The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Open accessAbstract
Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation, and renal function has remained stable for 2.0 to 5.3 years since transplantation. The T cells from these four recipients, tested in vitro, showed donor-specific unresponsiveness and in specimens from allograft biopsies, obtained after withdrawal of immunosuppressive therapy, there were high levels of P3 (FOXP3) messenger RNA (mRNA) but not granzyme B mRNA.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Cited by
Regeneration and experimental orthotopic transplantation of a bioengineered kidney
Song, J. J., Guyette, J. P., Gilpin, S. E., Gonzalez, G., Vacanti, J. P., & Ott, H. C. (2013) · Nature Medicine · doi:10.1038/nm.3154 · Cited by 793
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
Lei, J., Coronel, M. M., Yolcu, E. S., Deng, H., Grimany-Nuno, O., Hunckler, M. D., Ulker, V., Yang, Z., Lee, K. M., Zhang, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm9881 · Cited by 77
Wayengera, M. (2011) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-8-26 · Cited by 21
On minor histocompatibility antigens, mixed chimerism, and transplantation tolerance
Sánchez-Fueyo, A., & Dazzi, F. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16276 · Cited by 3
Metadata
- Authors
- Kawai, T., Cosimi, A. B., Spitzer, T. R., Tolkoff-Rubin, N., Suthanthiran, M., Saidman, S. L., Shaffer, J., Preffer, F. I., Ding, R., Sharma, V., Fishman, J. A., Dey, B., Ko, D. S. C., Hertl, M., Goes, N. B., Wong, W., Williams, W. W., Colvin, R. B., Sykes, M., & Sachs, D. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-01-24
- Volume
- 358
- Issue
- 4
- Pages
- 353-361
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4294349031
- Cited by
- 982
- References
- 1
- FWCI
- 78.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Kawai, T., Cosimi, A. B., Spitzer, T. R., Tolkoff-Rubin, N., Suthanthiran, M., Saidman, S. L., Shaffer, J., Preffer, F. I., Ding, R., Sharma, V., Fishman, J. A., Dey, B., Ko, D. S. C., Hertl, M., Goes, N. B., Wong, W., Williams, W. W., Colvin, R. B., Sykes, M., & Sachs, D. H. (2008). HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression. New England Journal of Medicine. https://doi.org/10.1056/nejmoa071074
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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