The DOI matches its Crossref record; 22 of the 23 references it cites were found in a registry or an index.
Less-Tight versus Tight Control of Hypertension in Pregnancy
Open accessAbstract
BACKGROUND: The effects of less-tight versus tight control of hypertension on pregnancy complications are unclear. METHODS: We performed an open, international, multicenter trial involving women at 14 weeks 0 days to 33 weeks 6 days of gestation who had nonproteinuric preexisting or gestational hypertension, office diastolic blood pressure of 90 to 105 mm Hg (or 85 to 105 mm Hg if the woman was taking antihypertensive medications), and a live fetus. Women were randomly assigned to less-tight control (target diastolic blood pressure, 100 mm Hg) or tight control (target diastolic blood pressure, 85 mm Hg). The composite primary outcome was pregnancy loss or high-level neonatal care for more than 48 hours during the first 28 postnatal days. The secondary outcome was serious maternal complications occurring up to 6 weeks post partum or until hospital discharge, whichever was later. RESULTS: Included in the analysis were 987 women; 74.6% had preexisting hypertension. The primary-outcome rates were similar among 493 women assigned to less-tight control and 488 women assigned to tight control (31.4% and 30.7%, respectively; adjusted odds ratio, 1.02; 95% confidence interval [CI], 0.77 to 1.35), as were the rates of serious maternal complications (3.7% and 2.0%, respectively; adjusted odds ratio, 1.74; 95% CI, 0.79 to 3.84), despite a mean diastolic blood pressure that was higher in the less-tight-control group by 4.6 mm Hg (95% CI, 3.7 to 5.4). Severe hypertension (≥160/110 mm Hg) developed in 40.6% of the women in the less-tight-control group and 27.5% of the women in the tight-control group (P<0.001). CONCLUSIONS: We found no significant between-group differences in the risk of pregnancy loss, high-level neonatal care, or overall maternal complications, although less-tight control was associated with a significantly higher frequency of severe maternal hypertension. (Funded by the Canadian Institutes of Health Research; CHIPS Current Controlled Trials number, ISRCTN71416914; ClinicalTrials.gov number, NCT01192412.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Data from the previously published Control of Hypertension in Pregnancy Study (CHIPS) supports a target blood pressure goal of 110-135/85 mmHg to reduce the risk of uncontrolled maternal hypertension and minimize impaired fetal growth (125-127).”
From 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2024 (2024) · cites this paper as [126]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The 2015 study (126) excluded pregnancies complicated by preexisting diabetes, and only 6% of participants had GDM at enrollment.”
From 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2024 (2024) · cites this paper as [126]
The cited source says what the claim attributes to it.
In the citing paper
“There was no difference in pregnancy loss, neonatal care, or other neonatal outcomes between the groups with tighter versus less tight control of hypertension (126).”
From 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2024 (2024) · cites this paper as [126]
The cited source says what the claim attributes to it.
In the citing paper
“In CHIPS, aiming for a diastolic blood pressure of 85 mmHg during pregnancy was associated with reduced likelihood of developing accelerated maternal hypertension and no demonstrable adverse outcome for infants compared with aiming for a higher diastolic blood pressure.”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [53]
In the citing paper
“The mean systolic blood pressure achieved in the more intensively treated group was 133.1 ± 0.5 mmHg, and the mean diastolic blood pressure achieved in that group was 85.3 ± 0.3 mmHg.”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2023 (2023) · cites this paper as [46]
In the citing paper
“In CHIPS, targeting a diastolic blood pressure of 85 mmHg during pregnancy was associated with reduced likelihood of developing accelerated maternal hypertension and no demonstrable adverse outcome for infants compared with targeting a higher diastolic blood pressure.”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2023 (2023) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2013) · doi:10.1097/01.aog.0000437382.03963.88 · Cited by 3,961
Saving Mothers’ Lives: Reviewing maternal deaths to make motherhood safer: 2006–2008
Cantwell, R., Clutton-Brock, T. H., COOPER, G. M., Dawson, A. H., Drife, J., Garrod, D., Harper, A., Hulbert, D., Lucas, S. B., McClure, J. H., et al. (2011) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2010.02847.x · Cited by 3,047
Steegers, E. A., von Dadelszen, P., Duvekot, J. J., & Pijnenborg, R. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60279-6 · Cited by 2,850
A New and Improved Population-Based Canadian Reference for Birth Weight for Gestational Age
Kramer, M. S., Platt, R. W., Wen, S. W., Joseph, K. S., Allen, A. C., Abrahamowicz, M., Blondel, B., Bréart, G., & Bréart, G. (2001) · PEDIATRICS · doi:10.1542/peds.108.2.e35 · Cited by 1,526
Antihypertensive drug therapy for mild to moderate hypertension during pregnancy
Abalos, E., Duley, L., & Steyn, D. W. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002252.pub3 · Cited by 705
Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy: Executive Summary
Magee, L. A., Pels, A., Helewa, M. E., Rey, É., von Dadelszen, P., Magee, L. A., Audibert, F., Bujold, E., Côté, A., Douglas, M. J., et al. (2014) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(15)30588-0 · Cited by 684
Self-citationvon Dadelszen, P., Payne, B. A., Li, J., Ansermino, J. M., Pipkin, F. B., Côté, A., Douglas, M. J., Gruslin, A., Hutcheon, J. A., Joseph, K. S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61351-7 · Cited by 593
Self-citationRETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy
Magee, L. A., Helewa, M. E., Rey, É., Cardew, S., Côté, A., Douglas, M. J., Firoz, T., Gibson, P., Gruslin, A., Lange, I. R., et al. (2008) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32776-1 · Cited by 581
Self-citationvon Dadelszen, P., Ornstein, M. P., Bull, S., Logan, A. G., Koren, G., & Magee, L. A. (2000) · The Lancet · doi:10.1016/s0140-6736(98)08049-0 · Cited by 509
Self-citationStroke and Severe Preeclampsia and Eclampsia: A Paradigm Shift Focusing on Systolic Blood Pressure
Martin, J. N., Jr., Thigpen, B. D., Moore, R., Rose, C. H., Cushman, J., & May, W. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000151116.84113.56 · Cited by 504
Epidemiology of preeclampsia and eclampsia in the United States, 1979-1986
Saftlas, A. F., Olson, D. R., Franks, A. L., Atrash, H. K., & Pokras, R. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)91176-d · Cited by 503
Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy
Magee, L. A., Pels, A., Helewa, M. E., Rey, É., & von Dadelszen, P. (2014) · Pregnancy Hypertension · doi:10.1016/j.preghy.2014.01.003 · Cited by 489
Self-citationThe confidential enquiry into maternal and child health (CEMACH)
Weindling, A. M. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.12.1034 · Cited by 483
Oral beta-blockers for mild to moderate hypertension during pregnancy
Magee, L. A., & Duley, L. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002863 · Cited by 228
Self-citationTreatment blood pressure targets for hypertension
Arguedas, J. A., Perez, M. I., & Wright, J. M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004349.pub2 · Cited by 207
von Dadelszen, P., & Magee, L. A. (2002) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)30592-8 · Cited by 137
Self-citationThe Control of Hypertension In Pregnancy Study pilot trial
Magee, L. A., von Dadelszen, P., Chan, S., Gafni, A., Gruslin, A., Helewa, M. E., Hewson, S. A., Kavuma, E., Lee, S. K., Logan, A. G., et al. (2007) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2007.01315.x · Cited by 83
Self-citationThe Importance of Nonproteinuric Hypertension in Pregnancy
Brown, M. A., & Buddie, M. L. (1995) · Hypertension in Pregnancy · doi:10.3109/10641959509058051 · Cited by 61
Control of hypertension in pregnancy
Magee, L. A., Abalos, E. J., von Dadelszen, P., Sibai, B. M., & Walkinshaw, S. A. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0073-y · Cited by 37
Self-citationPrediction of Adverse Maternal Outcomes in Preeclampsia
von Dadelszen, P., Payne, B. A., Li, J., Ansermino, J. M., Pipkin, F. B., Côté, A., Douglas, M. J., Gruslin, A., Hutcheon, J. A., Joseph, K. S., et al. (2012) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000410808.61878.a4 · Cited by 36
Self-citationThompson, S. G., Warn, D. E., & Turner, R. (2003) · Statistics in Medicine · doi:10.1002/sim.1567 · Cited by 27
guindy, A. E. A.-A. E., & Nabhan, A. F. (2008) · Journal of Perinatal Medicine · doi:10.1515/jpm.2008.060 · Cited by 23
Flagged first, then by citations
1 of the 23 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Abalos E, 2014, Cochrane Database Syst Rev, 2, CD002252
- Magee LA, 2003, Cochrane Database Syst Rev, CD002863
- Arguedas JA, 2009, Cochrane Database Syst Rev, CD004349
Cited by
Sorted by citations
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
2024 ESC Guidelines for the management of elevated blood pressure and hypertension
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae178 · Cited by 2,298
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
Metadata
- Authors
- Magee, L. A., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., Murphy, K. E., Menzies, J., Sanchez, J., Singer, J., Gafni, A., Gruslin, A., Helewa, M., Hutton, E., Lee, S. K., Lee, T., Logan, A. G., Ganzevoort, W., Welch, R., Thornton, J. G., & Moutquin, J.-M.
- Affiliations
- University of British Columbia (CA)
- University of Alberta (CA)
- University of Toronto (CA)
- McMaster University (CA)
- University of Ottawa (CA)
- University of Manitoba (CA)
- University of Amsterdam (NL)
- Derriford Hospital (GB)
- University of Nottingham (GB)
- Université de Sherbrooke (CA)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-01-29
- Volume
- 372
- Issue
- 5
- Pages
- 407-417
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2135528524
- Cited by
- 672
- References
- 23
- Citations by year
- 2026: 37 · 2025: 52 · 2024: 47 · 2023: 67 · 2022: 76 · 2021: 56 · 2020: 56 · 2019: 65 · 2018: 74 · 2017: 57 · 2016: 52 · 2015: 31
- FWCI
- 81.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (publishedVersion, other-oa)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Nottingham ePrints (University of Nottingham) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Funders
- Canadian Institutes of Health Research (87522_1)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- hypertension in pregnancy, blood pressure control, tight blood pressure control, gestational hypertension, pre-existing hypertension, miscarriage, neonatal intensive care, maternal complications, severe hypertension in pregnancy, antihypertensive therapy, postpartum complications, preeclampsia, eclampsia
- MeSH terms
- Abortion, Spontaneous, Adult, Antihypertensive Agents, Blood Pressure, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Puerperal Disorders, Intensive Care, Neonatal, Hypertension, Pregnancy-Induced, Perinatal Death
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
