Cited by 648Nonmelanoma Skin Cancer StudiesSkin Protection and AgingHead and Neck Cancer Studies

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

Chen, Andrew C., Martin, Andrew J., Choy, Bonita, Fernández-Peñas, Pablo, Dalziell, Robyn A., McKenzie, Catriona A., Scolyer, Richard A., Dhillon, Haryana M., Vardy, Janette L., Kricker, Anne, St. George, Gayathri, Chinniah, Niranthari, Halliday, Gary M., Damian, Diona L.·2015·New England Journal of Medicine

DOI 10.1056/nejmoa1506197

Open this paper in CoChat — free account

Abstract

BACKGROUND: Nonmelanoma skin cancers, such as basal-cell carcinoma and squamous-cell carcinoma, are common cancers that are caused principally by ultraviolet (UV) radiation. Nicotinamide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses. METHODS: In this phase 3, double-blind, randomized, controlled trial, we randomly assigned, in a 1:1 ratio, 386 participants who had had at least two nonmelanoma skin cancers in the previous 5 years to receive 500 mg of nicotinamide twice daily or placebo for 12 months. Participants were evaluated by dermatologists at 3-month intervals for 18 months. The primary end point was the number of new nonmelanoma skin cancers (i.e., basal-cell carcinomas plus squamous-cell carcinomas) during the 12-month intervention period. Secondary end points included the number of new squamous-cell carcinomas and basal-cell carcinomas and the number of actinic keratoses during the 12-month intervention period, the number of nonmelanoma skin cancers in the 6-month postintervention period, and the safety of nicotinamide. RESULTS: At 12 months, the rate of new nonmelanoma skin cancers was lower by 23% (95% confidence interval [CI], 4 to 38) in the nicotinamide group than in the placebo group (P=0.02). Similar differences were found between the nicotinamide group and the placebo group with respect to new basal-cell carcinomas (20% [95% CI, -6 to 39] lower rate with nicotinamide, P=0.12) and new squamous-cell carcinomas (30% [95% CI, 0 to 51] lower rate, P=0.05). The number of actinic keratoses was 11% lower in the nicotinamide group than in the placebo group at 3 months (P=0.01), 14% lower at 6 months (P<0.001), 20% lower at 9 months (P<0.001), and 13% lower at 12 months (P=0.001). No noteworthy between-group differences were found with respect to the number or types of adverse events during the 12-month intervention period, and there was no evidence of benefit after nicotinamide was discontinued. CONCLUSIONS: Oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients. (Funded by the National Health and Medical Research Council; ONTRAC Australian New Zealand Clinical Trials Registry number, ACTRN12612000625875.).

Integrity signals

Registry

Crossref · 10.1056/nejmoa1506197

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A systematic review of worldwide incidence of nonmelanoma skin cancer
Lomas, A., Leonardi‐Bee, J., & Bath-Hextall, F. J. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10830.x · Cited by 1,943
The epidemiology of UV induced skin cancer
Armstrong, B. K., & Kricker, A. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00198-1 · Cited by 1,811
Self-citation
Cutaneous Squamous-Cell Carcinoma
Alam, M., & Ratner, D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441306 · Cited by 1,311
Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial
Green, A., Williams, G., Nèale, R., Hart, V., Leslie, D., Parsons, P., Marks, G. C., Gaffney, P., Battistutta, D., Frost, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12168-2 · Cited by 976
Prevalence and Costs of Skin Cancer Treatment in the U.S., 2002−2006 and 2007−2011
Guy, G. P., Machlin, S. R., Ekwueme, D. U., & Yabroff, K. R. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.08.036 · Cited by 871
Reduced melanoma after regular sunscreen use: randomized trial follow-up
Green, A. C., Williams, G. M., Logan, V., & Strutton, G. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.7078 · Cited by 799
Reduction of Solar Keratoses by Regular Sunscreen Use
Thompson, S., Jolley, D., & Marks, R. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310143291602 · Cited by 782
Basal-Cell Carcinoma
Rubin, A. I., Chen, E. H., & Ratner, D. (2005) · New England Journal of Medicine · doi:10.1056/nejmra044151 · Cited by 772
Prevention of Skin Cancer in Xeroderma Pigmentosum with the Use of Oral Isotretinoin
Kraemer, K. H., DiGiovanna, J. J., Moshell, A. N., Tarone, R. E., & Peck, G. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806233182501 · Cited by 574
Safety of high-dose nicotinamide: a review
Knip, M., Douek, I. F., Moore, W. P. T., Gillmor, H. A., McLean, A. E. M., Bingley, P. J., & Gale, E. A. M. (2000) · Diabetologia · doi:10.1007/s001250051536 · Cited by 423

Flagged first, then by citations

Show all 38 references

1 of the 38 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

Yarosh DB, 2004, Cutis, 74, 10
Moon TE, 1997, Cancer Epidemiol Biomarkers Prev, 6, 949
Marquez C, 2010, J Drugs Dermatol, 9, 753
Shuttleworth D, 1988, Q J Med, 68, 717

Sorted by citations

Items 501–600 of 646

Skin Cancer: Prevention and Early Detection
Sanghvi, A. R. (2025) · Springer eBooks · doi:10.1007/978-3-032-00775-9_332 · Cited by 1
Neue Ansätze zur Prävention aktinischer Keratosen
Stege, H., & Krutmann, J. (2017) · Der Hautarzt · doi:10.1007/s00105-017-3980-x · Cited by 1
Nicotinamide for prevention of nonmelanoma skin cancers: a change in practice?
Nestor, L. A., Clowry, J., Molloy, K., Connolly, M., Salim, A., & Tobin, A. (2017) · Clinical and Experimental Dermatology · doi:10.1111/ced.13244 · Cited by 1
Risk Stratification: Should All Actinic Keratoses in All Patients Be Treated?
Ruiz, E. S., & Schmults, C. D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0217-x · Cited by 1
Skin Health and Healthy Aging: Skin Disease
Kelsey, A., Parikh, S. A., Finch, J. J., & Grant-Kels, J. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-06200-2_11 · Cited by 1
Prise en charge thérapeutique des kératoses actiniques
Herms, F. (2019) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(19)30202-9 · Cited by 1
Plattenepithelkarzinom der Haut
Meiwes, A., & Leiter, U. (2019) · Der Onkologe · doi:10.1007/s00761-019-0620-3 · Cited by 1
Therapiespektrum wird größer
Bradfisch, F., Henning, B., Lang, B. M., & Grabbe, S. (2019) · Der Deutsche Dermatologe · doi:10.1007/s15011-019-2704-1 · Cited by 1
Cutaneous Disease in Kidney Transplantation Patients
Marano, A. L., Hooten, J. N., & Myers, S. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-53186-3.00034-6 · Cited by 1
The Skin, Selected Dermatologic Conditions, and Medical Nutrition Therapy
Stone, P. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-30730-1_52 · Cited by 1
Quality of clinical trials for the prevention of keratinocyte cancer
Morales‐Sánchez, M. A., Barragán‐Dessavre, M., Peralta‐Pedrero, M. L., Quezada‐Morales, R. P., & Cruz, F. J. (2020) · International Journal of Dermatology · doi:10.1111/ijd.14903 · Cited by 1
Complementary and Alternative Medicine and Dermatooncology
Zafar, F. S., & Lio, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-53437-0_12 · Cited by 1
Kutanes Plattenepithelkarzinom
Leiter, U., Gutzmer, R., Alter, M., Ulrich, C., Lonsdorf, A. S., Sachse, M., & Hillen, U. (2017) · Der Onkologe · doi:10.1007/s00761-017-0185-y · Cited by 1
Management of skin cancer in the elderly
Ali, F. R., & Craythorne, E. E. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.03.007 · Cited by 1
Rice
Nealon, N. J., & Ryan, E. P. (2019) · Wiley eBooks · doi:10.1002/9781119129486.ch4 · Cited by 1
Chemoprevention Trials
Kadakia, K. C., Matusz‐Fisher, A., & Kim, E. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.96067-7 · Cited by 1
Long-Term Complications of Kidney Transplantation
Edwards, A. R., & Ibrahim, H. N. (2022) · Nephrology Self-Assessment Program · doi:10.1681/nsap.00252022 · Cited by 1
Nicotinylation is a histone mark generated from the nicotinic acid metabolite nicotinyl-CoAPreprint
Zhang, H., Jiang, Y., Li, Y., Zhang, L., Yan, H., Qin, Z., Li, Q., Peng, Y., Liu, J., Weng, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4384441/v1 · Cited by 2
Nicotinamide chemoprevention trial success
Shipman, L. (2015) · Nature reviews. Cancer · doi:10.1038/nrc4049
Chemoprevention of basal cell carcinoma: reply from authors
Hoorens, I., & Brochez, L. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14945
Genetics, Nutrition, and Skin
Norman, R. A., Sanghvi, A., & Barksdale, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-41088-3_8
Die Prävention und Therapie Aktinischer Keratosen
Gollnick, H. P. M. (2017) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-017-9045-3
Cancer After Kidney Transplantation
Snanoudj, R., Dantal, J., Lebbé, C., & Legendre, C. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801734-0.00037-0
A Patient With CKD Develops Cholestatic Liver Injury During a Clinical Trial
Wagener, E. D. A., Souma, N., Hodakowski, A. J., Martinez, C., Fox, P., Mehta, R. C., O’Brien, M. J., Bolon, M. K., Kulik, L., Yang, G., et al. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.07.012
“Another study found NAM to be effective in reducing new nonmelanoma skin cancers and actinic keratosis in high-risk patients, and it reported no harmful adverse effects of NAM administration.(17) The doses of NAM studied in these trials were similar to those administered in the COMBINE study.”
Result
Management of Actinic Keratosis
Bhatia, N. D. (2017) · Current Dermatology Reports · doi:10.1007/s13671-017-0206-5
Skin, Vision, and Hearing
Seidel, I., & Sevier, J. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190466268.003.0024
Cutaneous Carcinogenesis in Organ Transplant Recipients
Yuan, J. T., Twigg, A. R., & Arron, S. T. (2019) · Springer eBooks · doi:10.1007/978-3-030-02023-1_60
Systemic Drugs Used in Dermatology
Novice, K., & Pritchett, E. (2019) · Springer eBooks · doi:10.1007/978-3-030-18015-7_10
Epidemiologic studies of cancers of the skin
Dusingize, J. C. (2019) · The University of Queensland · doi:10.14264/uql.2019.970
Is nicotinamide a sustainable therapy for resistant actinic keratoses?
Paugam, C., & Dréno, B. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16501
FR - Prevención farmacológica del cáncer cutáneo no-melanoma en pacientes de alto riesgo
Bosch‐Amate, X., Morgado‐Carrasco, D., & Martínez, N. (2020) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2019.01.016
Is oral nicotinamide effective for prevention of skin cancer?
Rivich, J., & Thompson, A. (2018) · Evidence-Based Practice · doi:10.1097/ebp.0000000000000037
Skin Cancer, Back to Basics
Davis, K. E. (2020) · Journal of the Dermatology Nurses’ Association · doi:10.1097/jdn.0000000000000576
“Unfortunately, this chemopreventive effect was lost after discontinuation of the supplement (Chen et al., 2015).”
BackgroundInfluential
Estrategias farmacológicas y no farmacológicas para la prevención del cáncer cutáneo no melanoma
Morgado‐Carrasco, D., Piquero‐Casals, J., & Bosch‐Amate, X. (2021) · Piel · doi:10.1016/j.piel.2020.10.016 · Cited by 1
“A los 6 meses postratamiento ya no se observaba este efecto protector 56 .”
RF - Pharmacological Prevention of Nonmelanoma Skin Cancer in High-Risk Patients
Bosch‐Amate, X., Morgado‐Carrasco, D., & Martínez, N. (2020) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2019.01.023
The use of photodynamic therapy in combined treatment of actinic keratosis
Małkińska, K., Bartosińska, J., Kwaśny, M., & Krasowska, D. (2020) · Dermatology Review · doi:10.5114/dr.2020.103889
Surgical Approach to Cutaneous Malignancy with Systemic Implications
Richey, P. M., & Ferguson, N. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-53437-0_5
Guarding against nonmelanoma skin cancer in solid organ transplant recipients
Morris (2021) · The Journal of Family Practice · doi:10.12788/jfp.0172
“Efficacy has been demonstrated in reducing development of new AKs and cSCC in immunocompetent patients with a history of more than 2 keratinocyte carcinomas within a 5-year span.(27,35) Nicotinamide is especially relevant to the SOTR population because it reduces the level of cutaneous immunity suppression induced by…”
Background
Chemoprevention of Keratinocyte Carcinomas
Lucero, O. M., Zwald, F. O., & Lambert, D. (2021) · Springer eBooks · doi:10.1007/978-3-030-50593-6_21
Diagnosis and Management of Intraoral Epithelial Dysplasia
Pogrel, M. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-69852-2_3
Die Kopfhaut im Alter: Ein dermatoonkologischer Schwerpunktbereich
Wroblewski, N., Wylon, K., & Ulrich, C. (2017) · Der Hautarzt
The Systemic Exclusion of Native Americans from Cancer Clinical Trials
Cayatineto, H. W., Clyde, C. S., Yazzie, G. A., Selassie, G., & de Soto, J. A. (2021) · Research Review · doi:10.52845/jmrhs/2021-4-8-4
Actinic keratoses: The latest in therapy
Berman, B., & Berman, D. K. (2021) · Dermatological Reviews · doi:10.1002/der2.96
“Unfortunately, there was no evidence of continued benefit after the nicotinamide was discontinued.(5)”
Background
Manejo de las queratosis actínicas y del campo de cancerización cutáneo
Morgado‐Carrasco, D., Piquero‐Casals, J., & de Castañeda, P. A. R. (2021) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2020.10.015
Avaliação da eficácia do 5‐fluorouracil 5% tópico intermitente e da nicotinamida oral no tratamento do campo de cancerização cutâneo: um ensaio clínico randomizado
Ferreira, E. R., Miola, A. C., Lima, T. R. R., Schmitt, J. V., Abbade, L. P. F., & Miot, H. A. (2021) · doi:10.1016/j.abdp.2021.09.012
Lamento ante la supresión de "Archivos Leoneses"
Neira, D. Y. (1996) · Archivos Leoneses: revista de estudios y documentación de los Reinos Hispano-Occidentales
Standard English and Nonstandard Dialects: Elements of Syntax.
Politzer, R. L., & Bartley, D. E. (1969)
Rhetoric: Save Their Lives, Save Their Futures
Cervantes, L. W. (2011) · DigitalCommons - CalPoly (California State Polytechnic University)
Aktuelles Management des Basalzellkarzinoms
Krieter, M., & Schultz, E. S. (2021) · Aktuelle Dermatologie · doi:10.1055/a-1487-3853
Melanoma Prevention
Orrin, E., Cassidy, P. B., Kulkarni, R. P., Berry, E., & Leachman, S. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-82639-0_1 · Cited by 1
Andere Tumoren
Heinzerling, L., Hartmann, A., & Hund, M. (2019) · Springer eBooks · doi:10.1007/978-3-662-58012-7_4
Nicotinamide and Nonmelanoma Skin Cancers
Jamison, A., & Malhotra, R. (2022) · Ophthalmic Plastic and Reconstructive Surgery · doi:10.1097/iop.0000000000002133
Interventions for preventing keratinocytic cancer in patients with a history of a previous keratinocytic carcinoma: A systematic review
García-Alonso, M. J., Peralta‐Pedrero, M. L., Cruz, F. J., & Morales‐Sánchez, M. A. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16225
Photoprotection
Warren, L. J., & Casey, G. (2019) · Wiley eBooks · doi:10.1002/9781119142812.ch79 · Cited by 1
Management of Skin Cancers in Solid Organ Transplant Recipients
Lederhandler, M. H., Stevenson, M. L., & Carucci, J. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-50593-6_17
Scientific surgery
(2015) · British journal of surgery · doi:10.1002/bjs.10078
Tumores epidérmicos
Millan, G. G., & López‐Bran, E. (2018) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2017.12.008
Field Cancerization in Dermatology: Updates on Treatment Considerations and Emerging Therapies
Chen, A. (2022) · Cutis · doi:10.12788/cutis.0510
Self-citation
Dermatology in Kidney Disease
Ismail, F., & Anand, R. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-76419-7_40
Sonnenschutz der Zukunft: Herausforderungen und Möglichkeiten
Wolf, P., & Krutmann, J. (2022) · hautnah · doi:10.1007/s12326-022-00520-7
Disparities of Cutaneous Malignancies in the US Military
Patel (2022) · Cutis · doi:10.12788/cutis.0614
Leveraging statistical genetics approaches to explore skin cancer risk, prediction, causation and survival
Seviiri, M. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.236969
Epitheliale Tumore im Kopf-Hals-Bereich
Gesierich, A., & Schilling, B. (2022) · Springer eBooks · doi:10.1007/978-3-662-62808-9_9
Dermatochirurgie – von der operativen Alternative zum integralen Bestandteil der dermatologischen Therapie
Hafner, J., Löser, C. R., & Roka, F. (2023) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15048_g
Skin Cancer Chemoprevention for Solid Organ Transplant Recipients - The Search Continues
Kaufman, H. L., Patel, V. A., Shalhout, S. Z., Ear, M. E. A., Gupta, S., Ear, M. E. A., Cohen, S., Brownell, I., & Miller, D. M. (2023) · Journal of Cutaneous Oncology · doi:10.59449/joco.2023.03.22
Frühjahrsmüdigkeit
Weninger, W. (2023) · hautnah · doi:10.1007/s12326-023-00586-x
Neuroprotection and neuroenhancement
Gillmann, K., & Goldberg, J. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88442-6.00014-5
Cutaneous Malignancies in the Immunocompromised Patient
de Oliveira, W. R. P., Pincelli, M. S., Miotto, I. Z., & Corrêa, P. Y. S. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-29277-4_24
Basal Cell Carcinoma
Awni, B. M., Ferrer, S. M. R., Molina, A. S., Fugimori, M. L., Sahade, M., Munhoz, R. R., & Abdalla, C. M. Z. (2023) · Springer eBooks · doi:10.1007/978-3-031-29277-4_14
Actinic Keratosis, Other Precursors, and Squamous Cell Tumors
Abdalla, C. M. Z., Bakos, R. M., de Lima, L. G. C. A., Abdalla, B. M. Z., Tovo, L. F. R., Belfort, F. A., & Munhoz, R. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-29277-4_13
Aktuelles Management des Basalzellkarzinoms
Krieter, M., & Schultz, E. S. (2023) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1958-2603
Nicotinamide for skin cancer chemoprevention in transplant recipients: a critically appraised topic
Riddle, A. O., & Jambusaria‐Pahlajani, A. (2023) · British Journal of Dermatology · doi:10.1093/bjd/ljad318
Basal Cell Carcinoma
Papakostas, D., & Stockfleth, E. (2023) · Springer eBooks · doi:10.1007/978-3-031-15130-9_9
NAD+ Metabolism-Related Gene Profile Can Be a Relevant Source of Squamous Cell Carcinoma Biomarkers
Minafò, Y. A., Antonini, D., & Dellambra, E. (2024) · Cancers · doi:10.3390/cancers16020309
“Clinical trials indicate that NAM oral administration displays chemopreventive effects against skin SCC development and recurrence in high-risk immunocompetent [13] and in immunocompromised patients [14].”
Background
Predicting Tacrolimus Concentrations in the Skin of Adult Kidney Transplant Recipients: A Feasibility Study
Sartain, F. K., Viecelli, A. K., Veitch, M., Franklin, M. E., Dymock, B. W., Wells, J. W., & Campbell, S. B. (2024) · Transplant International · doi:10.3389/ti.2024.12019
Dermatological Manifestations of Metal Poisoning
Nambi, R. (2024) · doi:10.1002/9781119709268.rook120
Skin Cancer in the Immunocompromised Patient
Harwood, C. A., Matin, R., & Proby, C. M. (2024) · doi:10.1002/9781119709268.rook147
Skin Aging
Mehta, N., & Gupta, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-0411-8_2
Mikroskopisch kontrolliert exzidieren
Persa, O. (2024) · Deutsche Dermatologie · doi:10.1007/s15011-024-6525-5
Sunscreens—Where are we now?
Gao, D. X., Lim, H. W., & Mohammad, T. F. (2024) · Dermatological Reviews · doi:10.1002/der2.230
“55 Polypodium leucotomos extract has also demonstrated antioxidant, anti ‐ inflammatory, and immunomodulatory properties.”
Background
Carcinoma escamoso cutáneo en pacientes trasplantados de órgano sólido: revisión de la literatura
Oteiza‐Rius, I., Morelló‐Vicente, A., & Gil, L. A. (2024) · Medicina Clínica · doi:10.1016/j.medcli.2024.05.005
Therapie bei malignen Lidtumoren
Bergua, A. (2024) · Springer Reference Medizin · doi:10.1007/978-3-662-65929-8_165-1
Squamous cell carcinoma in solid organ transplant recipients: Review of the literature
Oteiza‐Rius, I., Morelló‐Vicente, A., & Gil, L. A. (2024) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2024.05.024
The state of cancer care in Russia: malignant tumors of the skin (C44). One- and five-years survival of patients, age characteristics. Part II
Vm, M., Демидов, Л. В., Belyaev, А. М., Гафтон, Г. И., Samoilenko, I. V., & Perelygin, V. V. (2024) · Pharmacy Formulas · doi:10.17816/phf641607
A new frontier in drug discovery for skin cancer through electronic medical records
Dousset, L., & Khosrotehrani, K. (2024) · British Journal of Dermatology · doi:10.1093/bjd/ljae489
Long-Term Complications of Kidney Transplantation
Hebert, S. A., & Ibrahim, H. N. (2024) · Nephrology Self-Assessment Program · doi:10.58483/nsap.00522024
Neue Möglichkeiten zur Optimierung der Behandlung
Kuchner, M., Schmitz, L., & Dirschka, T. (2025) · Deutsche Dermatologie · doi:10.1007/s15011-025-6813-8
Systematic Review on Dietary Supplements in the Prevention and/or Treatment of Actinic Keratosis and Field Cancerization
Rodríguez-Luna, A., Zamarrón, A., Longo, C., Pellacani, G., Peris, K., Calzavara‐Pinton, P., de Galvez, M. V., Gilaberte, Y., de Troya-Martín, M., Juarranz, Á., et al. (2025) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2024.12.019
[Artículo traducido] Revisión sistemática sobre suplementos dietéticos en la prevención y/o tratamiento de la queratosis actínica y el campo de cancerización
Rodríguez-Luna, A., Zamarrón, A., Longo, C., Pellacani, G., Peris, K., Calzavara-Pinton, P., de Galvez, M. V., Gilaberte, Y., de Troya-Martín, M., Juarranz, Á., et al. (2025) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2025.04.001
Chemoprevention of Keratinocyte Cancers: Could Aspirin Be the Solution?
Hiscutt, E. L., Orchard, S. G., Wolfe, R. S., & Mar, V. (2025) · Journal of Cancer Prevention · doi:10.15430/jcp.25.007
Therapie bei malignen Lidtumoren
Bergua, A. (2025) · Springer Reference Medizin · doi:10.1007/978-3-662-65823-9_165
[Translated article] An Overview of Actinic Keratoses: Understanding Etiology, Diagnosis, and Treatment Approaches
Cañueto, J., Turrión, L., & Ferrándiz‐Pulido, C. (2025) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2025.05.015
Bioinformatics-based analysis of nicotinamide adenine dinucleotide metabolism-related genes to predict immune status and prognosis for head and neck squamous cell carcinoma patients
Guan, Z., Gu, X., & Zheng, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1609175
“Clinical trials demonstrate that the oral administration of NAM exhibits chemopreventive properties in the development and recurrence of skin squamous cell carcinoma among both high-risk immunocompetent individuals and those with compromised immune systems (77, 78).”
Systemic Associations of Eyelid Tumors
Kapoor, S., Traboulsi, E. I., & Singh, A. D. (2025) · doi:10.1093/med/9780197659403.003.0056
Nonmelanoma Skin Cancers
Lizalek, J., & Santamaria‐Barria, J. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-88954-7_12
Special Considerations for Mohs Micrographic Surgery in Organ Transplant Recipients
Algarin, Y. A., Collins, L. K., Stasko, T., & Christiansen, D. L. (2025) · Springer eBooks · doi:10.1007/978-3-031-82552-1_27
Long-Term Complications in Heart Transplantation
Stern, L. K., Kransdorf, E. P., & Manla, Y. (2025) · Springer eBooks · doi:10.1007/978-3-031-88290-6_22
Safety and Preliminary Effectiveness of a Natural, Multi-modal Therapeutic in Postmenopausal Women with ObesityPreprint
Thompson, T., Tanwar, V., Hoskinson, W., Peterson, K. R., SOTHERN, M. S., McKibbin, C. L., Missikpode, C., Kapahi, P., & Dhar, S. (2025) · medRxiv · doi:10.1101/2025.09.04.25335119
Nicotinamide Promotes Apoptosis in Malignant Melanoma via PARP1 Inhibition and Mitochondrial Pathway Activation
Yu, Y., Ni, Z., Ge, B., & Zhou, J. (2025) · Journal of Cellular Biochemistry · doi:10.1002/jcb.70064
“Its effectiveness has been widely validated in the treatment of dermatological diseases such as bullous pem-phigoid [15], acne [16], and certain types of cancers [17, 18].”
The evolving role of immune checkpoint inhibitors in cutaneous squamous cell carcinoma: Across the disease spectrum
Ladwa, R., McLean, L. S., McGrath, M. E., & Liu, J. (2025) · EJC Skin Cancer · doi:10.1016/j.ejcskn.2025.100767

Authors: Chen, A. C., Martin, A. J., Choy, B., Fernández-Peñas, P., Dalziell, R. A., McKenzie, C. A., Scolyer, R. A., Dhillon, H. M., Vardy, J. L., Kricker, A., St. George, G., Chinniah, N., Halliday, G. M., & Damian, D. L.
Affiliations: The University of Sydney (AU)
ORCID: Chen, Andrew C.
Martin, Andrew J.
McKenzie, Catriona A.
Scolyer, Richard A.
Dhillon, Haryana M.
Vardy, Janette L.
Kricker, Anne
Halliday, Gary M.
Damian, Diona L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2015-10-22
Volume: 373
Issue: 17
Pages: 1618-1626
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1506197
OpenAlex: W1852538637
Cited by: 648
References: 38
Citations by year: 2026: 53 · 2025: 66 · 2024: 59 · 2023: 74 · 2022: 61 · 2021: 75 · 2020: 55 · 2019: 57 · 2018: 49 · 2017: 51 · 2016: 38 · 2015: 4
FWCI: 37.14
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords: nicotinamide, nicotinic acid, skin cancer chemoprevention, non-melanoma skin cancer, basal cell carcinoma, squamous cell carcinoma, actinic keratosis, ultraviolet radiation, UV-induced DNA damage, NADPH oxidase, NADPH oxidase inhibitors, adverse events, drug safety, recurrence prevention, long-term follow-up
MeSH terms: Adult, Aged, Aged, 80 and over, Basal Cell Carcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Double-Blind Method, Female, Humans, Male, Middle Aged, Niacinamide, Skin Neoplasms, Vitamin B Complex, Secondary Prevention, Keratosis, Actinic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks