The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Adenoma Detection Rate and Risk of Colorectal Cancer and Death
Open accessAbstract
BACKGROUND: The proportion of screening colonoscopic examinations performed by a physician that detect one or more adenomas (the adenoma detection rate) is a recommended quality measure. However, little is known about the association between this rate and patients' risks of a subsequent colorectal cancer (interval cancer) and death. METHODS: Using data from an integrated health care delivery organization, we evaluated the associations between the adenoma detection rate and the risks of colorectal cancer diagnosed 6 months to 10 years after colonoscopy and of cancer-related death. With the use of Cox regression, our estimates of attributable risk were adjusted for the demographic characteristics of the patients, indications for colonoscopy, and coexisting conditions. RESULTS: We evaluated 314,872 colonoscopies performed by 136 gastroenterologists; the adenoma detection rates ranged from 7.4 to 52.5%. During the follow-up period, we identified 712 interval colorectal adenocarcinomas, including 255 advanced-stage cancers, and 147 deaths from interval colorectal cancer. The unadjusted risks of interval cancer according to quintiles of adenoma detection rates, from lowest to highest, were 9.8, 8.6, 8.0, 7.0, and 4.8 cases per 10,000 person-years of follow-up, respectively. Among patients of physicians with adenoma detection rates in the highest quintile, as compared with patients of physicians with detection rates in the lowest quintile, the adjusted hazard ratio for any interval cancer was 0.52 (95% confidence interval [CI], 0.39 to 0.69), for advanced-stage interval cancer, 0.43 (95% CI, 0.29 to 0.64), and for fatal interval cancer, 0.38 (95% CI, 0.22 to 0.65). Each 1.0% increase in the adenoma detection rate was associated with a 3.0% decrease in the risk of cancer (hazard ratio, 0.97; 95% CI, 0.96 to 0.98). CONCLUSIONS: The adenoma detection rate was inversely associated with the risks of interval colorectal cancer, advanced-stage interval cancer, and fatal interval cancer. (Funded by the Kaiser Permanente Community Benefit program and the National Cancer Institute.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Siegel, R., Naishadham, D., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21166 · Cited by 11,825
Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths
Zauber, A. G., Winawer, S. J., O’Brien, M. J., Lansdorp‐Vogelaar, I., van Ballegooijen, M., Hankey, B. F., Shi, W., Bond, J. H., Schapiro, M., Panish, J. F., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1100370 · Cited by 3,185
Self-citationQuality Indicators for Colonoscopy and the Risk of Interval Cancer
Kaminski, M. F., Reguła, J., Kraszewska, E., Polkowski, M., Wojciechowska, U. E., Didkowska, J. A., Zwierko, M., Rupiński, M., Nowacki, M. P., & Butruk, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907667 · Cited by 2,012
Edwards, B. K., Ward, E., Kohler, B. A., Eheman, C., Zauber, A. G., Anderson, R. N., Jemal, A., Schymura, M. J., Lansdorp‐Vogelaar, I., Seeff, L. C., et al. (2010) · Cancer · doi:10.1002/cncr.24760 · Cited by 2,002
Self-citationLieberman, D. A., Rex, D. K., Winawer, S. J., Giardiello, F. M., Johnson, D. A., & Levin, T. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.001 · Cited by 1,889
Self-citationRegression analysis of multivariate incomplete failure time data by modeling marginal distributions
Wei, L. J., Lin, D. Y., & Weissfeld, L. (1989) · Journal of the American Statistical Association · doi:10.1080/01621459.1989.10478873 · Cited by 1,868
Quality indicators for colonoscopy
Rex, D. K., Schoenfeld, P. S., Cohen, J., Pike, I. M., Adler, D. G., Fennerty, M. B., Lieb, J. G., Park, W. G., Rizk, M. K., Sawhney, M. S., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2014.07.058 · Cited by 1,764
Krieger, N. R. (1992) · American Journal of Public Health · doi:10.2105/ajph.82.5.703 · Cited by 1,661
Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies
Rex, D. K., Cutler, C., Lemmel, G. T., Rahmani, E. Y., Clark, D., Helper, D. J., Lehman, G. A., & Mark, D. G. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70214-2 · Cited by 1,552
Quality Indicators for Colonoscopy
Rex, D. K., Schoenfeld, P., Cohen, J., Pike, I. M., Adler, D. G., Fennerty, B. M., Lieb, J. G., II, Park, W. G., Rizk, M. K., Sawhney, M., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.385 · Cited by 1,401
Colonoscopic Withdrawal Times and Adenoma Detection during Screening Colonoscopy
Barclay, R. L., Vicari, J. J., Doughty, A. S., Johanson, J. F., & Greenlaw, R. L. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055498 · Cited by 1,312
Quality Indicators for Colonoscopy
Rex, D. K., Petrini, J. L., Baron, T. H., Chak, A., Cohen, J., Deal, S. E., Hoffman, B., Jacobson, B. C., Mergener, K., Petersen, B. T., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00673.x · Cited by 866
Protection From Colorectal Cancer After Colonoscopy
Brenner, H., Chang-Claude, J. C., Seiler, C. M., Rickert, A., & Hoffmeister, M. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-1-201101040-00004 · Cited by 774
Incomplete Polyp Resection During Colonoscopy—Results of the Complete Adenoma Resection (CARE) Study
Pohl, H., Srivastava, A., Bensen, S. P., Anderson, P., Rothstein, R. I., Gordon, S. R., Levy, L. C., Toor, A., MacKenzie, T. A., Rösch, T., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.043 · Cited by 756
Bressler, B. L., Paszat, L. F., Chen, Z., Rothwell, D. M., Vinden, C., & Rabeneck, L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.10.027 · Cited by 626
Rex, D. K., Rahmani, E. Y., Haseman, J., Lemmel, G. T., Kaster, S., & Buckley, J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70213-0 · Cited by 576
Complications of Colonoscopy in an Integrated Health Care Delivery System
Levin, T. R., Zhao, W. K., Conell, C. A., Seeff, L. C., Manninen, D. L., Shapiro, J. A., & Schulman, J. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-12-200612190-00004 · Cited by 550
Self-citationBaxter, N. N., Sutradhar, R., Forbes, S. S., Paszat, L. F., Saskin, R., & Rabeneck, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.006 · Cited by 518
Location of Adenomas Missed by Optical Colonoscopy
Pickhardt, P. J., Nugent, P. A., Mysliwiec, P. A., Choi, J.-Y., & Schindler, W. R. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-5-200409070-00009 · Cited by 445
Colorectal Cancer in Patients Under Close Colonoscopic Surveillance
Robertson, D. J., Greenberg, E. R., Beach, M. L., Sandler, R. S., Ahnen, D. J., Haile, R. W., Burke, C. A., Snover, D. C., Bresalier, R. S., McKeown‐Eyssen, G., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.012 · Cited by 442
Seeff, L. C., Richards, T. B., Shapiro, J. A., Nadel, M. R., Manninen, D. L., Given, L. S., Dong, F., Winges, L. D., & McKenna, M. T. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.051 · Cited by 431
Chen, S. C., & Rex, D. K. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.01054.x · Cited by 403
Mitchell, S. L., Teno, J. M., Roy, J., Kabumoto, G., & Mor, V. (2003) · JAMA · doi:10.1001/jama.290.1.41 · Cited by 363
Prospective Study of the Frequency and Size Distribution of Polyps Missed by Colonoscopy
Hixson, L. J., Fennerty, M. B., Sampliner, R. E., McGee, D., & Garewal, H. S. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.22.1769 · Cited by 338
Colonoscopic miss rates for right-sided colon cancer: A population-based analysis
Bressler, B. L., Paszat, L. F., Vinden, C., Li, C., He, J., & Rabeneck, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.032 · Cited by 332
Colorectal Cancers Found After a Complete Colonoscopy
Farrar, W. D., Sawhney, M., Nelson, D. B., Lederle, F. A., & Bond, J. H. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.07.012 · Cited by 329
Microsatellite Instability in Interval Colon Cancers
Sawhney, M., Farrar, W. D., Gudiseva, S., Nelson, D. B., Lederle, F. A., Rector, T. S., & Bond, J. H. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.022 · Cited by 322
Regression Analysis of Multivariate Incomplete Failure Time Data by Modeling Marginal Distributions
Wei, L. J., Lin, D. Y., & Weissfeld, L. A. (1989) · Journal of the American Statistical Association · doi:10.2307/2290084 · Cited by 267
Singh, H., Nugent, Z. J., Demers, A. A., & Bernstein, C. N. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.390 · Cited by 261
Five-Year Risk of Colorectal Neoplasia after Negative Screening Colonoscopy
Imperiale, T. F., Glowinski, E. A., Lin, C. Y., Larkin, G. N., Rogge, J. D., & Ransohoff, D. F. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0803597 · Cited by 253
Corley, D. A., Jensen, C. D., Marks, A. R., Zhao, W. K., de Boer, J., Levin, T. R., Doubeni, C. A., FIREMAN, B. H., & Quesenberry, C. P. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.09.010 · Cited by 242
Self-citationPrevalence and predictors of interval colorectal cancers in Medicare beneficiaries
Cooper, G. S., Xu, F., Barnholtz‐Sloan, J. S., SCHLUCHTER, M. D., & Koroukian, S. M. (2011) · Cancer · doi:10.1002/cncr.26602 · Cited by 234
Wide variation in adenoma detection rates at screening flexible sigmoidoscopy
Atkin, W. S., Rogers, P., Cardwell, C. R., Cook, C., Cuzick, J. M., Wardle, J., & Edwards, R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.023 · Cited by 175
Reasons for Failure to Diagnose Colorectal Carcinoma at Colonoscopy
Leaper, M., Johnston, M. J., Barclay, M. L., Dobbs, B. R., & Frizelle, F. (2004) · Endoscopy · doi:10.1055/s-2004-814399 · Cited by 142
Evaluation of Polyp Detection in Relation to Procedure Time of Screening or Surveillance Colonoscopy
Sánchez, W., Harewood, G. C., & Petersen, B. T. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40569.x · Cited by 132
Can we improve adenoma detection rates? A systematic review of intervention studies
Corley, D. A., Jensen, C. D., & Marks, A. R. (2011) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2011.04.017 · Cited by 120
Self-citationWang, Y. R., Cangemi, J. R., Loftus, E. V., & Picco, M. F. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.429 · Cited by 79
Optimal Intervals and Techniques for Screening Sigmoidoscopy--Reply
Schoen, R. E. (2003) · JAMA · doi:10.1001/jama.290.16.2123-b · Cited by 78
Invasive Colorectal Cancer Detected up to 3 Years after a Colonoscopy Negative for Cancer
Hosokawa, O., Shirasaki, S., Kaizaki, Y., Hayashi, H., Douden, K., & Hattori, M. (2003) · Endoscopy · doi:10.1055/s-2003-39665 · Cited by 70
Rogal, S. S., Pinsky, P. F., & Schoen, R. E. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.08.002 · Cited by 44
Efficacy and Effectiveness of Colonoscopy: How Do We Bridge the Gap?
Hewett, D. G., Kahi, C. J., & Rex, D. K. (2010) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2010.07.011 · Cited by 43
Bretthauer, M., Skovlund, E., Grotmol, T., THIISEVENSEN, E., Gondal, G., Huppertz‐Hauss, G., Efskind, P., Hofstad, B., Holmsen, S. T., Eide, T. J., et al. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310006513 · Cited by 34
Nakao, S. K., Fassler, S. A., Sucandy, I., Kim, S., & Zebley, D. M. (2012) · Surgical Endoscopy · doi:10.1007/s00464-012-2543-6 · Cited by 16
Meester, R. G. S., Corley, D. A., Doubeni, C. A., Fletcher, R. H., Jensen, C. D., Levin, T. R., Quinn, V. P., Schottinger, J. E., Zauber, A. G., & van Ballegooijen, M. (2013) · Gastroenterology · doi:10.1016/s0016-5085(13)60670-8 · Cited by 2
Self-citation
Research works printed but not linked: 1
- CPT (current procedural terminology) 2011: professional edition. Chicago: American Medical Association Press, 2010.
Cited by
Sorted by citations
Dekker, E., Tanis, P. J., Vleugels, J. L. A., Kasi, P. M., & Wallace, M. B. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32319-0 · Cited by 5,499
Quality indicators for colonoscopy
Rex, D. K., Schoenfeld, P. S., Cohen, J., Pike, I. M., Adler, D. G., Fennerty, M. B., Lieb, J. G., Park, W. G., Rizk, M. K., Sawhney, M. S., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2014.07.058 · Cited by 1,764
Peery, A. F., Crockett, S. D., Murphy, C. C., Lund, J. L., Dellon, E. S., Williams, J. L., Jensen, E. T., Shaheen, N. J., Barritt, A. S., Lieber, S. R., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.08.063 · Cited by 1,619
Kuipers, E. J., Grady, W. M., Lieberman, D. A., Seufferlein, T. T. W., Sung, J. J. �., Boelens, P. G., van de Velde, C. J. �., & Watanabe, T. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.65 · Cited by 1,746
Quality Indicators for Colonoscopy
Rex, D. K., Schoenfeld, P., Cohen, J., Pike, I. M., Adler, D. G., Fennerty, B. M., Lieb, J. G., II, Park, W. G., Rizk, M. K., Sawhney, M., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.385 · Cited by 1,401
Metadata
- Authors
- Corley, D. A., Jensen, C. D., Marks, A. R., Zhao, W. K., Lee, J. K., Doubeni, C. A., Zauber, A. G., de Boer, J., Fireman, B. H., Schottinger, J. E., Quinn, V. P., Ghai, N. R., Levin, T. R., & Quesenberry, C. P.
- Affiliations
- Kaiser Permanente (US)
- University of Pennsylvania (US)
- Memorial Sloan Kettering Cancer Center (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-04-03
- Volume
- 370
- Issue
- 14
- Pages
- 1298-1306
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4036494
- OpenAlex
- W2111147183
- Semantic Scholar
- e0cb208735832bc600fef49a5303a037928bd5e6
- Cited by
- 2,270
- References
- 44
- Citations by year
- 2026: 164 · 2025: 211 · 2024: 198 · 2023: 211 · 2022: 224 · 2021: 218 · 2020: 217 · 2019: 187 · 2018: 177 · 2017: 145 · 2016: 126 · 2015: 126 · 2014: 59
- FWCI
- 73.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01ca151736-06)
- National Cancer Institute (U01 CA-151736, U54CA163262, U24CA171524, P30CA008748)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007007)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- adenoma detection rate, colonoscopy, colorectal cancer, interval cancer, colorectal cancer mortality, advanced colorectal cancer, colonoscopy quality, colorectal adenocarcinoma, gastroenterologists
- MeSH terms
- Adenoma, Aged, Colonoscopy, Humans, Middle Aged, Risk, United States, Colorectal Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
