Cited by 7,482Palliative Care and End-of-Life IssuesPalliative and Oncologic CareLung Cancer Diagnosis and Treatment

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer

Temel, Jennifer S., Greer, Joseph A., Muzikansky, Alona, Gallagher, Emily R., Admane, Sonal, Jackson, Vicki A., Dahlin, Constance M., Blinderman, Craig D., Jacobsen, Juliet, Pirl, William F., Billings, J. Andrew, Lynch, Thomas J.·2010·New England Journal of Medicine

DOI 10.1056/nejmoa1000678

Open this paper in CoChat — free account

Abstract

BACKGROUND: Patients with metastatic non-small-cell lung cancer have a substantial symptom burden and may receive aggressive care at the end of life. We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes and end-of-life care among ambulatory patients with newly diagnosed disease. METHODS: We randomly assigned patients with newly diagnosed metastatic non-small-cell lung cancer to receive either early palliative care integrated with standard oncologic care or standard oncologic care alone. Quality of life and mood were assessed at baseline and at 12 weeks with the use of the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale and the Hospital Anxiety and Depression Scale, respectively. The primary outcome was the change in the quality of life at 12 weeks. Data on end-of-life care were collected from electronic medical records. RESULTS: Of the 151 patients who underwent randomization, 27 died by 12 weeks and 107 (86% of the remaining patients) completed assessments. Patients assigned to early palliative care had a better quality of life than did patients assigned to standard care (mean score on the FACT-L scale [in which scores range from 0 to 136, with higher scores indicating better quality of life], 98.0 vs. 91.5; P=0.03). In addition, fewer patients in the palliative care group than in the standard care group had depressive symptoms (16% vs. 38%, P=0.01). Despite the fact that fewer patients in the early palliative care group than in the standard care group received aggressive end-of-life care (33% vs. 54%, P=0.05), median survival was longer among patients receiving early palliative care (11.6 months vs. 8.9 months, P=0.02). CONCLUSIONS: Among patients with metastatic non-small-cell lung cancer, early palliative care led to significant improvements in both quality of life and mood. As compared with patients receiving standard care, patients receiving early palliative care had less aggressive care at the end of life but longer survival. (Funded by an American Society of Clinical Oncology Career Development Award and philanthropic gifts; ClinicalTrials.gov number, NCT01038271.)

Integrity signals

Registry

Crossref · 10.1056/nejmoa1000678

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
Toxicity and response criteria of the Eastern Cooperative Oncology Group
Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E., Mcfadden, E. T., & Carbone, P. P. (1982) · American Journal of Clinical Oncology · doi:10.1097/00000421-198212000-00014 · Cited by 11,686
Cancer statistics, 2009
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials
Non-small Cell Lung Cancer Collaborative Group (1995) · BMJ · doi:10.1136/bmj.311.7010.899 · Cited by 3,054
Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
Villalba, J. B. (1996) · Lung Cancer · doi:10.1016/0169-5002(96)85918-6 · Cited by 2,510
Effects of a Palliative Care Intervention on Clinical Outcomes in Patients With Advanced Cancer: The Project ENABLE II Randomized Controlled Trial
Bakitas, M., Lyons, K. D., Hegel, M. T., Balan, S., Brokaw, F. C., Seville, J., Hull, J. G., Li, Z., Tosteson, T. D., Byock, I. R., et al. (2009) · JAMA · doi:10.1001/jama.2009.1198 · Cited by 1,726
Aggressiveness of Cancer Care Near the End of Life: Is It a Quality-of-Care Issue?
Earle, C. C., Landrum, M. B., Souza, J. M., Neville, B. A., Weeks, J. C., & Ayanian, J. Z. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.8253 · Cited by 957
Reliability and validity of the functional assessment of cancer therapy—lung (FACT-L) quality of life instrument
Cella, D. F., Bonomi, A. E., Lloyd, S. R., Tulsky, D. S., Kaplan, E. J., & Bonomi, P. (1995) · Lung Cancer · doi:10.1016/0169-5002(95)00450-f · Cited by 750
Phase III Trial of Gemcitabine Plus Cisplatin Versus Cisplatin Alone in Patients With Locally Advanced or Metastatic Non–Small-Cell Lung Cancer
Sandler, A. B., Nemunaitis, J. J., Denham, C. A., von Pawel, J., Cormier, Y. F., Gatzemeier, U., Mattson, K. V., Manegold, C., Palmer, M., Gregor, A., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.1.122 · Cited by 712

Flagged first, then by citations

Show all 38 references

Sorted by citations

Items 301–400 of 1,027

Advance care planning in COPD
Patel, K. B., Janssen, D. J. A., & Curtis, J. R. (2011) · Respirology · doi:10.1111/j.1440-1843.2011.02087.x · Cited by 139
The Palliative Care Model for Emergency Department Patients with Advanced Illness
Grudzen, C. R., Stone, S. C., & Morrison, R. S. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2011.0011 · Cited by 139
Inpatient Hospitalization of Oncology Patients: Are We Missing an Opportunity for End-of-Life Care?
Rocque, G. B., Barnett, A. E., Illig, L., Eickhoff, J. C., Bailey, H. H., Campbell, T. C., Stewart, J. A., & Cleary, J. F. (2013) · Journal of Oncology Practice · doi:10.1200/jop.2012.000698 · Cited by 139
Definition of supportive care
Hui, D. (2014) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000086 · Cited by 138
Association of Coloproctology of Great Britain & Ireland ( ACPGBI ): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Multidisciplinary Management
Gollins, S., Moran, B. J., Adams, R., Cunningham, C., Bach, S. P., Myint, A. S., Renehan, A. G., Karandikar, S. S., Goh, V., Prezzi, D., et al. (2017) · Colorectal Disease · doi:10.1111/codi.13705 · Cited by 138
2022 KLCA-NCC Korea Practice Guidelines for the Management of Hepatocellular Carcinoma
(2022) · Korean Journal of Radiology · doi:10.3348/kjr.2022.0822 · Cited by 143
Best Practices for Reducing Unplanned Acute Care for Patients With Cancer
Handley, N. R., Schuchter, L. M., & Bekelman, J. E. (2018) · Journal of Oncology Practice · doi:10.1200/jop.17.00081 · Cited by 137
Prospective Comparison of Prognostic Scores in Palliative Care Cancer Populations
Maltoni, M. C., Scarpi, E., Pittureri, C., Martini, F., Montanari, L., Amaducci, E., Derni, S., Fabbri, L., Rosati, M., Amadori, D., et al. (2012) · The Oncologist · doi:10.1634/theoncologist.2011-0397 · Cited by 137
2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
(2022) · Journal of Liver Cancer · doi:10.17998/jlc.2022.11.07 · Cited by 145
Early Interdisciplinary Supportive Care in Patients With Previously Untreated Metastatic Esophagogastric Cancer: A Phase III Randomized Controlled Trial
Lu, Z., Fang, Y., Liu, C. X., Zhang, X., Xin, X., He, Y., Cao, Y., Jiao, X., Sun, T., Pang, Y. K., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.01254 · Cited by 136
Research into palliative care in sub-Saharan Africa
Harding, R., Selman, L. E., Powell, R. A., Namisango, E., Downing, J. D., Merriman, A., Ali, Z. V., Gikaara, N., Gwyther, L., & Higginson, I. J. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70396-0 · Cited by 135
Critical care of patients with cancer
Shimabukuro‐Vornhagen, A., Böll, B., Kochanek, M., Azoulay, E., & von Bergwelt‐Baildon, M. S. (2016) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21351 · Cited by 136
Experiences of patients and caregivers with early palliative care: A qualitative study
Hannon, B. L., Swami, N., Rodin, G., Pope, A. J., & Zimmermann, C. (2016) · Palliative Medicine · doi:10.1177/0269216316649126 · Cited by 134
Increasing age predicts poor cervical cancer prognosis with subsequent effect on treatment and overall survival
Quinn, B. A., Deng, X., Colton, A., Bandyopadhyay, D., Carter, J. S., & Fields, E. C. (2018) · Brachytherapy · doi:10.1016/j.brachy.2018.08.016 · Cited by 134
Impact of Interdisciplinary Outpatient Specialty Palliative Care on Survival and Quality of Life in Adults With Advanced Cancer: A Meta-Analysis of Randomized Controlled Trials
Hoerger, M. P., Wayser, G. R., Schwing, G., Suzuki, A., & Perry, L. M. (2018) · Annals of Behavioral Medicine · doi:10.1093/abm/kay077 · Cited by 134
Palliative Care Early in the Care Continuum among Patients with Serious Respiratory Illness: An Official ATS/AAHPM/HPNA/SWHPN Policy Statement
Sullivan, D. R., Iyer, A. S., Enguidanos, S. M., Cox, C. E., Farquhar, M. C., Janssen, D. J. A., Lindell, K. O., Mularski, R. A., Smallwood, N., Turnbull, A. E., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202207-1262st · Cited by 134
Envisioning a Better U.S. Health Care System for All: Coverage and Cost of Care
Crowley, R. J., Daniel, H., Cooney, T. G., & Engel, L. S. (2020) · Annals of Internal Medicine · doi:10.7326/m19-2415 · Cited by 144
Stress management interventions to facilitate psychological and physiological adaptation and optimal health outcomes in cancer patients and survivors
Antoni, M. H., Moreno, P. I., & Penedo, F. J. (2023) · Annual Review of Psychology · doi:10.1146/annurev-psych-030122-124119 · Cited by 132
Treatment Paradigms for Patients with Metastatic Non-Small-Cell Lung Cancer: First-, Second-, and Third-Line
Leighl, N. B. (2012) · Current Oncology · doi:10.3747/co.19.1114 · Cited by 134
The development of evidence-based European guidelines on the management of depression in palliative cancer care
Rayner, L., Price, A. C., Hotopf, M. H., & Higginson, I. J. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.027 · Cited by 132
Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature
Archie, P., Bruera, E. D., & Cohen, L. G. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1841-4 · Cited by 141
The end‐of‐life experience: Modifiable predictors of caregivers' bereavement adjustment
Garrido, M. M., & Prigerson, H. G. (2013) · Cancer · doi:10.1002/cncr.28495 · Cited by 131
Increasing Physical Activity and Exercise in Lung Cancer: Reviewing Safety, Benefits, and Application
Bade, B. C., Thomas, D. D., Scott, J. B., & Silvestri, G. A. (2015) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000536 · Cited by 134
Update on End-of-Life Care Training During Nephrology Fellowship: A Cross-sectional National Survey of Fellows
Combs, S., Culp, S., Matlock, D. D., Kutner, J. S., Holley, J. L., & Moss, A. H. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.07.018 · Cited by 134
Attitudes and Beliefs Toward Supportive and Palliative Care Referral Among Hematologic and Solid Tumor Oncology Specialists
Hui, D., Park, M., Liu, D., Reddy, A. S., Dalal, S., & Bruera, E. D. (2015) · The Oncologist · doi:10.1634/theoncologist.2015-0240 · Cited by 131
ECCO Essential Requirements for Quality Cancer Care: Soft Tissue Sarcoma in Adults and Bone Sarcoma. A critical review
Andritsch, E., Beishon, M., Bielack, S., Bonvalot, S., Casali, P. G., Crul, M., Bolton, R. C. D., Donati, D. M., Douis, H., Haas, R. L., et al. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.12.002 · Cited by 131
Current multidisciplinary management of brain metastases
Moravan, M. J., Fecci, P. E., Anders, C. K., Clarke, J. M., Salama, A. K. S., Adamson, J. D., Floyd, S., Torok, J. A., Salama, J. K., Sampson, J. H., et al. (2020) · Cancer · doi:10.1002/cncr.32714 · Cited by 138
Health insurance status and cancer stage at diagnosis and survival in the United States
Zhao, J., Han, X., Nogueira, L., Fedewa, S. A., Jemal, A., Halpern, M. T., & Yabroff, K. R. (2022) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21732 · Cited by 131
Looking up: Recent advances in understanding and treating peritoneal carcinomatosis
Lambert, L. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21277 · Cited by 130
Does Palliative Care Have a Future in the Emergency Department? Discussions With Attending Emergency Physicians
Grudzen, C. R., Richardson, L. D., Hopper, S. S., Ortiz, J. M., Whang, C., & Morrison, R. S. (2011) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.03.022 · Cited by 130
A Systematic Review in Support of the National Consensus Project Clinical Practice Guidelines for Quality Palliative Care, Fourth Edition
Ahluwalia, S. C., Chen, C. I., Raaen, L. B., Motala, A., Walling, A. M., Chamberlin, M. E., O’Hanlon, C. E., Larkin, J., Lorenz, K., Akinniranye, O., et al. (2018) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2018.09.008 · Cited by 130
Hospital-Free Days: A Pragmatic and Patient-centered Outcome for Trials among Critically and Seriously Ill Patients
Auriemma, C. L., Taylor, S. P., Harhay, M. O., Courtright, K. R., & Halpern, S. D. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202104-1063pp · Cited by 140
Cancer Patient Navigator Tasks across the Cancer Care Continuum
Braun, K. L., Kagawa‐Singer, M., Holden, A. E. C., Burhansstipanov, L., Tran, J. H., Seals, B. F., Corbie-Smith, G. M., Tsark, J. '., Harjo, L. D., Foo, M. A., et al. (2012) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2012.0029 · Cited by 130
Emergency Department Attendance by Patients With Cancer in Their Last Month of Life: A Systematic Review and Meta-Analysis
Henson, L. A., Gao, W., Higginson, I. J., Smith, M., Davies, J. M., Ellis-Smith, C. I., & Daveson, B. A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.3568 · Cited by 129
Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic Bone Metastases: A Multicenter, Randomized Phase II Clinical Trial
Gillespie, E. F., Yang, J. C., Mathis, N. J., Marine, C. B., White, C., Zhang, Z., Barker, C. A., Kotecha, R. R., McIntosh, A. F., Vaynrub, M., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.00753 · Cited by 129
Values and options in cancer care (VOICE): study design and rationale for a patient-centered communication and decision-making intervention for physicians, patients with advanced cancer, and their caregivers
Hoerger, M. P., Epstein, R. M., Winters, P., Fiscella, K. A., Duberstein, P. R., Gramling, R. E., Butow, P. N., Mohile, S. G., Kaesberg, P. R., Tang, W., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-188 · Cited by 127
Raising the Bar for the Care of Seriously Ill Patients
Schaefer, K. G., Chittenden, E., Sullivan, A. M., Periyakoil, V. S., Morrison, L. J., Carey, E. C., Sanchez-Reilly, S. E., & Block, S. D. (2014) · Academic Medicine · doi:10.1097/acm.0000000000000271 · Cited by 127
The Integration of Early Palliative Care With Oncology Care: The Time Has Come for a New Tradition
Bauman, J. R., & Temel, J. S. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0177 · Cited by 127
Self-citation
The effect of real-time electronic monitoring of patient-reported symptoms and clinical syndromes in outpatient workflow of medical oncologists: E-MO AIC, a multicenter cluster-randomized phase III study (SAKK 95/06)
Strasser, F., Blum, D., von Moos, R., Cathomas, R. L., Ribi, K., Aebi, S. P., Betticher, D. C., Hayoz, S., Klingbiel, D., Brauchli, P., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv576 · Cited by 127
Lung cancer: diagnosis, treatment principles, and screening.
Latimer, K. M., & Mott, T. F. (2015) · PubMed · Cited by 127
Neoadjuvant Chemotherapy With Cisplatin and Gemcitabine Followed by Chemoradiation Versus Chemoradiation for Locally Advanced Cervical Cancer: A Randomized Phase II Trial
da Costa, S. C. S., Bonadio, R. C., Gabrielli, F. C. G., Aranha, A., Genta, M. L. N. D., Miranda, V. D. C., Freitas, D., Filho, E. A., Ferreira, P. A. O., Machado, K. K., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.00674 · Cited by 127
The Evolution of Therapies in Non-Small Cell Lung Cancer
Boolell, V., Alamgeer, M., Watkins, D. N., & Ganju, V. (2015) · Cancers · doi:10.3390/cancers7030864 · Cited by 130
Survival prediction for advanced cancer patients in the real world: A comparison of the Palliative Prognostic Score, Delirium-Palliative Prognostic Score, Palliative Prognostic Index and modified Prognosis in Palliative Care Study predictor model
Baba, M., Maeda, I., Morita, T., Inoue, S., Ikenaga, M., Matsumoto, Y., Sekine, R., Yamaguchi, T., Hirohashi, T., Tajima, T., et al. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.04.025 · Cited by 126
Symptoms tell it all: A systematic review of the value of symptom assessment to predict survival in advanced cancer patients
Trajkovic, M., de Graeff, A., Voest, E. E., & Teunissen, S. C. C. M. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.02.011 · Cited by 126
Cost analysis of a prospective multi-site cohort study of palliative care consultation teams for adults with advanced cancer: Where do cost-savings come from?
May, P., Garrido, M. M., Cassel, J. B., Kelley, A. S., Meier, D. E., Normand, C. E. M., Smith, T. J., & Morrison, R. S. (2017) · Palliative Medicine · doi:10.1177/0269216317690098 · Cited by 126
Pediatric palliative care in the community
Kaye, E. C., Rubenstein, J., Levine, D. R., Baker, J. N., Dabbs, D., & Friebert, S. E. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21280 · Cited by 125
Integrated palliative care in Europe: a qualitative systematic literature review of empirically-tested models in cancer and chronic disease
Siouta, N., Beek, K. V., van der Eerden, M. E., Preston, N. J., Hasselaar, J. G. J., Hughes, S. P. F., Garralda, E., Centeno, C., Csikós, Á., Groot, M. M., et al. (2016) · BMC Palliative Care · doi:10.1186/s12904-016-0130-7 · Cited by 125
Palliative Care Consultations in Nursing Homes and Reductions in Acute Care Use and Potentially Burdensome End‐of‐Life Transitions
Miller, S. C., Lima, J. C., Intrator, O. K., Martin, E. W., Bull, J., & Hanson, L. C. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14469 · Cited by 131
Malignant Glioma
Wang, L. M., Englander, Z. K., Miller, M. L., & Bruce, J. N. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-23705-8_1 · Cited by 133
What Is Different About Patients With Hematologic Malignancies? A Retrospective Cohort Study of Cancer Patients Referred to a Hospice Research Network
LeBlanc, T. W., Abernethy, A. P., & Casarett, D. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2014.07.003 · Cited by 124
Does it matter what you call it? A randomized trial of language used to describe palliative care services
Maciasz, R., Arnold, R. M., Chu, E., Park, S. Y., White, D. B., Vater, L. B., & Schenker, Y. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1919-z · Cited by 124
The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy
Quist, M., Adamsen, L., Rørth, M. R., Laursen, J. H., Christensen, K. B., & Langer, S. W. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415572887 · Cited by 131
Clinical evaluation and optimal management of cancer cachexia
Tuca, A., Jiménez‐Fonseca, P., & Gascón, P. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.07.015 · Cited by 126
Defining a standard set of patient-centred outcomes for lung cancer
Mak, K. S., van Bommel, A. C. M., Stowell, C. J., Abrahm, J. L., Baker, M., Baldotto, C. S. D. R., Baldwin, D., Borthwick, D., Carbone, D. P., Chen, A. B., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.02049-2015 · Cited by 122
Barriers to Use of Palliative Care and Advance Care Planning Discussions for Patients With End-Stage Liver Disease
Ufere, N. N., Donlan, J., Waldman, L. P., Dienstag, J. L., Friedman, L. S., Corey, K. E., Hashemi, N., Carolan, P. J., Mullen, A. C., Thiim, M., et al. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.03.022 · Cited by 122
Self-citation
How continuity of care is experienced within the context of integrated palliative care: A qualitative study with patients and family caregivers in five European countries
den Herder-van der Eerden, M., Hasselaar, J., Payne, S., Varey, S., Schwabe, S., Radbruch, L., Van Beek, K., Menten, J., Busa, C., Csikos, A., et al. (2017) · Palliative Medicine · doi:10.1177/0269216317697898 · Cited by 121
Access to palliative care by disease trajectory: a population-based cohort of Ontario decedents
Seow, H. Y., O’Leary, E. M., Perez, R., & Tanuseputro, P. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-021147 · Cited by 121
Medicaid Expansion and Mortality Among Patients With Breast, Lung, and Colorectal Cancer
Lam, M. B., Phelan, J., Orav, E. J., Jha, A. K., & Keating, N. L. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.24366 · Cited by 121
The Impact of Patient Participation in Health Decisions Within Medical Encounters
Clayman, M. L., Bylund, C. L., Chewning, B. A., & Makoul, G. T. (2015) · Medical Decision Making · doi:10.1177/0272989x15613530 · Cited by 127
Acupuncture for Pain Management in Cancer: A Systematic Review and Meta‐Analysis
Hu, C., Zhang, H., Wu, W., Weiqing, Y., Li, Y., Bai, J., Luo, B., & Li, S. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/1720239 · Cited by 120
Comprehensive and Integrated Palliative Care for People With Advanced Chronic Conditions: An Update From Several European Initiatives and Recommendations for Policy
Gómez‐Batiste, X., Murray, S. A., Thomas, K., Blay, C., Boyd, K. J., Moine, S., Gignon, M., den Eynden, B. V., Leysen, B., Wens, J., et al. (2016) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2016.10.361 · Cited by 123
Identification of patients with potential palliative care needs: A systematic review of screening tools in primary care
ElMokhallalati, Y., Bradley, S. H., Chapman, E., Ziegler, L. E., Murtagh, F. E., Johnson, M. J., & Bennett, M. (2020) · Palliative Medicine · doi:10.1177/0269216320929552 · Cited by 119
Guía de Práctica Clínica para el Diagnóstico y Tratamiento de Pacientes con Enfermedad Pulmonar Obstructiva Crónica (EPOC) - Guía Española de la EPOC (GesEPOC)
Task Force of GesEPOC Grupo de Trabajo de GesEPOC (2012) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(12)70035-2 · Cited by 111
The Quality of Dying and Death in Cancer and Its Relationship to Palliative Care and Place of Death
Hales, S., Chiu, A., Husain, A. F., Braun, M., Rydall, A. C., Gagliese, L., Zimmermann, C., & Rodin, G. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.12.240 · Cited by 119
The assessment and impact of sarcopenia in lung cancer: a systematic literature review
Collins, J., Noble, S., Chester, J. D., Coles, B., & Byrne, A. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-003697 · Cited by 119
How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient
Hansen, E., Woods, R. J., & Read, A. F. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001110 · Cited by 123
Knowledge, Attitudes, and Preferences of Advance Decisions, End-of-Life Care, and Place of Care and Death in Hong Kong. A Population-Based Telephone Survey of 1067 Adults
Chung, R. Y., Wong, E. L., Kiang, N., Chau, P. Y. K., Lau, J. Y. C., Wong, S. Y. S., Yeoh, E., & Woo, J. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.12.066 · Cited by 118
Therapeutic applications of curcumin for patients with pancreatic cancer.
Kanai, M. (2014) · PubMed Central · doi:10.3748/wjg.v20.i28.9384 · Cited by 117
Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer
Greer, J. A., Temel, J. S., El-Jawahri, A. R., Rinaldi, S. P., Kamdar, M. M., Park, E. R., Horick, N., Pintro, K., Rabideau, D. J., Schwamm, L. H., et al. (2024) · JAMA · doi:10.1001/jama.2024.13964 · Cited by 117
Self-citation
Etoposide and cisplatin versus irinotecan and cisplatin in patients with limited-stage small-cell lung cancer treated with etoposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy (JCOG0202): a randomised phase 3 study
Kubota, K., Hida, T., Ishikura, S., Mizusawa, J., Nishio, M., Kawahara, M., Yokoyama, A., Imamura, F., Takeda, K., Negoro, S., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70511-4 · Cited by 117
Pediatric oncology providers perceptions of barriers and facilitators to early integration of pediatric palliative care
Dalberg, T., Jacob‐Files, E., Carney, P. A., Meyrowitz, J., Fromme, E. K., & Thomas, G. A. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24673 · Cited by 116
Top 10 Things Palliative Care Clinicians Wished Everyone Knew About Palliative Care
Strand, J. J., Kamdar, M. M., & Carey, E. C. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.05.020 · Cited by 116
Comparison of Palliative Care Delivery in the Last Year of Life Between Adults With Terminal Noncancer Illness or Cancer
Quinn, K. L., Wegier, P., Stukel, T. A., Huang, A., Bell, C. M., & Tanuseputro, P. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.0677 · Cited by 126
Clinical Cancer Advances 2015: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology
Masters, G. A., Krilov, L., Bailey, H. H., Brose, M. S., Burstein, H. J., Diller, L., Dizon, D. S., Fine, H. A., Kalemkerian, G. P., Moasser, M. M., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.9746 · Cited by 119
Palliative Care among Heart Failure Patients in Primary Care: A Comparison to Cancer Patients Using English Family Practice Data
Gadoud, A., Kane, E. V., Macleod, U., Ansell, P., Oliver, S. E., & Johnson, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113188 · Cited by 115
Putting the Value Framework to Work
Lee, T. H.-Y. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1013111 · Cited by 115
Intensive care in patients with lung cancer: a multinational study
Soares, M., Toffart, A., Timsit, J., Burghi, G., Irrazábal, C., Pattison, N. A., Tobar, E. A., Almeida, B. F. C., Silva, U. V. A., Azevedo, L. C. P., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu234 · Cited by 115
Does surgery have a role in managing incurable gastric cancer?
Thrumurthy, S. G., Chaudry, M. A., Chau, I., & Allum, W. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.132 · Cited by 115
Early initiation of palliative care is associated with reduced late-life acute-hospital use: A population-based retrospective cohort study
Qureshi, D., Tanuseputro, P., Perez, R., Pond, G. R., & Seow, H. Y. (2018) · Palliative Medicine · doi:10.1177/0269216318815794 · Cited by 115
Knowledge of and beliefs about palliative care in a nationally-representative U.S. sample
Taber, J. M., Ellis, E. M., Reblin, M., Ellington, L., & Ferrer, R. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219074 · Cited by 115
Examining the Knowledge, Awareness, and Perceptions of Palliative Care in the General Public Over Time: A Scoping Literature Review
Patel, P., & Lyons, L. (2019) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909119885899 · Cited by 114
Palliative Care in Advanced Cancer Patients: How and When?
Bruera, E. D., & Yennurajalingam, S. (2012) · The Oncologist · doi:10.1634/theoncologist.2011-0219 · Cited by 114
Palliative care and hematologic oncology: The promise of collaboration
Epstein, A. S., Goldberg, G. R., & Meier, D. E. (2012) · Blood Reviews · doi:10.1016/j.blre.2012.07.001 · Cited by 116
Differences in end‐of‐life communication for children with advanced cancer who were referred to a palliative care team
Kassam, A., Skiadaresis, J., Alexander, S. W., & Wolfe, J. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25530 · Cited by 113
Optimizing quality of life in patients with idiopathic pulmonary fibrosis
van Manen, M. J. G., Geelhoed, J. J. M., Tak, N. C., & Wijsenbeek, M. S. (2017) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465816686743 · Cited by 115
Effect of a Lay Health Worker Intervention on Goals-of-Care Documentation and on Health Care Use, Costs, and Satisfaction Among Patients With Cancer
Patel, M. I., H, V. S. M. P., Desai, M., Periyakoil, V. S., Kahn, J. S., Bhattacharya, J., Asch, S. M., Milstein, A. S., & Bundorf, M. K. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.2446 · Cited by 113
Symptom Management in Metastatic Breast Cancer
Irvin, W., Muss, H. B., & Mayer, D. K. (2011) · The Oncologist · doi:10.1634/theoncologist.2011-0159 · Cited by 112
Identifying Older Adults with Serious Illness: A Critical Step toward Improving the Value of Health Care
Kelley, A. S., Covinsky, K. E., Gorges, R. J., McKendrick, K., Bollens‐Lund, E., Morrison, R. S., & Ritchie, C. S. (2016) · Health Services Research · doi:10.1111/1475-6773.12479 · Cited by 112
Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic
Kang, S., Gergich, K., Lubiniecki, G. M., de Alwis, D. P., Chen, C., Tice, M. A. B., & Rubin, E. H. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx076 · Cited by 113
State of palliative care services at US cancer centers: An updated national survey
Hui, D., Rosa, A. D. L., Chen, J., Dibaj, S. S., Guay, M. D., Heung, Y. J., Liu, D., & Bruera, E. D. (2020) · Cancer · doi:10.1002/cncr.32738 · Cited by 112
Palliative Care Needs in the Neuro-ICU
Creutzfeldt, C. J., Engelberg, R. A., Healey, L., Cheever, C., Becker, K. J., Holloway, R. G., & Curtis, J. R. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001018 · Cited by 112
Effects of a Problem-Solving Intervention (COPE) on Quality of Life for Patients with Advanced Cancer on Clinical Trials and their Caregivers: Simultaneous Care Educational Intervention (SCEI): Linking Palliation and Clinical Trials
Meyers, F. J., Carducci, M. A., Loscalzo, M. J., Linder, J. F., Greasby, T. A., & Beckett, L. A. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0416 · Cited by 120
The impact of routine Edmonton Symptom Assessment System (ESAS) use on overall survival in cancer patients: results of a population-based retrospective matched cohort analysis
Barbera, L., Sutradhar, R., Seow, H., Mittmann, N., Howell, D., Earle, C. C., Li, Q., & Thiruchelvam, D. (2020) · Cancer Medicine · doi:10.1002/cam4.3374 · Cited by 111
Hospice Care and Survival among Elderly Patients with Lung Cancer
Saito, A. M., Landrum, M. B., Neville, B. A., Ayanian, J. Z., Weeks, J. C., & Earle, C. C. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0522 · Cited by 111
Systemic treatment of advanced pancreatic cancer
Heinemann, V., Haas, M., & Boeck, S. H. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.12.004 · Cited by 111
Identifying patients with advanced chronic conditions for a progressive palliative care approach: a cross-sectional study of prognostic indicators related to end-of-life trajectories
Amblàs-Novellas, J., Murray, S. A., Espaulella, J., Martori, J. C., Oller, R., Martínez-Muñoz, M., Molist‐Brunet, N., Blay, C., & Gómez‐Batiste, X. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012340 · Cited by 120
End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review
Walbert, T., & Khan, M. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1393-6 · Cited by 111
The burden of idiopathic pulmonary fibrosis: An unmet public health need
Lee, A. S., Mira-Avendano, I. C., Ryu, J. H., & Daniels, C. E. (2014) · Respiratory Medicine · doi:10.1016/j.rmed.2014.03.015 · Cited by 111
A Nurse Practitioner Directed Intervention Improves the Quality of Life of Patients with Metastatic Cancer: Results of a Randomized Pilot Study
Dyar, S., Lesperance, M., Shannon, R. P., Sloan, J. A., & Colón‐Otero, G. (2012) · Journal of Palliative Medicine · doi:10.1089/jpm.2012.0014 · Cited by 111
Timing of end-of-life care discussion with performance on end-of-life quality indicators in ovarian cancer
Lopez-Acevedo, M., Havrilesky, L. J., Broadwater, G., Kamal, A. H., Abernethy, A. P., Berchuck, A., Secord, A. A., Tulsky, J. A., Valea, F. A., & Lee, P. S. (2013) · Gynecologic Oncology · doi:10.1016/j.ygyno.2013.04.010 · Cited by 111

Authors: Temel, J. S., Greer, J. A., Muzikansky, A., Gallagher, E. R., Admane, S., Jackson, V. A., Dahlin, C. M., Blinderman, C. D., Jacobsen, J., Pirl, W. F., Billings, J. A., & Lynch, T. J.
Affiliations: Massachusetts General Hospital (US)
University at Buffalo, State University of New York (US)
Columbia University Irving Medical Center (US)
Yale University (US)
ORCID: Temel, Jennifer S.
Greer, Joseph A.
Muzikansky, Alona
Gallagher, Emily R.
Admane, Sonal
Jackson, Vicki A.
Dahlin, Constance M.
Blinderman, Craig D.
Jacobsen, Juliet
Pirl, William F.
Lynch, Thomas J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2010-08-19
Volume: 363
Issue: 8
Pages: 733-742
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1000678
OpenAlex: W2147016542
Semantic Scholar: 0cd2002df2a3b3cdf8d351b2a4a7273463c2f318
Cited by: 7,482
References: 38
Citations by year: 2026: 384 · 2025: 413 · 2024: 447 · 2023: 455 · 2022: 513 · 2021: 530 · 2020: 523 · 2019: 515 · 2018: 540 · 2017: 595 · 2016: 528 · 2015: 480 · 2014: 452 · 2013: 405 · 2012: 358
FWCI: 344.27
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Keywords: early palliative care, metastatic non-small cell lung cancer, quality of life, depressive symptoms, end-of-life care, aggressive end-of-life care, survival, patient-reported outcomes, newly diagnosed cancer, outpatients
MeSH terms: Affect, Aged, Carcinoma, Non-Small-Cell Lung, Depression, Female, Humans, Lung Neoplasms, Male, Middle Aged, Palliative Care, Quality of Life, Terminal Care, Time Factors, Linear Models, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks