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Evidence for Adult Lung Growth in Humans
Open accessAbstract
A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement of the remaining left lung and an increase in tissue density. Magnetic resonance imaging (MRI) with the use of hyperpolarized helium-3 gas showed overall acinar-airway dimensions that were consistent with an increase in the alveolar number rather than the enlargement of existing alveoli, but the alveoli in the growing lung were shallower than in normal lungs. This study provides evidence that new lung growth can occur in an adult human.
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Citations
Cited by
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Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W., & Hogan, B. L. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68782 · Cited by 1,776
Schittny, J. C. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2545-0 · Cited by 677
Early lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390
Chung, M.-I., Bujnis, M., Barkauskas, C. E., Kobayashi, Y., & Hogan, B. L. M. (2018) · Development · doi:10.1242/dev.163014 · Cited by 323
Air pollution during pregnancy and lung development in the child
Korten, I., Ramsey, K., & Latzin, P. (2017) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2016.08.008 · Cited by 205
Metadata
- Authors
- Butler, J. P., Loring, S. H., Patz, S., Tsuda, A., Yablonskiy, D. A., & Mentzer, S. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-07-19
- Volume
- 367
- Issue
- 3
- Pages
- 244-247
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2142022122
- Cited by
- 273
- References
- 0
- FWCI
- 18.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Butler, J. P., Loring, S. H., Patz, S., Tsuda, A., Yablonskiy, D. A., & Mentzer, S. J. (2012). Evidence for Adult Lung Growth in Humans. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1203983
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
