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Cited by 303Infectious Encephalopathies and EncephalitisViral Infections and Immunology ResearchViral Infections and Outbreaks Research

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Clinical Spectrum of Enterovirus 71 Infection in Children in Southern Taiwan, with an Emphasis on Neurological Complications

Wang, Shih‐Min, Liu, Ching‐Chuan, Tseng, Hui‐Wan, Wang, Jen‐Ren, Huang, Chao‐Ching, Chen, Yung‐Jung, Yang, Yao‐Jong, Lin, Shio‐Jean, Yeh, Tsu‐Fuh·1999·Clinical Infectious Diseases
DOI 10.1086/520149
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Abstract

An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan in 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent of the patients were younger than age 5 years. Hand-foot-and-mouth syndrome occurred in 79% of the children and central nervous system (CNS) involvement in 35%, including nine fatal cases. The predominant neurological presentations were myoclonus (68%), vomiting (53%), and ataxia (35%). Brain stem encephalitis was the cardinal feature of EV71 CNS involvement during this outbreak. Magnetic resonance imaging and pathological findings illustrated that the midbrain, pons, and medulla were the target areas. EV71 brain stem encephalitis can present either with cerebellar signs and an initially mild, reversible course or with overwhelming neurogenic shock and neurogenic pulmonary edema (NPE) resulting in a fatal outcome. Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosis in this epidemic. Early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.

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Crossref · 10.1086/520149

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29 of 29 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Wang, S., Liu, C., Tseng, H., Wang, J., Huang, C., Chen, Y., Yang, Y., Lin, S., & Yeh, T.
Affiliations
  • National Cheng Kung University Hospital (TW)
  • National Cheng Kung University (TW)
Corresponding author
Liu, Ching‐Chuan
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1999-07
Volume
29
Issue
1
Pages
184-190
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/520149
OpenAlex
W2017093959
Cited by
303
References
29
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 6 · 2020: 12 · 2019: 16 · 2018: 10 · 2017: 18 · 2016: 20 · 2015: 10 · 2014: 33 · 2013: 22 · 2012: 21
FWCI
4.94
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cheng Kung University Hospital
  • Chi Mei Medical Center
Topics
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords
enterovirus 71, hand, foot and mouth disease, brainstem encephalitis, neurological complications, neurogenic pulmonary edema, neurogenic shock, myoclonus, ataxia, fatal outcome, children, prognosis
MeSH terms
Adolescent, Animals, Chlorocebus aethiops, Child, Child, Preschool, Disease Outbreaks, Enterovirus Infections, Enterovirus, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Retrospective Studies, Taiwan, Tumor Cells, Cultured, Vero Cells, Treatment Outcome, Encephalitis, Viral

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