The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Early Treatment with Prednisolone or Acyclovir in Bell's Palsy
Open accessAbstract
BACKGROUND: Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain. METHODS: We conducted a double-blind, placebo-controlled, randomized, factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of symptoms. Patients were randomly assigned to receive 10 days of treatment with prednisolone, acyclovir, both agents, or placebo. The primary outcome was recovery of facial function, as rated on the House-Brackmann scale. Secondary outcomes included quality of life, appearance, and pain. RESULTS: Final outcomes were assessed for 496 of 551 patients who underwent randomization. At 3 months, the proportions of patients who had recovered facial function were 83.0% in the prednisolone group as compared with 63.6% among patients who did not receive prednisolone (P<0.001) and 71.2% in the acyclovir group as compared with 75.7% among patients who did not receive acyclovir (adjusted P=0.50). After 9 months, these proportions were 94.4% for prednisolone and 81.6% for no prednisolone (P<0.001) and 85.4% for acyclovir and 90.8% for no acyclovir (adjusted P=0.10). For patients treated with both drugs, the proportions were 79.7% at 3 months (P<0.001) and 92.7% at 9 months (P<0.001). There were no clinically significant differences between the treatment groups in secondary outcomes. There were no serious adverse events in any group. CONCLUSIONS: In patients with Bell's palsy, early treatment with prednisolone significantly improves the chances of complete recovery at 3 and 9 months. There is no evidence of a benefit of acyclovir given alone or an additional benefit of acyclovir in combination with prednisolone. (Current Controlled Trials number, ISRCTN71548196 [controlled-trials.com].).
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Cites
House, J. W., & Brackmann, D. E. (1985) · Otolaryngology–Head and Neck Surgery · doi:10.1177/019459988509300202 · Cited by 3,877
Keller, S., Bann, C. M., Dodd, S. L., Schein, J., Mendoza, T. R., & Cleeland, C. S. (2004) · The Clinical Journal of Pain · doi:10.1097/00002508-200409000-00005 · Cited by 1,233
Peitersen, E. (2002) · Acta Oto-Laryngologica · doi:10.1080/000164802760370736 · Cited by 1,189
Use of the Inactivated Intranasal Influenza Vaccine and the Risk of Bell's Palsy in Switzerland
Mutsch, M., Zhou, W., Rhodes, P., Bopp, M., Chen, R. T., Linder, T., Spyr, C., & Steffen, R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030595 · Cited by 916
Human Papillomavirus and Papanicolaou Tests to Screen for Cervical Cancer
Naucler, P., Ryd, W., Törnberg, S., Strand, A., Wadell, G., Elfgren, K., Rådberg, T., Strander, B., Johansson, B., Forslund, O., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073204 · Cited by 797
Furlong, W. J., Feeny, D. H., Torrance, G. W., & Barr, R. D. (2001) · Annals of Medicine · doi:10.3109/07853890109002092 · Cited by 751
Bell Palsy and Herpes Simplex Virus: Identification of Viral DNA in Endoneurial Fluid and Muscle
Murakami, S., Mizobuchi, M., Nakashiro, Y., Doi, T., Hato, N., & Yanagihara, N. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-1_part_1-199601010-00005 · Cited by 743
Development of a sensitive clinical facial grading system
ROSS, B., FRADET, G., & NEDZELSKI, J. (1996) · Otolaryngology - Head and Neck Surgery · doi:10.1016/s0194-5998(96)70206-1 · Cited by 524
Corticosteroids for Bell's palsy (idiopathic facial paralysis)
Madhok, V. B., Gagyor, I., Daly, F., Somasundara, D., Sullivan, M., Gammie, F., & Sullivan, F. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001942.pub5 · Cited by 390
Self-citationIncidence, clinical features, and prognosis in Bell's palsy, Rochester, Minnesota, 1968–1982
Katusic, S. K., Beard, C. M., Wiederholt, W. C., et al. (1986) · Annals of Neurology · doi:10.1002/ana.410200511 · Cited by 328
Cited by
Bell's palsy: aetiology, clinical features and multidisciplinary care
Eviston, T. J., Croxson, G. R., Kennedy, P. G. E., Hadlock, T., & Krishnan, A. V. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309563 · Cited by 317
The case for randomized controlled trials to assess the impact of clinical information systems
Liu, J. L. Y., & Wyatt, J. C. (2011) · Journal of the American Medical Informatics Association · doi:10.1136/jamia.2010.010306 · Cited by 66
Ear, Nose, and Throat Manifestations during Pregnancy
Kumar, R., Hayhurst, K. L., & Robson, A. K. (2011) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599811407572 · Cited by 37
Siemann, I., Sanches, E. E., de Jongh, F. W., Luijmes, R., Ingels, K. J. A. O., Beurskens, C. H. G., Monstrey, S. J., Ramnarain, D., Marres, H. A. M., & Pouwels, S. (2022) · Journal of Plastic, Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2021.11.079 · Cited by 7
Metadata
- Authors
- Sullivan, F. M., Swan, I. R. C., Donnan, P. T., Morrison, J. M., Smith, B. H., McKinstry, B., Davenport, R. J., Vale, L. D., Clarkson, J. E., Hammersley, V., Hayavi, S., McAteer, A., Stewart, K., & Daly, F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-10-18
- Volume
- 357
- Issue
- 16
- Pages
- 1598-1607
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2106852126
- Cited by
- 771
- References
- 20
- FWCI
- 28.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sullivan, F. M., Swan, I. R. C., Donnan, P. T., Morrison, J. M., Smith, B. H., McKinstry, B., Davenport, R. J., Vale, L. D., Clarkson, J. E., Hammersley, V., Hayavi, S., McAteer, A., Stewart, K., & Daly, F. (2007). Early Treatment with Prednisolone or Acyclovir in Bell's Palsy. New England Journal of Medicine. https://doi.org/10.1056/nejmoa072006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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