Cited by 799Skin Protection and AgingCutaneous Melanoma Detection and Managementmelanin and skin pigmentation

Reduced melanoma after regular sunscreen use: randomized trial follow-up

Open access
Green, Adèle C., Williams, Gail M., Logan, Valerie, Strutton, Geoffrey M.·2011·Journal of Clinical Oncology

Abstract

Purpose: Regular sunscreen use prevents cutaneous squamous cell carcinoma long term, but the effect on melanoma is highly controversial. We evaluated whether long-term application of sunscreen decreases risk of cutaneous melanoma. Participants and Methods: In 1992, 1,621 randomly selected residents of Nambour, a township in Queensland, Australia, age 25 to 75 years, were randomly assigned to daily or discretionary sunscreen application to head and arms in combination with 30 mg beta carotene or placebo supplements until 1996. Participants were observed until 2006 with questionnaires and/or through pathology laboratories and the cancer registry to ascertain primary melanoma occurrence. Results: Ten years after trial cessation, 11 new primary melanomas had been identified in the daily sunscreen group, and 22 had been identified in the discretionary group, which represented a reduction of the observed rate in those randomly assigned to daily sunscreen use (hazard ratio [HR], 0.50; 95% CI, 0.24 to 1.02; P = .051). The reduction in invasive melanomas was substantial (n = 3 in active v 11 in control group; HR, 0.27; 95% CI, 0.08 to 0.97) compared with that for preinvasive melanomas (HR, 0.73; 95% CI, 0.29 to 1.81). Conclusion: Melanoma may be preventable by regular sunscreen use in adults.

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Crossref · 10.1200/jco.2010.28.7078

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Authors
Green, A. C., Williams, G. M., Logan, V., & Strutton, G. M.
Affiliations
The University of Queensland (AU)
Venue
Journal of Clinical Oncology
Published
2011-01-20
Volume
29
Issue
3
Pages
257-263
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
OpenAlex
W2110372729
Cited by
799
References
4
Citations by year
2026: 31 · 2025: 39 · 2024: 51 · 2023: 49 · 2022: 39 · 2021: 50 · 2020: 60 · 2019: 60 · 2018: 63 · 2017: 50 · 2016: 53 · 2015: 59 · 2014: 53 · 2013: 38 · 2012: 55
FWCI
54.55
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Clinical Oncology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
sunscreen use, cutaneous melanoma, melanoma prevention, beta-carotene supplementation, sun protection, invasive melanoma, long-term follow-up
MeSH terms
Adult, Aged, Female, Follow-Up Studies, Humans, Male, Melanoma, Middle Aged, Queensland, Skin Neoplasms, Sunscreening Agents, Incidence

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