Pickkers, Peter

Swarm Learning for decentralized and confidential clinical machine learning

Warnat-Herresthal, S., Schultze, H., Shastry, K. L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N. A., et al. (2021) · Nature

Privacy-Preserving Technologies in DataBlockchain Technology Applications and Security

Cited by 884

A guiding map for inflammation

Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., et al. (2017) · Nature Immunology

Immune Response and InflammationInflammation biomarkers and pathways

Cited by 831

Decontamination of the digestive tract and oropharynx in ICU patients

de Smet, A. M. G. A., Kluytmans, J. A. J. W., Cooper, B. S., Mascini, E. M., Benus, R. F. J., van der Werf, T. S., van der Hoeven, J. G., Pickkers, P., Bogaers-Hofman, D., van der Meer, N. J. M., et al. (2009) · New England Journal of Medicine

Nosocomial Infections in ICUSepsis Diagnosis and Treatment

Cited by 813

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Cheng, S.-C., Scicluna, B. P., Arts, R. J. W., Gresnigt, M. S., Lachmandas, E., Giamarellos-Bourboulis, E. J., Kox, M., Manjeri, G. R., Wagenaars, J. A. L., Cremer, O. L., et al. (2016) · Nature Immunology

Sepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Cited by 637

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

Kemna, E., Pickkers, P., Nemeth, E., van der Hoeven, H., & Swinkels, D. (2005) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 498

Delirium in critically ill patients: Impact on long-term health-related quality of life and cognitive functioning*

van den Boogaard, M., Schoonhoven, L., Evers, A. W. M., van der Hoeven, J. G., van Achterberg, T., & Pickkers, P. (2012) · Critical Care Medicine

Intensive Care Unit Cognitive DisordersTraumatic Brain Injury Research

Cited by 361

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Kox, M., Waalders, N. J. B., Kooistra, E. J., Gerretsen, J., & Pickkers, P. (2020) · JAMA

COVID-19 Clinical Research StudiesSepsis Diagnosis and Treatment

Cited by 333

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

Kox, M., van Eijk, L. T., Zwaag, J., van den Wildenberg, J., Sweep, F. C. G. J., van der Hoeven, J. G., & Pickkers, P. (2014) · Proceedings of the National Academy of Sciences

Vagus Nerve Stimulation ResearchStress Responses and Cortisol

Cited by 268

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

(DeCOI), G. C.-1. O. I., Aschenbrenner, A. C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., et al. (2021) · Genome Medicine

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 255

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

Lebrun, L. J., Lenaerts, K., Kiers, D., Pais de Barros, J.-P., Le Guern, N., Plesnik, J., Thomas, C., Bourgeois, T., Dejong, C. H. C., Kox, M., et al. (2017) · Cell Reports

Diabetes Treatment and ManagementImmune Response and Inflammation

Cited by 238

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

Schwoebel, F., van Eijk, L. T., Zboralski, D., Sell, S., Buchner, K., Maasch, C., Purschke, W. G., Humphrey, M., Zöllner, S., Eulberg, D., et al. (2013) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 158

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

Laterre, P.-F., Berry, S. M., Blemings, A., Carlsen, J. E., François, B., Graves, T., Jacobsen, K., Lewis, R. J., Opal, S. M., Perner, A., et al. (2019) · JAMA

Sepsis Diagnosis and TreatmentHemodynamic Monitoring and Therapy

Cited by 147

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

the RCI-COVID-19 Study Group, Kooistra, E. J., Waalders, N. J. B., Grondman, I., Janssen, N. A. F., de Nooijer, A. H., Netea, M. G., van de Veerdonk, F. L., Ewalds, E., van der Hoeven, J. G., et al. (2020) · Critical Care

COVID-19 Clinical Research StudiesRespiratory Support and Mechanisms

Cited by 119

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans

van Eijk, L. T., John, A. S. E., Schwoebel, F., Summo, L., Vauléon, S., Zöllner, S., Laarakkers, C. M., Kox, M., van der Hoeven, J. G., Swinkels, D. W., et al. (2014) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 110

Endotoxemia-induced inflammation and the effect on the human brain

van den Boogaard, M., Ramakers, B. P., van Alfen, N., van der Werf, S. P., Fick, W. F., Hoedemaekers, C. W., Verbeek, M. M., Schoonhoven, L., van der Hoeven, J. G., & Pickkers, P. (2010) · Critical Care

Intensive Care Unit Cognitive DisordersSepsis Diagnosis and Treatment

Cited by 84

Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients

van Lier, D., Kox, M., Santos, K., van der Hoeven, H., Pillay, J., & Pickkers, P. (2021) · ERJ Open Research

Renin-Angiotensin System StudiesCOVID-19 Clinical Research Studies

Cited by 73

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

The LOVIT-COVID Investigators, O. B. O. T. C. C. C. T. G., Florescu, S., Stanciu, D., Zaharia, M., Kosa, A., Codreanu, D., Fareed, K., Kidwai, A., Kaye, C., Coutts, A., et al. (2023) · JAMA

Vitamin C and Antioxidants ResearchCOVID-19 Clinical Research Studies

Cited by 55

The Influence of Concentration/Meditation on Autonomic Nervous System Activity and the Innate Immune Response: A Case Study

Kox, M., Stoffels, M., Smeekens, S. P., van Alfen, N., Gomes, M., Eijsvogels, T. M. H., Hopman, M. T. E., van der Hoeven, J. G., Netea, M. G., & Pickkers, P. (2012) · Psychosomatic Medicine

Mindfulness and Compassion InterventionsStress Responses and Cortisol

Cited by 53

Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study

van Eijk, L. T., Kroot, J. J., Tromp, M., van der Hoeven, J. G., Swinkels, D. W., & Pickkers, P. (2011) · Critical Care

Iron Metabolism and DisordersSepsis Diagnosis and Treatment

Cited by 48