Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works

Functional diversity of helper T lymphocytes

Abbas, A. K., MURPHY, K. M. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,383 · see citing works

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

Transforming growth factor-β induces development of the TH17 lineage

Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Thornton, A. M., & Shevach, E. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.287 · Cited by 2,637 · see citing works

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848 · see citing works

The lineage decisions of helper T cells

MURPHY, K. M. M., & Reiner, S. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri954 · Cited by 1,675 · see citing works

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology · doi:10.1038/ni1376 · Cited by 955 · see citing works

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

Suzuki, H., Kündig, T. M., Furlonger, C. L., Wakeham, A. C., Timms, E. M., Matsuyama, T., Schmits, R., Simard, J. J. L., Ohashi, P. S., Griesser, H., et al. (1995) · Science · doi:10.1126/science.7770771 · Cited by 870 · see citing works

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., & Ghilardi, N. (2006) · Nature Immunology · doi:10.1038/ni1375 · Cited by 815 · see citing works

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

Li, M. O., Sanjabi, S., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.011 · Cited by 794 · see citing works

Understanding the IL-23–IL-17 immune pathway

McKenzie, B. S., Kastelein, R. A., & Cua, D. J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.10.003 · Cited by 761 · see citing works

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 652 · see citing works

Asthma: an epidemic of dysregulated immunity

Umetsu, D. T., McIntire, J. J., Akbari, O., Macaubas, C., & DeKruyff, R. H. (2002) · Nature Immunology · doi:10.1038/ni0802-715 · Cited by 601 · see citing works

The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells

Shevach, E. M., DiPaolo, R. J., Andersson, J., Zhao, D., Stephens, G. L., & Thornton, A. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00415.x · Cited by 589 · see citing works

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Yao, Z., Kanno, Y., Kerenyi, M. A., Stephens, G. L., Durant, L. R., Watford, W. T., Laurence, A. D. J., Robinson, G. W., Shevach, E. M., Moriggl, R., et al. (2007) · Blood · doi:10.1182/blood-2006-11-055756 · Cited by 575 · see citing works

Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

Cui, Y., Riedlinger, G., Miyoshi, K., Tang, W., Li, C., Deng, C., Robinson, G. W., & Hennighausen, L. G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8037-8047.2004 · Cited by 497 · see citing works

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480 · see citing works

Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease

Veldhoen, M., Hocking, R. J., Flavell, R., & Stockinger, B. (2006) · Nature Immunology · doi:10.1038/ni1391 · Cited by 459 · see citing works

Stat5a/b are essential for normal lymphoid development and differentiation

Yao, Z., Cui, Y., Watford, W. T., Bream, J. H., Yamaoka, K., Hissong, B. D., Li, D., Durum, S. K., Jiang, Q., Bhandoola, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507350103 · Cited by 391 · see citing works

The main function of IL-2 is to promote the development of T regulatory cells

Malek, T. R. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603272 · Cited by 330 · see citing works

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

Lee, C.-K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., DePinho, R. A., & Levy, D. E. (2002) · Immunity · doi:10.1016/s1074-7613(02)00336-9 · Cited by 242 · see citing works

Activation of JAK kinases and STAT proteins by interleukin‐2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

Beadling, C., Guschin, D. Y., Witthuhn, B. A., et al. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06898.x · Cited by 215 · see citing works

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

Antov, A., Yang, L., Vig, M., Baltimore, D., & Parijs, L. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3435 · Cited by 204 · see citing works

The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease

Strober, W., Ludviksson, B. R., & Fuss, I. J. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-10-199805150-00009 · Cited by 164 · see citing works

Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation

McKarns, S. C., Schwartz, R. H., & Kaminski, N. E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4275 · Cited by 141 · see citing works

Interleukins 2, 4, 7, and 15 Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrates 1 and 2 in T Cells POTENTIAL ROLE OF JAK KINASES

Johnston, J. A., Wang, L.-M., Hanson, E. P., Sun, X., White, M. F., Oakes, S. A., Pierce, J. H., & O’Shea, J. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28527 · Cited by 135 · see citing works

Loss of Tolerance and Autoimmunity Affecting Multiple Organs in STAT5A/5B -Deficient Mice

Snow, J. W., Abraham, N., Ma, M. C., HERNDIER, B. G., Pastuszak, A. W., & Goldsmith, M. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5042 · Cited by 128 · see citing works

Lineage commitment in lymphocytes: controlling the immune response.

Lh, G. (2001) · PubMed · Cited by 61 · see citing works

The control of T cell activation vs. tolerance

Abbas, A. K. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(03)00028-4 · Cited by 59 · see citing works

Approaches to Define Antigen Receptor-induced Serine Kinase Signal Transduction Pathways

Astoul, E., Laurence, A. D. J., Totty, N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211252200 · Cited by 42 · see citing works

The transcription factor Stat3 is dispensable for pancreatic β-cell development and function

Lee, J., & Hennighausen, L. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.162 · Cited by 40 · see citing works

Genetic models of abnormal apoptosis in lymphocytes

Refaeli, Y., Parijs, L. V., & Abbas, A. K. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01322.x · Cited by 38 · see citing works

The molecular basis of T cell differentiation

Flavell, R. A. (1999) · Immunologic Research · doi:10.1007/bf02786484 · Cited by 25 · see citing works

The Role of Cytokines in Autoimmunity

Cava, A. L., & Sarvetnick, N. (1999) · KARGER eBooks · doi:10.1159/000060495 · Cited by 16 · see citing works

Role of cytokines in autoimmunity.

Refaeli, Y., & Abbas, A. K. (1998) · PubMed · Cited by 6 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982 · see citing works

Phenotypic and functional features of human Th17 cells

Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585 · see citing works

Plasticity of CD4+ T Cell Lineage Differentiation

Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · see citing works

IL-6 in inflammation, autoimmunity and cancer

Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works

CD4 ⁺ T Cells: Differentiation and Functions

Luckheeram, R. V., Zhou, R., Verma, A. D., & Xia, B. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/925135 · Cited by 1,381 · see citing works

Mechanisms and consequences of Jak–STAT signaling in the immune system

Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221 · see citing works

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works

TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064 · see citing works

Late Developmental Plasticity in the T Helper 17 Lineage

Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053 · see citing works

Regulation of the immune response by the aryl hydrocarbon receptor

Gutiérrez-Vázquez, C., & Quintana, F. J. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.012 · Cited by 985 · see citing works

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940 · see citing works

JAKs and STATs in immunity, immunodeficiency, and cancer

O'Shea, J. J., Holland, S. M., & Staudt, L. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1202117 · Cited by 927 · see citing works

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., & Sallusto, F. (2012) · Nature · doi:10.1038/nature10957 · Cited by 919 · see citing works

Dynamic regulatory network controlling TH17 cell differentiation

Yosef, N., Shalek, A. K., Gaublomme, J. T., Jin, H., Lee, Y., Awasthi, A., Wu, C., Karwacz, K., Xiao, S., Jorgolli, M., et al. (2013) · Nature · doi:10.1038/nature11981 · Cited by 682 · see citing works

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

Toscano, M. A., Bianco, G. A., Ilarregui, J. M., Croci, D. O., Correale, J., Hernandez, J. D., Zwirner, N. W., Poirier, F., Riley, E. M., Baum, L. G., et al. (2007) · Nature Immunology · doi:10.1038/ni1482 · Cited by 653 · see citing works

Biology and regulation of IL-2: from molecular mechanisms to human therapy

Spolski, R., Li, P., & Leonard, W. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0046-y · Cited by 637 · see citing works

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in <i>STAT3</i>

Ma, C. S., Chew, G. Y. J., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G., & Cook, M. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080218 · Cited by 652 · see citing works

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583 · see citing works

The Role of IL-17 and related cytokines in inflammatory autoimmune diseases

Kuwabara, T., Ishikawa, F., Kondo, M., & Kakiuchi, T. (2017) · Mediators of Inflammation · doi:10.1155/2017/3908061 · Cited by 519 · see citing works

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity

Romano, M., Fanelli, G., Albany, C. J., Giganti, G., & Lombardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00043 · Cited by 512 · see citing works

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

Li, M. O., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.003 · Cited by 501 · see citing works

Cytokine mediated tissue fibrosis

Borthwick, L. A., Wynn, T. A., & Fisher, A. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.014 · Cited by 375 · see citing works

Th17 cells in immunity to Candida albicans

Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2012.04.008 · Cited by 361 · see citing works

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., & O'Shea, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075058 · Cited by 342 · see citing works

A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

Gaffen, S. L., & Hajishengallis, G. (2008) · Journal of Dental Research · doi:10.1177/154405910808700908 · Cited by 334 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Discovery of stimulation-responsive immune enhancers with CRISPR activation

Simeonov, D. R., Gowen, B. G., Boontanrart, M., Roth, T. L., Gagnon, J. D., Mumbach, M. R., Satpathy, A. T., Lee, Y., Bray, N. L., Chan, A. Y., et al. (2017) · Nature · doi:10.1038/nature23875 · Cited by 297 · see citing works

Genomic views of STAT function in CD4+ T helper cell differentiation

O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295 · see citing works

Interleukin-17 in chronic inflammatory neurological diseases

Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250 · see citing works

Effects of aging on T cell function

Haynes, L., & Maue, A. C. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.009 · Cited by 244 · see citing works

The Th17 family: flexibility follows function

Basu, R., Hatton, R. D., & Weaver, C. T. (2013) · Immunological Reviews · doi:10.1111/imr.12035 · Cited by 229 · see citing works

A formal analysis of cytokine networks in chronic fatigue syndrome

Broderick, G., Fuite, J., Kreitz, A., Vernon, S. D., Klimas, N., & Fletcher, M. A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.04.012 · Cited by 202 · see citing works

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

Sheng, W., Yang, F., Zhou, Y., Yang, H., Low, P. Y., Kemeny, D. M., Tan, P., Moh, A., Kaplan, M. H., Zhang, Y., et al. (2014) · Cell Research · doi:10.1038/cr.2014.154 · Cited by 203 · see citing works

Collateral damage: Insights into bacterial mechanisms that predispose host cells to cancer

Gagnaire, A., Nadel, B., Raoult, D., Neefjes, J., & Gorvel, J.-P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.171 · Cited by 189 · see citing works

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Rowley, A. T., Nagalla, R. R., Wang, S., & Liu, W. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801578 · Cited by 193 · see citing works

Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes

Ono, M. (2020) · Immunology · doi:10.1111/imm.13178 · Cited by 187 · see citing works

Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells

Stummvoll, G. H., DiPaolo, R. J., Huter, E. N., Davidson, T. S., Glass, D., Ward, J. M., & Shevach, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1908 · Cited by 170 · see citing works

T _H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity

Harbour, S. N., DiToro, D. F., Witte, S. J., Zindl, C. L., Gao, M., Schoeb, T. R., Jones, G. W., Jones, S. A., Hatton, R. D., & Weaver, C. T. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaw2262 · Cited by 151 · see citing works

<i>CISH</i> and Susceptibility to Infectious Diseases

Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D., Rautanen, A., Mills, T. C., Chang, K.-C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0905606 · Cited by 136 · see citing works

The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling

Garg, A. V., Ahmed, M., Vallejo, A. N., Ma, A., & Gaffen, S. L. (2013) · Science Signaling · doi:10.1126/scisignal.2003699 · Cited by 128 · see citing works

STAT3, a master regulator of anti-tumor immune response

Rébé, C., & Ghiringhelli, F. (2019) · Cancers · doi:10.3390/cancers11091280 · Cited by 129 · see citing works

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

Niedbala, W., Alves-Filho, J. C., Fukada, S. Y., Vieira, S. M., Mitani, A., Sonego, F., Mirchandani, A., Nascimento, D. C., Cunha, F. Q., & Liew, F. Y. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100667108 · Cited by 117 · see citing works

NAD+ protects against EAE by regulating CD4+ T-cell differentiation

Tullius, S. G., Biefer, H. R. C., Li, S., Trachtenberg, A. J., Edtinger, K., Quante, M., Krenzien, F., Uehara, H., Yang, X., Kissick, H. T., et al. (2014) · Nature Communications · doi:10.1038/ncomms6101 · Cited by 107 · see citing works

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3

Steward-Tharp, S. M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A. V., Sciume, G., Kuchen, S., Resch, W., Wohlfert, E. A., Jiang, K., et al. (2014) · Blood · doi:10.1182/blood-2013-09-523167 · Cited by 87 · see citing works

Signal transduction and Th17 cell differentiation

O'Shea, J. J., Steward-Tharp, S. M., Laurence, A., Watford, W. T., Wei, L., Adamson, A. S., & Fan, S. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.04.007 · Cited by 73 · see citing works

Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue

Broderick, G., Katz, B. Z., Fernandes, H., Fletcher, M. A., Klimas, N., Smith, F. A., O’Gorman, M. R., Vernon, S. D., & Taylor, R. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-191 · Cited by 72 · see citing works

A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome

Smylie, A. L., Broderick, G., Fernandes, H., Razdan, S., Barnes, Z., Collado, F., Sol, C., Fletcher, M. A., & Klimas, N. (2013) · BMC Immunology · doi:10.1186/1471-2172-14-29 · Cited by 71 · see citing works

NAD+ regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent

Elkhal, A., Rodriguez Cetina Biefer, H., Heinbokel, T., Uehara, H., Quante, M., Seyda, M., Schuitenmaker, J. M., Krenzien, F., Camacho, V., de la Fuente, M. A., et al. (2016) · Scientific Reports · doi:10.1038/srep22325 · Cited by 46 · see citing works

The imbalance between regulatory and IL-17-secreting CD4+T cells in multiple-trauma rat

Dai, H., Sun, T., Liu, Z., Zhang, J., & Zhou, M. (2013) · Injury · doi:10.1016/j.injury.2013.03.015 · Cited by 31 · see citing works

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E., & Bliska, J. B. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31021-3

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

Loh, C.-Y., Arya, A., Naema, A. F., Wong, W. F., Sethi, G., & Looi, C. Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00048 · Cited by 351 · see citing works

Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome

Zheng, Y., Wang, Z., Deng, L., et al. (2015) · Clinical Immunology · doi:10.1016/j.clim.2014.12.012 · Cited by 44 · see citing works

Signal Transducers and Activators of Transcription (STATs): Novel Targets of Chemopreventive and Chemotherapeutic Drugs

Klampfer, L. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906776056491 · Cited by 171 · see citing works

The Genes Induced by Signal Transducer and Activators of Transcription (STAT)3 and STAT5 in Mammary Epithelial Cells Define the Roles of these STATs in Mammary Development

Clarkson, R. W. E., Boland, M. P., Kritikou, E. A., Lee, J. M., Freeman, T. C., Tiffen, P. G., & Watson, C. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0392 · Cited by 129 · see citing works