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The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

Open access
Diacon, Andreas H., Pym, Alexander, Grobusch, Martin P., de los Rios, Jorge M., Gotuzzo, Eduardo, Vasilyeva, Irina, Leimane, Vaira, Andries, Koen, Bakare, Nyasha, De Marez, Tine, Haxaire-Theeuwes, Myriam, Lounis, Nacer, Meyvisch, Paul, De Paepe, Els, van Heeswijk, Rolf P.G., Dannemann, Brian·2014·New England Journal of Medicine
DOI 10.1056/nejmoa1313865
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Abstract

BACKGROUND: Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks. METHODS: In this phase 2b trial, we randomly assigned 160 patients with newly diagnosed, smear-positive, multidrug-resistant tuberculosis to receive either 400 mg of bedaquiline once daily for 2 weeks, followed by 200 mg three times a week for 22 weeks, or placebo, both in combination with a preferred background regimen. The primary efficacy end point was the time to sputum-culture conversion in liquid broth. Patients were followed for 120 weeks from baseline. RESULTS: Bedaquiline reduced the median time to culture conversion, as compared with placebo, from 125 days to 83 days (hazard ratio in the bedaquiline group, 2.44; 95% confidence interval, 1.57 to 3.80; P<0.001 by Cox regression analysis) and increased the rate of culture conversion at 24 weeks (79% vs. 58%, P=0.008) and at 120 weeks (62% vs. 44%, P=0.04). On the basis of World Health Organization outcome definitions for multidrug-resistant tuberculosis, cure rates at 120 weeks were 58% in the bedaquiline group and 32% in the placebo group (P=0.003). The overall incidence of adverse events was similar in the two groups. There were 10 deaths in the bedaquiline group and 2 in the placebo group, with no causal pattern evident. CONCLUSIONS: The addition of bedaquiline to a preferred background regimen for 24 weeks resulted in faster culture conversion and significantly more culture conversions at 120 weeks, as compared with placebo. There were more deaths in the bedaquiline group than in the placebo group. (Funded by Janssen Pharmaceuticals; TMC207-C208 ClinicalTrials.gov number, NCT00449644.).

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Metadata

Authors
Diacon, A. H., Pym, A., Grobusch, M. P., de los Rios, J. M., Gotuzzo, E., Vasilyeva, I., Leimane, V., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., De Paepe, E., van Heeswijk, R. P. G., & Dannemann, B.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2014-08-21
Volume
371
Issue
8
Pages
723-732
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1313865
OpenAlex
W2318000940
Cited by
746
References
13
FWCI
51.92
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. https://app.cochat.ai/papers/10.1056/nejmoa1313865
The paper
Diacon, A. H., Pym, A., Grobusch, M. P., de los Rios, J. M., Gotuzzo, E., Vasilyeva, I., Leimane, V., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., De Paepe, E., van Heeswijk, R. P. G., & Dannemann, B. (2014). Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1313865

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.