The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Severe Hypoglycemia and Risks of Vascular Events and Death
Open accessAbstract
BACKGROUND: Severe hypoglycemia may increase the risk of a poor outcome in patients with type 2 diabetes assigned to an intensive glucose-lowering intervention. We analyzed data from a large study of intensive glucose lowering to explore the relationship between severe hypoglycemia and adverse clinical outcomes. METHODS: We examined the associations between severe hypoglycemia and the risks of macrovascular or microvascular events and death among 11,140 patients with type 2 diabetes, using Cox proportional-hazards models with adjustment for covariates measured at baseline and after randomization. RESULTS: During a median follow-up period of 5 years, 231 patients (2.1%) had at least one severe hypoglycemic episode; 150 had been assigned to intensive glucose control (2.7% of the 5571 patients in that group), and 81 had been assigned to standard glucose control (1.5% of the 5569 patients in that group). The median times from the onset of severe hypoglycemia to the first major macrovascular event, the first major microvascular event, and death were 1.56 years (interquartile range, 0.84 to 2.41), 0.99 years (interquartile range, 0.40 to 2.17), and 1.05 years (interquartile range, 0.34 to 2.41), respectively. During follow-up, severe hypoglycemia was associated with a significant increase in the adjusted risks of major macrovascular events (hazard ratio, 2.88; 95% confidence interval [CI], 2.01 to 4.12), major microvascular events (hazard ratio, 1.81; 95% CI, 1.19 to 2.74), death from a cardiovascular cause (hazard ratio, 2.68; 95% CI, 1.72 to 4.19), and death from any cause (hazard ratio, 2.69; 95% CI, 1.97 to 3.67) (P<0.001 for all comparisons). Similar associations were apparent for a range of nonvascular outcomes, including respiratory, digestive, and skin conditions (P<0.01 for all comparisons). No relationship was found between repeated episodes of severe hypoglycemia and vascular outcomes or death. CONCLUSIONS: Severe hypoglycemia was strongly associated with increased risks of a range of adverse clinical outcomes. It is possible that severe hypoglycemia contributes to adverse outcomes, but these analyses indicate that hypoglycemia is just as likely to be a marker of vulnerability to such events. (Funded by Servier and the National Health and Medical Research Council of Australia; ClinicalTrials.gov number, NCT00145925.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the frequency of severe hypoglycemia in these trials was 2 to 3 times higher in the intensive therapy groups”
From Targets for Glycemic Control (2018) · cites this paper as [31]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In people with type 2 diabetes and established, or very high risk for, cardiovascular disease (CVD), there is a clear association between an increased mortality and severe hypoglycemia (62,63) and symptomatic hypoglycemia (64).”
From Hypoglycemia (2018) · cites this paper as [63]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Post hoc analysis of clinical trials examining the effects of strict glycemic control on cardiovascular outcomes showed that exposure to severe hypoglycemia was strongly associated with a range of adverse outcomes, including death (2, 3).”
From Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial (2025) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“In ADVANCE, where rates of hypoglycemia were low, a similar pattern was found (47).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [47]
The cited source says what the claim attributes to it.
In the citing paper
“a higher mortality was reported in participants with 1 or more episodes of severe hypoglycemia in the ACCORD (30), ADVANCE (31) and VADT trials (25), irrespective of the different treatment arms in which individual participants were allocated.”
From Targets for Glycemic Control (2018) · cites this paper as [31]
The cited source says what the claim attributes to it.
In the citing paper
“An association of level 3 hypoglycemia with mortality was also found in the ADVANCE trial and in clinical practice (77,78).”
From 6. Glycemic Goals, Hypoglycemia, and Hyperglycemic Crises: Standards of Care in Diabetes-2026. (2026) · cites this paper as [77]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“U500 regular insulin (contains 500 units/mL of regular insulin) may improve glycemia in the therapy of persons with DM who have severe insulin resistance (eg, require >200 total units of insulin/day).1102–1105”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1105]
Experimental — accuracy not yet measuredIn the citing paper
“multiple studies have shown a strong relationship between hypoglycemia (severe or not severe) and cardiovascular events and mortality”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [197]
In the citing paper
“All three trials clearly demonstrated that an episode of severe hypoglycemia was associated with an increased risk of subsequent mortality.”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [47]
In the citing paper
“In ADVANCE, where rates of hypoglycemia were low, a similar pattern was found (47).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [47]
In the citing paper
“An association of level 3 hypoglycemia with mortality was also found in the ADVANCE trial (90).”
From 6. Glycemic Targets: Standards of Care in Diabetes—2023 (2023) · cites this paper as [90]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649
Effects of Intensive Glucose Lowering in Type 2 Diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802987 · Cited by 7,397
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493
Glucose control and vascular complications in veterans with type 2 diabetes
Duckworth, W., Abraira, C., Moritz, T., Reda, D., Emanuele, N., Reaven, P. D., Zieve, F. J., Marks, J., Davis, S. N., Hayward, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808431 · Cited by 4,762
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Patel, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61303-8 · Cited by 2,054
Self-citationIntensive glucose control and macrovascular outcomes in type 2 diabetes
Turnbull, F. M., Abraira, C., Anderson, R. J., Byington, R. P., Chalmers, J. P., Duckworth, W. C., Evans, G. W., Gerstein, H. C., Holman, R. R., Moritz, T. E., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1470-0 · Cited by 1,189
Self-citationGerstein, H. C., Miller, M., & Byington, R. P. (2010) · Cited by 981
Bonds, D. E., Miller, M. E., Bergenstal, R. M., Buse, J. B., Byington, R. P., Cutler, J. A., Dudl, R. J., Ismail-Beigi, F., Kimel, A. R., Hoogwerf, B., et al. (2010) · BMJ · doi:10.1136/bmj.b4909 · Cited by 933
Flagged first, then by citations
Research works printed but not linked: 3
- Therneau TM, Grambsch PM. Modelling survival data: extending the Cox model. New York: Springer, 2000.
- Hoekstra JBL, 2009, Diabetologia, 52, 237
- Miller ME, 2009, Diabetologia, 52, 63
Cited by
Sorted by citations
Items 601–700 of 1,002
The cardiovascular effects of insulin
Younk, L. M., Lamos, E. M., & Davis, S. N. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.919256 · Cited by 20
Simeone, J. C., & Quilliam, B. J. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q352 · Cited by 20
Hypoglycemic Potential of Current and Emerging Pharmacotherapies in Type 2 Diabetes Mellitus
Brunton, S. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.07.2570 · Cited by 19
Intensive Glycemic Therapy in Patients With Type 2 Diabetes on β-Blockers
Tsujimoto, T., Sugiyama, T., Noda, M., & Kajio, H. (2016) · Diabetes Care · doi:10.2337/dc16-0721 · Cited by 19
Brown, K., Setji, T. L., Hale, S. L., Cooper, A. A., Hong, B. D., Herbst, R., Musser, R. C., Freeman, S., Shaikewitz, T., Greenlee, J., et al. (2018) · American Journal of Medical Quality · doi:10.1177/1062860618764610 · Cited by 19
HAMSCs/HBMSCs coculture system ameliorates osteogenesis and angiogenesis against glucolipotoxicity
Zhang, C., Du, Y., Yuan, H., Jiang, F., Shen, M., Wang, Y., & Wang, R. (2018) · Biochimie · doi:10.1016/j.biochi.2018.06.028 · Cited by 19
Lysy, Z., Fung, K., Giannakeas, V., Fischer, H. D., Bell, C. M., & Lipscombe, L. L. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-04849-3 · Cited by 19
Ma, S., Schreiner, P. J., Seaquist, E. R., Ugurbil, M., Zmora, R., & Chow, L. S. (2020) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2020.103379 · Cited by 20
Abdelhamid, Y. A., Bernjak, A., Phillips, L. K., Summers, M. J., Weinel, L. M., Lange, K. M., Chow, E., Kar, P., Horowitz, M., Heller, S. R., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004810 · Cited by 19
Self-citationHypoglycemia and Adverse Outcomes: Marker or Mediator?
Lipska, K. J., & Kosiborod, M. (2011) · Reviews in Cardiovascular Medicine · doi:10.3909/ricm0586 · Cited by 19
Castaldo, E., Sabato, D., Lauro, D., Sesti, G., & Marini, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028312 · Cited by 19
Sejling, A., Schouwenberg, B., Færch, L., Thorsteinsson, B., de Galan, B. E., & Pedersen‐Bjergaard, U. (2015) · Diabetic Medicine · doi:10.1111/dme.12810 · Cited by 20
Zhu, L., Ang, L. C., Tan, W. B., Xin, X., Bee, Y. M., Goh, S., & Teh, M. M. (2017) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018817707422 · Cited by 19
Pawaskar, M. D., Witt, E. A., Engel, S. S., Rajpathak, S. N., & Iglay, K. (2018) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.11 · Cited by 19
Severe hypoglycemia and incidence of QT interval prolongation among adults with type 2 diabetes
Kaze, A. D., Yuyun, M. F., Erqou, S., Fonarow, G. C., & Echouffo-Tcheugui, J. B. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac195 · Cited by 18
Russo, G. T., Nicolucci, A., Lucisano, G., Rossi, M. C., Ceriello, A., Prattichizzo, F., Manicardi, V., Rocca, A., Bartolo, P. D., Cosmo, S. D., et al. (2024) · Diabetes · doi:10.2337/db24-0166 · Cited by 19
Stidsen, J. V., Nielsen, J. S., Henriksen, J. E., Friborg, S. G., Thomsen, R. W., Olesen, T. B., Olsen, M. H., & Beck‐Nielsen, H. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017493 · Cited by 18
Management of Hyperglycemia in Older Adults with Type 2 Diabetes
Gandhi, G. Y., & Mooradian, A. D. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00910-1 · Cited by 18
He, A., Guo, Y., Xu, Z., Yan, J., Xie, L., Li, Y., Lv, D., & Luo, M. (2022) · Microvascular Research · doi:10.1016/j.mvr.2022.104468 · Cited by 18
Burden of impaired awareness of hypoglycemia in people with diabetes undergoing hemodialysis
Habte‐Asres, H. H., Jiang, Y., Rosenthal, M. J., & Wheeler, D. C. (2024) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2023-003730 · Cited by 18
Williams, M. E., Garg, R., Wang, W., Lacson, R. C., Maddux, F. W., & Lacson, E. (2013) · Hemodialysis International · doi:10.1111/hdi.12110 · Cited by 18
Zhang, X., Liu, Y., Zhang, F., Li, J., & Tong, N. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.03.015 · Cited by 18
Al-Omary, F. A. M. (2017) · Profiles of drug substances, excipients, and related methodology · doi:10.1016/bs.podrm.2017.02.003 · Cited by 18
Diabetes: how to manage patients experiencing hypoglycaemia
Lowe, R. N., Williams, B., & Claus, L. W. (2022) · Drugs in Context · doi:10.7573/dic.2021-9-11 · Cited by 23
Mezquita‐Raya, P., Reyes‐García, R., Moreno, Ó., Muñoz‐Torres, M., Merino-Torres, J. F., Martínez, J. J. G., Jódar-Gimeno, E., Martín, J. E. S., Gargallo-Fernández, M., Soto-González, A., et al. (2013) · Endocrinología y Nutrición (English Edition) · doi:10.1016/j.endoen.2013.11.009 · Cited by 18
Herrmann, K., Zhou, M., Wang, A., & de Bruin, T. W. (2016) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-016-0030-z · Cited by 18
Making Insulin Accessible: Does Inhaled Insulin Fill an Unmet Need?
McGill, J. B., Ahn, D. T., Edelman, S. V., Kilpatrick, C. R., & Cavaiola, T. S. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0370-1 · Cited by 18
Jeon, J. Y., Kim, S. R., Kim, H. J., Kim, D. J., Lee, K. W., Lee, J.-D., & Han, S. J. (2016) · Medicine · doi:10.1097/md.0000000000005365 · Cited by 18
Challenges and unmet needs in basal insulin therapy: lessons from the Asian experience
Chan, W. B., Chen, J.-F., Goh, S., Vũ, T. T. H., Isip-Tan, I. T., Mudjanarko, S. W., Bajpai, S., Mabunay, M. A., & Bunnag, P. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s143046 · Cited by 18
Jiang, D. H., Herrin, J., Van Houten, H. K., & McCoy, R. G. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.50602 · Cited by 17
Christiaens, A., Henrard, S., Boland, B. B., & Sinclair, A. J. (2022) · Diabetic Medicine · doi:10.1111/dme.14994 · Cited by 17
Kirsh, S. R., & Aron, D. C. (2011) · Drugs & Aging · doi:10.2165/11594750-000000000-00000 · Cited by 17
Chang, L.-H., Lin, L., Tsai, M., How, C., Chiang, J., Hsieh, V. C., Hu, S.-Y., & Hsieh, M. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012233 · Cited by 17
Cha, S., Yun, J., Lim, T., Kang, Y., Lee, K., Song, K., Yoo, K., Park, Y., Ko, S., & Ahn, Y. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.6.463 · Cited by 18
Diabetes and cardiovascular disease: from new mechanisms to new therapies
Gajos, G. (2018) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.4227 · Cited by 17
Hellmund, R., Weitgasser, R., & Blissett, D. B. (2018) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2018.14.2.86 · Cited by 17
Misra‐Hebert, A. D., Ji, X., Pantalone, K. M., Hu, B., Dey, T., Milinovich, A., Bauman, J. M., Zimmerman, R. S., & Kattan, M. W. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.107490 · Cited by 17
Pearson, S. M., Whittam, B., Kulavarasalingam, K., Mitchell-Gears, A., James, C., & Ajjan, R. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01204-3 · Cited by 17
Lim, L., Lau, E. S. H., Cheung, J. T. K., Chan, S. P., Ji, L., Lim, S. K., Sirinvaravong, S., Unnikrishnan, A., Luk, A. O. Y., Cortese, V., et al. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14865 · Cited by 18
Access to emergency room for hypoglycaemia in people with diabetes
Salutini, E., Bianchi, C., Santini, M., Dardano, A., Daniele, G., Penno, G., Miccoli, R., & Prato, S. D. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2667 · Cited by 17
Economic Burden of Hypoglycemia in Patients with Type 2 Diabetes Mellitus from Korea
Kim, G., Lee, Y., Han, M. H., Lee, E., Kim, C. H., Kwon, H., Jeong, I., Kang, E. S., & Kim, D. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151282 · Cited by 17
Tsujimoto, T., Sugiyama, T., & Kajio, H. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12878 · Cited by 17
Impact of Glycemic Variability on Cardiovascular Risk in Diabetes
Klimontov, V. V. (2018) · Kardiologiia · doi:10.18087/cardio.2018.10.10152 · Cited by 17
The presence of two reduced function variants in CYP2C9 influences the acute response to glipizide
Chen, L., Li, J. H., Kaur, V., Muhammad, A., Fernandez, M., Hudson, M., Goldfine, A. B., & Florez, J. C. (2019) · Diabetic Medicine · doi:10.1111/dme.14176 · Cited by 17
Christiaens, A., Boland, B. B., Germanidis, M., Dalleur, O., & Henrard, S. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01780-9 · Cited by 17
Pilla, S. J., Kraschnewski, J. L., Lehman, E. B., Kong, L., Francis, E., Poger, J. M., Bryce, C. L., Maruthur, N. M., & Yeh, H.-C. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2021-002153 · Cited by 16
Hypoglykämie und Herzrhythmusstörungen bei Patienten mit Diabetes Typ 2
Hanefeld, M., Ganz, X., & Nolte, C. (2014) · Herz · doi:10.1007/s00059-014-4086-1 · Cited by 17
Taking hypoglycaemia seriously: diabetes, dementia and heart disease
Holt, P. (2011) · British Journal of Community Nursing · doi:10.12968/bjcn.2011.16.5.246 · Cited by 16
GLP-1 receptor agonists in the treatment of Type 2 diabetes
Åhrén, B. (2013) · Diabetes Management · doi:10.2217/dmt.13.41 · Cited by 16
DAILEY, G. E., Gao, L., Aurand, L. A., & Garg, S. K. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12131 · Cited by 16
A Review of Cardiovascular Outcomes in the Treatment of People with Type 2 Diabetes
DAILEY, G. E., & Wang, E. (2014) · Diabetes Therapy · doi:10.1007/s13300-014-0091-x · Cited by 16
Hypoglycaemia: a therapeutic concern in type 2 diabetes
Garber, A. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60947-7 · Cited by 16
Emons, M. F., Bae, J. P., Hoogwerf, B. J., Kindermann, S. L., Taylor, R., & Nathanson, B. H. (2016) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2015-000160 · Cited by 17
Goh, S., Hussein, Z. B., & Rudijanto, A. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12647 · Cited by 16
Ratter, J. M., Rooijackers, H. M. M., Jacobs, C. W. M., de Galan, B. E., Tack, C. J., & Stienstra, R. (2018) · Diabetologia · doi:10.1007/s00125-018-4683-2 · Cited by 16
Hypoglycaemia and Cardiovascular Disease Risk in Patients with Diabetes
Katsiki, N., Kotsa, K., Stoian, A. P., & Mikhailidis, D. P. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200909142658 · Cited by 16
Glycaemic variabilities: Key questions in pursuit of clarity
Monnier, L., Owens, D. R., Colette, C., & Bonnet, F. (2021) · Diabetes & Metabolism · doi:10.1016/j.diabet.2021.101283 · Cited by 16
The Hypoglycemic Risk of Glyburide (Glibenclamide) Compared with Modified-Release Gliclazide
Clemens, K. K., McArthur, E., Dixon, S. N., Fleet, J. L., HRAMIAK, I. M., & Garg, A. X. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.09.087 · Cited by 16
Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease
Clemmer, J. S., Shafi, T., & Obi, Y. (2022) · Current Hypertension Reports · doi:10.1007/s11906-022-01203-7 · Cited by 16
Therapeutic management of diabetic kidney disease
Koya, D., Araki, S., & Haneda, M. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2011.00112.x · Cited by 16
Prevention and management of transplant-associated diabetes
Jenssen, T. G., & Hartmann, A. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.628936 · Cited by 16
Effects of Incretin-Based Therapies on Diabetic Microvascular Complications
Kang, Y. M., & Jung, C. H. (2017) · Endocrinology and Metabolism · doi:10.3803/enm.2017.32.3.316 · Cited by 16
New Glucose-Lowering Agents for Diabetic Kidney Disease
de Vos, L. C., Hettige, T., & Cooper, M. E. (2018) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2018.01.002 · Cited by 16
Bajpai, S., Cambron‐Mellott, M. J., Peck, E. Y., Poon, J. L., Wang, Q., Mitchell, B. D., Babrowicz, J., Child, C. J., RAIBULET, N. K., & Beusterien, K. M. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.08.006 · Cited by 16
Zoungas, S. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13968 · Cited by 16
Self-citationHeller, S. R., Lingvay, I., Marso, S. P., Philis‐Tsimikas, A., Pieber, T. R., Poulter, N. R., Pratley, R. E., HACHMANN-NIELSEN, E., Kvist, K., Lange, M., et al. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14208 · Cited by 16
Self-citationHolstein, J. D., Kovacs, P. L., Patzer, O. M., Stümvoll, M., & Holstein, A. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.150 · Cited by 16
Choi, I. J., Choo, E. H., Kim, H. J., Lim, S., Moon, D., Lee, K. Y., Hwang, B., Kim, C. J., Park, M., Lee, J. M., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01428-x · Cited by 15
Chishiki, T., Nagatomo, Y., Saji, M., Takei, M., Goda, A., Kohno, T., Nakano, S., Nishihata, Y., Ikegami, Y., Shiraishi, Y., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.07.041 · Cited by 15
Moser, O., Rafferty, J., Eckstein, M. L., Aziz, F., Bain, S. C., Bergenstal, R. M., Sourij, H., & Thomas, R. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15102 · Cited by 17
Hypoglycemia and Cardiovascular Outcomes in the CARMELINA and CAROLINA Trials of Linagliptin
Marx, N., Kolkailah, A. A., Rosenstock, J., Johansen, O. E., Cooper, M. E., Alexander, J. H., Toto, R. D., Wanner, C., Espeland, M. A., Mattheus, M., et al. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2023.4602 · Cited by 15
Mellot, M., Jawal, L., Morel, T., Fournier, J., Tubach, F., Cadwallader, J., Christiaens, A., & Zerah, L. (2024) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.11.025 · Cited by 15
Abdelmalak, B., Maheshwari, A., Kovaci, B., Mascha, E. J., Cywiński, J. B., Kurz, A. M., Kashyap, V. S., & Sessler, D. I. (2011) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-011-9509-3 · Cited by 15
Hypoglycemia in Type 2 Diabetes: Current Controversies and Changing Practices
Bloomgarden, Z. T., & EINHORN, D. F. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00066 · Cited by 15
Odawara, M., Kadowaki, T., & Naito, Y. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-20 · Cited by 15
Bozorgmanesh, M., Hadaegh, F., Sheikholeslami, F. H., Ghanbarian, A., & Azizi, F. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-69 · Cited by 15
Wang, J., Lee, I., Lee, W., Lin, S.-D., Su, S., Tu, S., Tseng, Y., Lin, S., & Sheu, W. H. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.12.010 · Cited by 15
Living with type 1 diabetes as experienced by young adults
Carlsund, Å., & Söderberg, S. (2018) · Nursing Open · doi:10.1002/nop2.222 · Cited by 21
Sheikhi, M., Moradi, M., Shahsavary, S., Alimoradi, Z., & Salimi, H. (2020) · BMC Psychology · doi:10.1186/s40359-020-00450-0 · Cited by 15
Defining clinically important hypoglycemia in patients with postbariatric hypoglycemia
Craig, C. M., & McLaughlin, T. (2021) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2021.06.013 · Cited by 15
Porcellati, F., Mauro, S. D., Mazzieri, A., Scamporrino, A., Filippello, A., Fano, M. D., Fanelli, C. G., Purrello, F., Malaguarnera, R., & Piro, S. (2021) · Biomolecules · doi:10.3390/biom11091281 · Cited by 15
Longato, E., Camillo, B. D., Sparacino, G., Tramontan, L., Avogaro, A., & Fadini, G. P. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01414-3 · Cited by 15
Chrysant, S. G., & Chrysant, G. S. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.02.319 · Cited by 15
Gu, W., Ren, Y., Ji, L., Hong, T., Mu, Y., Guo, L., Li, Q., Tian, Q., & Yang, X. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.12.024 · Cited by 16
Self-citationBuysman, E. K., Anderson, A. J., Bacchus, S., & Ingham, M. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0500-4 · Cited by 15
Miao, L., Li, L., Zhu, M., Dong, X., Elwan, H. A. M., & Zou, X. (2019) · Poultry Science · doi:10.3382/ps/pez443 · Cited by 15
Hsieh, Y., Liao, Y., Li, C., Lin, J., Weng, C., Lin, C., Lo, C., Huang, K., Huang, J., Lin, C., et al. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3226 · Cited by 15
Choi, S.-Y., & Ko, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.327 · Cited by 15
Cardiovascular effects of basal insulins
Mannucci, E., Giannini, S., & Dicembrini, I. (2015) · Drug Healthcare and Patient Safety · doi:10.2147/dhps.s43300 · Cited by 14
Cahn, A., Raz, I., Mosenzon, O., Leibowitz, G., Yanuv, I., Rozenberg, A., Iqbal, N., Hirshberg, B., Sjöstrand, M., Stahre, C., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2763 · Cited by 16
Avoiding hypoglycaemia: a new target of care for elderly diabetic patients
Wong, C. (2015) · Hong Kong Medical Journal · doi:10.12809/hkmj144494 · Cited by 14
Luk, A. O. Y., Ho, T. S. T., Lau, E. S. H., Ko, G. T. C., Ozaki, R., Tsang, C.-C., Kong, A. P. S., Ronald, C. W., So, W., Chow, F. C. C., et al. (2016) · Medicine · doi:10.1097/md.0000000000005183 · Cited by 14
Lajara, R., Cengiz, E., & Tanenberg, R. J. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1298522 · Cited by 14
Ohkuma, T., Zoungas, S., Jun, M., Lisheng, L., Mancia, G., Marre, M., Rodgers, A., Williams, B., Woodward, M., Chalmers, J. P., et al. (2019) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13878 · Cited by 14
Self-citationBanerjee, M., Pal, R., Maisnam, I., & Mukhopadhyay, S. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.102943 · Cited by 14
Winhofer, Y., Krššák, M., Wolf, P. S., Anderwald, C. H., Geroldinger, A., Heinze, G., Baumgartner-Parzer, S. M., Marculescu, R., Stulnig, T. M., Wolzt, M., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00371.2014 · Cited by 14
Quality Indicators and Performance Measures in Diabetes Care
Aron, D. C. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0472-y · Cited by 14
Kim, H. M., Lim, J. S., Lee, B., Kang, E. S., Lee, H. C., & Soo, B. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.1.84 · Cited by 14
Wojciechowski, P., Niemczyk-Szechowska, P., Olewińska, E., Jaros, P., Mierzejewska, B., Skarzynska-Duk, J., Malecki, M. T., & Rys, P. (2015) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.2705 · Cited by 14
Effect of Hypoglycemia on the Incidence of Revision in Total Knee Arthroplasty
Roche, M. W., Law, T. Y., Triplet, J. J., Hubbard, Z., Kurowicki, J., & Rosas, S. (2016) · The Journal of Arthroplasty · doi:10.1016/j.arth.2016.07.014 · Cited by 14
Metadata
- Authors
- Zoungas, S., Patel, A., Chalmers, J., de Galan, B. E., Li, Q., Billot, L., Woodward, M., Ninomiya, T., Neal, B., MacMahon, S., Grobbee, D. E., Kengne, A. P., Marre, M., & Heller, S.
- Affiliations
- The University of Sydney (AU)
- University Medical Center Utrecht (NL)
- Hôpital Bichat-Claude-Bernard (FR)
- National Health Service (GB)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-10-07
- Volume
- 363
- Issue
- 15
- Pages
- 1410-1418
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2097995302
- Semantic Scholar
- b73e51368b0f6c3d0c425e6670188db927bc8b09
- Cited by
- 1,471
- References
- 31
- Citations by year
- 2026: 33 · 2025: 49 · 2024: 64 · 2023: 60 · 2022: 66 · 2021: 103 · 2020: 119 · 2019: 99 · 2018: 113 · 2017: 103 · 2016: 107 · 2015: 147 · 2014: 106 · 2013: 98 · 2012: 103
- FWCI
- 71.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- severe hypoglycemia, type 2 diabetes, tight glycemic control, macrovascular events, cardiovascular mortality, all-cause mortality, adverse clinical outcomes, diabetes complications, UKPDS
- MeSH terms
- Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Gliclazide, Humans, Hypoglycemia, Hypoglycemic Agents, Male, Middle Aged, Risk Factors, Vascular Diseases, Proportional Hazards Models, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
