The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
German Outbreak of Escherichia coli O104:H4 Associated with Sprouts
Open accessAbstract
BACKGROUND: A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection was undetermined. METHODS: We conducted a matched case-control study and a recipe-based restaurant cohort study, along with environmental, trace-back, and trace-forward investigations, to determine the source of infection. RESULTS: The case-control study included 26 case subjects with the hemolytic-uremic syndrome and 81 control subjects. The outbreak of illness was associated with sprout consumption in univariable analysis (matched odds ratio, 5.8; 95% confidence interval [CI], 1.2 to 29) and with sprout and cucumber consumption in multivariable analysis. Among case subjects, 25% reported having eaten sprouts, and 88% reported having eaten cucumbers. The recipe-based study among 10 groups of visitors to restaurant K included 152 persons, among whom bloody diarrhea or diarrhea confirmed to be associated with Shiga-toxin-producing E. coli developed in 31 (20%). Visitors who were served sprouts were significantly more likely to become ill (relative risk, 14.2; 95% CI, 2.6 to ∞). Sprout consumption explained 100% of cases. Trace-back investigation of sprouts from the distributor that supplied restaurant K led to producer A. All 41 case clusters with known trading connections could be explained by producer A. The outbreak strain could not be identified on seeds from the implicated lot. CONCLUSIONS: Our investigations identified sprouts as the most likely outbreak vehicle, underlining the need to take into account food items that may be overlooked during subjects' recall of consumption.
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Cites
Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
Tarr, P. I., Gordon, C. A., & Chandler, W. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71144-2 · Cited by 1,774
Michino, H., Araki, K., Minami, S., Takaya, S., Sakai, N., Miyazaki, M., Ono, A., & Yanagawa, H. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010082 · Cited by 508
Infections Associated with Eating Seed Sprouts: An International Concern
Taormina, P. J., Beuchat, L. R., & Slutsker, L. (1999) · Emerging Infectious Diseases · doi:10.3201/eid0505.990503 · Cited by 410
An Outbreak of Hepatitis A Associated with Green Onions
Wheeler, C., Vogt, T. M., Armstrong, G. L., Vaughan, G., Weltman, A., Nainan, O. V., Dato, V., Xia, G., Waller, K., Amon, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050855 · Cited by 311
Large and ongoing outbreak of haemolytic uraemic syndrome, Germany, May 2011
Frank, C., Faber, M. S., Askar, M., Bernard, H., Fruth, A., Gilsdorf, A., Höhle, M., Karch, H., Krause, G., Prager, R., et al. (2011) · Eurosurveillance · doi:10.2807/ese.16.21.19878-en · Cited by 162
Self-citationGault, G., Weill, F., Mariani‐Kurkdjian, P., Silva, N. J., King, L., Aldabe, B. E. M. D. M., Charron, M., Ong, N., Castor, C., Macé, M., et al. (2011) · Eurosurveillance · doi:10.2807/ese.16.26.19905-en · Cited by 101
Askar, M., Faber, M. S., Frank, C., Bernard, H., Gilsdorf, A., Fruth, A., Prager, R., Höhle, M., Suess, T., Wadl, M., et al. (2011) · Eurosurveillance · doi:10.2807/ese.16.22.19883-en · Cited by 88
Self-citationMody, R. K., Greene, S. A., Gaul, L. K., Sever, A. E., Pichette, S., Zambrana, I., Dang, T., Gass, A., Wood, R., Herman, K. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016579 · Cited by 77
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Environmental factors influencing the development and spread of antibiotic resistance
Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux053 · Cited by 1,167
Epidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany
Frank, C., Werber, D., Cramer, J. P., Askar, M., Faber, M., an der Heiden, M., Bernard, H., Fruth, A., Prager, R., Spode, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106483 · Cited by 1,139
Self-citationRole of the Environment in the Transmission of Antimicrobial Resistance to Humans: A Review
Huijbers, P. M. C., Blaak, H., de Jong, M. C. M., Graat, E. A. M., Vandenbroucke-Grauls, C. M. J. E., & de Roda Husman, A. M. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b02566 · Cited by 425
Pandemic lineages of extraintestinal pathogenic Escherichia coli
Riley, L. W. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12646 · Cited by 412
Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action
Carlet, J., Jarlier, V., Harbarth, S., Voss, A., Goossens, H., Pittet, D., & Forum, T. P. O. T. 3. W. H.-A. I. (2012) · Antimicrobial Resistance and Infection Control · doi:10.1186/2047-2994-1-11 · Cited by 350
Metadata
- Authors
- Buchholz, U., Bernard, H., Werber, D., Böhmer, M. M., Remschmidt, C., Wilking, H., Deleré, Y., an der Heiden, M., Adlhoch, C., Dreesman, J., Ehlers, J., Ethelberg, S., Faber, M., Frank, C., Fricke, G., Greiner, M., Höhle, M., Ivarsson, S., Jark, U., Kirchner, M., Koch, J., Krause, G., Luber, P., Rosner, B., Stark, K., & Kühne, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-11-10
- Volume
- 365
- Issue
- 19
- Pages
- 1763-1770
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2327529204
- Cited by
- 721
- References
- 8
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Buchholz, U., Bernard, H., Werber, D., Böhmer, M. M., Remschmidt, C., Wilking, H., Deleré, Y., an der Heiden, M., Adlhoch, C., Dreesman, J., Ehlers, J., Ethelberg, S., Faber, M., Frank, C., Fricke, G., Greiner, M., Höhle, M., Ivarsson, S., Jark, U., . . . Kühne, M. (2011). German Outbreak of Escherichia coli O104:H4 Associated with Sprouts. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1106482
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
