The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure
Abstract
BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that early intervention with cardiac-resynchronization therapy with a defibrillator (CRT-D) in patients with an electrocardiographic pattern showing left bundle-branch block was associated with a significant reduction in heart-failure events over a median follow-up of 2.4 years, as compared with defibrillator therapy alone. METHODS: We evaluated the effect of CRT-D on long-term survival in the MADIT-CRT population. Post-trial follow-up over a median period of 5.6 years was assessed among all 1691 surviving patients (phase 1) and subsequently among 854 patients who were enrolled in post-trial registries (phase 2). All reported analyses were performed on an intention-to-treat basis. RESULTS: At 7 years of follow-up after initial enrollment, the cumulative rate of death from any cause among patients with left bundle-branch block was 18% among patients randomly assigned to CRT-D, as compared with 29% among those randomly assigned to defibrillator therapy alone (adjusted hazard ratio in the CRT-D group, 0.59; 95% confidence interval [CI], 0.43 to 0.80; P<0.001). The long-term survival benefit of CRT-D in patients with left bundle-branch block did not differ significantly according to sex, cause of cardiomyopathy, or QRS duration. In contrast, CRT-D was not associated with any clinical benefit and possibly with harm in patients without left bundle-branch block (adjusted hazard ratio for death from any cause, 1.57; 95% CI, 1.03 to 2.39; P=0.04; P<0.001 for interaction of treatment with QRS morphologic findings). CONCLUSIONS: Our findings indicate that in patients with mild heart-failure symptoms, left ventricular dysfunction, and left bundle-branch block, early intervention with CRT-D was associated with a significant long-term survival benefit. (Funded by Boston Scientific; ClinicalTrials.gov numbers, NCT00180271, NCT01294449, and NCT02060110.).
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Citations
Cites
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
Cleland, J. G. F., Daubert, J.-C., Erdmann, E., Freemantle, N., Gras, D., Kappenberger, L., & Tavazzi, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050496 · Cited by 6,276
Self-citationBristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events
Moss, A. J., Hall, W. J., Cannom, D. S., Klein, H., Brown, M. W., Daubert, J. P., Estes, N. A. M., Foster, E., Greenberg, H., Higgins, S. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906431 · Cited by 3,157
Self-citationCardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure
Tang, A. S. L., Wells, G. A., Talajic, M., Arnold, M. O., Sheldon, R., Connolly, S., Hohnloser, S. H., Nichol, G., Birnie, D. H., Sapp, J. L., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1009540 · Cited by 1,859
Linde, C., Abraham, W. T., Gold, M. R., St. John Sutton, M., Ghio, S., & Daubert, C. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.027 · Cited by 1,261
Zareba, W., Klein, H., Cygankiewicz, I., Hall, W. J., McNitt, S., Brown, M., Cannom, D., Daubert, J. P., Eldar, M., Gold, M. R., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.960898 · Cited by 839
Self-citationBradley, D. J., Bradley, E. A., Baughman, K. L., Berger, R. D., Calkins, H., Goodman, S. N., Kass, D. A., & Powe, N. R. (2003) · JAMA · doi:10.1001/jama.289.6.730 · Cited by 710
Cleland, J. G. F., Daubert, J.-C., Erdmann, E., Freemantle, N., Gras, D., Kappenberger, L., Tavazzi, L., & on behalf of The CARE-HF Study Investigators (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl099 · Cited by 654
Self-citationAuricchio, A., Fantoni, C., Regoli, F., Carbucicchio, C., Goette, A., Geller, C., Kloss, M., & Klein, H. (2004) · Circulation · doi:10.1161/01.cir.0000118502.91105.f6 · Cited by 585
Self-citationYpenburg, C., van Bommel, R. J., Delgado, V., Mollema, S. A., Bleeker, G. B., Boersma, E., Schalij, M. J., & Bax, J. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.046 · Cited by 379
Cited by
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab670 · Cited by 19,442
2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz425 · Cited by 7,166
Self-citation2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Metadata
- Authors
- Goldenberg, I., Kutyifa, V., Klein, H. U., Cannom, D. S., Brown, M. W., Dan, A., Daubert, J. P., Estes, N. A. M., Foster, E., Greenberg, H., Kautzner, J., Klempfner, R., Kuniss, M., Merkely, B., Pfeffer, M. A., Quesada, A., Viskin, S., McNitt, S., Polonsky, B., Ghanem, A., Solomon, S. D., Wilber, D., Zareba, W., & Moss, A. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-05
- Volume
- 370
- Issue
- 18
- Pages
- 1694-1701
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2158671861
- Cited by
- 357
- References
- 14
- FWCI
- 31.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goldenberg, I., Kutyifa, V., Klein, H. U., Cannom, D. S., Brown, M. W., Dan, A., Daubert, J. P., Estes, N. A. M., Foster, E., Greenberg, H., Kautzner, J., Klempfner, R., Kuniss, M., Merkely, B., Pfeffer, M. A., Quesada, A., Viskin, S., McNitt, S., Polonsky, B., . . . Moss, A. J. (2014). Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1401426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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