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Cited by 3,023MicroRNA in disease regulationCancer-related molecular mechanisms researchLung Cancer Research Studies

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

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Yanaihara, Nozomu, Caplen, Natasha, Bowman, Elise, Seike, Masahiro, Kumamoto, Kensuke, Yi, Ming, Stephens, Robert M., Okamoto, Aikou +6 more·2006·Cancer Cell
DOI 10.1016/j.ccr.2006.01.025
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Abstract

MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and cross-validated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.

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  • miR-21 expression levels are useful prognostic markers in non-small cell lung cancer.

    “Recently, miR-21 expression levels have proven useful prognostic markers in non-small cell lung cancer (Markou et al., 2008; Yanaihara et al., 2006).”

    From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Yanaihara et al., 2006

    The Results report that high hsa-mir-21 expression was associated with significantly worse survival in lung adenocarcinoma patients. They do not establish miR-21 as a validated prognostic marker across non-small cell lung cancer: the reported prognostic validation focused on other miRNAs. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Authors
Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., Stephens, R. M., Okamoto, A., Yokota, J., Tanaka, T., Calin, G. A., Liu, C.-G., Croce, C. M., & Harris, C. C.
Affiliations
  • National Institutes of Health (US)
  • National Cancer Institute (US)
  • Jikei University School of Medicine (JP)
  • National Cancer Center Research Institute (JP)
  • The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
Corresponding author
Harris, Curtis C.
ORCID
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2006-03
Volume
9
Issue
3
Pages
189-198
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccr.2006.01.025
OpenAlex
W2006797972
Cited by
3,023
References
1
Citations by year
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FWCI
67.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Funders
  • National Institutes of Health (n01co12400-79-0-22)
  • National Cancer Institute (N01CO12400, CA76259, P01CA076259)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
Keywords
microRNA expression profiles, lung cancer, lung adenocarcinoma, prognostic factors, diagnostic biomarkers, tumor histology, survival, lung carcinogenesis, miRNA microarray
MeSH terms
Adenocarcinoma, Aged, Female, Humans, Lung Neoplasms, Male, Middle Aged, Prognosis, Biomarkers, Tumor, Survival Analysis, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs

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