The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area
Open accessAbstract
BACKGROUND: The medial temporal structures, including the hippocampus and the entorhinal cortex, are critical for the ability to transform daily experience into lasting memories. We tested the hypothesis that deep-brain stimulation of the hippocampus or entorhinal cortex alters memory performance. METHODS: We implanted intracranial depth electrodes in seven subjects to identify seizure-onset zones for subsequent epilepsy surgery. The subjects completed a spatial learning task during which they learned destinations within virtual environments. During half the learning trials, focal electrical stimulation was given below the threshold that elicits an afterdischarge (i.e., a neuronal discharge that occurs after termination of the stimulus). RESULTS: Entorhinal stimulation applied while the subjects learned locations of landmarks enhanced their subsequent memory of these locations: the subjects reached these landmarks more quickly and by shorter routes, as compared with locations learned without stimulation. Entorhinal stimulation also resulted in a resetting of the phase of the theta rhythm, as shown on the hippocampal electroencephalogram. Direct hippocampal stimulation was not effective. In this small series, no adverse events associated with the procedure were observed. CONCLUSIONS: Stimulation of the entorhinal region enhanced memory of spatial information when applied during learning. (Funded by the National Institutes of Health and the Dana Foundation.).
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Deep Brain Stimulation for Treatment-Resistant Depression
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Bilateral Deep-Brain Stimulation of the Globus Pallidus in Primary Generalized Dystonia
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Cited by
Probing and regulating dysfunctional circuits using deep brain stimulation
Lozano, A. M., & Lipsman, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.020 · Cited by 665
Targeted enhancement of cortical-hippocampal brain networks and associative memory
Wang, J. X., Rogers, L. M., Gross, E. Z., Ryals, A. J., Dokucu, M. E., Brandstatt, K. L., Hermiller, M. S., & Voss, J. L. (2014) · Science · doi:10.1126/science.1252900 · Cited by 620
Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
Ezzyat, Y., Wanda, P. A., Levy, D. F., Kadel, A., Aka, A., Pedisich, I., Sperling, M. R., Sharan, A. D., Lega, B. C., Burks, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02753-0 · Cited by 347
Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia
Kuhn, J., Hardenacke, K., Lenartz, D., Gruendler, T., Ullsperger, M., Bartsch, C., Mai, J. K., Zilles, K., Bauer, A., Matusch, A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.32 · Cited by 262
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Metadata
- Authors
- Suthana, N., Haneef, Z., Stern, J., Mukamel, R., Behnke, E., Knowlton, B., & Fried, I.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-02-09
- Volume
- 366
- Issue
- 6
- Pages
- 502-510
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2168720389
- Cited by
- 494
- References
- 33
- FWCI
- 18.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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