The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Age of Transfused Blood in Critically Ill Adults
Open accessAbstract
BACKGROUND: Fresh red cells may improve outcomes in critically ill patients by enhancing oxygen delivery while minimizing the risks of toxic effects from cellular changes and the accumulation of bioactive materials in blood components during prolonged storage. METHODS: In this multicenter, randomized, blinded trial, we assigned critically ill adults to receive either red cells that had been stored for less than 8 days or standard-issue red cells (the oldest compatible units available in the blood bank). The primary outcome measure was 90-day mortality. RESULTS: Between March 2009 and May 2014, at 64 centers in Canada and Europe, 1211 patients were assigned to receive fresh red cells (fresh-blood group) and 1219 patients were assigned to receive standard-issue red cells (standard-blood group). Red cells were stored a mean (±SD) of 6.1±4.9 days in the fresh-blood group as compared with 22.0±8.4 days in the standard-blood group (P<0.001). At 90 days, 448 patients (37.0%) in the fresh-blood group and 430 patients (35.3%) in the standard-blood group had died (absolute risk difference, 1.7 percentage points; 95% confidence interval [CI], -2.1 to 5.5). In the survival analysis, the hazard ratio for death in the fresh-blood group, as compared with the standard-blood group, was 1.1 (95% CI, 0.9 to 1.2; P=0.38). There were no significant between-group differences in any of the secondary outcomes (major illnesses; duration of respiratory, hemodynamic, or renal support; length of stay in the hospital; and transfusion reactions) or in the subgroup analyses. CONCLUSIONS: Transfusion of fresh red cells, as compared with standard-issue red cells, did not decrease the 90-day mortality among critically ill adults. (Funded by the Canadian Institutes of Health Research and others; Current Controlled Trials number, ISRCTN44878718.).
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Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion
Carson, J. L., Stanworth, S. J., Roubinian, N., Fergusson, D. A., Triulzi, D., Doree, C., & Hebert, P. C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002042.pub4 · Cited by 1,250
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2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery
Pagano, D., Milojevic, M., Meesters, M. I., Benedetto, U., Bolliger, D., von Heymann, C., Jeppsson, A., Koster, A., Osnabrugge, R. L., Ranucci, M., et al. (2018) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx325 · Cited by 481
2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery
Boer, C., Meesters, M. I., Milojevic, M., Benedetto, U., Bolliger, D., von Heymann, C., Jeppsson, A., Koster, A., Osnabrugge, R. L., Ranucci, M., et al. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2017.06.026 · Cited by 466
Metadata
- Authors
- Lacroix, J., Hébert, P. C., Fergusson, D. A., Tinmouth, A., Cook, D. J., Marshall, J. C., Clayton, L., McIntyre, L., Callum, J., Turgeon, A. F., Blajchman, M. A., Walsh, T. S., Stanworth, S. J., Campbell, H., Capellier, G., Tiberghien, P., Bardiaux, L., van de Watering, L., van der Meer, N. J., Sabri, E., & Vo, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-04-09
- Volume
- 372
- Issue
- 15
- Pages
- 1410-1418
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2151125432
- Cited by
- 552
- References
- 30
- FWCI
- 64.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lacroix, J., Hébert, P. C., Fergusson, D. A., Tinmouth, A., Cook, D. J., Marshall, J. C., Clayton, L., McIntyre, L., Callum, J., Turgeon, A. F., Blajchman, M. A., Walsh, T. S., Stanworth, S. J., Campbell, H., Capellier, G., Tiberghien, P., Bardiaux, L., van de Watering, L., van der Meer, N. J., . . . Vo, D. (2015). Age of Transfused Blood in Critically Ill Adults. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1500704
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
