The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana
Open accessAbstract
BACKGROUND: The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are unknown. METHODS: We randomly assigned 560 HIV-1-infected pregnant women (CD4+ count, > or = 200 cells per cubic millimeter) to receive coformulated abacavir, zidovudine, and lamivudine (the nucleoside reverse-transcriptase inhibitor [NRTI] group) or lopinavir-ritonavir plus zidovudine-lamivudine (the protease-inhibitor group) from 26 to 34 weeks' gestation through planned weaning by 6 months post partum. A total of 170 women with CD4+ counts of less than 200 cells per cubic millimeter received nevirapine plus zidovudine-lamivudine (the observational group). Infants received single-dose nevirapine and 4 weeks of zidovudine. RESULTS: The rate of virologic suppression to less than 400 copies per milliliter was high and did not differ significantly among the three groups at delivery (96% in the NRTI group, 93% in the protease-inhibitor group, and 94% in the observational group) or throughout the breast-feeding period (92% in the NRTI group, 93% in the protease-inhibitor group, and 95% in the observational group). By 6 months of age, 8 of 709 live-born infants (1.1%) were infected (95% confidence interval [CI], 0.5 to 2.2): 6 were infected in utero (4 in the NRTI group, 1 in the protease-inhibitor group, and 1 in the observational group), and 2 were infected during the breast-feeding period (in the NRTI group). Treatment-limiting adverse events occurred in 2% of women in the NRTI group, 2% of women in the protease-inhibitor group, and 11% of women in the observational group. CONCLUSIONS: All regimens of HAART from pregnancy through 6 months post partum resulted in high rates of virologic suppression, with an overall rate of mother-to-child transmission of 1.1%. (ClinicalTrials.gov number, NCT00270296.)
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Antiretroviral Therapy during Pregnancy and the Risk of an Adverse Outcome
Tuomala, R. E., Shapiro, D. E., Mofenson, L. M., Bryson, Y., Culnane, M., Hughes, M. D., O'Sullivan, M. J., Scott, G., Stek, A. M., Wara, D., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa991159 · Cited by 347
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Breastfeeding and the use of human milk
BREASTFEEDING, S. O., Eidelman, A. I., Schanler, R. J., Johnston, M., Landers, S., Noble, L., Szucs, K., & Viehmann, L. (2012) · Pediatrics · doi:10.1542/peds.2011-3552 · Cited by 4,357
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Dryden-Peterson, S., Bennett, K., Hughes, M. D., Veres, A., John, O., Pradhananga, R., Boyer, M., Brown, C., Sakyi, B., van Widenfelt, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117181 · Cited by 37
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Metadata
- Authors
- Shapiro, R. L., Hughes, M. D., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., Jayeoba, O., Moko, E., Souda, S., Lubega, E., Akhtar, M., Wester, C., Tuomola, R., Snowden, W., Martinez-Tristani, M., Mazhani, L., & Essex, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-06-17
- Volume
- 362
- Issue
- 24
- Pages
- 2282-2294
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2116914456
- Cited by
- 521
- References
- 25
- FWCI
- 38.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shapiro, R. L., Hughes, M. D., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., . . . Essex, M. (2010). Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0907736
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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