Cited by 1,012Statistical Methods in Clinical TrialsStatistical Methods in EpidemiologyProbability and Statistical Research

Introduction to sample size determination and power analysis for clinical trials

Lachin, John M.·1981·Controlled Clinical Trials

Abstract

The importance of sample size evaluation in clinical trials is reviewed and a general method is presented from which specific equations are derived for sample size determination or the analysis of power for a wide variety os statistical procedures. The method is discussed and illustrated in relation to the t test, tests for proportions, tests of survival time, and tests for correlations as they commonly occur in clinical trials. Most of the specific equations reduce to a simple general form for which tables are presented.

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Crossref · 10.1016/0197-2456(81)90001-5

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Authors
Lachin, J. M.
Affiliations
George Washington University (US)
Corresponding author
Lachin, John M.
Venue
Controlled Clinical Trials
Publisher
Elsevier BV
Published
1981-06
Volume
2
Issue
2
Pages
93-113
ISSN
0197-2456 (ISSN-L)
OpenAlex
W1997182468
Cited by
1,012
References
25
Citations by year
2026: 13 · 2025: 27 · 2024: 37 · 2023: 21 · 2022: 24 · 2021: 32 · 2020: 23 · 2019: 33 · 2018: 25 · 2017: 30 · 2016: 30 · 2015: 38 · 2014: 35 · 2013: 27 · 2012: 23
FWCI
13.44
Type
journal article
Language
en
Open access
closed
Locations
  • Controlled Clinical Trials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
  • Physical Sciences › Mathematics › Statistics and Probability › Probability and Statistical Research
Keywords
sample size determination, statistical power, clinical trials, t-test, survival analysis, correlation test, statistical tables
MeSH terms
Clinical Trials as Topic, Research Design, Sampling Studies, Statistics as Topic

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