The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease
Open accessAbstract
BACKGROUND: The prevalence and characteristics of pulmonary hypertension in adults with sickle cell disease have not been clearly established. METHODS: In this prospective study, we evaluated 398 outpatients with sickle cell disease (mean age, 34 years) at referral centers in France. All patients underwent Doppler echocardiography, with measurement of tricuspid-valve regurgitant jet velocity. Right heart catheterization was performed in 96 patients in whom pulmonary hypertension was suspected on the basis of a tricuspid regurgitant jet velocity of at least 2.5 m per second. Pulmonary hypertension was defined as a mean pulmonary arterial pressure of at least 25 mm Hg. RESULTS: The prevalence of a tricuspid regurgitant jet velocity of at least 2.5 m per second was 27%. In contrast, the prevalence of pulmonary hypertension as confirmed on catheterization was 6%. The positive predictive value of echocardiography for the detection of pulmonary hypertension was 25%. Among the 24 patients with confirmed pulmonary hypertension, the pulmonary-capillary wedge pressure was 15 mm Hg or less (indicating precapillary pulmonary hypertension) in 11 patients. Patients with confirmed pulmonary hypertension were older and had poorer functional capacity and higher levels of N-terminal pro-brain natriuretic peptide than other patients. In contrast, patients who had a tricuspid regurgitant jet velocity of at least 2.5 m per second without pulmonary hypertension and patients with a tricuspid regurgitant jet velocity of less than 2.5 m per second had similar clinical characteristics. CONCLUSIONS: In this study of adults with sickle cell disease, the prevalence of pulmonary hypertension as confirmed on right heart catheterization was 6%. Echocardiographic evaluation alone had a low positive predictive value for pulmonary hypertension. (Funded by the French Ministry of Health and Assistance Publique-Hôpitaux de Paris; ClinicalTrials.gov number, NCT00434902.).
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Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Updated clinical classification of pulmonary hypertension
Simonneau, G., Gatzoulis, M. A., Adatia, I., Celermajer, D., Denton, C., Ghofrani, A., Gomez Sanchez, M. A., Krishna Kumar, R., Landzberg, M., Machado, R. F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.029 · Cited by 4,191
Self-citationPulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease
Gladwin, M. T., Sachdev, V., Jison, M. L., Shizukuda, Y., Plehn, J. F., Minter, K., Brown, B., Coles, W. A., Nichols, J. S., Ernst, I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035477 · Cited by 1,325
Research works printed but not linked: 23
- 10.1016/0002-9149(94)90760-9 · DOI · Paper page
- 10.1053/hupa.2002.128059 · DOI · Paper page
- 10.1182/blood-2002-03-0948 · DOI · Paper page
- 10.1164/rccm.200610-1498OC · DOI · Paper page
- 10.1056/NEJMra040291 · DOI · Paper page
- 10.1016/j.jacc.2009.04.012 · DOI · Paper page
- 10.1183/09031936.00139009 · DOI · Paper page
- 10.1093/eurheartj/ehp297 · DOI · Paper page
- 10.1111/j.1365-2141.2006.06110.x · DOI · Paper page
- 10.1002/ajh.21058 · DOI · Paper page
- 10.1002/ajh.21016 · DOI
- 10.1016/j.jacc.2009.04.011 · DOI · Paper page
- 10.1002/art.21433 · DOI · Paper page
- 10.1164/rccm.200704-541OC · DOI · Paper page
- 10.1161/CIRCULATIONAHA.108.803221 · DOI · Paper page
- 10.1067/mje.2002.120202 · DOI · Paper page
- 10.1111/j.1540-8175.2006.00305.x · doi:10.1111/j.1540-8175.2006.00305.x
- 10.1016/S0735-1097(85)80172-8 · DOI · Paper page
- 10.1016/0002-9149(90)90711-9 · DOI · Paper page
- 10.1067/mhj.2002.126350 · DOI
- 10.1016/j.jacc.2004.02.032 · DOI · Paper page
- 10.1016/j.echo.2010.05.010 · DOI · Paper page
- 10.1182/blood-2010-02-268193 · DOI · Paper page
Cited by
Updated clinical classification of pulmonary hypertension
Simonneau, G., Gatzoulis, M. A., Adatia, I., Celermajer, D., Denton, C., Ghofrani, A., Gomez Sanchez, M. A., Krishna Kumar, R., Landzberg, M., Machado, R. F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.029 · Cited by 4,191
Self-citationHaemodynamic definitions and updated clinical classification of pulmonary hypertension
Simonneau, G., Montani, D., Celermajer, D. S., Denton, C. P., Gatzoulis, M. A., Krowka, M., Williams, P. G., & Souza, R. (2019) · European Respiratory Journal · doi:10.1183/13993003.01913-2018 · Cited by 3,813
Self-citationRees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61029-x · Cited by 2,504
Management of Sickle Cell Disease: Summary of the 2014 Evidence-Based Report by Expert Panel Members
Yawn, B. P., Buchanan, G. R., Afenyi-Annan, A. N., Ballas, S. K., Hassell, K. L., James, A. H., Jordan, L., Lanzkron, S. M., Lottenberg, R., Savage, W. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.10517 · Cited by 1,599
Pathophysiology of Sickle Cell Disease
Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813
Metadata
- Authors
- Parent, F., Bachir, D., Inamo, J., Lionnet, F., Driss, F., Loko, G., Habibi, A., Bennani, S., Savale, L., Adnot, S., Maitre, B., Yaïci, A., Hajji, L., O'Callaghan, D. S., Clerson, P., Girot, R., Galacteros, F., & Simonneau, G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-07-07
- Volume
- 365
- Issue
- 1
- Pages
- 44-53
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2071771677
- Cited by
- 512
- References
- 3
- FWCI
- 21.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Parent, F., Bachir, D., Inamo, J., Lionnet, F., Driss, F., Loko, G., Habibi, A., Bennani, S., Savale, L., Adnot, S., Maitre, B., Yaïci, A., Hajji, L., O'Callaghan, D. S., Clerson, P., Girot, R., Galacteros, F., & Simonneau, G. (2011). A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1005565
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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