction of 35% or less, symptoms of congestive heart failure, and a history of atrial fibrillation. The primary outcome was the time to death from cardiovascular causes. RESULTS: A total of 1376 patients were enrolled (682 in the rhythm-control group and 694 in the rate-control group) and were followed for a mean of 37 months. Of these patients, 182 (27%) in the rhythm-control group died from cardiovascular causes, as compared with 175 (25%) in the rate-control group (hazard ratio in the rhythm-control group, 1.06; 95% confidence interval, 0.86 to 1.30; P=0.59 by the log-rank test). Secondary outcomes were similar in the two groups, including death from any cause (32% in the rhythm-control group and 33% in the rate-control group), stroke (3% and 4%, respectively), worsening heart failure (28% and 31%), and the composite of death from cardiovascular causes, stroke, or worsening heart failure (43% and 46%). There were also no significant differences favoring either strategy in any predefined subgroup. CONCLUSIONS: In patients with atrial fibrillation and congestive heart failure, a routine strategy of rhythm control does not reduce the rate of death from cardiovascular causes, as compared with a rate-control strategy. (ClinicalTrials.gov number, NCT00597077.)
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“Antiarrhythmic drugs approximately double the rate of sinus rhythm compared with placebo.[580][581][582][583][584]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [582]
Citations
Cites
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McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Self-citation2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145
Metadata
- Authors
- Roy, D., Talajic, M., Nattel, S., Wyse, D. G., Dorian, P., Lee, K. L., Bourassa, M. G., Arnold, J. M. O., Buxton, A. E., Camm, A. J., Connolly, S. J., Dubuc, M., Ducharme, A., Guerra, P. G., Hohnloser, S. H., Lambert, J., Le Heuzey, J.-Y., O'Hara, G., Pedersen, O. D., Rouleau, J.-L., Singh, B. N., Stevenson, L. W., Stevenson, W. G., Thibault, B., & Waldo, A. L.
- Affiliations
- Montreal Heart Institute (CA)
- Libin Cardiovascular Institute of Alberta (CA)
- St. Michael's Hospital (CA)
- Duke Medical Center (US)
- London Health Sciences Centre (CA)
- Rhode Island Hospital (US)
- St George's Hospital (GB)
- Population Health Research Institute (CA)
- Goethe University Frankfurt (DE)
- Bispebjerg Hospital (DK)
- VA West Los Angeles Medical Center (US)
- Brigham and Women's Hospital (US)
- University Hospitals Cleveland Medical Center (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-06-19
- Volume
- 358
- Issue
- 25
- Pages
- 2667-2677
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2131260805
- Cited by
- 1,585
- References
- 41
- Citations by year
- 2026: 42 · 2025: 33 · 2024: 69 · 2023: 55 · 2022: 76 · 2021: 86 · 2020: 77 · 2019: 82 · 2018: 96 · 2017: 87 · 2016: 73 · 2015: 75 · 2014: 87 · 2013: 123 · 2012: 114
- FWCI
- 97.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- atrial fibrillation, heart failure, rhythm control, rate control, sinus rhythm maintenance, ventricular rate control, cardiovascular mortality, congestive heart failure, stroke, worsening heart failure, left ventricular ejection fraction
- MeSH terms
- Adrenergic beta-Antagonists, Aged, Amiodarone, Angiotensin-Converting Enzyme Inhibitors, Anti-Arrhythmia Agents, Atrial Fibrillation, Cardiovascular Diseases, Combined Modality Therapy, Digitalis Glycosides, Electric Countershock, Female, Follow-Up Studies, Heart Failure, Heart Rate, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Ventricular Dysfunction, Left, Kaplan-Meier Estimate
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