The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events
Abstract
BACKGROUND: This trial was designed to determine whether cardiac-resynchronization therapy (CRT) with biventricular pacing would reduce the risk of death or heart-failure events in patients with mild cardiac symptoms, a reduced ejection fraction, and a wide QRS complex. METHODS: During a 4.5-year period, we enrolled and followed 1820 patients with ischemic or nonischemic cardiomyopathy, an ejection fraction of 30% or less, a QRS duration of 130 msec or more, and New York Heart Association class I or II symptoms. Patients were randomly assigned in a 3:2 ratio to receive CRT plus an implantable cardioverter-defibrillator (ICD) (1089 patients) or an ICD alone (731 patients). The primary end point was death from any cause or a nonfatal heart-failure event (whichever came first). Heart-failure events were diagnosed by physicians who were aware of the treatment assignments, but they were adjudicated by a committee that was unaware of assignments. RESULTS: During an average follow-up of 2.4 years, the primary end point occurred in 187 of 1089 patients in the CRT-ICD group (17.2%) and 185 of 731 patients in the ICD-only group (25.3%) (hazard ratio in the CRT-ICD group, 0.66; 95% confidence interval [CI], 0.52 to 0.84; P=0.001). The benefit did not differ significantly between patients with ischemic cardiomyopathy and those with nonischemic cardiomyopathy. The superiority of CRT was driven by a 41% reduction in the risk of heart-failure events, a finding that was evident primarily in a prespecified subgroup of patients with a QRS duration of 150 msec or more. CRT was associated with a significant reduction in left ventricular volumes and improvement in the ejection fraction. There was no significant difference between the two groups in the overall risk of death, with a 3% annual mortality rate in each treatment group. Serious adverse events were infrequent in the two groups. CONCLUSIONS: CRT combined with ICD decreased the risk of heart-failure events in relatively asymptomatic patients with a low ejection fraction and wide QRS complex. (ClinicalTrials.gov number, NCT00180271.)
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“In MADIT-CRT, CRT-D treatment, compared with optimal medical therapy plus ICD, led to a similar reduction in the risk of all-cause death or HF hospitalization in patients with and without T2DM (adjusted HRs 0.56 and 0.67, respectively).169,173”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [169]
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Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Self-citationMoss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885
Self-citationAmiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
Cleland, J. G. F., Daubert, J., Erdmann, E., Freemantle, N., Gras, D., KAPPENBERGER, L. J., & Tavazzi, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050496 · Cited by 6,300
Self-citationBristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
Self-citationThe DAVID Trial Investigators* (2002) · JAMA · doi:10.1001/jama.288.24.3115 · Cited by 2,056
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities
Epstein, A. E., Dimarco, J., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Circulation · doi:10.1161/circualtionaha.108.189742 · Cited by 1,772
Self-citationLinde, C. M., Abraham, W. T., Gold, M. R., Sutton, M. S. J., Ghio, S., & Daubert, J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.027 · Cited by 1,269
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Sherazi, S., Kutyifa, V., McNitt, S., Aktas, M. K., Couderc, J.-P., Peterson, B., Bloch Thomsen, P. E., Kautzner, J., Moss, A. J., & Zareba, W. (2015) · JACC: Clinical Electrophysiology · doi:10.1016/j.jacep.2015.03.004 · Cited by 13
Self-citationCzech Society of Cardiology Guidelines for the Diagnosis and Treatment of Chronic Heart Failure 2011
Špinar, J., Vítovec, J., Hradec, J., Málek, I., Meluzín, J., Špinarová, L., Hošková, L., Hegarová, M., Ludka, O., & Táborský, M. (2012) · Cor et Vasa · doi:10.1016/j.crvasa.2012.03.002 · Cited by 10
Metadata
- Authors
- Moss, A. J., Hall, W. J., Cannom, D. S., Klein, H., Brown, M. W., Daubert, J. P., Estes, N. A. M., Foster, E., Greenberg, H., Higgins, S. L., Pfeffer, M. A., Solomon, S. D., Wilber, D., & Zareba, W.
- Affiliations
- University of Rochester Medicine (US)
- Good Samaritan Hospital (US)
- Duke Medical Center (US)
- University of California, San Francisco (US)
- St. Luke's-Roosevelt Hospital Center (US)
- Scripps Memorial Hospital (US)
- Brigham and Women's Hospital (US)
- Loyola University Medical Center (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-10
- Volume
- 361
- Issue
- 14
- Pages
- 1329-1338
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2146521529
- Cited by
- 3,157
- References
- 17
- Citations by year
- 2026: 106 · 2025: 116 · 2024: 137 · 2023: 188 · 2022: 140 · 2021: 155 · 2020: 163 · 2019: 173 · 2018: 174 · 2017: 199 · 2016: 210 · 2015: 210 · 2014: 227 · 2013: 243 · 2012: 267
- FWCI
- 151.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- cardiac resynchronization therapy, implantable cardioverter-defibrillator, heart failure prevention, reduced ejection fraction, wide QRS complex, ischemic cardiomyopathy, non-ischemic cardiomyopathy, left ventricular volume, ejection fraction, mortality, asymptomatic patients
- MeSH terms
- Aged, Cardiac Pacing, Artificial, Electric Countershock, Female, Heart Failure, Humans, Male, Middle Aged, Pacemaker, Artificial, Stroke Volume, Defibrillators, Implantable, Disease-Free Survival, Kaplan-Meier Estimate
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