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Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer
Abstract
BACKGROUND: Patients with metastatic non-small-cell lung cancer have a substantial symptom burden and may receive aggressive care at the end of life. We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes and end-of-life care among ambulatory patients with newly diagnosed disease. METHODS: We randomly assigned patients with newly diagnosed metastatic non-small-cell lung cancer to receive either early palliative care integrated with standard oncologic care or standard oncologic care alone. Quality of life and mood were assessed at baseline and at 12 weeks with the use of the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale and the Hospital Anxiety and Depression Scale, respectively. The primary outcome was the change in the quality of life at 12 weeks. Data on end-of-life care were collected from electronic medical records. RESULTS: Of the 151 patients who underwent randomization, 27 died by 12 weeks and 107 (86% of the remaining patients) completed assessments. Patients assigned to early palliative care had a better quality of life than did patients assigned to standard care (mean score on the FACT-L scale [in which scores range from 0 to 136, with higher scores indicating better quality of life], 98.0 vs. 91.5; P=0.03). In addition, fewer patients in the palliative care group than in the standard care group had depressive symptoms (16% vs. 38%, P=0.01). Despite the fact that fewer patients in the early palliative care group than in the standard care group received aggressive end-of-life care (33% vs. 54%, P=0.05), median survival was longer among patients receiving early palliative care (11.6 months vs. 8.9 months, P=0.02). CONCLUSIONS: Among patients with metastatic non-small-cell lung cancer, early palliative care led to significant improvements in both quality of life and mood. As compared with patients receiving standard care, patients receiving early palliative care had less aggressive care at the end of life but longer survival. (Funded by an American Society of Clinical Oncology Career Development Award and philanthropic gifts; ClinicalTrials.gov number, NCT01038271.)
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“Previous studies have demonstrated the benefit of early integration of palliative care (PC) in oncology.”
In the citing paper
“Furthermore, they found that the patients who received early PC were submitted to fewer aggressive treatments in the final stages of life.”
In the citing paper
“A post-hoc analysis inclusively demonstrated a 2.7-month increase in the overall survival rate of patients who received PC.”
In the citing paper
“Temel et al. [6] evaluated the early integration of PC in non-small cell lung cancer patients who were starting first-line palliative chemotherapy. An improvement in the QL scores and a decrease in the symptoms of depression were evident 12 weeks after randomization.”
In the citing paper
“In distinction from chemotherapy after the second-line setting, palliative care has been associated with equal103–106 or longer107–109 survival in randomized and nonrandomized110 trials of patients with advanced cancer.”
From Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (2015) · cites this paper as [106]
In the citing paper
“In addition, a cluster RCT published since the provisional clinical opinion, which included participants with NSCLC, showed important improvements in QoL, symptoms, and caregiver distress.106”
From Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (2015) · cites this paper as [106]
Citations
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
Toxicity and response criteria of the Eastern Cooperative Oncology Group
Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E., Mcfadden, E. T., & Carbone, P. P. (1982) · American Journal of Clinical Oncology · doi:10.1097/00000421-198212000-00014 · Cited by 11,686
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
Non-small Cell Lung Cancer Collaborative Group (1995) · BMJ · doi:10.1136/bmj.311.7010.899 · Cited by 3,054
Villalba, J. B. (1996) · Lung Cancer · doi:10.1016/0169-5002(96)85918-6 · Cited by 2,510
Bakitas, M., Lyons, K. D., Hegel, M. T., Balan, S., Brokaw, F. C., Seville, J., Hull, J. G., Li, Z., Tosteson, T. D., Byock, I. R., et al. (2009) · JAMA · doi:10.1001/jama.2009.1198 · Cited by 1,726
Aggressiveness of Cancer Care Near the End of Life: Is It a Quality-of-Care Issue?
Earle, C. C., Landrum, M. B., Souza, J. M., Neville, B. A., Weeks, J. C., & Ayanian, J. Z. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.8253 · Cited by 957
Cella, D. F., Bonomi, A. E., Lloyd, S. R., Tulsky, D. S., Kaplan, E. J., & Bonomi, P. (1995) · Lung Cancer · doi:10.1016/0169-5002(95)00450-f · Cited by 750
Sandler, A. B., Nemunaitis, J. J., Denham, C. A., von Pawel, J., Cormier, Y. F., Gatzemeier, U., Mattson, K. V., Manegold, C., Palmer, M., Gregor, A., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.1.122 · Cited by 712
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2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862
Novello, S., Barlesi, F., Califano, R., Cufer, T., Ekman, S., Levra, M. G., Kerr, K., Popat, S., Reck, M., Senan, S., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw326 · Cited by 2,631
Vincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,678
Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy275 · Cited by 2,274
Happy People Live Longer: Subjective Well‐Being Contributes to Health and Longevity
Diener, E., & Chan, M. Y. (2011) · Applied Psychology: Health and Well-Being · doi:10.1111/j.1758-0854.2010.01045.x · Cited by 2,260
FERRELL, B. R., Temel, J. S., Temin, S., Alesi, E. R., Balboni, T. A., Basch, E., Firn, J. I., Paice, J. A., Peppercorn, J. M., Phillips, T., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.1474 · Cited by 2,148
Self-citation2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M. L., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T. B., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8776 · Cited by 2,234
Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial
Zimmermann, C., Swami, N., Krzyzanowska, M., Hannon, B., Leighl, N., Oza, A., Moore, M., Rydall, A., Rodin, G., Tannock, I., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62416-2 · Cited by 1,781
Li, D., Xie, K., Wolff, R. A., & Abbruzzese, J. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15841-8 · Cited by 1,731
Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology
Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A. E., ELIAS, A. D., Farrar, W. B., Forero, A., Giordano, S. H., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0012 · Cited by 1,612
The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer
Guthrie, G. J. K., Charles, K. A., Roxburgh, C. S. D., Horgan, P. G., McMillan, D. C., & Clarke, S. J. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.03.010 · Cited by 1,584
Generalist plus Specialist Palliative Care — Creating a More Sustainable Model
Quill, T. E., & Abernethy, A. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmp1215620 · Cited by 1,464
Knaul, F. M., Farmer, P. E., Krakauer, E. L., De Lima, L., Bhadelia, A., Jiang Kwete, X., Arreola-Ornelas, H., Gómez-Dantés, O., Rodriguez, N. M., Alleyne, G. A. O., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32513-8 · Cited by 1,456
Communication About Serious Illness Care Goals: A Review and Synthesis of Best Practices
Bernacki, R. E., & Block, S. D. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.5271 · Cited by 1,422
McMillan, D. C. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.08.003 · Cited by 1,409
Chemotherapy for advanced gastric cancer
Wagner, D., Syn, N. L. X., Moehler, M. H., Grothe, W., Yong, W. P., Tai, B., Ho, J., & Unverzagt, S. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004064.pub4 · Cited by 1,399
Feldman, D. S., Pamboukian, S. V., Teuteberg, J. J., Birks, E. J., Lietz, K., Moore, S. A., Morgan, J. A., Arabía, F. A., Bauman, M. E., Buchholz, H. W., et al. (2013) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2012.09.013 · Cited by 1,384
Smith, T. J., Temin, S., Alesi, E. R., Abernethy, A. P., Balboni, T. A., Basch, E., FERRELL, B. R., Loscalzo, M., Meier, D. E., Paice, J. A., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.5161 · Cited by 1,313
Bakitas, M. A., Tosteson, T. D., Li, Z., Lyons, K. D., Hull, J. G., Li, Z., Dionne-Odom, J. N., Frost, J., Dragnev, K. H., Hegel, M. T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.6362 · Cited by 1,219
Association Between Palliative Care and Patient and Caregiver Outcomes
Kavalieratos, D., Corbelli, J. A., Zhang, D., Dionne-Odom, J. N., Ernecoff, N. C., Hanmer, J., Hoydich, Z., Ikejiani, D. Z., Klein‐Fedyshin, M., Zimmermann, C., et al. (2016) · JAMA · doi:10.1001/jama.2016.16840 · Cited by 1,183
Gridelli, C., Rossi, A., Carbone, D. P., Guarize, J., Karachaliou, N., Mok, T. S. K., Petrella, F., Spaggiari, L., & Rosell, R. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.9 · Cited by 1,162
Marital Status and Survival in Patients With Cancer
Aizer, A. A., Chen, M., McCarthy, E. P., Mendu, M. L., Koo, S., Wilhite, T. J., Graham, P. L., Choueiri, T. K., Hoffman, K. E., Martin, N. E., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.6489 · Cited by 1,053
van der Steen, J. T., Radbruch, L., Hertogh, C. M., de Boer, M. E., Hughes, J. C., Larkin, P., Francke, A. L., Jünger, S., Gove, D., Firth, P., et al. (2014) · Palliative Medicine · doi:10.1177/0269216313493685 · Cited by 997
Change in End-of-Life Care for Medicare Beneficiaries
Teno, J. M., Gozalo, P. L., Bynum, J., Leland, N. E., Miller, S. C., Morden, N. E., Scupp, T., Goodman, D. C., & Mor, V. (2013) · JAMA · doi:10.1001/jama.2012.207624 · Cited by 998
Shared decision making: Concepts, evidence, and practice
Stiggelbout, A. M., Pieterse, A. H., & de Haes, J. C. J. M. (2015) · Patient Education and Counseling · doi:10.1016/j.pec.2015.06.022 · Cited by 1,010
Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis
Levit, L. A., Balogh, E. P., Nass, S. J., & Ganz, P. A. (2014) · Cited by 956
Peters, S., Adjei, A. A., Gridelli, C., Reck, M., Kerr, K. M., & Felip, E. (2012) · Annals of Oncology · doi:10.1093/annonc/mds226 · Cited by 940
Non–Small Cell Lung Cancer, Version 4.2024
Riely, G. J., Wood, D. E., Ettinger, D. S., Aisner, D. L., Akerley, W., Bauman, J. R., Bharat, A., Bruno, D. S., Chang, J. Y., Chirieac, L. R., et al. (2024) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2204.0023 · Cited by 945
Treatment of epithelial ovarian cancer
Kuroki, L. M., & Guntupalli, S. R. (2020) · BMJ · doi:10.1136/bmj.m3773 · Cited by 904
Sleeman, K. E., de Brito, M. F., Etkind, S. N., Nkhoma, K. B., Guo, P., Higginson, I. J., Gomes, B., & Harding, R. (2019) · The Lancet Global Health · doi:10.1016/s2214-109x(19)30172-x · Cited by 875
Masters, G. A., Temin, S., Azzoli, C. G., Giaccone, G., Baker, S., Brahmer, J. R., Ellis, P. M., Gajra, A., Rackear, N., Schiller, J. H., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.1342 · Cited by 850
Nasim, F., Sabath, B. F., & Eapen, G. A. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.12.006 · Cited by 860
Temel, J. S., Greer, J. A., El-Jawahri, A. R., Pirl, W. F., Park, E. R., Jackson, V. A., Back, A. L., Kamdar, M. M., Jacobsen, J. C., Chittenden, E., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.5046 · Cited by 839
Self-citationIntegration of oncology and palliative care: a Lancet Oncology Commission
Kaasa, S., Loge, J. H., Aapro, M., Albreht, T., Anderson, R., Bruera, E. D., Brunelli, C., Caraceni, A. T., Cervantes, A. M. R., Currow, D. C., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30415-7 · Cited by 879
Cherny, N. I., Sullivan, R., Dafni, U., Kerst, J. M., Sobrero, A., Zielinski, C., de Vries, E. G. E., & Piccart, M. J. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv249 · Cited by 818
Decision Making in Advanced Heart Failure
Allen, L. A., Stevenson, L. W., Grady, K. L., Goldstein, N. E., Matlock, D. D., Arnold, R. M., Cook, N. R., Felker, G. M., Francis, G. S., Hauptman, P. J., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31824f2173 · Cited by 833
Palliative Care for the Seriously Ill
Kelley, A. S., & Morrison, R. S. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1404684 · Cited by 817
Gomes, B., Calanzani, N., Curiale, V., McCrone, P., Higginson, I. J., & de Brito, M. F. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007760.pub2 · Cited by 848
Early palliative care for adults with advanced cancer
Haun, M. W., Estel, S., Rücker, G., Friederich, H.-C., Villalobos, M., Thomas, M., & Hartmann, M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011129.pub2 · Cited by 757
NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 4.2016
Ettinger, D. S., Wood, D. E., Akerley, W., Bazhenova, L. A., Borghaei, H., Camidge, D. R., Cheney, R. T., Chirieac, L. R., D’Amico, T. A., Dilling, T. J., et al. (2016) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2016.0031 · Cited by 744
_, _. (2008) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2008.0021 · Cited by 737
Happy People Live Longer: Subjective Well-Being Contributes to Health and Longevity
Diener, E., & Chan, M. Y. (2010) · PsycEXTRA Dataset · doi:10.1037/e675972011-001 · Cited by 727
Delivering affordable cancer care in high-income countries
Sullivan, R., Peppercorn, J., Sikora, K., Zalcberg, J., Meropol, N. J., Amir, E., Khayat, D., Boyle, P., Autier, P., Tannock, I. F., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70141-3 · Cited by 718
Management of non-small-cell lung cancer: recent developments
Reck, M., Heigener, D. F., Mok, T. S. K., Soria, J., & Rabe, K. F. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61502-0 · Cited by 730
Temel, J. S., Greer, J. A., Admane, S., Gallagher, E. R., Jackson, V. A., Lynch, T. J., Lennes, I. T., Dahlin, C., & Pirl, W. F. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.4459 · Cited by 700
Self-citationNates, J. L., Nunnally, M., Kleinpell, R., Blosser, S., Goldner, J., Birriel, B., Fowler, C. S., Byrum, D., Miles, W. S., Bailey, H., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001856 · Cited by 683
Reck, M., Popat, S., Reinmuth, N., Ruysscher, D. D., Kerr, K. M., & Peters, S. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu199 · Cited by 688
de Moor, J. S., Mariotto, A. B., Parry, C., Alfano, C. M., Padgett, L., Kent, E. E., Forsythe, L., Scoppa, S., Hachey, M., & Rowland, J. H. (2013) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-1356 · Cited by 670
Guiding Principles for the Care of Older Adults with Multimorbidity: An Approach for Clinicians
American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04188.x · Cited by 681
Adult Cancer Pain, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
Swarm, R. A., Paice, J. A., Anghelescu, D. L., Are, M., Bruce, J. Y., Buga, S., Chwistek, M., Cleeland, C. S., Craig, D. S., Gafford, E. F., et al. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.0038 · Cited by 641
Rehospitalization for Heart Failure
Desai, A. S., & Stevenson, L. W. (2012) · Circulation · doi:10.1161/circulationaha.112.125435 · Cited by 616
Higginson, I. J., Bausewein, C., Reilly, C. C., Gao, W., Gysels, M., Dzingina, M., McCrone, P., Booth, S., Jolley, C. J., & Moxham, J. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70226-7 · Cited by 605
Palliative Care in Heart Failure
Rogers, J. G., Patel, C. B., Mentz, R. J., Granger, B. B., Steinhauser, K. E., Fiuzat, M., Adams, P. A., Speck, A., Johnson, K. S., Krishnamoorthy, A., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.030 · Cited by 603
Greer, J. A., Pirl, W. F., Jackson, V. A., Muzikansky, A., Lennes, I. T., Heist, R. S., Gallagher, E. R., & Temel, J. S. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.7996 · Cited by 586
Self-citationEricsson, K. A. (2015) · Academic Medicine · doi:10.1097/acm.0000000000000939 · Cited by 542
Peppercorn, J. M., Smith, T. J., Helft, P. R., Debono, D. J., Berry, S. R., Wollins, D. S., Hayes, D. M., Roenn, J. H. V., & Schnipper, L. E. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.1744 · Cited by 541
Greco, M. T., Roberto, A., Corli, O., Deandrea, S., Bandieri, E., Cavuto, S., & Apolone, G. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.0383 · Cited by 509
Addressing the challenges of pancreatic cancer: Future directions for improving outcomes
Hidalgo, M. M., Cascinu, S., Kleeff, J. H., Labianca, R., Löhr, M. J., Neoptolemos, J. P., Real, F. X., Laethem, J. V., & Heinemann, V. (2014) · Pancreatology · doi:10.1016/j.pan.2014.10.001 · Cited by 530
Li, D., Sun, C., Kim, H., Soto‐Pérez‐de‐Celis, E., Chung, V. M., Koczywas, M., Fakih, M., Chao, J., Chien, L. C., Charles, K., et al. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.4158 · Cited by 499
Portenoy, R. K. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60236-5 · Cited by 491
Racial and Ethnic Disparities in Palliative Care
Johnson, K. S. (2013) · Journal of Palliative Medicine · doi:10.1089/jpm.2013.9468 · Cited by 483
Denis, F., Lethrosne, C., Pourel, N., Molinier, O., Pointreau, Y., Domont, J., Bourgeois, H., Senellart, H., Trémolières, P., Lizée, T., et al. (2017) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djx029 · Cited by 482
Vanbutsele, G., Pardon, K., Belle, S. V., Surmont, V. F. M., Laat, M. D., Colman, R., Eecloo, K., Cocquyt, V., Geboes, K., & Deliëns, L. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30060-3 · Cited by 479
Palliative Care Consultation Teams Cut Hospital Costs For Medicaid Beneficiaries
Morrison, R. S., Dietrich, J., Ladwig, S., Quill, T. E., Sacco, J., Tangeman, J. C., & Meier, D. E. (2011) · Health Affairs · doi:10.1377/hlthaff.2010.0929 · Cited by 469
Recent advances in the management of lung cancer
Jones, G. S., & Baldwin, D. (2018) · Clinical Medicine · doi:10.7861/clinmedicine.18-2-s41 · Cited by 478
Seow, H. Y., Barbera, L. C., Sutradhar, R., Howell, D., Dudgeon, D. J., Atzema, C. L., Liu, Y., Husain, A. F., SUSSMAN, J. S., & Earle, C. C. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.7173 · Cited by 456
Hui, D., Kim, S., Roquemore, J., Dev, R., Chisholm, G. B., & Bruera, E. D. (2014) · Cancer · doi:10.1002/cncr.28628 · Cited by 451
Cancer in Adolescents and Young Adults
Barr, R. D., Ferrari, A., Ries, L., Whelan, J., & Bleyer, W. A. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.4689 · Cited by 462
Bernacki, R., Hutchings, M., Vick, J. B., Smith, G., Paladino, J., Lipsitz, S. R., Gawande, A. A., & Block, S. D. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009032 · Cited by 468
Hui, D., Hannon, B. L., Zimmermann, C., & Bruera, E. D. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21490 · Cited by 443
Curtis, J. R., Back, A. L., Ford, D. W., Downey, L., Shannon, S. E., Doorenbos, A. Z., Kross, E. K., Reinke, L. F., Feemster, L. C., Edlund, B., et al. (2013) · JAMA · doi:10.1001/jama.2013.282081 · Cited by 426
Integrating palliative care into the trajectory of cancer care
Hui, D., & Bruera, E. D. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.201 · Cited by 425
Family Perspectives on Aggressive Cancer Care Near the End of Life
Wright, A. A., Keating, N. L., Ayanian, J. Z., Chrischilles, E. A., Kahn, K. L., Ritchie, C. S., Weeks, J. C., Earle, C. C., & Landrum, M. B. (2016) · JAMA · doi:10.1001/jama.2015.18604 · Cited by 425
End-of-Life Care Discussions Among Patients With Advanced Cancer: A Cohort Study
Mack, J. W., Cronin, A., Taback, N., Huskamp, H. A., Keating, N. L., Malin, J. L., Earle, C. C., & Weeks, J. C. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-3-201202070-00008 · Cited by 420
Ho, T. H., Barbera, L. C., Saskin, R., Lu, H., Neville, B. A., & Earle, C. C. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.9897 · Cited by 411
Technology Growth and Expenditure Growth in Health Care
Chandra, A., & Skinner, J. (2011) · Journal of Economic Literature · doi:10.1257/jel.50.3.645 · Cited by 412
Higginson, I. J., & Evans, C. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181f684e5 · Cited by 405
The impact of psychosocial stress and stress management on immune responses in patients with cancer
Antoni, M. H., & Dhabhar, F. S. (2019) · Cancer · doi:10.1002/cncr.31943 · Cited by 419
Downar, J., Goldman, R., Pinto, R. L., Englesakis, M. F., & Adhikari, N. K. J. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.160775 · Cited by 402
El-Jawahri, A. R., LeBlanc, T. W., Vandusen, H. B., Traeger, L. N., Greer, J. A., Pirl, W. F., Jackson, V. A., Telles, J., Rhodes, A., Spitzer, T. R., et al. (2016) · JAMA · doi:10.1001/jama.2016.16786 · Cited by 399
Self-citationBending the Cost Curve in Cancer Care
Smith, T. J., & Hillner, B. E. (2011) · New England Journal of Medicine · doi:10.1056/nejmsb1013826 · Cited by 397
Gaertner, J., Siemens, W., Meerpohl, J. J., Antes, G., Meffert, C., Xander, C. J., Stock, S., Müeller, D., Schwarzer, G., & Becker, G. (2017) · BMJ · doi:10.1136/bmj.j2925 · Cited by 396
Dobs, A. S., Boccia, R. V., Croot, C. C., Gabrail, N. Y., Dalton, J. T., Hancock, M. L., Johnston, M. A., & Steiner, M. S. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70055-x · Cited by 391
(2019) · Gut and Liver · doi:10.5009/gnl19024 · Cited by 390
Advances in systemic therapy for non-small cell lung cancer
Miller, M., & Hanna, N. H. (2021) · BMJ · doi:10.1136/bmj.n2363 · Cited by 396
Effect of the Serious Illness Care Program in Outpatient Oncology
Bernacki, R., Paladino, J., Neville, B. A., Hutchings, M., Kavanagh, J. E., Geerse, O. P., Lakin, J. R., Sanders, J. J., Miller, K., Lipsitz, S. R., et al. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.0077 · Cited by 383
Perceptions of palliative care among patients with advanced cancer and their caregivers
Zimmermann, C., Swami, N., Krzyzanowska, M. K., Leighl, N. B., Rydall, A. C., Rodin, G., Tannock, I. F., & Hannon, B. L. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.151171 · Cited by 413
Henson, L. A., Maddocks, M. M., Evans, C., Davidson, M., Hicks, S., & Higginson, I. J. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.00470 · Cited by 381
Meier, D. E. (2011) · Milbank Quarterly · doi:10.1111/j.1468-0009.2011.00632.x · Cited by 378
Aldridge, M. D., Hasselaar, J. G. J., Garralda, E., der Eerden, M. D. H.-V., Stevenson, D. G., McKendrick, K., Centeno, C., & Meier, D. E. (2015) · Palliative Medicine · doi:10.1177/0269216315606645 · Cited by 377
Lown, B. A., Rosen, J. A., & Marttila, J. (2011) · Health Affairs · doi:10.1377/hlthaff.2011.0539 · Cited by 376
Cancer and systemic inflammation: treat the tumour and treat the host
Roxburgh, C. S. D., & McMillan, D. C. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.90 · Cited by 367
Dolan, R. D., McSorley, S. T., Horgan, P. G., Laird, B. J. A., & McMillan, D. C. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.06.002 · Cited by 359
Models of Palliative Care Delivery for Patients With Cancer
Hui, D., & Bruera, E. D. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.18.02123 · Cited by 350
Ettinger, D. S., Akerley, W., Borghaei, H., Chang, A. C., Cheney, R. T., Chirieac, L. R., D’Amico, T. A., Demmy, T. L., Ganti, A. K., Govindan, R., et al. (2012) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2012.0130 · Cited by 352
2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
Korean Liver Cancer Association (KLCA), & National Cancer Center (NCC) Korea (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0294 · Cited by 364
Stress and cancer: mechanisms, significance and future directions
Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00395-5 · Cited by 348
Greer, J. A., Jackson, V. A., Meier, D. E., & Temel, J. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21192 · Cited by 346
Self-citation
Metadata
- Authors
- Temel, J. S., Greer, J. A., Muzikansky, A., Gallagher, E. R., Admane, S., Jackson, V. A., Dahlin, C. M., Blinderman, C. D., Jacobsen, J., Pirl, W. F., Billings, J. A., & Lynch, T. J.
- Affiliations
- Massachusetts General Hospital (US)
- University at Buffalo, State University of New York (US)
- Columbia University Irving Medical Center (US)
- Yale University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-08-19
- Volume
- 363
- Issue
- 8
- Pages
- 733-742
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2147016542
- Semantic Scholar
- 0cd2002df2a3b3cdf8d351b2a4a7273463c2f318
- Cited by
- 7,482
- References
- 38
- Citations by year
- 2026: 384 · 2025: 413 · 2024: 447 · 2023: 455 · 2022: 513 · 2021: 530 · 2020: 523 · 2019: 515 · 2018: 540 · 2017: 595 · 2016: 528 · 2015: 480 · 2014: 452 · 2013: 405 · 2012: 358
- FWCI
- 344.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- early palliative care, metastatic non-small cell lung cancer, quality of life, depressive symptoms, end-of-life care, aggressive end-of-life care, survival, patient-reported outcomes, newly diagnosed cancer, outpatients
- MeSH terms
- Affect, Aged, Carcinoma, Non-Small-Cell Lung, Depression, Female, Humans, Lung Neoplasms, Male, Middle Aged, Palliative Care, Quality of Life, Terminal Care, Time Factors, Linear Models, Kaplan-Meier Estimate
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