The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
CISH and Susceptibility to Infectious Diseases
Open accessAbstract
BACKGROUND: The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS: Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bacteremia, tuberculosis, and severe malaria) in blood samples from 8402 persons in Gambia, Hong Kong, Kenya, Malawi, and Vietnam. We had previously tested 20 other immune-related genes in one or more of these sample collections. RESULTS: We observed associations between variant alleles of multiple CISH polymorphisms and increased susceptibility to each infectious disease in each of the study populations. When all five single-nucleotide polymorphisms (SNPs) (at positions -639, -292, -163, +1320, and +3415 [all relative to CISH]) within the CISH-associated locus were considered together in a multiple-SNP score, we found an association between CISH genetic variants and susceptibility to bacteremia, malaria, and tuberculosis (P=3.8x10(-11) for all comparisons), with -292 accounting for most of the association signal (P=4.58x10(-7)). Peripheral-blood mononuclear cells obtained from adult subjects carrying the -292 variant, as compared with wild-type cells, showed a muted response to the stimulation of interleukin-2 production--that is, 25 to 40% less CISH expression. CONCLUSIONS: Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens, suggesting that negative regulators of cytokine signaling have a role in immunity against various infectious diseases. The overall risk of one of these infectious diseases was increased by at least 18% among persons carrying the variant CISH alleles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent GWAS identified multiple polymorphisms in cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a SOCS family member that controls IL-2 signaling, that were associated with increased susceptibility to bacteremia, tuberculosis, and severe malaria in persons in Gambia, Hong Kong, Kenya, Malawi, and Vietnam (77).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Update on the Application of Interleukin-2 in the Treatment of Renal Cell Carcinoma
McDermott, D. F. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1872 · Cited by 63
RetractedHaploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,563
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,804
Self-citationWacholder, S., Chanock, S. J., García‐Closas, M., ghormli, L. K. E., & Rothman, N. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh075 · Cited by 1,753
Common West African HLA antigens are associated with protection from severe malaria
Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,573
Self-citationInterleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507
Akira, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300028200 · Cited by 1,499
Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., & Lenardo, M. J. (2007) · Nature Immunology · doi:10.1038/ni1536 · Cited by 1,277
Toll-Like Receptor Signaling Pathways
Barton, G. M., & Medzhitov, R. M. (2003) · Science · doi:10.1126/science.1085536 · Cited by 1,270
Annane, D., Bellissant, É., & Cavaillon, J. (2005) · The Lancet · doi:10.1016/s0140-6736(04)17667-8 · Cited by 1,262
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–133 of 133
Identification of mutations in porcine STAT5A that contributes to the transcription of CISH
Yao, D., Guo, D., Zhang, Y., Chen, Z., Gao, X., Xing, G., Yang, X., Wang, X., Di, S., Cai, J., et al. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1090833 · Cited by 3
Susceptibility and Response to Infection
Murray, M. F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00047-1 · Cited by 4
Li, Z., Guo, W., Ding, S., Feng, K., Lü, L., Huang, T., & Cai, Y. (2022) · Biology · doi:10.3390/biology11040607 · Cited by 2
Lakkavaram, A. L., Maymand, S., Naser, W., Ward, A. C., & de Koning‐Ward, T. F. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1288876 · Cited by 2
Buy one, get one free: Additional functions of GM‐CSF in DC maturation
Lutz, M. B. (2011) · European Journal of Immunology · doi:10.1002/eji.201142271 · Cited by 2
Blum, H. E. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01155.x · Cited by 2
BCG Immunization: Efficacy, Limitations, and Future Needs
Chang, K. C., & Leung, C. C. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6667-7_20 · Cited by 2
Self-citationReversible blindness: severe pneumococcal induced uveitis following septicaemia
Collins, A., Cortes, N., Matthews, B. N., Kerr, D. E., & McCormick, R. (2011) · BMJ Case Reports · doi:10.1136/bcr.03.2011.3960 · Cited by 2
Niu, B., Guo, D., Liu, Z., Han, X., & Wang, X. (2017) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.16.0169 · Cited by 2
Evolution of Genetic Resistance/Susceptibility to Malaria Infection
Ghosh, K., & Ghosh, K. K. (2012) · Wiley eBooks · doi:10.1002/9780470015902.a0022492 · Cited by 2
Munshi, A., Almontasheri, A. A., Arab, R., & Alshehri, M. (2024) · Cureus · doi:10.7759/cureus.70737 · Cited by 1
Berman, J. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814393-3.00006-8 · Cited by 1
Seyfarth, J., Ahlert, H., Rosenbauer, J., Bächle, C., Roden, M., Holl, R. W., Mayatepek, E., Meißner, T., & Jacobsen, M. (2018) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-018-0080-7 · Cited by 1
Genomics and DNA Variation: Determinants of Susceptibility and Outcomes in Microbial Diseases
Khor, C. C., Chapman, S. J., & Hill, A. V. S. (2011) · Molecular Microbiology · doi:10.1128/9781555816834.ch51 · Cited by 1
Self-citationGenetics of Susceptibility to Mycobacterial Disease
Selvaraj, P., Alagarasu, K., & Raghavan, S. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0023875
Prédispositions génétiques aux pneumonies
Textoris, J., Wiramus, S., & Léone, M. (2013) · Réanimation · doi:10.1007/s13546-013-0680-4
Cytokine et susceptibilité aux pathologies infectieuses
Marais, O. (2010) · Option/Bio · doi:10.1016/s0992-5945(10)70506-7
Infectious disease: bad luck or bad genes?
Chapman, S. J. (2012) · Clinical Medicine · doi:10.7861/clinmedicine.12-6-s12
Self-citationSuppressor of cytokine signaling 4 and 5 in zebrafish development
Trengove, M. C. (2015)
Case 2-2011: A Woman with Shock after Treatment of a Furuncle
Milazzo, L., & Antinori, S. (2011) · New England Journal of Medicine · doi:10.1056/nejmc1101921
CISH and Susceptibility to Infectious Diseases
Kantarjian, H. M., & Shah, N. P. (2010)
Berman, J. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-419988-0.00007-9
The pharmacogenetic and immunomodulatory response to Vitamin D in tuberculosis
Hawthorne, G. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)
Single-Nucleotide Polymorphisms and Inflammation
Giamarellos‐Bourboulis, E. J. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch52
Introduction to biomedical logic
Berman, J. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821364-3.00001-2
The Role of Host Genetics (and Genomics) in Tuberculosis
Naranbhai, V. (2017) · ASM Press eBooks · doi:10.1128/9781555819569.ch19
Internal Checkpoint Regulates T Cell Neoantigen Reactivity and Susceptibility to PD1 BlockadePreprint
Palmer, D. C., Webber, B. R., Patel, Y. K., Johnson, M. J., Kariya, C. M., Lahr, W. S., Parkhurst, M. R., Gartner, J. J., Prickett, T. D., Lowery, F. J., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3751760
Human Genetic Factors and Resistance to Malaria
Timmann, C., & Meyer, C. G. (2018) · Springer eBooks · doi:10.1007/978-1-4614-8326-7_138
Human infectious disease susceptibility: key perspectives
Bharathi, G., Bharathi, A., & Sivakumar, K. S. (2026) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-025-00825-1
Zhu, T., Zhao, N., Hua, J., Lu, S., Sun, H., Wang, W., Tao, W., Badran, M. F., Saleh, M., Aboueleila, R. H. M., et al. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103376
Tchitchek, N., Rosenzwajg, M., Lorenzon, R., Rinchai, D., Chaussabel, D., Malek, T. R., & Klatzmann, D. (2026) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2026.07.021
Metadata
- Authors
- Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D., Rautanen, A., Mills, T. C., Chang, K.-C., Kam, K.-M., Crampin, A. C., Ngwira, B., Leung, C.-C., Tam, C.-M., Chan, C.-Y., Sung, J. J. Y., Yew, W.-W., Toh, K.-Y., Tay, S. K. H., Kwiatkowski, D., Lienhardt, C., Hien, T.-T., Day, N. P., Peshu, N., Marsh, K., Maitland, K., Scott, J. A., Williams, T. N., Berkley, J. A., Floyd, S., Tang, N. L. S., Fine, P. E. M., Goh, D. L. M., & Hill, A. V. S.
- Affiliations
- Centre for Human Genetics (GB)
- Genome Institute of Singapore (SG)
- University of Oxford (GB)
- Singapore Institute for Clinical Sciences (SG)
- Kenya Medical Research Institute (KE)
- London School of Hygiene & Tropical Medicine (GB)
- ORCID
- Khor, Chiea C.
- Vannberg, Fredrik O.
- Chapman, Stephen J.
- Wong, Sunny H.
- Walley, Andrew J.
- Vukcevic, Damjan
- Crampin, Amelia C.
- Ngwira, Bagrey
- Sung, Joseph J.Y.
- Toh, Kai-Yee
- Tay, Stacey K.H.
- Kwiatkowski, Dominic
- Lienhardt, Christian
- Day, Nicholas P.
- Marsh, Kevin
- Maitland, Kathryn
- Scott, J. Anthony
- Williams, Thomas N.
- Berkley, James A.
- Floyd, Sian
- Tang, Nelson L.S.
- Fine, Paul E.M.
- Hill, Adrian V.S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-06-03
- Volume
- 362
- Issue
- 22
- Pages
- 2092-2101
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3646238
- OpenAlex
- W2142222423
- Cited by
- 136
- References
- 58
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 12 · 2013: 22 · 2012: 15
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Wellcome Trust (061089, 091758, 079828, 076934, 081835)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- CISH, suppressor of cytokine signaling, interleukin-2 signaling, bacteremia, tuberculosis, severe malaria, single nucleotide polymorphisms, cytokine signaling regulation, immune response, genetic association
- MeSH terms
- Adult, Child, Genotype, Humans, Interleukin-2, Malaria, Risk, Tuberculosis, Linkage Disequilibrium, Gene Expression, Odds Ratio, Case-Control Studies, Bacteremia, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Suppressor of Cytokine Signaling Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
