2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
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Early diagnosis of low EF, particularly in asymptomatic patients, is critical in reducing lifetime risk of morbidity and mortality.
“Early diagnosis of low EF, particularly in asymptomatic patients, is critical in reducing lifetime risk of mobility and mortality.[15][16][17]”
From Clinician Adoption of an Artificial Intelligence Algorithm to Detect Left Ventricular Systolic Dysfunction in Primary Care. (2022) · cites this paper as [16]
Section 6 recommends treatment for asymptomatic patients with reduced left ventricular function to prevent or delay heart failure and, in some groups, prolong life. This supports the value of identifying low EF before symptoms develop, but the guidelines attribute the benefits to treatment, not to early diagnosis itself, and do not establish a reduction in lifetime risk. (LLM, conf=0.82)
Experimental — accuracy not yet measuredEchocardiograms are considered the test of choice for the definitive diagnosis of left ventricular dysfunction.
“Echocardiograms are considered the test of choice for the definitive diagnosis of left ventricular dysfunction.16”
From Clinician Adoption of an Artificial Intelligence Algorithm to Detect Left Ventricular Systolic Dysfunction in Primary Care. (2022) · cites this paper as [16]
Natriuretic peptide levels are part of the diagnostic assessment of HFpEF, although natriuretic peptide levels are elevated in AF patients and the optimum diagnostic cut-off is still unknown.
“Natriuretic peptide levels are part of the diagnostic assessment of HFpEF, 222 although natriuretic peptide levels are elevated in AF patients and the optimum diagnostic cut-off is still unknown.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [222]
Diltiazem and verapamil can have negative inotropic effects in patients with LVEF < 40%.
“as diltiazem and verapamil can have negative inotropic effects in patients with LVEF < 40%.222,534,535”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [222]
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Self-citationSpironolactone for heart failure with preserved ejection fraction
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Self-citation2018 ESC/ESH Guidelines for the management of arterial hypertension
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Self-citation2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
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Self-citationSacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure
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Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology
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Symptom Diary Use and Improved Survival for Patients With Heart Failure
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- Authors
- Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., Jessup, M., Linde, C., Nihoyannopoulos, P., Parissis, J. T., Pieske, B., Riley, J. P., Rosano, G. M. C., Ruilope, L. M., Ruschitzka, F., Rutten, F. H., van der Meer, P., ESC Scientific Document Group, Filippatos, G., McMurray, J. J. V., Aboyans, V., Achenbach, S., Agewall, S., Al-Attar, N., Atherton, J. J., Bauersachs, J., John Camm, A., Carerj, S., Ceconi, C., Coca, A., Elliott, P., Erol, Ç., Ezekowitz, J., Fernández-Golfín, C., Fitzsimons, D., Guazzi, M., Guenoun, M., Hasenfuss, G., Hindricks, G., Hoes, A. W., Iung, B., Jaarsma, T., Kirchhof, P., Knuuti, J., Kolh, P., Konstantinides, S., Lainscak, M., Lancellotti, P., Lip, G. Y. H., Maisano, F., Mueller, C., Petrie, M. C., Piepoli, M. F., Priori, S. G., Torbicki, A., Tsutsui, H., van Veldhuisen, D. J., Windecker, S., Yancy, C., Zamorano, J. L., Zamorano, J. L., Aboyans, V., Achenbach, S., Agewall, S., Badimon, L., Barón-Esquivias, G., Baumgartner, H., Bax, J. J., Bueno, H., Carerj, S., Dean, V., Erol, Ç., Fitzsimons, D., Gaemperli, O., Kirchhof, P., Kolh, P., Lancellotti, P., Lip, G. Y. H., Nihoyannopoulos, P., Piepoli, M. F., Ponikowski, P., Roffi, M., Torbicki, A., Vaz Carneiro, A., Windecker, S., Sisakian, H. S., Isayev, E., Kurlianskaya, A., Mullens, W., Tokmakova, M., Agathangelou, P., Melenovsky, V., Wiggers, H., Hassanein, M., Uuetoa, T., Lommi, J., Kostovska, E. S., Juillière, Y., Aladashvili, A., Luchner, A., Chrysohoou, C., Nyolczas, N., Thorgeirsson, G., Marc Weinstein, J., Di Lenarda, A., Aidargaliyeva, N., Bajraktari, G., Beishenkulov, M., Kamzola, G., Abdel-Massih, T., Celutkiene, J., Noppe, S., Cassar, A., Vataman, E., Abir-Khalil, S., van Pol, P., Mo, R., Straburzynska-Migaj, E., Fonseca, C., Chioncel, O., Shlyakhto, E., Otasevic, P., Goncalvesová, E., Lainscak, M., Díaz Molina, B., Schaufelberger, M., Suter, T., Yilmaz, M. B., Voronkov, L., & Davies, C.
- Affiliations
- University Medical Center Groningen (NL)
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05-20
- Volume
- 37
- Issue
- 27
- Pages
- 2129-2200
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2397911846
- Cited by
- 11,429
- References
- 635
- Citations by year
- 2026: 266 · 2025: 574 · 2024: 713 · 2023: 821 · 2022: 1320 · 2021: 2191 · 2020: 1892 · 2019: 1462 · 2018: 1172 · 2017: 830 · 2016: 179 · 2015: 2
- FWCI
- 1001.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- European Heart Journal (publishedVersion, other-oa)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- American Heart Association
- American College of Cardiology Foundation
- National Institute for Health and Care Research (NF-SI-0611-10227)
- Parkinson's UK (G-0907)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- heart failure, acute heart failure, chronic heart failure, diagnosis, treatment
- MeSH terms
- Healthy Lifestyle, Acute Disease, Algorithms, Angina Pectoris, Arthritis, Cardiotonic Agents, Central Nervous System Diseases, Chronic Disease, Coronary Disease, Echocardiography, Electrocardiography, Exercise Therapy, Genetic Testing, Heart Failure, Heart Valve Diseases, Humans, Hypercalcemia, Hyperlipidemias, Hypertension, Hypokalemia, Erectile Dysfunction, Kidney Diseases, Lung Diseases, Male, Myocardial Revascularization, Neoplasms, Terminology as Topic, Obesity, Physical Examination, Prognosis, Sleep Wake Disorders, Stroke Volume, Biomarkers, Heart Transplantation, Ventricular Dysfunction, Anemia, Iron-Deficiency, Evidence-Based Medicine, Diabetes Complications, Cardiac Imaging Techniques, Cardiac Resynchronization Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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