Cited by 813Nosocomial Infections in ICUSepsis Diagnosis and TreatmentAntifungal resistance and susceptibility

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Decontamination of the Digestive Tract and Oropharynx in ICU Patients

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de Smet, A.M.G.A., Kluytmans, J.A.J.W., Cooper, B.S., Mascini, E.M., Benus, R.F.J., van der Werf, T.S., van der Hoeven, J.G., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.J.M., Bernards, A.T., Kuijper, E.J., Joore, J.C.A., Leverstein-van Hall, M.A., Bindels, A.J.G.H., Jansz, A.R., Wesselink, R.M.J., de Jongh, B.M., Dennesen, P.J.W., van Asselt, G.J., te Velde, L.F., Frenay, I.H.M.E., Kaasjager, K., Bosch, F.H., van Iterson, M., Thijsen, S.F.T., Kluge, G.H., Pauw, W., de Vries, J.W., Kaan, J.A., Arends, J.P., Aarts, L.P.H.J., Sturm, P.D.J., Harinck, H.I.J., Voss, A., Uijtendaal, E.V., Blok, H.E.M., Thieme Groen, E.S., Pouw, M.E., Kalkman, C.J., Bonten, M.J.M.·2009·New England Journal of Medicine

DOI 10.1056/nejmoa0800394

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Abstract

BACKGROUND: Selective digestive tract decontamination (SDD) and selective oropharyngeal decontamination (SOD) are infection-prevention measures used in the treatment of some patients in intensive care, but reported effects on patient outcome are conflicting. METHODS: We evaluated the effectiveness of SDD and SOD in a crossover study using cluster randomization in 13 intensive care units (ICUs), all in The Netherlands. Patients with an expected duration of intubation of more than 48 hours or an expected ICU stay of more than 72 hours were eligible. In each ICU, three regimens (SDD, SOD, and standard care) were applied in random order over the course of 6 months. Mortality at day 28 was the primary end point. SDD consisted of 4 days of intravenous cefotaxime and topical application of tobramycin, colistin, and amphotericin B in the oropharynx and stomach. SOD consisted of oropharyngeal application only of the same antibiotics. Monthly point-prevalence studies were performed to analyze antibiotic resistance. RESULTS: A total of 5939 patients were enrolled in the study, with 1990 assigned to standard care, 1904 to SOD, and 2045 to SDD; crude mortality in the groups at day 28 was 27.5%, 26.6%, and 26.9%, respectively. In a random-effects logistic-regression model with age, sex, Acute Physiology and Chronic Health Evaluation (APACHE II) score, intubation status, and medical specialty used as covariates, odds ratios for death at day 28 in the SOD and SDD groups, as compared with the standard-care group, were 0.86 (95% confidence interval [CI], 0.74 to 0.99) and 0.83 (95% CI, 0.72 to 0.97), respectively. CONCLUSIONS: In an ICU population in which the mortality rate associated with standard care was 27.5% at day 28, the rate was reduced by an estimated 3.5 percentage points with SDD and by 2.9 percentage points with SOD. (Controlled Clinical Trials number, ISRCTN35176830.)

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Consort 2010 statement: extension to cluster randomised trials
Campbell, M. K., Piaggio, G., Elbourne, D. R., Altman, D. G., & for the CONSORT Group (2012) · BMJ · doi:10.1136/bmj.e5661 · Cited by 3,510
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Campbell, M. K., Elbourne, D. R., & Altman, D. G. (2004) · BMJ · doi:10.1136/bmj.328.7441.702 · Cited by 2,557
Colonization resistance of the digestive tract in conventional and antibiotic-treated mice
van der Waaij, D., Vries, J. M. B.-D., & der Wees, J. E. C. L.-V. (1971) · Journal of Hygiene · doi:10.1017/s0022172400021653 · Cited by 907
The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients
Stoutenbeek, C. P., SAENE, H. K. F. V., Miranda, D. R., & Zandstra, D. F. (1984) · Intensive Care Medicine · doi:10.1007/bf00259435 · Cited by 711
Nosocomial infections in adult intensive-care units
Vincent, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13644-6 · Cited by 704
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
de Jonge, E., Schultz, M. J., Spanjaard, L., Bossuyt, P. M., Vroom, M. B., Dankert, J., & Kesecioğlu, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14409-1 · Cited by 585
Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials
D’Amico, R., Pifferi, S., Leonetti, C., Torri, V., Tinazzi, A., & Liberati, A. (1998) · BMJ · doi:10.1136/bmj.316.7140.1275 · Cited by 443
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Koeman, M., van der Ven, A. J. A. M., Hak, E., Joore, H. C. A., Kaasjager, K. A. H., de Smet, A. M. G. A., Ramsay, G., Dormans, T. P. J., Aarts, L. P. H. J., de Bel, E. E., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200505-820oc · Cited by 410
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Nosocomial Pneumonia
Klompas, M. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00303-9 · Cited by 8
Selective Digestive Decontamination: A Comprehensive Approach to Reducing Nosocomial Infections and Antimicrobial Resistance in the ICU
Martínez-Pérez, M., Fernández-Fernández, R., Morón, R., Nieto-Sánchez, M. T., Yuste, M. E., Díaz-Villamarín, X., Fernández-Varón, E., Blanquiño, A. V., Romano, A. A., Barrera, J. C., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216482 · Cited by 8
Topical oropharyngeal vancomycin to control methicillin-resistant Staphylococcus aureus lower airway infection in ventilated patients.
Silvestri, L., Solidoro, A., Milanese, M., Hk, V. S., Fontana, F., Gregori, D., & Gullo, A. (2010) · PubMed · Cited by 8
Genome-wide analysis in Escherichia coli unravels a high level of genetic homoplasy associated with cefotaxime resistance
Coolen, J. P. M., den Drijver, E., Verweij, J. J., Schildkraut, J. A., Neveling, K., Melchers, W. J. G., Kolwijck, E., Wertheim, H. F. L., Kluytmans, J. A. J. W., & Huynen, M. A. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000556 · Cited by 8
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Hurley, J. C. (2022) · Intensive Care Medicine Experimental · doi:10.1186/s40635-022-00429-8 · Cited by 8
Selective decontamination of the digestive tract: concept and application
Álvarez, E. E. T., & López, M. Á. D. L. C. (2023) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2023.05.018 · Cited by 8
Indirect (herd) effects of topical antibiotic prophylaxis and oral care versus non-antimicrobial methods increase mortality among ICU patients: realigning Cochrane review data to emulate a three-tier cluster randomised trial
Hurley, J. C. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-064256 · Cited by 8
A prospective observational study of the effect of critical illness on ultrastructural and microscopic morphology of duodenal mucosa
Liew, V. Y., Chapman, M. J., Nguyen, N. Q., Cousins, C. E., Plummer, M. P., Chapple, L. S., Abdelhamid, Y. A., Manton, N. D., Swalling, A., Sutton‐Smith, P., et al. (2016) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00999-7 · Cited by 8
Prevention of Staphylococcus aureus Ventilator-Associated Pneumonia: Conventional Antibiotics Won’t Cut It
Burnham, J. P., & Kollef, M. H. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix060 · Cited by 8
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Opal, S. M., & LaRosa, S. P. (2009) · Critical Care · doi:10.1186/cc7945 · Cited by 8
Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity
Seinen, J., Engelke, R., Abdullah, M. R., Voß, F., Michalik, S., Dhople, V. M., Dieperink, W., de Smet, A. M. G. A., Völker, U., van Dijl, J. M., et al. (2021) · mSystems · doi:10.1128/msystems.00702-20 · Cited by 8
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Streit, M., Businger, F., Schmid, E. R., & Folláth, F. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13125 · Cited by 8
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Haas, L. E. M., & Schultz, M. J. (2010) · Critical Care Research and Practice · doi:10.1155/2010/501031 · Cited by 5
Advances in Critical Care and Emergency Medicine
Mayer, S. A., & Schwab, S. (2010) · Stroke · doi:10.1161/strokeaha.109.575399 · Cited by 5
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Silvestri, L., Negri, C., Taylor, N., Zandstra, D. F., & van Saene, H. K. F. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.00152-13 · Cited by 5
Selective digestive decontamination: We must make an international decision on this 40-year old controversy
Carlet, J. M. (2023) · Intensive Care Medicine · doi:10.1007/s00134-023-07289-0 · Cited by 5
Use of selective gut decontamination in critically ill children: PICnIC a pilot RCT and mixed-methods study
Brown, A., Ferrando-Vivas, P., Popa, M., de la Fuente, G. M., Pappachan, J., Cuthbertson, B. H., Drikite, L., Feltbower, R. G., Gouliouris, T., Sale, I., et al. (2024) · Health Technology Assessment · doi:10.3310/hdkv1008 · Cited by 4
Prevention of Hospital-Acquired Infections by Selective Digestive Decontamination
Reed, R. L. (2011) · Surgical Infections · doi:10.1089/sur.2011.031 · Cited by 4
Rebound Inverts the Staphylococcus aureus Bacteremia Prevention Effect of Antibiotic Based Decontamination Interventions in ICU Cohorts with Prolonged Length of Stay
Hurley, J. C. (2024) · Antibiotics · doi:10.3390/antibiotics13040316 · Cited by 4
Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review
Geetha, H. S., Teo, Y. X., Ravichandran, S., & Lal, A. (2025) · Medicina · doi:10.3390/medicina61010078 · Cited by 4
Selective decontamination regimens in French ICUs: association with reduced infection and resistance emergence
Massart, N., Léone, M., Reizine, F., Duclos, G., Machut, A., Vacheron, C., Savey, A., Hammad, E., Friggeri, A., & Lepape, A. (2025) · Annals of Intensive Care · doi:10.1186/s13613-025-01465-9 · Cited by 4
Worlds Apart: Proof that SDD Works
Wunderink, R. G. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.182.12.1564a · Cited by 4
Chlorhexidine-Based Oral Care and Ventilator-Associated Pneumonia
Bonten, M. J. M. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.14017 · Cited by 4
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Vives-Soto, M., & Difabio, M. (2010) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0304-5412(10)70057-3 · Cited by 4
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Alves, J., Peña-López, Y., Rojas, J. N., Campins, M., & Rello, J. (2018) · Current treatment options in infectious diseases/Current treatment options in infectious disease · doi:10.1007/s40506-018-0164-x · Cited by 4
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Kaş, C., & Kutlutürkan, S. (2021) · Medical Journal of Western Black Sea · doi:10.29058/mjwbs.936579 · Cited by 4
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Fresenius, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-44933-8_11 · Cited by 4
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Wieringa, A., ter Horst, P. G. J., Wagenvoort, G. H. J., Dijkstra, A., Abdulla, A., Haringman, J. J., & Koch, B. C. P. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac334 · Cited by 4
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Park, J. H., Chae, J. N., & Choi, W.-I. (2010) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2010.69.2.75 · Cited by 4
Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients
Seinen, J., Dieperink, W., Mekonnen, S. A., Lisotto, P., Harmsen, H. J. M., Hiemstra, B., Ott, A., Schultz, D., Lalk, M., Oswald, S., et al. (2019) · Virulence · doi:10.1080/21505594.2019.1682797 · Cited by 5
Ventilator Associated Pneumonia in Adult Patients Preventive Measures: A Review of the Recent Advances
Batra, P., Misra, M., Kumari, M., Katoch, O., & Hasan, F. A. (2018) · Journal of Infectiology · doi:10.29245/2689-9981/2018/3.1122 · Cited by 4
Artificial Intelligence to Guide Empirical Antimicrobial Therapy–Ready for Prime Time?
van der Werf, T. S. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1585 · Cited by 4
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Du, H., Wei, L., Li, W., Huang, B., Liu, Y., Ye, X., Zhang, S., Wang, T., Chen, Y., Chen, D., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.723904 · Cited by 5
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Bartley, J. R. F., & Wong, C. (2013) · Springer eBooks · doi:10.1007/978-3-642-37250-6_37 · Cited by 4
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Fitton, N., & Thomas, J. S. J. (2009) · Surgery (Oxford) · doi:10.1016/j.mpsur.2009.09.005 · Cited by 4
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Mario Calvo, A., Luis Delpiano, M., Chacón, E., V, Jemenao, M. I., Anamaría Peña, D., & Alejandra Zambrano, G. (2011) · Revista chilena de infectología · doi:10.4067/s0716-10182011000500003 · Cited by 4
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Welte, T. (2010) · Pneumologie · doi:10.1055/s-0030-1255679 · Cited by 4
Selective decontamination of the digestive tract: What outcomes matter?*
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Antipathy against SDD is justified: No
Silvestri, L., van Saene, H. K. F., & Bion, J. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5144-6 · Cited by 4
Worlds Apart: Proof that SDD Works
Petros, A., Taylor, N., Damjanovic, V., van Saene, H. K., Abecasis, F., Silvestri, L., & de la Cal, M. A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.182.12.1564 · Cited by 4
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Martindale, R. G., Warren, M. M., & Tsikitis, V. L. (2015) · World Journal of Surgery · doi:10.1007/s00268-015-3173-7 · Cited by 3

Authors: de Smet, A. M. G. A., Kluytmans, J. A. J. W., Cooper, B. S., Mascini, E. M., Benus, R. F. J., van der Werf, T. S., van der Hoeven, J. G., Pickkers, P., Bogaers-Hofman, D., van der Meer, N. J. M., Bernards, A. T., Kuijper, E. J., Joore, J. C. A., Leverstein-van Hall, M. A., Bindels, A. J. G. H., Jansz, A. R., Wesselink, R. M. J., de Jongh, B. M., Dennesen, P. J. W., van Asselt, G. J., te Velde, L. F., Frenay, I. H. M. E., Kaasjager, K., Bosch, F. H., van Iterson, M., Thijsen, S. F. T., Kluge, G. H., Pauw, W., de Vries, J. W., Kaan, J. A., Arends, J. P., Aarts, L. P. H. J., Sturm, P. D. J., Harinck, H. I. J., Voss, A., Uijtendaal, E. V., Blok, H. E. M., Thieme Groen, E. S., Pouw, M. E., Kalkman, C. J., & Bonten, M. J. M.
Affiliations: University Medical Center Utrecht (NL)
Amphia Ziekenhuis (NL)
Rijnstate Hospital (NL)
Utrecht University (NL)
Leiden University Medical Center (NL)
Diakonessenhuis hospital (NL)
Catharina Ziekenhuis (NL)
ORCID: de Smet, A.M.G.A.
Kluytmans, J.A.J.W.
Cooper, B.S.
van der Werf, T.S.
van der Hoeven, J.G.
Pickkers, P.
van der Meer, N.J.M.
Kuijper, E.J.
Dennesen, P.J.W.
Kaasjager, K.
Bosch, F.H.
Thijsen, S.F.T.
Kluge, G.H.
Sturm, P.D.J.
Uijtendaal, E.V.
Kalkman, C.J.
Bonten, M.J.M.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2009-01
Volume: 360
Issue: 1
Pages: 20-31
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa0800394
OpenAlex: W2065088137
Cited by: 813
References: 34
Citations by year: 2026: 12 · 2025: 22 · 2024: 16 · 2023: 30 · 2022: 32 · 2021: 39 · 2020: 36 · 2019: 29 · 2018: 39 · 2017: 48 · 2016: 45 · 2015: 61 · 2014: 52 · 2013: 62 · 2012: 68
FWCI: 59.40
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: selective decontamination of the digestive tract, selective oropharyngeal decontamination, intensive care unit patients, nosocomial infection prevention, 28-day mortality, cefotaxime, tobramycin, colistin, amphotericin B, antibiotic resistance, intubation, critically ill patients
MeSH terms: Aged, Anti-Bacterial Agents, Cross Infection, Decontamination, Female, Gram-Negative Bacteria, Humans, Intensive Care Units, Male, Middle Aged, Oropharynx, Respiration, Artificial, Logistic Models, Bacteremia, Critical Illness, Infection Control, Cross-Over Studies, APACHE, Gastrointestinal Tract

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Decontamination of the Digestive Tract and Oropharynx in ICU Patients

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