The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
An Inactivated Enterovirus 71 Vaccine in Healthy Children
Open accessAbstract
BACKGROUND: Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease in children and may be fatal. A vaccine against EV71 is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled phase 3 trial involving healthy children 6 to 71 months of age in Guangxi Zhuang Autonomous Region, China. Two doses of an inactivated EV71 vaccine or placebo were administered intramuscularly, with a 4-week interval between doses, and children were monitored for up to 11 months. The primary end point was protection against hand, foot, and mouth disease caused by EV71. RESULTS: A total of 12,000 children were randomly assigned to receive vaccine or placebo. Serum neutralizing antibodies were assessed in 549 children who received the vaccine. The seroconversion rate was 100% 4 weeks after the two vaccinations, with a geometric mean titer of 170.6. Over the course of two epidemic seasons, the vaccine efficacy was 97.4% (95% confidence interval [CI], 92.9 to 99.0) according to the intention-to-treat analysis and 97.3% (95% CI, 92.6 to 99.0) according to the per-protocol analysis. Adverse events, such as fever (which occurred in 41.6% of the participants who received vaccine vs. 35.2% of those who received placebo), were significantly more common in the week after vaccination among children who received the vaccine than among those who received placebo. CONCLUSIONS: The inactivated EV71 vaccine elicited EV71-specific immune responses and protection against EV71-associated hand, foot, and mouth disease. (Funded by the National Basic Research Program and others; ClinicalTrials.gov number, NCT01569581.).
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An Epidemic of Enterovirus 71 Infection in Taiwan
Ho, M., Chen, E.-R., Hsu, K.-H., Twu, S.-J., Chen, K.-T., Tsai, S.-F., Wang, J.-R., & Shih, S.-R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411301 · Cited by 1,166
Self-citationHand, foot, and mouth disease in China, 2008–12: an epidemiological study
Xing, W., Liao, Q., Viboud, C., Zhang, J., Sun, J., Wu, J. T., Chang, Z., Liu, F., Fang, V. J., Zheng, Y., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70342-6 · Cited by 927
Enteroviruses : Polioviruses, Coxsackieviruses, Echoviruses, and Newer Enteroviruses
Pallansch, M. (2001) · Medical Entomology and Zoology · Cited by 890
Zhang, Y., Zhu, Z., Yang, W., Ren, J., Tan, X., Wang, Y., Mao, N., Xu, S., Zhu, S., Cui, A., et al. (2010) · Virology Journal · doi:10.1186/1743-422x-7-94 · Cited by 464
Self-citationWang, S., Liu, C., Tseng, H., Wang, J., Huang, C., Chen, Y., Yang, Y., Lin, S., & Yeh, T. (1999) · Clinical Infectious Diseases · doi:10.1086/520149 · Cited by 303
Self-citationTan, X., Huang, X., Zhu, S., Chen, H., Yu, Q., Wang, H., Huo, X., Zhou, J., Wu, Y., Yan, D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025662 · Cited by 162
Self-citationHu, M., Li, Z., Wang, J., Lin, J., Liao, Y., Lai, S., Guo, Y., Zhao, D., & Yang, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038978 · Cited by 141
Self-citationZhang, Y., Tan, X., Cui, A., Mao, N., Xu, L., Zhu, Z. H., Zhou, J., Shi, J. H., Zhao, Y., Wang, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056341 · Cited by 102
Self-citationSun, L., Huanying, Z., Zheng, H.-Z., Xue, G., He, J., Da-wei, G., Min, K., Liu, Z., Chang-wen, K., Li, J., et al. (2011) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.64.13 · Cited by 57
Self-citationStudy of the Integrated Immune Response Induced by an Inactivated EV71 Vaccine
Liu, L., Zhang, Y., Wang, J., Zhao, H., Jiang, L., Che, Y., Shi, H., Li, R., Mo, Z., Huang, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054451 · Cited by 52
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Enterovirus 71 infection and vaccines
Yi, E.-J., Shin, Y.-J., Kim, J.-H., Kim, T.-G., & Chang, S.-Y. (2017) · Clinical and Experimental Vaccine Research · doi:10.7774/cevr.2017.6.1.4 · Cited by 203
Enterovirus and parechovirus infection in children: a brief overview
de Crom, S. C. M., Rossen, J. W. A., van Furth, A. M., & Obihara, C. C. (2016) · European Journal of Pediatrics · doi:10.1007/s00431-016-2725-7 · Cited by 192
Metadata
- Authors
- Li, R., Liu, L., Mo, Z., Wang, X., Xia, J., Liang, Z., Zhang, Y., Li, Y., Mao, Q., Wang, J., Jiang, L., Dong, C., Che, Y., Huang, T., Jiang, Z., Xie, Z., Wang, L., Liao, Y., Liang, Y., Nong, Y., Liu, J., Zhao, H., Na, R., Guo, L., Pu, J., Yang, E., Sun, L., Cui, P., Shi, H., Wang, J., & Li, Q.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-02-27
- Volume
- 370
- Issue
- 9
- Pages
- 829-837
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2334359746
- Cited by
- 401
- References
- 11
- FWCI
- 28.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, R., Liu, L., Mo, Z., Wang, X., Xia, J., Liang, Z., Zhang, Y., Li, Y., Mao, Q., Wang, J., Jiang, L., Dong, C., Che, Y., Huang, T., Jiang, Z., Xie, Z., Wang, L., Liao, Y., Liang, Y., . . . Li, Q. (2014). An Inactivated Enterovirus 71 Vaccine in Healthy Children. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1303224
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