The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Increased risk of HIV-1 transmission in pregnancy: a prospective study among African HIV-1-serodiscordant couples
Open accessAbstract
BACKGROUND: Physiologic and behavioral changes during pregnancy may alter HIV-1 susceptibility and infectiousness. Prospective studies exploring pregnancy and HIV-1 acquisition risk in women have found inconsistent results. No study has explored the effect of pregnancy on HIV-1 transmission risk from HIV-1-infected women to male partners. METHODS: In a prospective study of African HIV-1-serodiscordant couples, we evaluated the relationship between pregnancy and the risk of HIV-1 acquisition among women and HIV-1 transmission from women to men. RESULTS: Three thousand three hundred and twenty-one HIV-1-serodiscordant couples were enrolled, 1085 (32.7%) with HIV-1 susceptible female partners and 2236 (67.3%) with susceptible male partners. HIV-1 incidence in women was 7.35 versus 3.01 per 100 person-years during pregnant and nonpregnant periods [hazard ratio 2.34, 95% confidence interval (CI) 1.33-4.09]. This effect was attenuated and not statistically significant after adjusting for sexual behavior and other confounding factors (adjusted hazard ratio 1.71, 95% CI 0.93-3.12). HIV-1 incidence in male partners of infected women was 3.46 versus 1.58 per 100 person-years when their partners were pregnant versus not pregnant (hazard ratio 2.31, 95% CI 1.22-4.39). This effect was not attenuated in adjusted analysis (adjusted hazard ratio 2.47, 95% CI 1.26-4.85). CONCLUSION: HIV-1 risk increased two-fold during pregnancy. Elevated risk of HIV-1 acquisition in pregnant women appeared in part to be explained by behavioral and other factors. This is the first study to show that pregnancy increased the risk of female-to-male HIV-1 transmission, which may reflect biological changes of pregnancy that could increase HIV-1 infectiousness.
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Cited by
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Baeten, J. M., Donnell, D., Ndase, P., Mugo, N. R., Campbell, J. D., Wangisi, J., Tappero, J. W., Bukusi, E. A., Cohen, C. R., Katabira, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1108524 · Cited by 3,256
Self-citationHIV infection: epidemiology, pathogenesis, treatment, and prevention
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Metadata
- Authors
- Mugo, N. R., Heffron, R., Donnell, D., Wald, A., Were, E. O., Rees, H., Celum, C., Kiarie, J. N., Cohen, C. R., Kayintekore, K., & Baeten, J. M.
- Venue
- AIDS
- Published
- 2011-09-24
- Volume
- 25
- Issue
- 15
- Pages
- 1887-1895
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2163974471
- Cited by
- 256
- References
- 20
- FWCI
- 18.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Mugo, N. R., Heffron, R., Donnell, D., Wald, A., Were, E. O., Rees, H., Celum, C., Kiarie, J. N., Cohen, C. R., Kayintekore, K., & Baeten, J. M. (2011). Increased risk of HIV-1 transmission in pregnancy: a prospective study among African HIV-1-serodiscordant couples. AIDS. https://doi.org/10.1097/qad.0b013e32834a9338
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