The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease
Open accessAbstract
BACKGROUND: The preferred initial treatment for patients with stable coronary artery disease is the best available medical therapy. We hypothesized that in patients with functionally significant stenoses, as determined by measurement of fractional flow reserve (FFR), percutaneous coronary intervention (PCI) plus the best available medical therapy would be superior to the best available medical therapy alone. METHODS: In patients with stable coronary artery disease for whom PCI was being considered, we assessed all stenoses by measuring FFR. Patients in whom at least one stenosis was functionally significant (FFR, ≤0.80) were randomly assigned to FFR-guided PCI plus the best available medical therapy (PCI group) or the best available medical therapy alone (medical-therapy group). Patients in whom all stenoses had an FFR of more than 0.80 were entered into a registry and received the best available medical therapy. The primary end point was a composite of death, myocardial infarction, or urgent revascularization. RESULTS: Recruitment was halted prematurely after enrollment of 1220 patients (888 who underwent randomization and 332 enrolled in the registry) because of a significant between-group difference in the percentage of patients who had a primary end-point event: 4.3% in the PCI group and 12.7% in the medical-therapy group (hazard ratio with PCI, 0.32; 95% confidence interval [CI], 0.19 to 0.53; P<0.001). The difference was driven by a lower rate of urgent revascularization in the PCI group than in the medical-therapy group (1.6% vs. 11.1%; hazard ratio, 0.13; 95% CI, 0.06 to 0.30; P<0.001); in particular, in the PCI group, fewer urgent revascularizations were triggered by a myocardial infarction or evidence of ischemia on electrocardiography (hazard ratio, 0.13; 95% CI, 0.04 to 0.43; P<0.001). Among patients in the registry, 3.0% had a primary end-point event. CONCLUSIONS: In patients with stable coronary artery disease and functionally significant stenoses, FFR-guided PCI plus the best available medical therapy, as compared with the best available medical therapy alone, decreased the need for urgent revascularization. In patients without ischemia, the outcome appeared to be favorable with the best available medical therapy alone. (Funded by St. Jude Medical; ClinicalTrials.gov number, NCT01132495.).
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Citations
Cites
Optimal Medical Therapy with or without PCI for Stable Coronary Disease
Boden, W. E., O'Rourke, R. A., Teo, K. K., Hartigan, P. M., Maron, D. J., Kostuk, W. J., Knudtson, M., Dada, M., Casperson, P., Harris, C. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070829 · Cited by 4,699
Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention
Tonino, P. A. L., De Bruyne, B., Pijls, N. H. J., Siebert, U., Ikeno, F., van `t Veer, M., Klauss, V., Manoharan, G., Engstrøm, T., Oldroyd, K. G., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807611 · Cited by 4,260
Self-citationAssessing the quality of controlled clinical trials
Jüni, P., Altman, D. G., & Egger, M. (2001) · BMJ · doi:10.1136/bmj.323.7303.42 · Cited by 3,309
Self-citationMeasurement of Fractional Flow Reserve to Assess the Functional Severity of Coronary-Artery Stenoses
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Self-citationA Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805796 · Cited by 1,939
Shaw, L. J., Berman, D. S., Maron, D. J., Mancini, G. B. J., Hayes, S. W., Hartigan, P. M., Weintraub, W. S., O’Rourke, R. A., Dada, M., Spertus, J. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.743963 · Cited by 1,605
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Percutaneous Coronary Intervention of Functionally Nonsignificant Stenosis
Pijls, N. H. J., van Schaardenburgh, P., Manoharan, G., Boersma, E., Bech, J.-W., van’t Veer, M., Bär, F., Hoorntje, J., Koolen, J., Wijns, W., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.087 · Cited by 1,516
Self-citationPijls, N. H., van Son, J. A., Kirkeeide, R. L., De Bruyne, B., & Gould, K. L. (1993) · Circulation · doi:10.1161/01.cir.87.4.1354 · Cited by 1,183
Self-citationBech, G. J. W., De Bruyne, B., Pijls, N. H. J., de Muinck, E. D., Hoorntje, J. C. A., Escaned, J., Stella, P. R., Boersma, E., Bartunek, J., Koolen, J. J., et al. (2001) · Circulation · doi:10.1161/01.cir.103.24.2928 · Cited by 911
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2018 ESC/EACTS guidelines on myocardial revascularization
Neumann, F.-J., Sousa-Uva, M., Ahlsson, A., Alfonso, F., Banning, A. P., Benedetto, U., Byrne, R. A., Collet, J.-P., Falk, V., Head, S. J., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy394 · Cited by 7,167
Self-citation2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz425 · Cited by 7,166
Self-citation2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
2024 ESC Guidelines for the management of chronic coronary syndromes
Vrints, C., Andreotti, F., Koskinas, K. C., Rossello, X., Adamo, M., Ainslie, J., Banning, A. P., Budaj, A., Buechel, R. R., Chiariello, G. A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae177 · Cited by 2,774
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001168 · Cited by 1,598
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Metadata
- Authors
- De Bruyne, B., Pijls, N. H. J., Kalesan, B., Barbato, E., Tonino, P. A. L., Piroth, Z., Jagic, N., Möbius-Winkler, S., Rioufol, G., Witt, N., Kala, P., MacCarthy, P., Engström, T., Oldroyd, K. G., Mavromatis, K., Manoharan, G., Verlee, P., Frobert, O., Curzen, N., Johnson, J. B., Jüni, P., & Fearon, W. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-09-13
- Volume
- 367
- Issue
- 11
- Pages
- 991-1001
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2133924558
- Cited by
- 2,772
- References
- 26
- FWCI
- 210.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- De Bruyne, B., Pijls, N. H. J., Kalesan, B., Barbato, E., Tonino, P. A. L., Piroth, Z., Jagic, N., Möbius-Winkler, S., Rioufol, G., Witt, N., Kala, P., MacCarthy, P., Engström, T., Oldroyd, K. G., Mavromatis, K., Manoharan, G., Verlee, P., Frobert, O., Curzen, N., . . . Fearon, W. F. (2012). Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1205361
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