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The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy

Open access
Rouse, Dwight J., Hirtz, Deborah G., Thom, Elizabeth, Varner, Michael W., Spong, Catherine Y., Mercer, Brian M., Iams, Jay D., Wapner, Ronald J., Sorokin, Yoram, Alexander, James M., Harper, Margaret, Thorp, John M., Ramin, Susan M., Malone, Fergal D., Carpenter, Marshall, Miodovnik, Menachem, Moawad, Atef, O'Sullivan, Mary J., Peaceman, Alan M., Hankins, Gary D.V., Langer, Oded, Caritis, Steve N., Roberts, James M.·2008·New England Journal of Medicine
DOI 10.1056/nejmoa0801187
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Abstract

BACKGROUND: Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy. METHODS: In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age. RESULTS: A total of 2241 women underwent randomization. The baseline characteristics were similar in the two groups. Follow-up was achieved for 95.6% of the children. The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.77 to 1.23). However, in a prespecified secondary analysis, moderate or severe cerebral palsy occurred significantly less frequently in the magnesium sulfate group (1.9% vs. 3.5%; relative risk, 0.55; 95% CI, 0.32 to 0.95). The risk of death did not differ significantly between the groups (9.5% vs. 8.5%; relative risk, 1.12; 95% CI, 0.85 to 1.47). No woman had a life-threatening event. CONCLUSIONS: Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors. (ClinicalTrials.gov number, NCT00014989.)

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Metadata

Authors
Rouse, D. J., Hirtz, D. G., Thom, E., Varner, M. W., Spong, C. Y., Mercer, B. M., Iams, J. D., Wapner, R. J., Sorokin, Y., Alexander, J. M., Harper, M., Thorp, J. M., Ramin, S. M., Malone, F. D., Carpenter, M., Miodovnik, M., Moawad, A., O'Sullivan, M. J., Peaceman, A. M., Hankins, G. D. V., Langer, O., Caritis, S. N., & Roberts, J. M.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2008-08-28
Volume
359
Issue
9
Pages
895-905
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0801187
OpenAlex
W2616116784
Cited by
708
References
26
FWCI
30.20
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy. https://app.cochat.ai/papers/10.1056/nejmoa0801187
The paper
Rouse, D. J., Hirtz, D. G., Thom, E., Varner, M. W., Spong, C. Y., Mercer, B. M., Iams, J. D., Wapner, R. J., Sorokin, Y., Alexander, J. M., Harper, M., Thorp, J. M., Ramin, S. M., Malone, F. D., Carpenter, M., Miodovnik, M., Moawad, A., O'Sullivan, M. J., Peaceman, A. M., . . . Roberts, J. M. (2008). A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0801187

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.