The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia
Open accessAbstract
BACKGROUND: A role of microRNAs in cancer has recently been recognized. However, little is known about the role of microRNAs in acute myeloid leukemia (AML). METHODS: Using microRNA expression profiling, we studied samples of leukemia cells from adults under the age of 60 years who had cytogenetically normal AML and high-risk molecular features--that is, an internal tandem duplication in the fms-related tyrosine kinase 3 gene (FLT3-ITD), a wild-type nucleophosmin (NPM1), or both. A microRNA signature that was associated with event-free survival was derived from a training group of 64 patients and tested in a validation group of 55 patients. For the latter, a microRNA compound covariate predictor (called a microRNA summary value) was computed on the basis of weighted levels of the microRNAs forming the outcome signature. RESULTS: Of 305 microRNA probes, 12 (including 5 representing microRNA-181 family members) were associated with event-free survival in the training group (P<0.005). In the validation group, the microRNA summary value was inversely associated with event-free survival (P=0.03). In multivariable analysis, the microRNA summary value remained associated with event-free survival (P=0.04) after adjustment for the allelic ratio of FLT3-ITD to wild-type FLT3 and for the white-cell count. Using results of gene-expression microarray analysis, we found that expression levels of the microRNA-181 family were inversely correlated with expression levels of predicted target genes encoding proteins involved in pathways of innate immunity mediated by toll-like receptors and interleukin-1beta. CONCLUSIONS: A microRNA signature in molecularly defined, high-risk, cytogenetically normal AML is associated with the clinical outcome and with target genes encoding proteins involved in specific innate-immunity pathways.
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Self-citationMicroRNAs Modulate Hematopoietic Lineage Differentiation
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Self-citationA MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
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Self-citationPhysiological and pathological roles for microRNAs in the immune system
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Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
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Metadata
- Authors
- Marcucci, G., Radmacher, M. D., Maharry, K., Mrózek, K., Ruppert, A. S., Paschka, P., Vukosavljevic, T., Whitman, S. P., Baldus, C. D., Langer, C., Liu, C.-G., Carroll, A. J., Powell, B. L., Garzon, R., Croce, C. M., Kolitz, J. E., Caligiuri, M. A., Larson, R. A., & Bloomfield, C. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-05
- Volume
- 358
- Issue
- 18
- Pages
- 1919-1928
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1969708590
- Cited by
- 441
- References
- 32
- FWCI
- 33.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Marcucci, G., Radmacher, M. D., Maharry, K., Mrózek, K., Ruppert, A. S., Paschka, P., Vukosavljevic, T., Whitman, S. P., Baldus, C. D., Langer, C., Liu, C.-G., Carroll, A. J., Powell, B. L., Garzon, R., Croce, C. M., Kolitz, J. E., Caligiuri, M. A., Larson, R. A., & Bloomfield, C. D. (2008). MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia. New England Journal of Medicine. https://doi.org/10.1056/nejmoa074256
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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